Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from History in Perspective: The prime pathological players and role of phytochemicals in Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
History in Perspective: How Alzheimer’s disease came to be where it is?
10.1016/j.brainres.2021.147342 · 2021 · External reference
A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Aβ25–35
10.1016/j.bbr.2007.03.001 · 2007 · External reference
The amyloid-β oligomer Aβ* 56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation
10.1126/scisignal.aal2021 · 2017 · External reference
Natural compounds for Alzheimer’s disease therapy: a systematic review of preclinical and clinical studies
10.3390/ijms20092313 · 2019 · External reference
Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease
10.1111/jnc.14033 · 2017 · External reference
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
10.1038/nrn2194 · 2007 · External reference
Lipid peroxidation-derived aldehydes, 4-hydroxynonenal and malondialdehyde in aging-related disorders
10.3390/antiox7080102 · 2018 · External reference
Nuclear factor-κB dysregulation and α-synuclein pathology: critical interplay in the pathogenesis of Parkinson’s disease
10.3389/fnagi.2020.00068 · 2020 · External reference
Current status on Alzheimer disease molecular genetics: from past, to present, to future
10.1093/hmg/ddq142 · 2010 · External reference
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes
10.1016/j.bbr.2011.01.022 · 2011 · External reference
Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease
10.1016/j.febslet.2004.09.011 · 2004 · External reference
Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update
10.1007/s00204-015-1517-6 · 2015 · External reference
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
10.1038/s41583-019-0132-6 · 2019 · External reference
Mitochondrial dysfunction contributes to the pathogenesis of Alzheimer’s disease
10.1155/2015/509654 · 2015 · External reference
Role of RAGE in Alzheimer’s disease
10.1007/s10571-015-0233-3 · 2016 · External reference
The cochaperone BAG2 sweeps paired helical filament-insoluble tau from the microtubule
10.1523/jneurosci.4660-08.2009 · 2009 · External reference
Carnosine prevents Aβ-induced oxidative stress and inflammation in microglial cells: a key role of TGF-β1
10.3390/cells8010064 · 2019 · External reference
Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view
10.1155/2019/2105607 · 2019 · External reference
Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines. Nature communications
10.1038/ncomms2238 · 2012 · External reference
Efficacy of morin as a potential therapeutic phytocomponent: insights into the mechanism of action
2017 · External reference
Cholinesterase inhibitors: a new class of psychotropic compounds
10.1176/ajp.157.1.4 · 2000 · External reference
Phytochemicals in the treatment of Alzheimer’s disease: a systematic review
2017 · External reference
Unresolved reference
2019 · External reference
Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer’s-like dementia: involvement of acetylcholinesterase and cell death
10.1016/j.neuro.2016.10.008 · 2016 · External reference
Mechanisms of free radical-induced damage to DNA
10.3109/10715762.2011.653969 · 2012 · External reference
Targeting of NF-κB to dendritic spines is required for synaptic signaling and spine development
10.1523/jneurosci.2663-16.2018 · 2018 · External reference
Cellular specificity of NF-κB function in the nervous system
10.3389/fimmu.2019.01043 · 2019 · External reference
Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model
10.1016/j.neurobiolaging.2012.02.016 · 2012 · External reference
Alzheimer’s disease as a membrane disorder: Spatial cross-talk among beta-amyloid peptides, nicotinic acetylcholine receptors and lipid rafts
10.3389/fncel.2019.00309 · 2019 · External reference
Functional expression of the capsule polymerase of Neisseria meningitidis serogroup X: a new perspective for vaccine development
10.1093/glycob/cwt102 · 2014 · External reference
Promoting autophagic clearance: viable therapeutic targets in Alzheimer’s disease
10.1007/s13311-014-0320-z · 2015 · External reference
The role of astrocytes in amyloid production and Alzheimer's disease
10.1098/rsob.170228 · 2017 · External reference
Increased nuclear DNA oxidation in the brain in Alzheimer's disease
10.1046/j.1471-4159.1998.71052034.x · 1998 · External reference
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer’s disease and Parkinson’s disease
10.2147/dddt.s130514 · 2017 · External reference
Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer’s disease
10.1016/j.bbr.2015.06.045 · 2015 · External reference
Structural and functional differences between 3-repeat and 4-repeat tau isoforms: implications for normal tau function and the onset of neurodegenerative disease
10.1074/jbc.m007489200 · 2000 · External reference
Oxidized docosahexaenoic acid species and lipid peroxidation products increase amyloidogenic amyloid precursor protein processing
10.1159/000440839 · 2016 · External reference
Neuroprotective effect of trans-resveratrol in mild to moderate Alzheimer disease: a randomized, double-blind trial
10.1007/s40120-021-00271-2 · 2021 · External reference
Cyclooxygenase-2 is critical for the propagation of β-amyloid protein and reducing the glycosylation of tau in Alzheimer’s disease
10.1038/s41423-019-0294-1 · 2019 · External reference
Roles of microglial and monocyte chemokines and their receptors in regulating Alzheimer's disease-associated amyloid-β and tau pathologies
10.3389/fneur.2018.00549 · 2018 · External reference
The up‐regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α
10.1111/j.1471-4159.2008.05858.x · 2009 · External reference
Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic
10.1038/s41582-018-0079-7 · 2018 · External reference
Effects and mechanisms of actions of phytochemicals on Alzheimer’s disease neuropathology
2018 · External reference
Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease
10.1016/j.exger.2017.02.004 · 2017 · External reference
Role of Oxidative Stress in Alzheimer’s Disease
10.3892/br.2016.630 · 2016 · External reference
Tau in Alzheimer disease and related tauopathies
10.2174/156720510793611592 · 2010 · External reference
Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet
10.2337/db11-1498 · 2012 · External reference
Molecular basis of inhibitory activities of berberine against pathogenic enzymes in Alzheimer's disease
10.1100/2012/823201 · 2012 · External reference
Quercetin protects against okadaic acid-induced injury via MAPK and PI3K/Akt/GSK3β signaling pathways in HT22 hippocampal neurons
2016 · External reference
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
10.1038/nature11283 · 2012 · External reference
microRNA dysregulation in neurodegenerative diseases: a systematic review
10.1016/j.pneurobio.2019.101664 · 2019 · External reference
Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis
10.1073/pnas.96.16.9409 · 1999 · External reference
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
10.1038/nrd3505 · 2011 · External reference
Phytochemicals as therapeutic interventions in neurodegenerative diseases
2020 · External reference
1, 8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells: relevance to Alzheimer’s disease
10.1007/s11064-013-1231-9 · 2014 · External reference
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs
10.1074/jbc.m707142200 · 2008 · External reference
Cerebrospinal fluid levels of β-amyloid 40 and β-amyloid 42 are proportionately decreased in amyloid positron-emission tomography negative idiopathic normal-pressure hydrocephalus patients
10.3988/jcn.2019.15.3.353 · 2019 · External reference
Naturally occurring phytochemicals for the prevention of Alzheimer’s disease
10.1111/j.1471-4159.2009.06562.x · 2010 · External reference
l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways
10.1016/j.freeradbiomed.2009.09.008 · 2009 · External reference
Updates on the association of brain injury and Alzheimer’s disease
10.4103/bc.bc_18_20 · 2020 · External reference
Review of beneficial effects of resveratrol in neurodegenerative diseases such as Alzheimer’s disease
10.1016/j.advms.2020.08.002 · 2020 · External reference
Tauopathies
10.1016/b978-0-12-802395-2.00025-0 · 2018 · External reference
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations
10.1152/ajpregu.00327.2006 · 2007 · External reference
Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain
10.1016/j.neurobiolaging.2014.09.025 · 2015 · External reference
Novel Alzheimer disease risk loci and pathways in African American individuals using the African genome resources panel: a meta-analysis
10.1001/jamaneurol.2020.3536 · 2021 · External reference
Alzheimer's disease patients activate attention networks in a short-term memory task
10.1016/j.nicl.2019.101892 · 2019 · External reference
Amyloid-beta peptide detection via aptamer-functionalized nanowire sensors exploiting single-trap phenomena
10.1016/j.bios.2020.112053 · 2020 · External reference
Resveratrol reduces glutamate‐mediated monocyte chemotactic protein‐1 expression via inhibition of extracellular signal‐regulated kinase 1/2 pathway in rat hippocampal slice cultures
10.1111/j.1471-4159.2009.06564.x · 2010 · External reference
Glial contributions to neurodegeneration in tauopathies
10.1186/s13024-017-0192-x · 2017 · External reference
Pterostilbene inhibits amyloid‐β‐induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase‐1 inflammasome pathway
10.1002/jcb.27023 · 2018 · External reference
Natural product 1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
10.1038/s41401-021-00653-0 · 2022 · External reference
Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K/Akt and SIRT1/PGC1α pathway
10.2147/jpr.s185873 · 2019 · External reference
APOE genotype and early β-amyloid accumulation in older adults without dementia
10.1212/wnl.0000000000004336 · 2017 · External reference
Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts
10.1007/s11357-014-9705-5 · 2014 · External reference
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
10.1038/nrneurol.2012.263 · 2013 · External reference
Free radicals, antioxidants and functional foods: Impact on human health
10.4103/0973-7847.70902 · 2010 · External reference
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease
10.1093/nar/gkm821 · 2007 · External reference
Bacteroides fragilis lipopolysaccharide and inflammatory signaling in Alzheimer’s disease
10.3389/fmicb.2016.01544 · 2016 · External reference
Post-translational modifications of tau protein: implications for Alzheimer's disease
10.1016/j.neuint.2010.12.023 · 2011 · External reference
Oxidative stress and advanced lipoxidation and glycation end products (ALEs and AGEs) in aging and age-related diseases
10.1155/2019/3085756 · 2019 · External reference
Advanced glycation endproducts are associated with Hirano bodies in Alzheimer's disease
10.1016/s0006-8993(98)00328-x · 1998 · External reference
Synaptic dysfunction in Alzheimer's disease: From the role of amyloid β-peptide to the α-secretase ADAM10
10.1016/j.ejphar.2017.06.018 · 2017 · External reference
Tau aggregation and its interplay with amyloid-β
10.1007/s00401-014-1371-2 · 2015 · External reference
Common germline variants of the human APOE gene modulate melanoma progression and survival
10.1038/s41591-020-0879-3 · 2020 · External reference
A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease
10.1038/s41582-018-0116-6 · 2019 · External reference
Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons
10.1016/j.neulet.2013.09.008 · 2013 · External reference
Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by δ-tocotrienol and quercetin
10.1186/1476-511x-10-239 · 2011 · External reference
Potential therapeutic role of phytochemicals to mitigate mitochondrial dysfunctions in Alzheimer’s disease
10.3390/antiox10010023 · 2020 · External reference
Resveratrol and Neuroprotection: Impact and its Therapeutic Potential in Alzheimer's disease
10.3389/fphar.2020.619024 · 2020 · External reference
Phytochemicals, antioxidants, and cholinesterase inhibitory profiles of Elatostema Papillosum leaves: An alternative approach for management of Alzheimer’s Disease
2018 · External reference
The amyloid cascade hypothesis in Alzheimer's disease: it's time to change our mind
10.2174/1570159x15666170116143743 · 2017 · External reference
A potential role of the curry spice curcumin in Alzheimer's disease
10.2174/1567205053585882 · 2005 · External reference
NF-κB p65 directs sex-specific neuroprotection in human neurons
10.1038/s41598-018-34394-8 · 2018 · External reference
An integrated bioinformatics strategy to elucidate the function of hub genes linked to Alzheimer's disease
10.1016/j.genrep.2022.101534 · 2022 · External reference
Occurrence and bioactivity of phytochemicals and their role in human health
2020 · External reference
Artemisia amygdalina upregulates Nrf2 and protects neurons against oxidative stress in Alzheimer disease
10.1007/s10571-019-00656-w · 2019 · External reference
Periodontitis and alzheimer´ s disease
2021 · External reference
Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms
10.1016/j.jnutbio.2020.108569 · 2021 · External reference
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease
10.1016/j.phrs.2017.11.030 · 2018 · External reference
Pharmacological actions of berberine on the central nervous system
10.1254/jjp.20.482 · 1970 · External reference
BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aβ production and memory deficit in Alzheimer’s disease mouse model
10.1016/j.bbadis.2017.05.014 · 2017 · External reference
Challenges for research on polyphenols from foods in Alzheimer’s disease: bioavailability, metabolism, and cellular and molecular mechanisms
10.1021/jf0735073 · 2008 · External reference
Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis
10.1517/14728222.2014.989834 · 2015 · External reference
Nuclear factor-kappa B: glucocorticoid-induced leucine zipper interface analogs suppress pathology in an Alzheimer’s disease model
10.1016/j.trci.2018.04.004 · 2018 · External reference
Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism
10.1186/1750-1326-9-51 · 2014 · External reference
Resveratrol: A review of plant sources, synthesis, stability, modification and food application
10.1002/jsfa.10152 · 2020 · External reference
Resveratrol‐enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice
10.1111/jcmm.12312 · 2014 · External reference
Piperine regulates glycogen synthase kinase-3β-related signaling and attenuates cognitive decline in D-galactose-induced aging mouse model
10.1016/j.jnutbio.2019.108261 · 2020 · External reference
Grape-derived polyphenolics prevent Aβ oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease
10.1523/jneurosci.0364-08.2008 · 2008 · External reference
Honokiol attenuates oligomeric amyloid β1-42-induced Alzheimer’s disease in mice through attenuating mitochondrial apoptosis and inhibiting the nuclear factor kappa-B signaling pathway
10.1159/000480320 · 2017 · External reference
Role of reactive oxygen species in LPS‐induced production of prostaglandin E2 in microglia
10.1046/j.1471-4159.2003.02242.x · 2004 · External reference
ERβ promotes Aβ degradation via the modulation of autophagy
2019 · External reference
Potential benefits of phytochemicals against Alzheimer’s disease
10.1017/s0029665116002962 · 2017 · External reference
Therapeutic approaches targeting apolipoprotein E function in Alzheimer’s disease
10.1186/s13024-020-0358-9 · 2020 · External reference
1, 3-Dichloro-2-propanol evokes inflammation and apoptosis in BV-2 microglia via MAPKs and NF-κB signaling pathways mediated by reactive oxygen species
10.1016/j.toxlet.2017.12.011 · 2018 · External reference
Cellular and molecular mediators of neuroinflammation in Alzheimer disease
10.5213/inj.1938184.092 · 2019 · External reference
Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells
10.3233/jad-2011-101779 · 2011 · External reference
Paeoniflorin atttenuates amyloidogenesis and the inflammatory responses in a transgenic mouse model of Alzheimer’s disease
10.1007/s11064-015-1632-z · 2015 · External reference
Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s disease
10.1016/s1734-1140(11)70629-6 · 2011 · External reference
Curcumin ameliorates memory decline via inhibiting BACE1 expression and β-Amyloid pathology in 5× FAD transgenic mice
10.1007/s12035-016-9802-9 · 2017 · External reference