References

Controlled trial of frusemide as an antiepileptic drug in focal epilepsy

10.1111/j.1365-2125.1976.tb04885.x · 1976 · External reference

A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro

10.1016/j.neuroscience.2004.07.007 · 2004 · External reference

Positive shifts of the GABA(A) receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus

10.1111/j.1528-1167.2011.03247.x · 2011 · External reference

Excitatory actions of GABA during development: the nature of the nurture

10.1038/nrn920 · 2002 · External reference

NKCC1 chloride importer antagonists attenuate many neurological and psychiatric disorders

10.1016/j.tins.2017.07.001 · 2017 · External reference

Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons

10.1523/jneurosci.5889-12.2013 · 2013 · External reference

KCC2 downregulation facilitates epileptic seizures

10.1038/s41598-017-00196-7 · 2017 · External reference

On the origin of interictal activity in human temporal lobe epilepsy in vitro

10.1126/science.1076510 · 2002 · External reference

Reciprocal regulation of KCC2 trafficking and synaptic activity

10.3389/fncel.2019.00048 · 2019 · External reference

Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors

10.1038/nrn1625 · 2005 · External reference

A novel view on the role of intracellular tails in surface delivery of the potassium-chloride cotransporter KCC2

2017 · External reference

Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family

10.1074/jbc.271.27.16237 · 1996 · External reference

Anticonvulsant actions of furosemide in vitro

10.1016/s0306-4522(98)00700-3 · 1999 · External reference

Furosemide and mannitol suppression of epileptic activity in the human brain

10.1152/jn.00944.2004 · 2005 · External reference

Molecular and evolutionary insights into the structural organization of cation chloride cotransporters

2014 · External reference

Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4

10.1074/jbc.m110.144063 · 2010 · External reference

Are certain diuretics also anticonvulsants?

10.1002/ana.1136 · 2001 · External reference

GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl(-)-sensitive WNK1 kinase

10.1038/s41467-017-01749-0 · 2017 · External reference

Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity

10.1126/science.270.5233.99 · 1995 · External reference

Extracellular chloride and the maintenance of spontaneous epileptiform activity in rat hippocampal slices

10.1152/jn.1999.81.1.49 · 1999 · External reference

Chloride-cotransport blockade desynchronizes neuronal discharge in the “epileptic” hippocampal slice

10.1152/jn.2000.83.1.406 · 2000 · External reference

Epileptiform activities generated in vitro by human temporal lobe tissue

10.1016/j.neuchi.2008.02.004 · 2008 · External reference

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy

10.1523/jneurosci.2761-07.2007 · 2007 · External reference

Intracerebroventricular injection of ethacrynic acid induces status epilepticus

10.1016/0014-2999(89)90688-2 · 1989 · External reference

GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition

10.1038/nrn2370 · 2008 · External reference

Basic mechanisms of focal epilepsies

10.1113/expphysiol.1990.sp003390 · 1990 · External reference

Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2

10.1016/j.tins.2013.08.006 · 2013 · External reference

Roles of the cation-chloride cotransporters in neurological disease

10.1038/ncpneuro0883 · 2008 · External reference

Cation-chloride cotransporters in neuronal development, plasticity and disease

10.1038/nrn3819 · 2014 · External reference

Downregulated GABA and BDNF-TrkB pathway in chronic cyclothiazide seizure model

10.1155/2014/310146 · 2014 · External reference

Cyclothiazide induces seizure behavior in freely moving rats

10.1016/j.brainres.2010.07.088 · 2010 · External reference

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents

10.1038/nn.2806 · 2011 · External reference

Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2

10.1016/j.mcn.2010.06.008 · 2010 · External reference

Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2

10.1074/jbc.m705053200 · 2007 · External reference

Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2

10.1016/j.mcn.2010.06.008 · 2010 · External reference

U-shape suppressive effect of phenol red on the epileptiform burst activity via activation of estrogen receptors in primary hippocampal culture

2013 · External reference

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

10.1016/j.neuropharm.2012.05.045 · 2013 · External reference

Furosemide potentiates the anticonvulsant action of valproate in the mouse maximal electroshock seizure model

10.1016/j.eplepsyres.2007.06.010 · 2007 · External reference

Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy

10.1016/j.eplepsyres.2006.01.005 · 2006 · External reference

On the cellular and network bases of epileptic seizures

10.1146/annurev.physiol.63.1.815 · 2001 · External reference

Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures

10.1073/pnas.1810134115 · 2018 · External reference

Depolarizing shift in the GABA-induced current reversal potential by lidocaine hydrochloride

10.1016/j.brainres.2010.05.052 · 2010 · External reference

Clinical pharmacology of the loop diuretics furosemide and bumetanide in neonates and infants

10.2165/11596620-000000000-00000 · 2012 · External reference

Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory

10.1073/pnas.0602979103 · 2006 · External reference

Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy

10.1523/jneurosci.4390-07.2007 · 2007 · External reference

Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+](0) regulation

10.1152/ajpcell.1997.273.5.c1516 · 1997 · External reference

Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain

10.1523/jneurosci.6265-11.2012 · 2012 · External reference

Cyclothiazide induces robust epileptiform activity in rat hippocampal neurons both in vitro and in vivo

10.1113/jphysiol.2005.103812 · 2006 · External reference

Modification of seizure activity by electrical stimulation. 3. Mechanisms

10.1016/0013-4694(72)90178-2 · 1972 · External reference

Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats

10.1016/s0006-8993(00)02121-1 · 2000 · External reference

BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion

10.1083/jcb.200209011 · 2002 · External reference

The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

10.1038/16697 · 1999 · External reference

Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2

10.1523/jneurosci.5265-03.2004 · 2004 · External reference

The loop diuretics: focus on furosemide and ethacrynic acid

1986 · External reference

KCC2 activity is critical in limiting the onset and severity of status epilepticus

10.1073/pnas.1415126112 · 2015 · External reference

Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo

10.1523/jneurosci.5205-14.2015 · 2015 · External reference

Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus

10.1111/j.1460-9568.2008.06234.x · 2008 · External reference

Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation

10.1523/jneurosci.3104-06.2007 · 2007 · External reference

Coordinated downregulation of KCC2 and GABAA receptor contributes to inhibitory dysfunction during seizure induction

10.1016/j.bbrc.2020.08.082 · 2020 · External reference

M-calpain activation facilitates seizure induced KCC2 down regulation

10.3389/fnmol.2018.00287 · 2018 · External reference

BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide

10.1016/j.neuropharm.2009.04.007 · 2009 · External reference

Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation

10.1074/jbc.m109.043620 · 2009 · External reference

A novel prophylactic effect of furosemide treatment on autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)

10.1016/j.eplepsyres.2013.08.018 · 2013 · External reference

Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism

10.1211/jpp.61.01.0007 · 2009 · External reference

N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain

10.1074/jbc.m112.395830 · 2012 · External reference