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References from Rational design of chimeric polyhydroxyalkanoate synthases suggests a conserved N-terminal domain-to-LID region network influencing 3HHx incorporation and granule morphology. Local targets link to admitted publications; unresolved targets remain external evidence.
The effects of micro-and nanoplastic on the central nervous system: a new threat to humanity?
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Bioaccumulation of microplastics in decedent human brains
2025 · External reference
A new wave of industrialization of PHA biopolyesters
2022 · External reference
Evolution of polyhydroxyalkanoate (PHA) production system by “enzyme evolution”: successful case studies of directed evolution
10.1002/mabi.200300111 · 2004 · External reference
Polyester synthases: natural catalysts for plastics
10.1042/bj20031254 · 2003 · External reference
Polyhydroxyalkanoate synthase (PhaC): the key enzyme for biopolyester synthesis
10.1016/j.crbiot.2022.01.002 · 2022 · External reference
Mechanical properties of uniaxially cold-drawn films of poly([R]-3-hydroxybutyrate)
10.1016/s0141-3910(02)00274-4 · 2003 · External reference
A review on biological synthesis of the biodegradable polymers polyhydroxyalkanoates and the development of multiple applications
10.3390/catal12030319 · 2022 · External reference
Structures of Polyhydroxyalkanoate synthase PhaC from Aeromonas caviae, producing biodegradable plastics
2025 · External reference
Enhanced synthesis of poly(3-hydroxybutyrate) in recombinant Escherichia coli by means of error-prone PCR mutagenesis, saturation mutagenesis, and in vitro recombination of the type II polyhydroxyalkanoate synthase gene
10.1093/jb/mvg015 · 2003 · External reference
Analysis of mutational effects of a polyhydroxybutyrate (PHB) polymerase on bacterial PHB accumulation using an in vivo assay system
10.1111/j.1574-6968.2001.tb10620.x · 2001 · External reference
In vitro evolution of a polyhydroxybutyrate synthase by intragenic suppression-type mutagenesis
10.1093/oxfordjournals.jbchem.a003168 · 2002 · External reference
Enhanced accumulation and changed monomer composition in polyhydroxyalkanoate (PHA) copolyester by in vitro evolution of Aeromonas caviae PHA synthase
10.1128/aem.68.5.2411-2419.2002 · 2002 · External reference
Combination of N149S and D171G mutations in Aeromonas caviae polyhydroxyalkanoate synthase and impact on polyhydroxyalkanoate biosynthesis
10.1111/j.1574-6968.2007.00958.x · 2007 · External reference
A microbial factory for lactate-based polyesters using a lactate-polymerizing enzyme
10.1073/pnas.0805653105 · 2008 · External reference
Engineering of Aeromonas caviae polyhydroxyalkanoate synthase through site-directed mutagenesis for enhanced polymerization of the 3-hydroxyhexanoate unit
10.3389/fbioe.2021.627082 · 2021 · External reference
Creation of sequence-regulating polyhydroxyalkanoate (PHA) synthases with improved thermostability using a full consensus design for the biosynthesis of 2-hydroxyalkanoate-based PHA block copolymers
10.1016/j.polymdegradstab.2025.111295 · 2025 · External reference
Characterization of site-specific mutations in a short-chain-length/medium-chain-length polyhydroxyalkanoate synthase: in vivo and in vitro studies of enzymatic activity and substrate specificity
10.1128/aem.00564-13 · 2013 · External reference
Chimeric enzyme composed of polyhydroxyalkanoate (PHA) synthases from Ralstonia eutropha and Aeromonas caviae enhances production of PHAs in recombinant Escherichia coli
10.1021/bm801386j · 2009 · External reference
Engineering chimeric polyhydroxyalkanoate synthases for enhanced copolymerization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate): a promising biotechnological approach
10.1016/j.biortech.2025.133307 · 2026 · External reference
Incremental truncation of PHA synthases results in altered product specificity
10.1016/j.enzmictec.2012.02.003 · 2012 · External reference
Molecular characterization of the poly(3-hydroxybutyrate) (PHB) synthase from Ralstonia eutropha: in vitro evolution, site-specific mutagenesis and development of a PHB synthase protein model
10.1016/s0167-4838(01)00299-0 · 2002 · External reference
A novel and wide substrate specific polyhydroxyalkanoate (PHA) synthase from unculturable bacteria found in mangrove soil
10.1007/s10965-017-1403-4 · 2018 · External reference
Cloning and expression of the PHA synthase gene from a locally isolated Chromobacterium sp. USM2
2010 · External reference
Evaluation of BP-M-CPF4 polyhydroxyalkanoate (PHA) synthase on the production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from plant oil using Cupriavidus necator transformants
10.1016/j.ijbiomac.2020.05.064 · 2020 · External reference
Identification of regions affecting enzyme activity, substrate binding, dimer stabilization and polyhydroxyalkanoate (PHA) granule morphology in the PHA synthase of Aquitalea sp. USM4
10.1016/j.ijbiomac.2021.07.041 · 2021 · External reference
Biosynthesis of novel polyhydroxyalkanoate containing 3-hydroxy-4-methylvalerate by Chromobacterium sp. USM2
10.1111/j.1365-2672.2011.05084.x · 2011 · External reference
Improved synthesis of P(3HB-co-3HV-co-3HHx) terpolymers by mutant Cupriavidus necator using the PHA synthase gene of Chromobacterium sp. USM2 with high affinity towards 3HV
10.1016/j.polymdegradstab.2009.12.018 · 2010 · External reference
Identification of a new polyhydroxyalkanoate (PHA) producer Aquitalea sp. USM4 (JCM 19919) and characterization of its PHA synthase
10.1016/j.jbiosc.2016.03.024 · 2016 · External reference
Characterization of the highly active polyhydroxyalkanoate synthase of Chromobacterium sp. strain USM2
10.1128/aem.01997-10 · 2011 · External reference
Grand challenges for industrializing polyhydroxyalkanoates (PHAs)
10.1016/j.tibtech.2020.11.010 · 2021 · External reference
A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in gram negative bacteria
10.1038/nbt1183-784 · 1983 · External reference
The clustal omega multiple alignment package
2020 · External reference
MEGA12: molecular evolutionary genetic analysis version 12 for adaptive and green computing
10.1093/molbev/msae263 · 2024 · External reference
ColabFold: making protein folding accessible to all
10.1038/s41592-022-01488-1 · 2022 · External reference
A sensitive, viable-colony staining method using Nile red for direct screening of bacteria that accumulate polyhydroxyalkanoic acids and other lipid storage compounds
10.1007/s002030050681 · 1999 · External reference
Roles of multiple acetoacetyl coenzyme A reductases in polyhydroxybutyrate biosynthesis in Ralstonia eutropha H16
10.1128/jb.00207-10 · 2010 · External reference
A two-tier architecture governs monomer incorporation and granule morphology in polyhydroxyalkanoate synthases: implications for bioplastic production
10.1016/j.ceja.2026.101457 · 2026 · External reference
A rapid gas chromatographic method for the determination of poly-β-hydroxybutyric acid in microbial biomass
10.1007/bf00500854 · 1978 · External reference
Recovery of the PHA copolymer P(HB-co-HHx) with non-halogenated solvents: influences on molecular weight and HHx-content
10.3389/fbioe.2020.00944 · 2020 · External reference
N-terminal truncation of PhaCBP-M-CPF4 and its effect on PHA production
10.1186/s12934-024-02329-w · 2024 · External reference
Location of functional region at N-terminus of polyhydroxyalkanoate (PHA) synthase by N-terminal mutation and its effects on PHA synthesis
10.1016/j.bej.2008.03.006 · 2008 · External reference
Molecular analysis of the Alcaligenes eutrophus poly(3-hydroxybutyrate) biosynthetic operon: identification of the N terminus of poly(3-hydroxybutyrate) synthase and identification of the promoter
10.1128/jb.173.1.168-175.1991 · 1991 · External reference
Mutation on N-terminus of polyhydroxybutyrate synthase of Ralstonia eutropha enhanced PHB accumulation
10.1007/s00253-006-0371-0 · 2006 · External reference
Characterization and functional analyses of R-specific enoyl coenzyme A hydratases in polyhydroxyalkanoate-producing Ralstonia eutropha
10.1128/aem.06937-11 · 2012 · External reference
Toward systematic metabolic engineering based on the analysis of metabolic regulation by the integration of different levels of information
10.1016/j.bej.2009.06.006 · 2009 · External reference
Active intermediates of polyhydroxyalkanoate synthase from Aeromonas caviae in polymerization reaction
10.1021/bm301276k · 2012 · External reference
Enzyme-catalyzed synthesis of poly [(R)-(−)-3-hydroxybutyrate]: formation of macroscopic granules in vitro
10.1073/pnas.92.14.6279 · 1995 · External reference
Biosynthesis and characterization of polyhydroxyalkanoate containing high 3-hydroxyhexanoate monomer fraction from crude palm kernel oil by recombinant Cupriavidus necator
10.1016/j.biortech.2012.07.015 · 2012 · External reference
Structure and function of the N-terminal domain of Ralstonia eutropha polyhydroxyalkanoate synthase, and the proposed structure and mechanisms of the whole enzyme
2017 · External reference
Evaluation of promoters for gene expression in polyhydroxyalkanoate-producing Cupriavidus necator H16
10.1007/s00253-011-3100-2 · 2011 · External reference
Asymmetric open-closed dimer mechanism of polyhydroxyalkanoate synthase PhaC
10.1016/j.isci.2020.101084 · 2020 · External reference
Analyses of a polyhydroxyalkanoic acid granule-associated 16-kilodalton protein and its putative regulator in the pha locus of Paracoccus denitrificans
10.1128/jb.181.9.2914-2921.1999 · 1999 · External reference
Compositional regulation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by replacement of granule-associated protein in Ralstonia eutropha
10.1186/s12934-015-0380-8 · 2015 · External reference
Manipulation of polyhydroxyalkanoate granular sizes in Halomonas bluephagenesis
10.1016/j.ymben.2019.03.011 · 2019 · External reference
A protein dynamics–based deep learning model enhances predictions of fitness and epistasis
10.1073/pnas.2502444122 · 2025 · External reference
Biosynthesis and compositional regulation of poly[(3-hydroxybutyrate)-co-(3-hydroxyhexanoate)] in recombinant Ralstonia eutropha expressing mutated polyhydroxyalkanoate synthase genes
10.1002/mabi.200300077 · 2004 · External reference
