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References from Mismetallation reveals metal tolerance and enhanced stability of human deoxyhypusine hydroxylase. Local targets link to admitted publications; unresolved targets remain external evidence.
Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor
10.1073/pnas.78.5.2869 · 1981 · External reference
Identification of the hypusine-containing protein Hy+ as translation initiation factor eIF-4D
10.1073/pnas.80.7.1854 · 1983 · External reference
Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein
10.1016/s0021-9258(18)94226-2 · 1989 · External reference
Hypusine formation in protein by a two-step process in cell lysates
10.1016/s0021-9258(18)48133-1 · 1987 · External reference
Assay of deoxyhypusine hydroxylase activity
10.1007/978-1-61779-034-8_13 · 2011 · External reference
Halfway to hypusine—structural basis for substrate recognition by human deoxyhypusine synthase
10.3390/biom10040522 · 2020 · External reference
Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization
10.1016/s0021-9258(17)35750-2 · 1986 · External reference
Deoxyhypusine hydroxylase is an Fe(II)-dependent, HEAT-repeat enzyme
10.1074/jbc.m601081200 · 2006 · External reference
eIF5A functions globally in translation elongation and termination
10.1016/j.molcel.2017.03.003 · 2017 · External reference
eIF5A has a function in the elongation step of translation in yeast
10.1016/j.bbrc.2009.01.148 · 2009 · External reference
Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae
10.1073/pnas.1008150108 · 2011 · External reference
Hypusine-containing protein eIF5A promotes translation elongation
10.1038/nature08034 · 2009 · External reference
The hypusine-containing translation factor eIF5A
10.3109/10409238.2014.939608 · 2014 · External reference
eIF5A facilitates translation termination globally and promotes the elongation of many non-polyproline-specific tripeptide sequences
10.1093/nar/gkx479 · 2017 · External reference
Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome
10.1093/nar/gkv1517 · 2016 · External reference
In vitro yeast reconstituted translation system reveals function of eIF5A for synthesis of long polypeptide
10.1093/jb/mvaa022 · 2020 · External reference
The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles
10.1186/s13578-021-00733-y · 2021 · External reference
The role of eukaryotic initiation factor 5A in the control of cell proliferation and apoptosis
10.1007/s007260170050 · 2001 · External reference
Independent roles of eIF5A and polyamines in cell proliferation
10.1042/bj20041477 · 2005 · External reference
Polyamine metabolism is a central determinant of helper T cell lineage fidelity
10.1016/j.cell.2021.06.007 · 2021 · External reference
Structure and mechanism of spermidine synthases
10.1021/bi602498k · 2007 · External reference
Revisiting the antizyme 1–ODC interaction reveals low-nanomolar affinity
10.1007/s00726-026-03519-z · 2026 · External reference
Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer
10.1007/s00726-016-2275-3 · 2016 · External reference
Eukaryotic translation initiation factor 5A in the pathogenesis of cancers
10.3892/ol.2020.11942 · 2020 · External reference
Identification and characterization of eukaryotic initiation factor 5A-2
10.1046/j.1432-1033.2003.03806.x · 2003 · External reference
Drug-induced reactivation of apoptosis abrogates HIV-1 infection
10.1371/journal.pone.0074414 · 2013 · External reference
Drug-based lead discovery: the novel ablative antiretroviral profile of deferiprone in HIV-1-infected cells and in HIV-infected treatment-naive subjects of a double-blind, placebo-controlled, randomized exploratory trial
10.1371/journal.pone.0154842 · 2016 · External reference
Inhibition of HIV-1 gene expression by ciclopirox and deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A
10.1186/1742-4690-6-90 · 2009 · External reference
Hypusination of eIF5A as a target for antiviral therapy
10.1089/dna.2016.3611 · 2017 · External reference
Recessive rare variants in deoxyhypusine synthase, an enzyme involved in the synthesis of hypusine, are associated with a neurodevelopmental disorder
10.1016/j.ajhg.2018.12.017 · 2019 · External reference
Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine
10.1038/s41467-021-21053-2 · 2021 · External reference
Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders
10.1038/s41467-023-37305-2 · 2023 · External reference
Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder
10.1016/j.ajhg.2022.06.010 · 2022 · External reference
eIF5A and hypusination-related disorders: literature review and case report of DOHH-related encephalopathy
10.1186/s11689-025-09649-x · 2025 · External reference
Case report: a new patient expanding the clinical spectrum of DOHH-associated syndrome with increased nuchal translucency, cardiomyopathy, hypoparathyroidism and mild intellectual disability
10.3389/fped.2026.1733592 · 2026 · External reference
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site
10.1016/s0969-2126(98)00004-5 · 1998 · External reference
Trypanosomatid deoxyhypusine synthase activity is dependent on shared active-site complementation between pseudoenzyme paralogs
10.1016/j.str.2018.07.012 · 2018 · External reference
Flexible NAD+ binding in deoxyhypusine synthase reflects the dynamic hypusine modification of translation factor IF5A
10.3390/ijms21155509 · 2020 · External reference
Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major
10.1371/journal.pntd.0008762 · 2020 · External reference
Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase
10.1111/febs.17207 · 2024 · External reference
ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activity
10.1016/j.celrep.2024.114831 · 2024 · External reference
Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism
10.1016/j.str.2024.03.008 · 2024 · External reference
The structural biology of deoxyhypusination complexes
10.1016/j.str.2024.12.011 · 2025 · External reference
Crystal structure of the peroxo-diiron(III) intermediate of deoxyhypusine hydroxylase, an oxygenase involved in hypusination
10.1016/j.str.2015.03.002 · 2015 · External reference
Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O 2 with a nonheme diiron center
10.1073/pnas.0904553106 · 2009 · External reference
Theoretical study on the catalytic mechanism of human deoxyhypusine hydroxylase
10.1039/d0cp03598j · 2020 · External reference
X-ray absorption spectroscopic characterization of the diferric-peroxo intermediate of human deoxyhypusine hydroxylase in the presence of its substrate eIF5a
10.1007/s00775-016-1373-8 · 2016 · External reference
Crystallographic fragment screening supports tool compound discovery and reveals conformational flexibility in human deoxyhypusine synthase
10.1038/s42004-026-01897-9 · 2026 · External reference
Protein identification and analysis tools on the ExPASy server
2005 · External reference
Optimization of protein buffer cocktails using Thermofluor
10.1107/s1744309112051858 · 2013 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
XDS
10.1107/s0907444909047337 · 2010 · External reference
XDSAPP: a graphical user interface for the convenient processing of diffraction data using XDS
10.1107/s0021889812011715 · 2012 · External reference
Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography
10.1107/s0907444913012274 · 2013 · External reference
Phaser crystallographic software
10.1107/s0021889807021206 · 2007 · External reference
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
10.1107/s2059798319011471 · 2019 · External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
Towards automated crystallographic structure refinement with phenix.refine
10.1107/s0907444912001308 · 2012 · External reference
Improving macromolecular structure refinement with metal-coordination restraints
10.1107/s2059798324011458 · 2024 · External reference
MolProbity: all-atom structure validation for macromolecular crystallography
10.1107/s0907444909042073 · 2010 · External reference
ANODE: anomalous and heavy-atom density calculation
10.1107/s0021889811041768 · 2011 · External reference
Structural analysis and optimization of context-independent anti-hypusine antibodies
10.1016/j.jmb.2016.01.006 · 2016 · External reference
Inverse tuning of metal binding affinity and protein stability by altering charged coordination residues in designed calcium binding proteins
10.1186/1757-5036-2-11 · 2009 · External reference
A thermodynamic study of mesophilic, thermophilic, and hyperthermophilic l-arabinose isomerases: the effects of divalent metal ions on protein stability at elevated temperatures
10.1016/j.febslet.2005.01.027 · 2005 · External reference
Influence of metal ions on folding pathway and conformational stability of bovine serum albumin
10.1016/j.molstruc.2007.07.013 · 2008 · External reference
Coordination contributions to protein stability in metal-substituted carbonic anhydrase
10.1007/s00775-016-1375-6 · 2016 · External reference
Metal substitutions at the diiron sites of hemerythrin and myohemerythrin: contributions of divalent metals to stability of a four-helix bundle protein
10.1073/pnas.89.15.7065 · 1992 · External reference
The crystal structures of human S100B in the zinc- and calcium-loaded state at three pH values reveal zinc ligand swapping
10.1016/j.bbamcr.2010.10.006 · 2011 · External reference
Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins
10.1039/c6sc02267g · 2016 · External reference
