Research graph
References from Cannabidiol and Cannabigerol Modulate Cariogenic Virulence in Cross-Kingdom Biofilms In Vitro. Local targets link to admitted publications; unresolved targets remain external evidence.
Oral diseases: a global public health challenge
10.1016/s0140-6736(19)31146-8 · 2019 · External reference
Global-, regional-, and country-level economic impacts of dental diseases in 2015
10.1177/0022034517750572 · 2018 · External reference
Addition of cariogenic pathogens to complex oral microflora drives significant changes in biofilm compositions and functionalities
10.1186/s40168-023-01561-7 · 2023 · External reference
Candida albicans promotes tooth decay by inducing oral microbial dysbiosis
10.1038/s41396-020-00823-8 · 2021 · External reference
Candida albicans and early childhood caries: a systematic review and meta-analysis
10.1159/000481833 · 2018 · External reference
Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo
10.1371/journal.ppat.1006407 · 2017 · External reference
Synergism of Streptococcus mutans and Candida albicans reinforces biofilm maturation and acidogenicity in saliva: an in vitro study
2020 · External reference
Interkingdom assemblages in human saliva display group-level surface mobility and disease-promoting emergent functions
10.1073/pnas.2209699119 · 2022 · External reference
Cannabidiol: state of the art and new challenges for therapeutic applications
10.1016/j.pharmthera.2017.02.041 · 2017 · External reference
Cannabidiol and neurodegeneration: from molecular mechanisms to clinical benefits
10.1016/j.arr.2024.102386 · 2024 · External reference
Antitumor effects of cannabidiol (CBD) on osteosarcoma by targeting TNF-α/NF-κB/CCL5 signaling axis
10.1016/j.phymed.2025.157066 · 2025 · External reference
Antimicrobial potential of cannabinoids: a scoping review of the past 5 years
10.3390/microorganisms13020325 · 2025 · External reference
Anti-bacterial effect of cannabidiol against the cariogenic Streptococcus mutans bacterium: an in vitro study
10.3390/ijms232415878 · 2022 · External reference
Anti-biofilm activity of cannabigerol against Streptococcus mutans
10.3390/microorganisms9102031 · 2021 · External reference
Antibiofilm and immune-modulatory activity of cannabidiol and cannabigerol in oral environments-in vitro study
2024 · External reference
The antibacterial effect of cannabigerol toward Streptococcus mutans is influenced by the autoinducers 21-CSP and AI-2
10.3390/biomedicines11030668 · 2023 · External reference
Anti-bacterial properties of cannabigerol toward Streptococcus mutans
10.3389/fmicb.2021.656471 · 2021 · External reference
Anti-biofilm activity of cannabidiol against Candida albicans
10.3390/microorganisms9020441 · 2021 · External reference
Potential combinatory effect of cannabidiol and triclosan incorporated into sustained release delivery system against oral candidiasis
10.3390/pharmaceutics14081624 · 2022 · External reference
Dual transcriptome of Streptococcus mutans and Candida albicans interplay in biofilms
2023 · External reference
Effect of probiotic lactobacillus plantarum on Streptococcus mutans and Candida albicans clinical isolates from children with early childhood caries
10.3390/ijms24032991 · 2023 · External reference
Natural antimicrobials ε-poly-L-lysine and nisin A for control of oral microflora
10.1007/s12602-009-9020-0 · 2009 · External reference
Oral candida predicts Streptococcus mutans emergence in underserved US infants
10.1177/00220345211012385 · 2022 · External reference
Quantification of biofilm structures by the novel computer program COMSTAT
10.1099/00221287-146-10-2395 · 2000 · External reference
HISAT: a fast spliced aligner with low memory requirements
10.1038/nmeth.3317 · 2015 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
clusterProfiler 4.0: a universal enrichment tool for interpreting omics data
2021 · External reference
Targeting microbial biofilms: current and prospective therapeutic strategies
10.1038/nrmicro.2017.99 · 2017 · External reference
Treatment of stage I-III periodontitis—the EFP S3 level clinical practice guideline
10.1111/jcpe.13290 · 2020 · External reference
The antimicrobial potential of cannabidiol
10.1038/s42003-020-01530-y · 2021 · External reference
Benefits, toxicity and current market of cannabidiol in edibles
10.1080/10408398.2021.2024493 · 2023 · External reference
Uncovering the hidden antibiotic potential of cannabis
10.1021/acsinfecdis.9b00419 · 2020 · External reference
Intracellular signaling by the comRS System in Streptococcus mutans genetic competence
10.1128/msphere.00444-18 · 2018 · External reference
Quorum sensing regulation of competence and bacteriocins in Streptococcus pneumoniae and mutans
10.3390/genes8010015 · 2017 · External reference
Mutacins from Streptococcus mutans UA159 are active against multiple streptococcal species
10.1128/aem.02320-10 · 2011 · External reference
Analogue regulated Streptococcus mutans and Streptococcus sanguinis dual-species biofilms
10.1016/j.identj.2024.11.010 · 2025 · External reference
Proteomic changes in methicillin-resistant Staphylococcus aureus exposed to cannabinoids
10.1021/acs.jnatprod.3c00064 · 2023 · External reference
Proteomic and metabolomic analyses reveal the antibacterial mechanism of cannabidiol against gram-positive bacteria
10.1016/j.jprot.2025.105411 · 2025 · External reference
Hsp90 governs dispersion and drug resistance of fungal biofilms
10.1371/journal.ppat.1002257 · 2011 · External reference
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
10.1073/pnas.0813394106 · 2009 · External reference
Effect of cannabidiol on human gingival fibroblast extracellular matrix metabolism: MMP production and activity, and production of fibronectin and transforming growth factor β
10.1111/j.1600-0765.2011.01435.x · 2012 · External reference
Proliferative effect of cannabidiol in human gingival fibroblasts via the mitogen-activated extracellular signal-regulated kinase (MEK) 1/2
10.1111/jre.13178 · 2023 · External reference
Acute and chronic cannabidiol treatment: in vitro toxicological aspects on human oral cells
10.1016/j.fct.2024.114513 · 2024 · External reference
Antibiofilm and immune-modulatory activity of cannabidiol and cannabigerol in oral environments—in vitro study
10.3390/antibiotics13040342 · 2024 · External reference
Phytocannabinoids regulate inflammation in IL-1β-stimulated human gingival fibroblasts
10.1111/jre.13050 · 2022 · External reference
Enhancement of cannabidiol oral bioavailability through the development of nanostructured lipid carriers: in vitro and in vivo evaluation studies
10.1007/s13346-024-01766-9 · 2025 · External reference
Lipid nanoparticle formulations for the skin delivery of cannabidiol
10.3390/pharmaceutics16121490 · 2024 · External reference
Cannabidiol-loaded nanostructured lipid carriers (NLCs) for dermal delivery: enhancement of photostability, cell viability, and anti-inflammatory activity
10.3390/pharmaceutics15020537 · 2023 · External reference
Natural antimicrobials ε-poly-L-lysine and nisin A for control of oral microflora
10.1007/s12602-009-9020-0 · ExternalCitation · doi-reference
Enhancement of cannabidiol oral bioavailability through the development of nanostructured lipid carriers: in vitro and in vivo evaluation studies
10.1007/s13346-024-01766-9 · ExternalCitation · doi-reference
Cannabidiol and neurodegeneration: from molecular mechanisms to clinical benefits
10.1016/j.arr.2024.102386 · ExternalCitation · doi-reference
Acute and chronic cannabidiol treatment: in vitro toxicological aspects on human oral cells
10.1016/j.fct.2024.114513 · ExternalCitation · doi-reference
Analogue regulated Streptococcus mutans and Streptococcus sanguinis dual-species biofilms
10.1016/j.identj.2024.11.010 · ExternalCitation · doi-reference
Proteomic and metabolomic analyses reveal the antibacterial mechanism of cannabidiol against gram-positive bacteria
10.1016/j.jprot.2025.105411 · ExternalCitation · doi-reference
Cannabidiol: state of the art and new challenges for therapeutic applications
10.1016/j.pharmthera.2017.02.041 · ExternalCitation · doi-reference
Antitumor effects of cannabidiol (CBD) on osteosarcoma by targeting TNF-α/NF-κB/CCL5 signaling axis
10.1016/j.phymed.2025.157066 · ExternalCitation · doi-reference
Oral diseases: a global public health challenge
10.1016/s0140-6736(19)31146-8 · ExternalCitation · doi-reference
Proteomic changes in methicillin-resistant Staphylococcus aureus exposed to cannabinoids
10.1021/acs.jnatprod.3c00064 · ExternalCitation · doi-reference
Uncovering the hidden antibiotic potential of cannabis
10.1021/acsinfecdis.9b00419 · ExternalCitation · doi-reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · ExternalCitation · doi-reference
HISAT: a fast spliced aligner with low memory requirements
10.1038/nmeth.3317 · ExternalCitation · doi-reference
Targeting microbial biofilms: current and prospective therapeutic strategies
10.1038/nrmicro.2017.99 · ExternalCitation · doi-reference
Candida albicans promotes tooth decay by inducing oral microbial dysbiosis
10.1038/s41396-020-00823-8 · ExternalCitation · doi-reference
The antimicrobial potential of cannabidiol
10.1038/s42003-020-01530-y · ExternalCitation · doi-reference
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
10.1073/pnas.0813394106 · ExternalCitation · doi-reference
Interkingdom assemblages in human saliva display group-level surface mobility and disease-promoting emergent functions
10.1073/pnas.2209699119 · ExternalCitation · doi-reference
Benefits, toxicity and current market of cannabidiol in edibles
10.1080/10408398.2021.2024493 · ExternalCitation · doi-reference
Quantification of biofilm structures by the novel computer program COMSTAT
10.1099/00221287-146-10-2395 · ExternalCitation · doi-reference
Effect of cannabidiol on human gingival fibroblast extracellular matrix metabolism: MMP production and activity, and production of fibronectin and transforming growth factor β
10.1111/j.1600-0765.2011.01435.x · ExternalCitation · doi-reference
Treatment of stage I-III periodontitis—the EFP S3 level clinical practice guideline
10.1111/jcpe.13290 · ExternalCitation · doi-reference
Phytocannabinoids regulate inflammation in IL-1β-stimulated human gingival fibroblasts
10.1111/jre.13050 · ExternalCitation · doi-reference
Proliferative effect of cannabidiol in human gingival fibroblasts via the mitogen-activated extracellular signal-regulated kinase (MEK) 1/2
10.1111/jre.13178 · ExternalCitation · doi-reference
Mutacins from Streptococcus mutans UA159 are active against multiple streptococcal species
10.1128/aem.02320-10 · ExternalCitation · doi-reference
Intracellular signaling by the comRS System in Streptococcus mutans genetic competence
10.1128/msphere.00444-18 · ExternalCitation · doi-reference
Candida albicans and early childhood caries: a systematic review and meta-analysis
10.1159/000481833 · ExternalCitation · doi-reference
Global-, regional-, and country-level economic impacts of dental diseases in 2015
10.1177/0022034517750572 · ExternalCitation · doi-reference
Oral candida predicts Streptococcus mutans emergence in underserved US infants
10.1177/00220345211012385 · ExternalCitation · doi-reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · ExternalCitation · doi-reference
Addition of cariogenic pathogens to complex oral microflora drives significant changes in biofilm compositions and functionalities
10.1186/s40168-023-01561-7 · ExternalCitation · doi-reference
Hsp90 governs dispersion and drug resistance of fungal biofilms
10.1371/journal.ppat.1002257 · ExternalCitation · doi-reference
Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo
10.1371/journal.ppat.1006407 · ExternalCitation · doi-reference
Anti-bacterial properties of cannabigerol toward Streptococcus mutans
10.3389/fmicb.2021.656471 · ExternalCitation · doi-reference
Antibiofilm and immune-modulatory activity of cannabidiol and cannabigerol in oral environments—in vitro study
10.3390/antibiotics13040342 · ExternalCitation · doi-reference
The antibacterial effect of cannabigerol toward Streptococcus mutans is influenced by the autoinducers 21-CSP and AI-2
10.3390/biomedicines11030668 · ExternalCitation · doi-reference
Quorum sensing regulation of competence and bacteriocins in Streptococcus pneumoniae and mutans
10.3390/genes8010015 · ExternalCitation · doi-reference
Anti-bacterial effect of cannabidiol against the cariogenic Streptococcus mutans bacterium: an in vitro study
10.3390/ijms232415878 · ExternalCitation · doi-reference
Effect of probiotic lactobacillus plantarum on Streptococcus mutans and Candida albicans clinical isolates from children with early childhood caries
10.3390/ijms24032991 · ExternalCitation · doi-reference
Antimicrobial potential of cannabinoids: a scoping review of the past 5 years
10.3390/microorganisms13020325 · ExternalCitation · doi-reference
Anti-biofilm activity of cannabidiol against Candida albicans
10.3390/microorganisms9020441 · ExternalCitation · doi-reference
Anti-biofilm activity of cannabigerol against Streptococcus mutans
10.3390/microorganisms9102031 · ExternalCitation · doi-reference
Potential combinatory effect of cannabidiol and triclosan incorporated into sustained release delivery system against oral candidiasis
10.3390/pharmaceutics14081624 · ExternalCitation · doi-reference
Cannabidiol-loaded nanostructured lipid carriers (NLCs) for dermal delivery: enhancement of photostability, cell viability, and anti-inflammatory activity
10.3390/pharmaceutics15020537 · ExternalCitation · doi-reference
Lipid nanoparticle formulations for the skin delivery of cannabidiol
10.3390/pharmaceutics16121490 · ExternalCitation · doi-reference
