Research graph
References from Repurposing Etoposide for Caries Prevention: In Vivo Efficacy and In Vitro Inhibition of Streptococcus mutans Virulence. Local targets link to admitted publications; unresolved targets remain external evidence.
Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the global burden of disease study 2021
10.1016/s0140-6736(24)02811-3 · 2025 · External reference
Oral biofilm-associated diseases: trends and implications for quality of life, systemic health and expenditures
10.1111/j.1600-0757.2010.00360.x · 2011 · External reference
The exopolysaccharide matrix: a virulence determinant of cariogenic biofilm
10.1177/0022034513504218 · 2013 · External reference
Biology of streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
10.1159/000324598 · 2011 · External reference
The biology of streptococcus mutans
10.1128/microbiolspec.gpp3-0051-2018 · 2019 · External reference
Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria
10.1093/femsre/fux010 · 2017 · External reference
Impact of brief exposure to lysozyme and lactoferrin on pathogenic attributes of oral candida
10.1016/j.identj.2024.04.003 · 2024 · External reference
In vitro antimicrobial effect of tetrahydrocannabinol on streptococcus mutans and its anticariogenic potential
10.1016/j.identj.2025.109386 · 2026 · External reference
Fluoride resistance in streptococcus mutans : a mini review
10.1080/20002297.2017.1344509 · 2017 · External reference
Drug repurposing: progress, challenges and recommendations
10.1038/nrd.2018.168 · 2019 · External reference
Reverse repurposing: potential utility of cancer drugs in nonmalignant illnesses
10.1016/j.medj.2024.04.008 · 2024 · External reference
Carmofur exhibits antimicrobial activity against streptococcus pneumoniae
10.3390/antibiotics14030231 · 2025 · External reference
Evaluating the antibacterial and antivirulence activities of floxuridine against streptococcus suis
2023 · External reference
Drug repurposing to overcome microbial resistance
10.1016/j.drudis.2022.05.006 · 2022 · External reference
Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
10.1038/s41467-018-05342-x · 2018 · External reference
Illuminating the oral microbiome and its host interactions: animal models of disease
10.1093/femsre/fuad018 · 2023 · External reference
Etoposide: four decades of development of a topoisomerase ii inhibitor
10.1016/s0959-8049(98)00228-7 · 1998 · External reference
Structural basis of dna gyrase inhibition by antibacterial qpt-1, anticancer drug etoposide and moxifloxacin
10.1038/ncomms10048 · 2015 · External reference
Repurposing the antibacterial activity of etoposide-a chemotherapeutic drug in combination with eggshell-derived hydroxyapatite
10.1021/acsbiomaterials.1c01481 · 2022 · External reference
A comparison of the adaptive response of staphylococcus aureus vs. streptococcus mutans and the development of chlorhexidine resistance
10.3389/fmicb.2022.861890 · 2022 · External reference
A comparison of the dental caries experience in male and female rats receiving the same amount of cariogenic diet
10.1177/00220345590380060401 · 1959 · External reference
Dental caries in the molar teeth of rats: i. distribution of lesions induced by high-carbohydrate low-fat diets
10.1177/00220345580370060801 · 1958 · External reference
Rodent model in caries research
10.1007/s10266-012-0091-0 · 2013 · External reference
Dental caries in the molar teeth of rats: II. a method for diagnosing and scoring several types of lesions simultaneously
10.1177/00220345580370060901 · 1958 · External reference
Inhibitory effects of berberine against streptococcus mutans: an in vitro insight on its anticaries potential
10.1128/spectrum.00700-25 · 2025 · External reference
Unresolved reference
2024 · External reference
Improved anti-biofilm effect against the oral cariogenic streptococcus mutans by combined triclosan/cbd treatment
10.3390/biomedicines11020521 · 2023 · External reference
Inhibition of biofilm formation and virulence factors of cariogenic oral pathogen streptococcus mutans by shikimic acid
2022 · External reference
Sulforaphane as a promising anti-caries agents: inhibitory effects on streptococcus mutans and caries control in a rat model
2024 · External reference
Zoliflodacin inhibits streptococcus mutans biofilms
10.3389/fcimb.2025.1750551 · 2026 · External reference
Dihydromyricetin attenuates biofilm formation and virulence in streptococcus mutans, the key pathogen underlying dental caries
10.1080/20002297.2026.2645305 · 2026 · External reference
Novel lactotransferrin-derived antimicrobial peptide lf-1 inhibits the cariogenic virulence factors of streptococcus mutans
10.3390/antibiotics12030563 · 2023 · External reference
Sodium houttuyfonate inhibits the cariogenic virulence of streptococcus mutans through the downregulation of vicrk two components pathway
10.1080/20002297.2025.2465345 · 2025 · External reference
Intra-oral hydrogen-ion concentrations associated with dental caries activity
10.1177/00220345440230040401 · 1944 · External reference
The biofilm matrix: multitasking in a shared space
10.1038/s41579-022-00791-0 · 2023 · External reference
Plant-derived exosome-like nanovesicles: current progress and prospects
10.2147/ijn.s420748 · 2023 · External reference
The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries
10.3389/fcimb.2025.1546816 · 2025 · External reference
d -histidine inhibits streptococcus mutans growth as a potential anti-caries agent
10.1080/20002297.2025.2533174 · 2025 · External reference
Etoposide, an anticancer drug involved in therapy-related secondary leukemia: enzymes at play
10.1016/j.tranon.2021.101169 · 2021 · External reference
Polymeric biomaterials for topical drug delivery in the oral cavity: advances on devices and manufacturing technologies
10.3390/pharmaceutics15010012 · 2022 · External reference
Applications of hydrogels in drug delivery for oral and maxillofacial diseases
10.3390/gels9020146 · 2023 · External reference
The virulence of streptococcus mutans and the ability to form biofilms
10.1007/s10096-013-1993-7 · 2014 · External reference
Role of streptococcus mutans surface proteins for biofilm formation
10.1016/j.jdsr.2017.08.002 · 2018 · External reference
A quorum-sensing signaling system essential for genetic competence in streptococcus mutans is involved in biofilm formation
10.1128/jb.184.10.2699-2708.2002 · 2002 · External reference
A vicrk signal transduction system in streptococcus mutans affects gtfbcd, gbpb, and ftf expression, biofilm formation, and genetic competence development
10.1128/jb.187.12.4064-4076.2005 · 2005 · External reference
The virulence of streptococcus mutans and the ability to form biofilms
10.1007/s10096-013-1993-7 · ExternalCitation · doi-reference
Rodent model in caries research
10.1007/s10266-012-0091-0 · ExternalCitation · doi-reference
Drug repurposing to overcome microbial resistance
10.1016/j.drudis.2022.05.006 · ExternalCitation · doi-reference
Impact of brief exposure to lysozyme and lactoferrin on pathogenic attributes of oral candida
10.1016/j.identj.2024.04.003 · ExternalCitation · doi-reference
In vitro antimicrobial effect of tetrahydrocannabinol on streptococcus mutans and its anticariogenic potential
10.1016/j.identj.2025.109386 · ExternalCitation · doi-reference
Role of streptococcus mutans surface proteins for biofilm formation
10.1016/j.jdsr.2017.08.002 · ExternalCitation · doi-reference
Reverse repurposing: potential utility of cancer drugs in nonmalignant illnesses
10.1016/j.medj.2024.04.008 · ExternalCitation · doi-reference
Etoposide, an anticancer drug involved in therapy-related secondary leukemia: enzymes at play
10.1016/j.tranon.2021.101169 · ExternalCitation · doi-reference
Trends in the global, regional, and national burden of oral conditions from 1990 to 2021: a systematic analysis for the global burden of disease study 2021
10.1016/s0140-6736(24)02811-3 · ExternalCitation · doi-reference
Etoposide: four decades of development of a topoisomerase ii inhibitor
10.1016/s0959-8049(98)00228-7 · ExternalCitation · doi-reference
Repurposing the antibacterial activity of etoposide-a chemotherapeutic drug in combination with eggshell-derived hydroxyapatite
10.1021/acsbiomaterials.1c01481 · ExternalCitation · doi-reference
Structural basis of dna gyrase inhibition by antibacterial qpt-1, anticancer drug etoposide and moxifloxacin
10.1038/ncomms10048 · ExternalCitation · doi-reference
Drug repurposing: progress, challenges and recommendations
10.1038/nrd.2018.168 · ExternalCitation · doi-reference
Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
10.1038/s41467-018-05342-x · ExternalCitation · doi-reference
The biofilm matrix: multitasking in a shared space
10.1038/s41579-022-00791-0 · ExternalCitation · doi-reference
Fluoride resistance in streptococcus mutans : a mini review
10.1080/20002297.2017.1344509 · ExternalCitation · doi-reference
Sodium houttuyfonate inhibits the cariogenic virulence of streptococcus mutans through the downregulation of vicrk two components pathway
10.1080/20002297.2025.2465345 · ExternalCitation · doi-reference
d -histidine inhibits streptococcus mutans growth as a potential anti-caries agent
10.1080/20002297.2025.2533174 · ExternalCitation · doi-reference
Dihydromyricetin attenuates biofilm formation and virulence in streptococcus mutans, the key pathogen underlying dental caries
10.1080/20002297.2026.2645305 · ExternalCitation · doi-reference
Illuminating the oral microbiome and its host interactions: animal models of disease
10.1093/femsre/fuad018 · ExternalCitation · doi-reference
Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria
10.1093/femsre/fux010 · ExternalCitation · doi-reference
Oral biofilm-associated diseases: trends and implications for quality of life, systemic health and expenditures
10.1111/j.1600-0757.2010.00360.x · ExternalCitation · doi-reference
A quorum-sensing signaling system essential for genetic competence in streptococcus mutans is involved in biofilm formation
10.1128/jb.184.10.2699-2708.2002 · ExternalCitation · doi-reference
A vicrk signal transduction system in streptococcus mutans affects gtfbcd, gbpb, and ftf expression, biofilm formation, and genetic competence development
10.1128/jb.187.12.4064-4076.2005 · ExternalCitation · doi-reference
The biology of streptococcus mutans
10.1128/microbiolspec.gpp3-0051-2018 · ExternalCitation · doi-reference
Inhibitory effects of berberine against streptococcus mutans: an in vitro insight on its anticaries potential
10.1128/spectrum.00700-25 · ExternalCitation · doi-reference
Biology of streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
10.1159/000324598 · ExternalCitation · doi-reference
The exopolysaccharide matrix: a virulence determinant of cariogenic biofilm
10.1177/0022034513504218 · ExternalCitation · doi-reference
Intra-oral hydrogen-ion concentrations associated with dental caries activity
10.1177/00220345440230040401 · ExternalCitation · doi-reference
Dental caries in the molar teeth of rats: i. distribution of lesions induced by high-carbohydrate low-fat diets
10.1177/00220345580370060801 · ExternalCitation · doi-reference
Dental caries in the molar teeth of rats: II. a method for diagnosing and scoring several types of lesions simultaneously
10.1177/00220345580370060901 · ExternalCitation · doi-reference
A comparison of the dental caries experience in male and female rats receiving the same amount of cariogenic diet
10.1177/00220345590380060401 · ExternalCitation · doi-reference
Plant-derived exosome-like nanovesicles: current progress and prospects
10.2147/ijn.s420748 · ExternalCitation · doi-reference
The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries
10.3389/fcimb.2025.1546816 · ExternalCitation · doi-reference
Zoliflodacin inhibits streptococcus mutans biofilms
10.3389/fcimb.2025.1750551 · ExternalCitation · doi-reference
A comparison of the adaptive response of staphylococcus aureus vs. streptococcus mutans and the development of chlorhexidine resistance
10.3389/fmicb.2022.861890 · ExternalCitation · doi-reference
Novel lactotransferrin-derived antimicrobial peptide lf-1 inhibits the cariogenic virulence factors of streptococcus mutans
10.3390/antibiotics12030563 · ExternalCitation · doi-reference
Carmofur exhibits antimicrobial activity against streptococcus pneumoniae
10.3390/antibiotics14030231 · ExternalCitation · doi-reference
Improved anti-biofilm effect against the oral cariogenic streptococcus mutans by combined triclosan/cbd treatment
10.3390/biomedicines11020521 · ExternalCitation · doi-reference
Applications of hydrogels in drug delivery for oral and maxillofacial diseases
10.3390/gels9020146 · ExternalCitation · doi-reference
Polymeric biomaterials for topical drug delivery in the oral cavity: advances on devices and manufacturing technologies
10.3390/pharmaceutics15010012 · ExternalCitation · doi-reference
