Research graph
References from Obesity Modulates Mitochondrial Quality Control in Peripheral Blood Mononuclear Cells After Periodontal Treatment. Local targets link to admitted publications; unresolved targets remain external evidence.
Periodontal diseases
10.1038/nrdp.2017.38 · 2017 · External reference
Current status and factors of periodontal disease among Japanese high school students: a cross-sectional study
10.1038/s41405-023-00149-5 · 2023 · External reference
The effectiveness of low-level laser therapy as an adjunct to non-surgical periodontal treatment: a meta-analysis
10.1111/jre.12361 · 2017 · External reference
Mitochondrial and redox changes in periodontitis and type 2 diabetes human blood mononuclear cells
10.3390/antiox12020226 · 2023 · External reference
Prevalence of inflammatory pathways over immuno-tolerance in peripheral blood mononuclear cells of recent-onset type 1 diabetes
10.3389/fimmu.2021.765264 · 2022 · External reference
Peripheral blood mononuclear phagocytes from patients with chronic periodontitis are primed for osteoclast formation
10.1902/jop.2013.130280 · 2014 · External reference
Pathways that regulate ROS scavenging enzymes, and their role in defense against tissue destruction in periodontitis
10.3389/fphys.2017.00351 · 2017 · External reference
Oxidative stress and autophagy: the clash between damage and metabolic needs
10.1038/cdd.2014.150 · 2015 · External reference
Mitochondrial quality control in human health and disease
2024 · External reference
Mitochondrial dysfunction in obesity
10.1016/j.lfs.2017.11.019 · 2018 · External reference
Roux-en-Y gastric bypass modulates AMPK, autophagy and inflammatory response in leukocytes of obese patients
10.3390/biomedicines10020430 · 2022 · External reference
Relationship between three body obesity indicators, WWI, BMI, WtHR, and periodontitis
10.1038/s41598-024-83963-7 · 2025 · External reference
Obesity and periodontal diseases: a review
10.6026/973206300220392 · 2026 · External reference
Mitochondrial quality control: from molecule to organelle
10.1007/s00018-021-03775-0 · 2021 · External reference
Mitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling
10.1083/jcb.201312066 · 2014 · External reference
Mitophagy in human diseases
10.3390/ijms22083903 · 2021 · External reference
Mitochondrial abnormalities are involved in periodontal ligament fibroblast apoptosis induced by oxidative stress
10.1016/j.bbrc.2018.12.143 · 2019 · External reference
Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis
10.1111/jre.12941 · 2022 · External reference
Mitochondrial biogenesis disorder and oxidative damage promote refractory apical periodontitis in rat and human
10.1111/iej.14106 · 2024 · External reference
Regulation of innate immune responses by autophagy: a goldmine for viruses
10.3389/fimmu.2020.578038 · 2020 · External reference
Exploring the role of autophagy-related gene 5 (ATG5) yields important insights into autophagy in autoimmune/autoinflammatory diseases
10.3389/fimmu.2018.02334 · 2018 · External reference
A diversity of selective autophagy receptors determines the specificity of the autophagy pathway
10.1016/j.molcel.2019.09.005 · 2019 · External reference
Mitophagy in the pathogenesis and management of disease
10.1038/s41422-025-01203-7 · 2026 · External reference
The role of autophagy in the pathogenesis of periodontal disease
10.1111/odi.13045 · 2020 · External reference
Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation
10.1186/1741-7015-10-122 · 2012 · External reference
PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages
10.1111/odi.14286 · 2023 · External reference
PINK1 mediated mitophagy attenuates early apoptosis of gingival epithelial cells induced by high glucose
10.1186/s12903-022-02167-5 · 2022 · External reference
Tooth loss leads to cognitive impairment and mitochondrial disturbance in Wistar rats
10.1016/j.identj.2025.03.027 · 2025 · External reference
SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells
10.1016/j.biochi.2019.12.001 · 2020 · External reference
Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity
10.1016/j.molmet.2018.10.005 · 2019 · External reference
Obesity as a determinant of periodontal therapy outcomes: insights on oxidative and endoplasmic reticulum stress pathways
10.1016/j.identj.2026.109472 · 2026 · External reference
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions
10.1111/jcpe.12940 · 2018 · External reference
Mitochondrial dysfunction in periodontitis and associated systemic diseases: implications for pathomechanisms and therapeutic strategies
10.3390/ijms25021024 · 2024 · External reference
Association between obesity and periodontal disease. A systematic review of epidemiological studies and controlled clinical trials
2017 · External reference
Influence of obesity on the outcome of non-surgical periodontal therapy—a systematic review
10.1186/s12903-016-0272-2 · 2016 · External reference
The impact of obesity on the outcome of periodontal disease treatment: systematic review and meta-analysis
10.4103/drj.drj_227_22 · 2023 · External reference
Non-surgical periodontal treatment improves mitochondrial bioenergetics in circulating immune cells of patients with chronic periodontitis
10.1016/j.freeradbiomed.2026.01.010 · 2026 · External reference
Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis
10.1016/j.freeradbiomed.2011.02.018 · 2011 · External reference
Mitochondria in the regulation of innate and adaptive immunity
10.1016/j.immuni.2015.02.002 · 2015 · External reference
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
10.1038/nature07813 · 2009 · External reference
Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
10.1016/j.redox.2018.04.006 · 2018 · External reference
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
10.1097/mol.0b013e328328d0a4 · 2009 · External reference
AMPK: guardian of metabolism and mitochondrial homeostasis
10.1038/nrm.2017.95 · 2018 · External reference
Mechanisms and therapeutic perspectives of mitochondrial dysfunction of macrophages in periodontitis
10.3389/fcimb.2025.1634909 · 2025 · External reference
Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells
10.1038/s41368-021-00134-4 · 2021 · External reference
Inhibition of dynamin-related protein 1-dependent mitochondrial fission ameliorates apical periodontitis by attenuating NLRP3 inflammasome-mediated M1 macrophage polarisation
2025 · External reference
Lipoteichoic acid stimulation of macrophages causes mitochondrial dysfunction
10.1016/j.identj.2025.109290 · 2026 · External reference
Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease
10.1002/jper.23-0072 · 2024 · External reference
The role of mitofusin-1 and mitofusin-2 in periodontal disease: a comprehensive review
10.3389/froh.2025.1540178 · 2025 · External reference
Effect of non-surgical periodontal treatment on oxidative stress markers in leukocytes and their interaction with the endothelium in obese subjects with periodontitis: a pilot study
10.3390/jcm9072117 · 2020 · External reference
Calorie restriction modulates mitochondrial dynamics and autophagy in leukocytes of patients with obesity
10.1016/j.freeradbiomed.2024.10.295 · 2024 · External reference
Mitophagy and its significance in periodontal disease
10.1111/odi.15279 · 2025 · External reference
PINK1 restrains periodontitis-induced bone loss by preventing osteoclast mitophagy impairment
10.1016/j.redox.2023.103023 · 2024 · External reference
Spermidine alleviates diabetic periodontitis by reversing human periodontal ligament stem cell senescence via mitophagy, Free Radic
2025 · External reference
Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease
10.1002/jper.23-0072 · ExternalCitation · doi-reference
Mitochondrial quality control: from molecule to organelle
10.1007/s00018-021-03775-0 · ExternalCitation · doi-reference
Mitochondrial abnormalities are involved in periodontal ligament fibroblast apoptosis induced by oxidative stress
10.1016/j.bbrc.2018.12.143 · ExternalCitation · doi-reference
SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells
10.1016/j.biochi.2019.12.001 · ExternalCitation · doi-reference
Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis
10.1016/j.freeradbiomed.2011.02.018 · ExternalCitation · doi-reference
Calorie restriction modulates mitochondrial dynamics and autophagy in leukocytes of patients with obesity
10.1016/j.freeradbiomed.2024.10.295 · ExternalCitation · doi-reference
Non-surgical periodontal treatment improves mitochondrial bioenergetics in circulating immune cells of patients with chronic periodontitis
10.1016/j.freeradbiomed.2026.01.010 · ExternalCitation · doi-reference
Tooth loss leads to cognitive impairment and mitochondrial disturbance in Wistar rats
10.1016/j.identj.2025.03.027 · ExternalCitation · doi-reference
Lipoteichoic acid stimulation of macrophages causes mitochondrial dysfunction
10.1016/j.identj.2025.109290 · ExternalCitation · doi-reference
Obesity as a determinant of periodontal therapy outcomes: insights on oxidative and endoplasmic reticulum stress pathways
10.1016/j.identj.2026.109472 · ExternalCitation · doi-reference
Mitochondria in the regulation of innate and adaptive immunity
10.1016/j.immuni.2015.02.002 · ExternalCitation · doi-reference
Mitochondrial dysfunction in obesity
10.1016/j.lfs.2017.11.019 · ExternalCitation · doi-reference
A diversity of selective autophagy receptors determines the specificity of the autophagy pathway
10.1016/j.molcel.2019.09.005 · ExternalCitation · doi-reference
Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity
10.1016/j.molmet.2018.10.005 · ExternalCitation · doi-reference
Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
10.1016/j.redox.2018.04.006 · ExternalCitation · doi-reference
PINK1 restrains periodontitis-induced bone loss by preventing osteoclast mitophagy impairment
10.1016/j.redox.2023.103023 · ExternalCitation · doi-reference
Oxidative stress and autophagy: the clash between damage and metabolic needs
10.1038/cdd.2014.150 · ExternalCitation · doi-reference
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
10.1038/nature07813 · ExternalCitation · doi-reference
Periodontal diseases
10.1038/nrdp.2017.38 · ExternalCitation · doi-reference
AMPK: guardian of metabolism and mitochondrial homeostasis
10.1038/nrm.2017.95 · ExternalCitation · doi-reference
Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells
10.1038/s41368-021-00134-4 · ExternalCitation · doi-reference
Current status and factors of periodontal disease among Japanese high school students: a cross-sectional study
10.1038/s41405-023-00149-5 · ExternalCitation · doi-reference
Mitophagy in the pathogenesis and management of disease
10.1038/s41422-025-01203-7 · ExternalCitation · doi-reference
Relationship between three body obesity indicators, WWI, BMI, WtHR, and periodontitis
10.1038/s41598-024-83963-7 · ExternalCitation · doi-reference
Mitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling
10.1083/jcb.201312066 · ExternalCitation · doi-reference
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
10.1097/mol.0b013e328328d0a4 · ExternalCitation · doi-reference
Mitochondrial biogenesis disorder and oxidative damage promote refractory apical periodontitis in rat and human
10.1111/iej.14106 · ExternalCitation · doi-reference
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions
10.1111/jcpe.12940 · ExternalCitation · doi-reference
The effectiveness of low-level laser therapy as an adjunct to non-surgical periodontal treatment: a meta-analysis
10.1111/jre.12361 · ExternalCitation · doi-reference
Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis
10.1111/jre.12941 · ExternalCitation · doi-reference
The role of autophagy in the pathogenesis of periodontal disease
10.1111/odi.13045 · ExternalCitation · doi-reference
PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages
10.1111/odi.14286 · ExternalCitation · doi-reference
Mitophagy and its significance in periodontal disease
10.1111/odi.15279 · ExternalCitation · doi-reference
Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation
10.1186/1741-7015-10-122 · ExternalCitation · doi-reference
Influence of obesity on the outcome of non-surgical periodontal therapy—a systematic review
10.1186/s12903-016-0272-2 · ExternalCitation · doi-reference
PINK1 mediated mitophagy attenuates early apoptosis of gingival epithelial cells induced by high glucose
10.1186/s12903-022-02167-5 · ExternalCitation · doi-reference
Peripheral blood mononuclear phagocytes from patients with chronic periodontitis are primed for osteoclast formation
10.1902/jop.2013.130280 · ExternalCitation · doi-reference
Mechanisms and therapeutic perspectives of mitochondrial dysfunction of macrophages in periodontitis
10.3389/fcimb.2025.1634909 · ExternalCitation · doi-reference
Exploring the role of autophagy-related gene 5 (ATG5) yields important insights into autophagy in autoimmune/autoinflammatory diseases
10.3389/fimmu.2018.02334 · ExternalCitation · doi-reference
Regulation of innate immune responses by autophagy: a goldmine for viruses
10.3389/fimmu.2020.578038 · ExternalCitation · doi-reference
Prevalence of inflammatory pathways over immuno-tolerance in peripheral blood mononuclear cells of recent-onset type 1 diabetes
10.3389/fimmu.2021.765264 · ExternalCitation · doi-reference
Pathways that regulate ROS scavenging enzymes, and their role in defense against tissue destruction in periodontitis
10.3389/fphys.2017.00351 · ExternalCitation · doi-reference
The role of mitofusin-1 and mitofusin-2 in periodontal disease: a comprehensive review
10.3389/froh.2025.1540178 · ExternalCitation · doi-reference
Mitochondrial and redox changes in periodontitis and type 2 diabetes human blood mononuclear cells
10.3390/antiox12020226 · ExternalCitation · doi-reference
Roux-en-Y gastric bypass modulates AMPK, autophagy and inflammatory response in leukocytes of obese patients
10.3390/biomedicines10020430 · ExternalCitation · doi-reference
Mitophagy in human diseases
10.3390/ijms22083903 · ExternalCitation · doi-reference
Mitochondrial dysfunction in periodontitis and associated systemic diseases: implications for pathomechanisms and therapeutic strategies
10.3390/ijms25021024 · ExternalCitation · doi-reference
Effect of non-surgical periodontal treatment on oxidative stress markers in leukocytes and their interaction with the endothelium in obese subjects with periodontitis: a pilot study
10.3390/jcm9072117 · ExternalCitation · doi-reference
The impact of obesity on the outcome of periodontal disease treatment: systematic review and meta-analysis
10.4103/drj.drj_227_22 · ExternalCitation · doi-reference
Obesity and periodontal diseases: a review
10.6026/973206300220392 · ExternalCitation · doi-reference
