Research graph
References from Porcine recombinant NK-lysin inhibits canine mammary tumor progression by targeting elongation factor 1-alpha and T-complex protein 1 subunit gamma to disrupt the organization of cytoskeletal architecture. Local targets link to admitted publications; unresolved targets remain external evidence.
Canine mammary cancer: state of the art and future perspectives
10.3390/ani13193147 · 2023 · External reference
Epidemiological investigation of canine mammary tumors in mainland China between 2017 and 2021
10.3389/fvets.2022.843390 · 2022 · External reference
Risk factor analysis and clinicopathological characteristics of female dogs with mammary tumours from a single-center retrospective study in Poland
10.1038/s41598-024-56194-z · 2024 · External reference
Epidemiology and classification for canine and feline mammary gland tumors: a histopathological survey of 437 mammary gland tumor biopsies performed in a secondary care hospital in Chiang Mai, Thailand from 2012 to 2019
10.7717/peerj.17077 · 2024 · External reference
Prognostic significance of immunohistochemical markers and histological classification in malignant canine mammary tumours
10.1111/vco.12603 · 2020 · External reference
Histopathological, immunohistochemical and imaging features of bone metastases of mammary carcinoma in bitches: cases report
10.29374/2527-2179.bjvm009124 · 2025 · External reference
Canine mammary tumors: classification, biomarkers, traditional and personalized therapies
10.3390/ijms25052891 · 2024 · External reference
Canine mammary tumors as a promising adjunct preclinical model for human breast cancer research: similarities, opportunities, and challenges
10.1007/s12272-024-01524-y · 2025 · External reference
Current research status of anti-cancer peptides: mechanism of action, production, and clinical applications
10.1016/j.biopha.2023.114996 · 2023 · External reference
Anticancer activities of natural antimicrobial peptides from animals
2023 · External reference
Antimicrobial peptides as potential therapeutics for breast cancer
10.1016/j.phrs.2021.105777 · 2021 · External reference
Anticancer potential of antimicrobial peptides: focus on breast cancer
10.1002/jbt.70525 · 2025 · External reference
Effect of NK-lysin peptides on bacterial growth, MIC, antimicrobial resistance, and viral activities
10.1080/10495398.2023.2290520 · 2024 · External reference
Expression and purification of the recombinant porcine NK-lysin in Pichia pastoris and observation of anticancer activity in vitro
10.1080/10826068.2014.979206 · 2016 · External reference
Recombinant porcine NK-lysin inhibits the invasion of hepatocellular carcinoma cells in vitro
10.1016/j.ijbiomac.2019.08.212 · 2019 · External reference
Porcine recombinant NK-lysin inhibits the growth and metastasis of murine hepatocellular carcinoma in vivo
10.3390/molecules30061234 · 2025 · External reference
Enhanced anti-tumor efficacy of prNK-lysin delivered by injectable pH-responsive hydrogel in the treatment of orthotopic breast cancer
10.1016/j.ijbiomac.2025.149754 · 2026 · External reference
Molecular principles of metastasis: a hallmark of cancer revisited
10.1038/s41392-020-0134-x · 2020 · External reference
Movers and shakers: cell cytoskeleton in cancer metastasis
10.1111/bph.12704 · 2014 · External reference
Cytoskeletal dynamics in epithelial-mesenchymal transition: insights into therapeutic targets for cancer metastasis
10.3390/cancers13081882 · 2021 · External reference
Roles of cytoskeleton in metastasis: from its mechanism to therapeutic strategies
10.1038/s12276-025-01608-9 · 2026 · External reference
Microtubule dynamics in cancer metastasis: harnessing the underappreciated potential for therapeutic interventions
10.1016/j.pharmthera.2024.108726 · 2024 · External reference
Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis
10.7150/ijbs.44943 · 2020 · External reference
High eEF1A1 protein levels mark aggressive prostate cancers and the in vitro targeting of eEF1A1 reveals the eEF1A1-actin complex as a new potential target for therapy
10.3390/ijms23084143 · 2022 · External reference
The eEF1A protein in cancer: clinical significance, oncogenic mechanisms, and targeted therapeutic strategies
10.1016/j.phrs.2024.107195 · 2024 · External reference
The role of the molecular chaperone CCT in protein folding and mediation of cytoskeleton-associated processes: implications for cancer cell biology
10.1007/s12192-018-0949-3 · 2019 · External reference
Advances in the study of CCT3 in malignant tumors: a review
10.1097/md.0000000000041069 · 2025 · External reference
Cyclopedic protein expression analysis of cultured canine mammary gland adenocarcinoma cells from six tumours
10.1016/j.rvsc.2005.07.011 · 2006 · External reference
Pore-forming peptides: a new treatment option for Cancer
10.2174/0929867328666211126150055 · 2022 · External reference
Advances in antimicrobial peptides: promising cancer treatments and vaccines
10.3389/fmed.2026.1783547 · 2026 · External reference
Anticancer peptides mechanisms, simple and complex
10.1016/j.cbi.2022.110194 · 2022 · External reference
The cytoskeleton and cancer
10.1007/s10555-008-9166-3 · 2009 · External reference
Filopodia in vitro and in vivo
10.1146/annurev-cellbio-020223-025210 · 2023 · External reference
The crossroads between RAS and RHO signaling pathways in cellular transformation, motility and contraction
10.3390/genes12060819 · 2021 · External reference
RhoA-ROCK2 signaling possesses complex pathophysiological functions in cancer progression and shows promising therapeutic potential
10.1186/s12935-024-03519-7 · 2024 · External reference
Vinculin and metavinculin: oligomerization and interactions with F-actin
10.1016/j.febslet.2013.02.042 · 2013 · External reference
Nuclear α-actinin-4 regulates breast cancer invasiveness and EMT
10.1002/cm.21901 · 2025 · External reference
ERM proteins support perinuclear actin rim formation
2025 · External reference
ERM proteins in cancer progression
10.1242/jcs.133108 · 2014 · External reference
The cofilin pathway in breast cancer invasion and metastasis
10.1038/nrc2148 · 2007 · External reference
Cofilin promotes vasculogenic mimicry by regulating the actin cytoskeleton in human breast cancer cells
10.1002/1873-3468.14594 · 2023 · External reference
Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells
2012 · External reference
eEF1A1 promotes colorectal cancer progression and predicts poor prognosis of patients
10.1002/cam4.4848 · 2023 · External reference
Suppression of CCT3 inhibits the proliferation and migration in breast cancer cells
10.1186/s12935-020-01314-8 · 2020 · External reference
Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth
10.18632/oncotarget.22838 · 2017 · External reference
RAF-MEK-ERK pathway in cancer evolution and treatment
10.1016/j.semcancer.2021.05.010 · 2022 · External reference
MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the rho-ROCK-LIM kinase pathway
10.1074/jbc.m202261200 · 2002 · External reference
An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
10.1016/j.cell.2022.12.025 · 2023 · External reference
CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer
10.1038/s41419-019-1894-5 · 2019 · External reference
