Research graph
References from Periodontitis Exacerbates Insulin Resistance via Gut Barrier Dysfunction and TLR4/NF-κB Activation. Local targets link to admitted publications; unresolved targets remain external evidence.
Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions
10.1111/jcpe.12946 · 2018 · External reference
Periodontitis: a polymicrobial disruption of host homeostasis
10.1038/nrmicro2337 · 2010 · External reference
Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease
10.1007/s00011-016-0992-4 · 2017 · External reference
Association between periodontal pathogens and systemic disease
10.1016/j.bj.2018.12.001 · 2019 · External reference
Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis
10.1038/s41467-024-45473-y · 2024 · External reference
The oral microbiota is modified by systemic diseases
10.1177/0022034518805739 · 2019 · External reference
Epidemiologic relationship between periodontitis and type 2 diabetes mellitus
10.1186/s12903-020-01180-w · 2020 · External reference
From focal sepsis to periodontal medicine: a century of exploring the role of the oral microbiome in systemic disease
10.1113/jp272427 · 2017 · External reference
Effects of non-surgical periodontal treatment on reactive oxygen metabolites and glycemic control in diabetic patients with chronic periodontitis
10.3390/antiox10071056 · 2021 · External reference
Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response
10.1136/gutjnl-2015-309897 · 2017 · External reference
The bacterial connection between the oral cavity and the gut diseases
10.1177/0022034520924633 · 2020 · External reference
Disruption of the epithelial barrier during intestinal inflammation: quest for new molecules and mechanisms
10.1016/j.bbamcr.2017.03.007 · 2017 · External reference
Contribution of the intestinal microbiome and gut barrier to hepatic disorders
10.1053/j.gastro.2020.04.077 · 2020 · External reference
Oral-gut axis in inflammation: periodontitis exacerbates ulcerative colitis via microbial dysbiosis and barrier disruption
10.1186/s12903-025-06269-8 · 2025 · External reference
Intestinal homeostasis disrupted by periodontitis exacerbates Alzheimer’s disease in APP/PS1 mice
10.1186/s12974-024-03256-8 · 2024 · External reference
Ligature-induced periodontitis drives colorectal cancer: an experimental model in mice
10.1177/00220345231158269 · 2023 · External reference
The intestinal microbiota fuelling metabolic inflammation
10.1038/s41577-019-0198-4 · 2020 · External reference
Gastric ulceration in diabetes mellitus: protective role of vitamin C
10.5402/2012/362805 · 2012 · External reference
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
10.1016/j.yfrne.2018.04.002 · 2018 · External reference
Periodontitis in elderly patients with type 2 diabetes mellitus: impact on gut microbiota and systemic inflammation
10.18632/aging.202174 · 2020 · External reference
Manipulation of neutrophils by Porphyromonas gingivalis in the development of periodontitis
10.3389/fcimb.2017.00197 · 2017 · External reference
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-kappaB pathway
10.1016/j.jep.2022.115001 · 2022 · External reference
Gut microbiota may mediate the influence of periodontitis on prediabetes
10.1177/00220345211009449 · 2021 · External reference
Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus
10.1111/prd.12271 · 2020 · External reference
Periodontitis induced by Porphyromonas gingivalis drives impaired glucose metabolism in mice
10.3389/fcimb.2022.998600 · 2022 · External reference
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review
10.1007/s11739-023-03374-w · 2024 · External reference
Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis
10.1016/j.chom.2022.07.015 · 2022 · External reference
Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome
10.1016/j.cell.2022.08.005 · 2022 · External reference
Expression of bacterial virulence factors and cytokines during in vitro macrophage infection by enteroinvasive Escherichia coli and Shigella flexneri: a comparative study
10.1590/s0074-02762010000600009 · 2010 · External reference
The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis
10.1016/j.cell.2020.05.048 · 2020 · External reference
Pathogenic microbial profile and antibiotic resistance associated with periodontitis
10.1007/s12088-020-00914-2 · 2021 · External reference
The effect of the “oral-gut” axis on periodontitis in inflammatory bowel disease: a review of microbe and immune mechanism associations
2023 · External reference
Periodontal bacteria influence systemic diseases through the gut microbiota
10.3389/fcimb.2024.1478362 · 2024 · External reference
Effect of periodontitis and periodontal therapy on oral and gut microbiota
10.1177/00220345231222800 · 2024 · External reference
Periodontitis may induce gut microbiota dysbiosis via salivary microbiota
10.1038/s41368-022-00183-3 · 2022 · External reference
Tight junctions as a key for pathogens invasion in intestinal epithelial cells
10.3390/ijms22052506 · 2021 · External reference
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
10.1053/j.gastro.2006.04.020 · 2006 · External reference
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
10.1083/jcb.141.7.1539 · 1998 · External reference
Inflammation and the intestinal barrier: leukocyte-epithelial cell interactions, cell junction remodeling, and mucosal repair
10.1053/j.gastro.2016.07.008 · 2016 · External reference
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF
10.1002/emmm.201202100 · 2013 · External reference
Bacterial translocation from the gut to the distant organs: an overview
10.1159/000479918 · 2017 · External reference
A RORgammat(+) cell instructs gut microbiota-specific T(reg) cell differentiation
10.1038/s41586-022-05089-y · 2022 · External reference
Intestinal bacterial colonization induces mutualistic regulatory T cell responses
10.1016/j.immuni.2011.03.021 · 2011 · External reference
Gut microbiota as regulators of Th17/Treg balance in patients with myasthenia gravis
10.3389/fimmu.2021.803101 · 2021 · External reference
Gut microflora modulates Th17/Treg cell differentiation in experimental autoimmune prostatitis via the short-chain fatty acid propionate
10.3389/fimmu.2022.915218 · 2022 · External reference
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis
10.1038/s41564-018-0333-1 · 2019 · External reference
Toll-like receptors signaling: a complex network for NF-kappaB activation in B-cell lymphoid malignancies
10.1016/j.semcancer.2016.07.001 · 2016 · External reference
Porphyromonas gingivalis lipopolysaccharides act exclusively through TLR4 with a resilience between mouse and human
10.1038/s41598-017-16190-y · 2017 · External reference
Investigation of TLR4 antagonists for prevention of intestinal inflammation
10.1007/s10753-022-01714-0 · 2022 · External reference
LPS-induced upregulation of the TLR4 signaling pathway inhibits osteogenic differentiation of human periodontal ligament stem cells under inflammatory conditions
2019 · External reference
TLR2 and TLR4 in Parkinson’s disease pathogenesis: the environment takes a toll on the gut
10.1186/s40035-021-00271-0 · 2021 · External reference
Lipopolysaccharide preparation derived from Porphyromonas gingivalis induces a weaker immuno-inflammatory response in BV-2 microglial cells than Escherichia coli by differentially activating TLR2/4-mediated NF-kappaB/STAT3 signaling pathways
10.3389/fcimb.2021.606986 · 2021 · External reference
TLR4 is a link between diabetes and Alzheimer’s disease
10.1016/j.bbr.2016.08.047 · 2017 · External reference
Association of lipopolysaccharide-Toll-like receptor 4 signaling and microalbuminuria in patients with type 2 diabetes mellitus
10.2147/dmso.s377776 · 2022 · External reference
Periodontitis and cardiometabolic disorders: the role of lipopolysaccharide and endotoxemia
10.1111/prd.12433 · 2022 · External reference
Collares-Buzato CB. High-fat diet induces disruption of the tight junction-mediated paracellular barrier in the proximal small intestine before the onset of type 2 diabetes and endotoxemia
10.1007/s10620-020-06664-x · 2020 · External reference
Negative effects of a high-fat diet on intestinal permeability: a review
10.1093/advances/nmz061 · 2020 · External reference
Effect of resveratrol on intestinal tight junction proteins and the gut microbiome in high-fat diet-fed insulin resistant mice
10.1080/09637486.2020.1754351 · 2020 · External reference
Periodontitis-associated metabolite isoleucine impairs intestinal barrier function and exacerbates intestinal inflammatory response by NF-κB signaling
10.3389/fcimb.2025.1684362 · 2025 · External reference
A proposed model linking inflammation to obesity, diabetes, and periodontal infections
10.1902/jop.2005.76.11-s.2075 · 2005 · External reference
A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy
10.1111/j.1600-0765.2009.01204.x · 2010 · External reference
