Research graph
References from Forsythiae Fructus polysaccharides mitigate DSS colitis by modulating gut microbiota–derived palmitic acid and PI3K/AKT pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
The global burden of inflammatory bowel disease: from 2025 to 2045
10.1038/s41575-025-01097-1 · 2025 · External reference
Medical management of inflammatory bowel diseases
10.1136/bmj-2025-079050 · 2025 · External reference
Mucosal glycans: key drivers of the development of inflammatory bowel disease and a potential new therapeutic target
10.1038/s41575-025-01164-7 · 2026 · External reference
ILC3s sense gut microbiota through STING to initiate immune tolerance
10.1016/j.immuni.2025.05.016 · 2025 · External reference
Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+T cells to confer protection against intestinal inflammation
10.1038/s42255-025-01396-6 · 2025 · External reference
A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules
10.1016/j.chom.2025.01.002 · 2025 · External reference
Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial
10.1001/jama.2018.20046 · 2019 · External reference
Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities
10.1038/s41579-025-01163-0 · 2025 · External reference
Short-chain fatty acids: linking diet, the microbiome and immunity
10.1038/s41577-024-01014-8 · 2024 · External reference
Gallic acid ameliorates colitis by trapping deleterious metabolite ammonia and improving gut microbiota dysbiosis
2023 · External reference
The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer
10.1038/s41579-024-01108-z · 2024 · External reference
Impact of diet on inflammatory bowel disease risk: systematic review, meta-analyses and implications for prevention
10.1016/j.eclinm.2025.103353 · 2025 · External reference
Potential of Dendrobium officinale oligosaccharides to alleviate chronic colitis by modulating inflammation and gut microbiota
10.26599/fmh.2025.9420077 · 2025 · External reference
Esculin alleviates palmitic acid-induced intestinal barrier damage via Nrf2/HO-1 signaling
10.62347/nscj5164 · 2025 · External reference
Evaluating the influence of oleic and palmitic acids on inflammatory markers and gut barrier integrity in a celiac disease Caco-2 model
10.1007/s11033-025-11044-7 · 2025 · External reference
A novel fructan from Atractylodes macrocephala ameliorates ulcerative colitis through gut microbiota-mediated PI3K/Akt signaling
2025 · External reference
Metabolic syndrome: molecular mechanisms and therapeutic interventions
10.1186/s43556-025-00303-5 · 2025 · External reference
Forsythia suspensa polyphenols regulate macrophage M1 polarization to alleviate intestinal inflammation in mice
10.1016/j.phymed.2024.155336 · 2024 · External reference
Forsythiaside a alleviates ulcerative colitis and inhibits neutrophil extracellular traps formation in the mice
10.1002/ptr.8440 · 2025 · External reference
Dietary glyphosate at the regulatory "safe" level worsens colitis via a gut microbiota-derived palmitic acid-JAK-STAT pathway
10.1021/acs.jafc.5c17487 · 2026 · External reference
Capsaicin shapes gut microbiota and pre-metastatic niche to facilitate cancer metastasis to liver
10.1016/j.phrs.2022.106643 · 2023 · External reference
Natural occurring polysaccharides from Panax ginseng C. A. Meyer: a review of isolation, structures, and bioactivities
10.1016/j.ijbiomac.2019.03.229 · 2019 · External reference
Pharmacokinetics, absorption and transport mechanism for ginseng polysaccharides
10.1016/j.biopha.2023.114610 · 2023 · External reference
Furanoid F-acid F6 uniquely induces NETosis compared to C16 and C18 fatty acids in human neutrophils
10.3390/biom8040144 · 2018 · External reference
High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT
10.1136/gutjnl-2023-330826 · 2024 · External reference
ACSL1 aggravates thromboinflammation by LPC/LPA metabolic axis in hyperlipidemia associated myocardial ischemia-reperfusion injury
2025 · External reference
Neutrophil extracellular trap reprograms cancer metabolism to form a metastatic niche promoting non-small cell lung cancer brain metastasis
2025 · External reference
Understanding the therapeutic toolkit for inflammatory bowel disease
10.1038/s41575-024-01035-7 · 2025 · External reference
Gut microbiome in IBD: past, present and the future
2025 · External reference
Administration of intestinal mesenchymal stromal cells reduces colitis-associated cancer in C57BL/6J mice modulating the immune response and gut dysbiosis
10.1016/j.phrs.2023.106891 · 2023 · External reference
Roseburia intestinalis-derived extracellular vesicles ameliorate colitis by modulating intestinal barrier, microbiome, and inflammatory responses
10.1002/jev2.12487 · 2024 · External reference
Research progress of natural plant polysaccharides inhibiting inflammatory signaling pathways and regulating intestinal flora and metabolism to protect inflammatory bowel disease
2023 · External reference
Research progress in the treatment of inflammatory bowel disease with natural polysaccharides and related structure-activity relationships
10.1039/d3fo04919a · 2024 · External reference
The regulatory effect of polysaccharides on the gut microbiota and their effect on human health: a review
10.1016/j.ijbiomac.2024.132170 · 2024 · External reference
Steam-exploded Dictyophora indusiata polysaccharide protect against inflammation by regulating gut barrier, microbiota and metabolites
10.26599/fmh.2026.9420107 · 2026 · External reference
Artemisia argyi polysaccharide alleviates intestinal inflammation and intestinal flora dysbiosis in lipopolysaccharide-treated mice
10.26599/fmh.2024.9420008 · 2024 · External reference
The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms
10.1007/s00011-019-01273-5 · 2019 · External reference
Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes
10.1038/s41419-019-1791-y · 2019 · External reference
Ginseng polysaccharides ameliorate ulcerative colitis via regulating gut microbiota and tryptophan metabolism
10.1016/j.ijbiomac.2024.130822 · 2024 · External reference
Akkermansia muciniphila-derived extracellular vesicles alleviate colitis-related cognitive impairment via tryptophan metabolic reprogramming of the gut–brain axis
10.1080/19490976.2025.2611546 · 2026 · External reference
Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial
10.1016/j.ebiom.2023.104873 · 2023 · External reference
Donor composition and fiber promote strain engraftment in a randomized controlled trial of fecal microbiota transplant for ulcerative colitis
10.1016/j.medj.2025.100707 · 2025 · External reference
Interindividual variability in gut microbiome mediates the efficacy of resistant starch on MASLD
10.1016/j.cmet.2025.10.017 · 2025 · External reference
