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References from OmpK36 Alterations Are Associated with Reduced Imipenem/Relebactam Susceptibility in KPC-2–Producing Klebsiella pneumoniae, with Dose-Dependent Restoration at Higher Relebactam Concentrations. Local targets link to admitted publications; unresolved targets remain external evidence.
Disease burden of bacteraemia with extended-spectrum beta-lactamase-producing and carbapenem-resistant Enterobacterales in Korea
10.1016/j.jhin.2023.11.013 · 2023 · External reference
Genomic analysis of carbapenem-resistant Klebsiella pneumoniae blood isolates from nationwide surveillance in South Korea
2025 · External reference
Meropenem/vaborbactam: a next generation β-lactam β-lactamase inhibitor combination
10.1080/14787210.2020.1756775 · 2020 · External reference
Pneumonia and renal replacement therapy are risk factors for ceftazidime-avibactam treatment failures and resistance among patients with carbapenem-resistant Enterobacteriaceae infections
10.1128/aac.02497-17 · 2018 · External reference
Antimicrobial activity of ceftazidime-avibactam against KPC-2-producing Enterobacterales: a cross-combination and dose-escalation titration study with relebactam and vaborbactam
10.1128/spectrum.00344-24 · 2024 · External reference
10.1093/jac/dkae450
10.1093/jac/dkae450 · 2025 · External reference
Comparison of the in vitro activities and resistance mechanisms against imipenem–relebactam and ceftazidime–avibactam in clinical KPC-producing Klebsiella pneumoniae isolated in China
10.1007/s15010-025-02474-3 · 2025 · External reference
In vitro development of imipenem/relebactam resistance in KPC-producing Klebsiella pneumoniae involves multiple mutations including OmpK36 disruption and KPC modification
10.1016/j.ijantimicag.2023.106935 · 2023 · External reference
Unresolved reference
2023 · External reference
Unresolved reference
External reference
SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing
10.1089/cmb.2012.0021 · 2012 · External reference
Clustal Omega for making accurate alignments of many protein sequences
10.1002/pro.3290 · 2018 · External reference
Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin
10.1128/aac.01069-13 · 2013 · External reference
Emergence of population heterogeneity in Klebsiella pneumoniae with a blaOXA-232-harboring plasmid: carbapenem resistance, virulence, and fitness
10.1186/s12929-024-01108-4 · 2025 · External reference
Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae
10.1371/journal.ppat.1010334 · 2022 · External reference
Impact of ompK36 genotype and KPC subtype on the in vitro activity of ceftazidime-avibactam, imipenem-relebactam and meropenem-vaborbactam against KPC-producing Klebsiella pneumoniae clinical isolates
10.1093/jacamr/dlad022 · 2023 · External reference
Role of the outer membrane and porins in susceptibility of β-lactamase-producing Enterobacteriaceae to ceftazidime-avibactam
2015 · External reference
Ceftazidime-avibactam use for Klebsiella pneumoniae carbapenemase-producing K. pneumoniae infections: a retrospective observational multicenter study
10.1093/cid/ciab176 · 2021 · External reference
Pharmacokinetics, safety, and tolerability of single and multiple doses of relebactam, a β-lactamase inhibitor, in combination with imipenem and cilastatin in healthy participants
10.1128/aac.00280-18 · 2018 · External reference
Phase 1 study assessing the steady-state concentration of ceftazidime and avibactam in plasma and epithelial lining fluid following two dosing regimens
10.1093/jac/dkv170 · 2015 · External reference
