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References from Radix Rehmanniae polysaccharides enhanced hypoglycaemic effect of metformin by stimulating glucagon-like peptide-1 secretion via gut microbiota-SCFA-GPCR43 axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Gut microbiota-based bioassay for the quality evaluation of different species of Dendrobium and their therapeutic potential in type 2 diabetes
10.1186/s13020-025-01107-z · 2025 · External reference
Effects of Radix astragali and Radix rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms
10.1016/j.phymed.2011.12.005 · 2012 · External reference
An integrated approach to discriminate the quality markers of traditional Chinese medicine preparation based on multi-dimensional characteristic network: Shenqi Jiangtang granule as a case
2022 · External reference
A systematic review on botany, processing, application, phytochemistry and pharmacological action of Radix Rehmnniae
10.1016/j.jep.2021.114820 · 2022 · External reference
Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix
10.1016/j.biopha.2023.115809 · 2023 · External reference
The herb pair Radix rehmanniae and Cornus officinalis attenuated testicular damage in mice with diabetes mellitus through butyric acid/glucagon-like Peptide-1/glucagon-like Peptide-1 receptor pathway mediated by gut microbiota
10.3389/fmicb.2022.831881 · 2022 · External reference
Pharmacokinetics and bioavailability of a metformin/glyburide tablet administered alone and with food
10.1177/009127000004001222 · 2000 · External reference
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
10.1038/nature15766 · 2015 · External reference
Efficacy and safety of traditional Chinese classic prescriptions combined with metformin in the treatment of type 2 diabetes mellitus: a Bayesian network meta-analysis
2026 · External reference
Pharmacokinetic interactions between metformin and berberine
10.1016/j.lfs.2019.116818 · 2019 · External reference
Efficacy and safety of initial combination therapy with alogliptin plus metformin versus either as monotherapy in drug-naïve patients with type 2 diabetes: a randomized, double-blind, 6-month study
10.1111/dom.12258 · 2014 · External reference
Assessment of pharmacodynamic and pharmacokinetic interaction of aqueous extract of Cassia auriculata L. and metformin in rats
10.4103/0973-1296.168986 · 2015 · External reference
Clinical efficacy of bolus of six drugs including Rehmannia as an adjunct to metformin in the treatment of senile Type-2 diabetes mellitus and its influence on insulin resistance, inflammatory factors and blood glucose-related indicators
10.12669/pjms.39.5.7262 · 2023 · External reference
Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice
10.1016/j.phymed.2022.154099 · 2022 · External reference
The impact of sample handling time on metformin serum concentration
10.1016/j.biopha.2020.110971 · 2021 · External reference
Anti-inflammatory activities of pentaherbs formula and its influence on gut microbiota in allergic asthma
10.3390/molecules23112776 · 2018 · External reference
Effects of Rehmanniae Radix Praeparata polysaccharides on LPS-induced immune activation in mice based on gut microbiota, metabolomics and transcriptomics
10.1016/j.ijbiomac.2025.143981 · 2025 · External reference
Structural characterization and immunomodulatory activities of two polysaccharides from Rehmanniae Radix Praeparata
10.1016/j.ijbiomac.2021.06.100 · 2021 · External reference
Role of gut microbiota on regulation potential of Dendrobium officinale Kimura & Migo in metabolic syndrome: in-vitro fermentation screening and in-vivo verification in db/db mice
10.1016/j.jep.2023.117437 · 2024 · External reference
Gastrointestinal metabolism of Astragalus membranaceus polysaccharides and its related hypoglycemic mechanism based on gut microbial transformation
2024 · External reference
Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1
10.1111/cas.13952 · 2019 · External reference
Metformin treatment and risk of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus in Beijing, China
2023 · External reference
Metabolic control in type 1 diabetes: is adjunctive therapy the way forward?
10.1007/s13300-018-0496-z · 2018 · External reference
Integrating plant metabolomics, chemometrics and mimic processing to elucidate dynamic changes and underlying mechanisms in the chemical profiles of Rehmanniae Radix Carbonisata during stir-frying carbonization
2026 · External reference
Pharmacokinetic interactions between metformin and berberine in rats: role of oral administration sequences and microbiota
10.1016/j.lfs.2019.116818 · 2019 · External reference
Mechanisms of action and therapeutic application of glucagon-like Peptide-1
10.1016/j.cmet.2018.03.001 · 2018 · External reference
Metabolic regulation of methionine restriction in diabetes
10.1002/mnfr.201700951 · 2018 · External reference
Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
10.2337/db11-1019 · 2012 · External reference
Influence of GLP-1 on myocardial glucose metabolism in healthy men during normo-or hypoglycemia
2014 · External reference
Evaluation of different commercial antibodies for their ability to detect human and mouse tissue factor by western blotting
10.1002/rth2.12363 · 2020 · External reference
Distinct properties of human HMGN5 reveal a rapidly evolving but functionally conserved nucleosome binding protein
10.1128/mcb.05216-11 · 2011 · External reference
Sodium butyrate improves liver glycogen metabolism in type 2 diabetes mellitus
10.1021/acs.jafc.9b02083 · 2019 · External reference
Gut Bifidobacteria populations in human health and aging
10.3389/fmicb.2016.01204 · 2016 · External reference
Gut microbiota and intestinal FXR mediate by metformin
10.1038/s41591-018-0222-4 · 2018 · External reference