Research graph
References from Hyaluronic acid-navigated nanoplatforms for oral cancer management: Current advances, translational perspectives, and future outlook—A review. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology and types of oral cancer
10.18203/2394-6040.ijcmph20220032 · 2022 · External reference
Oral Squamous Cell Carcinoma and Concomitant Primary Tumors, What Do We Know?
10.3390/curroncol30040283 · 2023 · External reference
Socio-demographic disparities in global trends of lip and oral cavity neoplasms from 1990 to 2021
10.1038/s41598-025-88684-z · 2025 · External reference
Oral squamous cell carcinomas: state of the field and emerging directions
10.1038/s41368-023-00249-w · 2023 · External reference
Holistic Approach for the Early Detection of Oral Cancer: A Comprehensive Training Module
10.1007/s12663-024-02198-1 · 2024 · External reference
Oral Cancer Prevalence
2022 · External reference
Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer
10.3389/fimmu.2024.1535649 · 2025 · External reference
Disulfiram-Encapsulated Poly(caprolactone) Nanofiber Scaffolds for Oral Squamous Cell Carcinoma Management
10.1007/s12668-025-02153-5 · 2025 · External reference
Oral Cavity Squamous Cell Carcinoma: An Update of the Pharmacological Treatment
10.3390/biomedicines11041112 · 2023 · External reference
Supramolecular self-assembled peptide-engineered nanofibers: A propitious proposition for cancer therapy
10.1016/j.ijbiomac.2023.128452 · 2024 · External reference
Advancing Head and Neck Cancer Therapies: From Conventional Treatments to Emerging Strategies
10.3390/biomedicines13051046 · 2025 · External reference
Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer
10.3389/fphar.2022.825266 · 2022 · External reference
Application of scaffold-based drug delivery in oral cancer treatment: a novel approach
2024 · External reference
Oral cavity: An open horizon for nanopharmaceuticals
10.1007/s40005-021-00530-2 · 2021 · External reference
Repurposing statins for the management of head and neck squamous cell carcinoma: A systematic review of preclinical and clinical evidence
10.1007/s12032-026-03302-w · 2026 · External reference
Targeting the oral mucosa: emerging drug delivery platforms and the therapeutic potential of glycosaminoglycans
10.3390/pharmaceutics17091212 · 2025 · External reference
The hyaluronan/CD44 axis: a double-edged sword in cancer
2023 · External reference
Design Strategies for Hyaluronic Acid-based Drug Delivery Systems in Cancer Immunotherapy
10.1016/j.jconrel.2025.113784 · 2025 · External reference
Application of Hyaluronic Acid in Enhancing the Efficacy and Safety of Paclitaxel Nanoformulations for Cancer Treatment
2026 · External reference
Cancer Stem Cells in Oral Squamous Cell Carcinoma: A Narrative Review on Experimental Characteristics and Methodological Challenges
10.3390/biomedicines12092111 · 2024 · External reference
Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy
10.3390/cells14020061 · 2025 · External reference
Hyaluronic acid-based drug nanocarriers as a novel drug delivery system for cancer chemotherapy: A systematic review
10.1007/s40199-021-00416-6 · 2021 · External reference
Recent advances in hyaluronic acid-based nanomedicines: Preparation and application in cancer therapy
10.1016/j.carbpol.2022.119662 · 2022 · External reference
Hyaluronic Acid: Production Strategies
2025 · External reference
Next-generation polymer-based nanofiber ocular inserts: fabrication innovations, therapeutic applications, regulatory perspectives, and future directions
10.1016/j.ijpharm.2026.126781 · 2026 · External reference
Effects of molecular weights on the bioactivity of hyaluronic acid: A review
10.1016/j.carres.2025.109472 · 2025 · External reference
Decoding Toll-like receptors: Recent insights and perspectives in innate immunity
10.1016/j.immuni.2024.03.004 · 2024 · External reference
The matrix reloaded—the role of the extracellular matrix in cancer
10.3390/cancers15072057 · 2023 · External reference
Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions
10.1515/ntrev-2020-0084 · 2020 · External reference
Applications of hyaluronic acid in ophthalmology and contact lenses
2021 · External reference
Hyaluronic acid prodrug micelles for tumour therapy
10.1080/1061186x.2021.1919125 · 2022 · External reference
Hyaluronic acid: its versatile use in ocular drug delivery with a specific focus on hyaluronic acid-based polyelectrolyte complexes
2022 · External reference
Effect of Hyaluronan Molecular Weight on the Stability and Biofunctionality of Microfibers Assembled by Interfacial Polyelectrolyte Complexation
10.1021/acsami.4c18335 · 2025 · External reference
Effect of solvent and ions on the structure and dynamics of a hyaluronan molecule
10.1016/j.carbpol.2020.115919 · 2020 · External reference
Polymeric Nanoparticles for Drug Delivery
10.1021/acs.chemrev.3c00705 · 2024 · External reference
Methods for Determining the High Molecular Weight of Hyaluronic Acid: A Review
10.3390/polym17243289 · 2025 · External reference
Molecular dynamics deconstruction of hyaluronic acid shear thinning: hydrogen bond network dynamics driving rheological response
10.1016/j.cmpb.2025.109120 · 2026 · External reference
Modulating Rheological Properties via Non-Cross-Linked Phase in Biphasic Hyaluronic Acid Fillers
10.1021/acsomega.5c02674 · 2025 · External reference
Fine-tuning the mechanical and degradation properties of chemically crosslinked hyaluronic acid hydrogels through salt treatment
10.1016/j.carbpol.2025.124682 · 2026 · External reference
Recent advances and prospects of hyaluronan as a multifunctional therapeutic system
10.1016/j.jconrel.2021.07.002 · 2021 · External reference
Chemical modification of hyaluronic acid as a strategy for the development of advanced drug delivery systems
10.1016/j.carbpol.2024.122145 · 2024 · External reference
Mucoadhesive hyaluronic acid composites for prolonged gastric retention
10.1016/j.ijpharm.2025.126371 · 2026 · External reference
The role of high molecular weight hyaluronic acid in mucoadhesion on an ocular surface model
10.1016/j.jmbbm.2023.105908 · 2023 · External reference
Harnessing electrospun nanofibers for comprehensive oral disease management: Current trends and future perspectives
10.1016/j.jddst.2025.106681 · 2025 · External reference
Chemical Modification of Hyaluronan and Their Biomedical Applications
10.3389/fchem.2022.830671 · 2022 · External reference
Synthesis, characterization of thiolated hyaluronic acid and evaluation of its encapsulation effects on Limosilactobacillus reuteri HR7
10.1016/j.ijbiomac.2025.143486 · 2025 · External reference
Comprehensive exploration on chemical functionalization and crosslinked injectable hyaluronic acid hydrogels for tissue engineering applications
10.1007/s40883-024-00368-8 · 2025 · External reference
Dual-Modified Hyaluronic Acid for Tunable Double Cross-Linked Hydrogel Adhesives
10.1021/acs.biomac.4c00194 · 2024 · External reference
Advancements in Hyaluronic Acid Synthetic Methodologies and Their Translational Relevance
10.1021/acs.chemrev.5c00790 · 2026 · External reference
Injectable Hyaluronic Acid Hydrogels Crosslinked by Structure-engineered Aldehyde-functionalized β-Cyclodextrin Derivatives for Long-term Controlled Voriconazole Delivery
10.1208/s12249-025-03212-6 · 2025 · External reference
Photo-cross-linkable hyaluronic acid bioinks for bone and cartilage tissue engineering applications
10.1080/09506608.2023.2167559 · 2023 · External reference
Norbornene homopolymerization limits cell spreading in thiol–ene photoclick hydrogels
10.1002/adhm.202502172 · 2025 · External reference
Granular disulfide-crosslinked hyaluronic hydrogels: a systematic study of reaction conditions on thiol substitution and injectability parameters
2023 · External reference
Optimizing phenol-modified hyaluronic acid for designing shape-maintaining biofabricated hydrogel scaffolds in soft tissue engineering
10.1016/j.ijbiomac.2023.125201 · 2023 · External reference
Hyaluronic acid–paclitaxel conjugate inhibits growth of human squamous cell carcinomas of the head and neck via a hyaluronic acid-mediated mechanism
10.1016/j.oraloncology.2011.07.029 · 2011 · External reference
Smart Polymer-Derived Injectable Hydrogels: Current Status and Future Perspectives
10.1021/acspolymersau.5c00053 · 2025 · External reference
Recent advances in hyaluronic acid-decorated nanocarriers for targeted cancer therapy
10.1016/j.drudis.2016.12.009 · 2016 · External reference
Complexed hyaluronic acid-based nanoparticles in cancer therapy and diagnosis: Research trends by natural language processing
10.1016/j.heliyon.2024.e41246 · 2025 · External reference
Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance
10.3390/cancers10120482 · 2018 · External reference
Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer
10.3390/cancers12051325 · 2020 · External reference
Interaction between CD44 and highly condensed hyaluronic acid through crosslinking with proteins
10.1016/j.bioorg.2022.105666 · 2022 · External reference
Analysis of CD44-Hyaluronan Interactions in an Artificial Membrane System: INSIGHTS INTO THE DISTINCT BINDING PROPERTIES OF HIGH AND LOW MOLECULAR WEIGHT HYALURONAN
10.1074/jbc.m110.137562 · 2010 · External reference
Evaluation of hyaluronic acid to modulate oral squamous cell carcinoma growth in vitro
10.3390/jfb11040072 · 2020 · External reference
Hyaluronic acid in the third millennium
2018 · External reference
Hyaluronic Acid-Based Bioink Composition Enabling 3D Bioprinting and Improving Quality of Deposited Cartilaginous Extracellular Matrix
10.1002/adhm.202000737 · 2020 · External reference
Hyaluronic acid and its synthases—current knowledge
10.3390/ijms26157028 · 2025 · External reference
Hyaluronic acid: a hydrating anti-inflammatory glycosaminoglycan polymer with multiple uses, International Journal of Polymeric Materials and Polymeric
2026 · External reference
Hyaluronan: An Architect and Integrator for Cancer and Neural Diseases
10.3390/ijms26115132 · 2025 · External reference
Targeted Hyaluronan Degradation Enhanced Tumor Growth Inhibition in Gastrointestinal Cancer Models
10.3390/cancers17213411 · 2025 · External reference
CD44/HA signaling mediates acquired resistance to a PI3Kα inhibitor
10.1038/s41419-020-03037-0 · 2020 · External reference
Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment
10.1002/adhm.202202118 · 2023 · External reference
The key role of hyaluronic acid molecular weight in HIF-1α pathway-mediated hypoxic microenvironment reprogramming
10.1016/j.ijbiomac.2025.146506 · 2025 · External reference
Advances in hyaluronic acid-based biomaterials: applications in cancer therapy, wound healing, and disease management
10.1007/s10856-025-06946-8 · 2025 · External reference
CD44 occurring alternative splicing promotes cisplatin resistance and evokes tumor immune response in oral squamous cell carcinoma cells
10.1016/j.tranon.2023.101644 · 2023 · External reference
Prognostic evaluation of tumour budding in oral squamous cell carcinoma: Evidenced by CD44 expression as a cancer stem cell marker
10.1016/j.prp.2023.154883 · 2023 · External reference
Molecular mechanisms and therapeutic role of intra-articular hyaluronic acid in osteoarthritis: a precision medicine perspective
2025 · External reference
Role of the extracellular matrix in cancer: insights into tumor progression and therapy
2025 · External reference
Hyaluronic acid/chitosan-coated poly (lactic-co-glycolic acid) nanoparticles to deliver single and co-loaded paclitaxel and temozolomide for CD44+oral cancer cells
10.1016/j.onano.2023.100166 · 2023 · External reference
Impact of CD44 alternative splicing on the response to anticancer drugs
10.1016/j.bcp.2026.118111 · 2026 · External reference
HMMR in human cancers: regulatory mechanism and biological function
10.1186/s12967-025-07260-1 · 2025 · External reference
Co-localization and crosstalk between CD44 and RHAMM depend on hyaluronan presentation
10.1016/j.actbio.2020.10.024 · 2021 · External reference
Hyaluronic acid interacting molecules mediated crosstalk between cancer cells and microenvironment from primary tumour to distant metastasis
2024 · External reference
Systemic glycosaminoglycan clearance by HARE/Stabilin-2 activates intracellular signaling
2020 · External reference
Advanced Generation Therapeutics: Biomimetic Nanodelivery System for Tumor Immunotherapy
10.1021/acsnano.3c10212 · 2023 · External reference
CD44 overexpression as a mediator of drug resistance in oral cancer: a meta-analysis unveiling molecular underpinnings and therapeutic implications
10.1007/s12672-025-03436-9 · 2025 · External reference
High expression of Stabilin-2 predicts poor prognosis in non-small-cell lung cancer
10.1080/21655979.2021.1943109 · 2021 · External reference
Role of toll-like receptor in the pathogenesis of oral cancer
2023 · External reference
QbD Manoeuvred Niclosamide Laden Polylactic-co-Glycolic Acid Nanoparticles-Impregnated Gelatin Nanofibers for the Management of Oral Carcinoma
2025 · External reference
The tumor stroma of squamous cell carcinoma: a complex environment that fuels cancer progression
2024 · External reference
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer
10.3389/fimmu.2015.00201 · 2015 · External reference
Hyaluronic Acid as a Modern Approach in Anticancer Therapy-Review
10.3390/ijms24010103 · 2022 · External reference
Stimulus-Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy
2024 · External reference
An injectable hydrogel with photothermal and chemodynamic therapies for targeted promotion of ferroptosis in oral squamous cell carcinoma
10.1039/d4nr05147e · 2025 · External reference
Local delivery of methotrexate/glycyrrhizin-loaded hyaluronic acid nanofiber for the management of oral cancer
10.1016/j.ijpharm.2024.124311 · 2024 · External reference
Next-Generation Transformable Nanomedicines: Revolutionizing Cancer Drug Delivery and Theranostics
10.1021/acs.molpharmaceut.4c01495 · 2025 · External reference
Combating breast cancer-associated metastasis using paclitaxel and tranilast-loaded human serum albumin nanoparticles
10.1080/03639045.2025.2509861 · 2025 · External reference
Developments in nanotechnology approaches for the treatment of solid tumors
10.1186/s40164-025-00656-1 · 2025 · External reference
Quality by design manoeuvred cabazitaxel-loaded polycaprolactone nanoparticles for management of melanoma: development, optimization, in silico modeling and in vitro studies
10.1007/s10876-026-03026-x · 2026 · External reference
Amelioration of breast cancer therapies through normalization of tumor vessels and microenvironment: paradigm shift to improve drug perfusion and nanocarrier permeation, Drug Deliv
2025 · External reference
Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer
10.1016/j.ijbiomac.2023.124528 · 2023 · External reference
Delivery of MTH1 inhibitor (TH287) and MDR1 siRNA via hyaluronic acid-based mesoporous silica nanoparticles for oral cancers treatment
10.1016/j.colsurfb.2018.09.076 · 2019 · External reference
Catechol-modified chitosan/hyaluronic acid nanoparticles as a new avenue for local delivery of doxorubicin to oral cancer cells
10.1016/j.colsurfb.2020.111279 · 2020 · External reference
Multilayered nanofibrous scaffold of Polyvinyl alcohol/gelatin/poly (lactic-co-glycolic acid) enriched with hemostatic/antibacterial agents for rapid acute hemostatic wound healing
10.1016/j.ijpharm.2023.122918 · 2023 · External reference
‘Nano-in-nano’ – Breaching the barriers of the tumor microenvironment using nanoparticle-incorporated nanofibers
10.1016/j.jddst.2023.105249 · 2024 · External reference
Docetaxel and niclosamide-loaded nanofiber systems for improved chemo-therapeutic activity and resistance reversal in prostate cancer, Drug Dev
10.1080/03639045.2025.2453533 · 2025 · External reference
Glycyrrhizin loaded hyaluronic acid nanofiber-based artificial saliva for the management of oral mucositis: Preparation, optimization and in-vitro evaluation
2023 · External reference
Minimally Invasive Injectable Hydrogels, Transdermal Applications of Minimally Invasive Drug Delivery Systems: Current Trends and Future
2025 · External reference
Hyaluronic acid-based composite hydrogels embedded with core-shell microgels with properties of mucosal adhesion and combined drug administration for chemoradiotherapy induced oral mucositis
10.1016/j.ijbiomac.2025.146575 · 2025 · External reference
Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions
10.1038/s41392-024-01852-x · 2024 · External reference
Advances in biodegradable and injectable hydrogels for biomedical applications
10.1016/j.jconrel.2020.12.008 · 2021 · External reference
Smart hydrogels and the promise of multi-responsive in-situ systems
10.1016/j.jddst.2025.106758 · 2025 · External reference
MMP-responsive in situ forming hydrogel loaded with doxorubicin-encapsulated biodegradable micelles for local chemotherapy of oral squamous cell carcinoma
10.1039/c9ra04343h · 2019 · External reference
Nanotechnology-mediated combinational drug delivery approach for cancer therapy
10.1016/b978-0-323-85873-1.00008-3 · 2022 · External reference
Environment-adaptive microneedle design strategies for precision oral disease treatment: From material innovation to clinical translation
10.1016/j.jconrel.2025.114402 · 2025 · External reference
CD44 targeting biocompatible and biodegradable hyaluronic acid cross-linked zein nanogels for curcumin delivery to cancer cells: In vitro and in vivo evaluation
10.1016/j.jconrel.2018.04.050 · 2018 · External reference
Curcumin analogue AC17-loaded dissolvable microneedles activate FOXO3 and enhance localized drug delivery for oral squamous cell carcinoma treatment
10.1016/j.ijpharm.2024.124385 · 2024 · External reference
Mouthwash Containing Vitamin E, Triamcinolon, and Hyaluronic Acid Compared to Triamcinolone Mouthwash Alone in Patients With Radiotherapy-Induced Oral Mucositis: Randomized Clinical Trial
10.3389/fonc.2021.614877 · 2021 · External reference
‘Two-faces’ of hyaluronan, a dynamic barometer of disease progression in tumor microenvironment
2023 · External reference
A paclitaxel-hyaluronan conjugate (ONCOFID-P-B™) in patients with BCG-unresponsive carcinoma in situ of the bladder: a dynamic assessment of the tumor microenvironment
10.1186/s13046-024-03028-5 · 2024 · External reference
Efficacy of a Solution Composed by Verbascoside, Polyvinylpyrrolidone (PVP) and Sodium Hyaluronate in the Treatment of Chemotherapy-induced Oral Mucositis in Children With Acute Lymphoblastic Leukemia
10.1097/mph.0000000000000669 · 2016 · External reference
The effects of a combination oral spray (Mucosamin®) for the prevention of oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation: a double blind randomized clinical trial
2022 · External reference
Effects of L-glutamine and hyaluronic acid associated with photobiomodulation on oral mucositis: a randomized clinical trial
2025 · External reference
Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications
10.3390/pharmaceutics17050623 · 2025 · External reference
Cytotoxicity towards Breast Cancer Cells of Pluronic F-127/Hyaluronic Acid Hydrogel Containing Nitric Oxide Donor and Silica Nanoparticles Loaded with Cisplatin
10.3390/pharmaceutics14122837 · 2022 · External reference
Analytical Procedure Development and Proposed Established Conditions: A Case Study of a Mass Spectrometry Based NDSRI Analytical Procedure
10.1016/j.xphs.2024.07.022 · 2024 · External reference
Microbial production of hyaluronic acid: The current advances, engineering strategies and trends
10.1016/j.jbiotec.2025.03.015 · 2025 · External reference
Validation of an Analytical Method for the Simultaneous Determination of Hyaluronic Acid Concentration and Molecular Weight by Size-Exclusion Chromatography
10.3390/molecules26175360 · 2021 · External reference
Chemically Modified Biopolymers for the Formation of Biomedical Hydrogels
10.1021/acs.chemrev.0c00923 · 2020 · External reference
Three-tiered approach for standard information requirements for polymers requiring registration under REACH
10.1016/j.yrtph.2023.105495 · 2023 · External reference
Unlocking the potential of hyaluronic acid: Exploring its physicochemical properties, modification, and role in food applications
10.1016/j.tifs.2023.104218 · 2023 · External reference
Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications
10.1002/adfm.202306554 · 2023 · External reference
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