Research graph
References from Structural and functional characterization of PDC-16 β-lactamase reveals a constrained active-site architecture associated with altered catalysis. Local targets link to admitted publications; unresolved targets remain external evidence.
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics
10.1038/s41392-022-01056-1 · 2022 · External reference
Antimicrobial resistance: impacts, challenges, and future prospects
10.1016/j.glmedi.2024.100081 · 2024 · External reference
Deciphering multidrug-resistant Pseudomonas aeruginosa: mechanistic insights and environmental risks
10.3390/toxics13040303 · 2025 · External reference
Evaluation and analysis of multidrug resistance- and hypervirulence-associated genes in carbapenem-resistant Pseudomonas aeruginosa strains among children in an area of China for five consecutive years
2023 · External reference
High prevalence of carbapenem-resistant Pseudomonas aeruginosa and identification of a novel VIM-type metallo-β-lactamase, VIM-92, in clinical isolates from northern China
2025 · External reference
Enhanced spread of carbapenem-resistant Pseudomonas aeruginosa in ICU environment during a COVID-19 upsurge period in China
10.2147/idr.s562352 · 2026 · External reference
Multidrug-resistant Pseudomonas aeruginosa: pathogenesis, resistance mechanisms, and novel therapeutic strategies
10.1080/21505594.2025.2580160 · 2025 · External reference
Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors
10.1099/mic.0.001333 · 2023 · External reference
Decoding antibiotic resistance in Pseudomonas aeruginosa: embracing innovative therapies beyond conventional antibiotics
10.1016/j.microb.2025.100233 · 2025 · External reference
β-Lactam potentiators to re-sensitize resistant pathogens: discovery, development, clinical use and the way forward
10.3389/fmicb.2022.1092556 · 2023 · External reference
New β-lactam–β-lactamase inhibitor combinations
10.1128/cmr.00115-20 · 2020 · External reference
New β-lactam/β-lactamase inhibitor combination antibiotics
10.3390/pathogens14040307 · 2025 · External reference
The latest advances in β-lactam/β-lactamase inhibitor combinations for the treatment of gram-negative bacterial infections
10.1080/14656566.2019.1660772 · 2019 · External reference
β-Lactam antibiotics and β-lactamase enzymes inhibitors, part 2: our limited resources
10.3390/ph15040476 · 2022 · External reference
Structural comparison of substrate-binding pockets of serine β-lactamases in classes a, C, and D
10.1080/14756366.2024.2435365 · 2025 · External reference
Updated functional classification of β-lactamases
10.1128/aac.01009-09 · 2010 · External reference
Structure-based classification of class a beta-lactamases, an update
10.1016/j.retram.2019.05.003 · 2019 · External reference
β-Lactamases and β-lactamase inhibitors in the 21st century
10.1016/j.jmb.2019.04.002 · 2019 · External reference
Metallo-β-lactamase structure and function
10.1111/j.1749-6632.2012.06796.x · 2013 · External reference
Combatting Pseudomonas aeruginosa with β-lactam antibiotics: a revived weapon?
10.3390/antibiotics14050526 · 2025 · External reference
Tackling the antibiotic resistance caused by class A β-lactamases through the use of β-lactamase inhibitory protein
10.3390/ijms19082222 · 2018 · External reference
Class C β-lactamases: molecular characteristics
10.1128/cmr.00150-21 · 2022 · External reference
Unresolved reference
2024 · External reference
Diversity in the common fold: structural insights into class D β-lactamases from gram-negative pathogens
10.3390/pathogens14080761 · 2025 · External reference
A Val292 substitution combined with an alanine duplication (ADUP) in the Ω loop of ADC β-lactamase confers reduced susceptibility to advanced β-lactam agents, including cefiderocol
10.1128/mbio.03518-25 · 2026 · External reference
Role of the Ω-loop in the activity, substrate specificity, and structure of class A β-lactamase
10.1021/bi972127f · 1998 · External reference
Conformational dynamics of the Helix 10 region as an allosteric site in class A β-lactamase inhibitory binding
10.1021/jacs.0c04088 · 2020 · External reference
Impact of extended-spectrum chromosomal AmpC (ESAC) of Escherichia coli on susceptibility to cefiderocol
10.1128/spectrum.00704-24 · 2024 · External reference
Prevalence and distribution of extended-spectrum β-lactamase and AmpC-producing Escherichia coli in two New Zealand dairy farm environments
10.3389/fmicb.2022.960748 · 2022 · External reference
Longitudinal evolution of the Pseudomonas-derived cephalosporinase (PDC) structure and activity in a cystic fibrosis patient treated with β-lactams
10.1128/mbio.01663-22 · 2022 · External reference
Genetic characteristics and diversity of PDC variants of Pseudomonas aeruginosa and its clinical relevance
10.1016/j.meegid.2024.105701 · 2024 · External reference
Deciphering the evolution of cephalosporin resistance to ceftolozane-tazobactam in Pseudomonas aeruginosa
10.1128/mbio.02085-18 · 2018 · External reference
Extended-spectrum cephalosporinases in Pseudomonas aeruginosa
10.1128/aac.01410-08 · 2009 · External reference
A standard numbering scheme for class C β-lactamases
10.1128/aac.01841-19 · 2020 · External reference
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM
10.1107/s0907444910048675 · 2011 · External reference
Phaser crystallographic software
10.1107/s0021889807021206 · 2007 · External reference
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
10.1107/s2059798319011471 · 2019 · External reference
Current developments in coot for macromolecular model building of Electron Cryo-microscopy and crystallographic data
10.1002/pro.3791 · 2020 · External reference
MolProbity: all-atom structure validation for macromolecular crystallography
10.1107/s0907444909042073 · 2010 · External reference
Unresolved reference
External reference
ParKVFinder: a thread-level parallel approach in biomolecular cavity detection
10.1016/j.softx.2020.100606 · 2020 · External reference
Fpocket: an open source platform for ligand pocket detection
10.1186/1471-2105-10-168 · 2009 · External reference
CavityPlus: a web server for protein cavity detection with pharmacophore modelling, allosteric site identification and covalent ligand binding ability prediction
10.1093/nar/gky380 · 2018 · External reference
CAVER 3.0: a tool for the analysis of transport pathways in dynamic protein structures
10.1371/journal.pcbi.1002708 · 2012 · External reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
10.1038/srep42717 · 2017 · External reference
ProTox 3.0: a webserver for the prediction of toxicity of chemicals
2024 · External reference
Unresolved reference
2019 · External reference
GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers
10.1016/j.softx.2015.06.001 · 2015 · External reference
CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data
10.1002/jcc.23354 · 2013 · External reference
Green tea catechin epigallocatechin gallate inhibits vegetative cell outgrowth and expression of beta-lactamase genes in penicillin-resistant Bacillus anthracis strain PCr
10.3390/pathogens13080699 · 2024 · External reference
Restoration of antibacterial activity of β-lactams by epigallocatechin gallate against β-lactamase-producing species depending on location of β-lactamase
10.1211/002235703765951320 · 2003 · External reference
The structure of Pseudomonas P51 cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function
10.1110/ps.0388503 · 2003 · External reference
Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases
10.1093/nar/gky976 · 2018 · External reference
Allosteric regulation of catalytic activity: Escherichia coli aspartate Transcarbamoylase versus yeast Chorismate mutase
10.1128/mmbr.65.3.404-421.2001 · 2001 · External reference
