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References from Non-coding RNAs in cerebral cavernous malformation: Regulatory roles and therapeutic implication. Local targets link to admitted publications; unresolved targets remain external evidence.
From genes and mechanisms to molecular-targeted therapies: the long climb to the cure of cerebral cavernous malformation (CCM) disease
10.1007/978-1-0716-0640-7_1 · 2020 · External reference
Endothelial adherens junctions at a glance
2013 · External reference
Cerebral cavernous malformations
2026 · External reference
10.1227/neu.0000000000003459
10.1227/neu.0000000000003459 · 2026 · External reference
Contribution of endothelial-to-mesenchymal transition to the pathogenesis of human cerebral and orbital cavernous malformations
10.1093/neuros/nyx078 · 2017 · External reference
Role of Delta-Notch signaling in cerebral cavernous malformations
10.1007/s10143-015-0699-y · 2016 · External reference
EndMT contributes to the onset and progression of cerebral cavernous malformations
10.1038/nature12207 · 2013 · External reference
Cerebral cavernous malformation: immune and inflammatory perspectives
10.3389/fimmu.2022.922281 · 2022 · External reference
Defective autophagy is a key feature of cerebral cavernous malformations
10.15252/emmm.201505316 · 2015 · External reference
Fluorescence analysis of reactive oxygen species (ROS) in cellular models of cerebral cavernous malformation disease
10.1007/978-1-0716-0640-7_34 · 2020 · External reference
Non-coding RNAs in disease: from mechanisms to therapeutics
10.1038/s41576-023-00662-1 · 2024 · External reference
Cavernous angiomas: deconstructing a neurosurgical disease
10.3171/2019.3.jns181724 · 2019 · External reference
Somatic PIK3CA mutations in sporadic cerebral cavernous malformations
10.1056/nejmoa2100440 · 2021 · External reference
Simplex cerebral cavernous malformations with MAP3K3 mutation have distinct clinical characteristics
10.3389/fneur.2022.946324 · 2022 · External reference
Cerebral cavernous malformations - an overview on genetics, clinical aspects and therapeutic strategies
10.1016/j.jns.2024.123044 · 2024 · External reference
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
10.1084/jem.20091258 · 2010 · External reference
Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling
10.1073/pnas.1000132107 · 2010 · External reference
Crystallographic studies of the cerebral cavernous malformations proteins
10.1007/978-1-0716-0640-7_21 · 2020 · External reference
CCM3 and cerebral cavernous malformation disease
10.1136/svn-2018-000195 · 2019 · External reference
Neuroinflammation plays a critical role in cerebral cavernous malformation disease
10.1161/circresaha.122.321129 · 2022 · External reference
Tooth loss and dementia amongst older adults residing in long-term care facilities in Vancouver: a case-control study
10.1111/ger.12677 · 2023 · External reference
Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex
10.1038/ncomms8937 · 2015 · External reference
Review of treatment and therapeutic targets in brain arteriovenous malformation
10.1177/0271678x211026771 · 2021 · External reference
Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling
10.1038/nature17178 · 2016 · External reference
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
10.15252/emmm.201505433 · 2016 · External reference
Regulation of beta1 integrin-Klf2-mediated angiogenesis by CCM proteins
10.1016/j.devcel.2014.12.016 · 2015 · External reference
DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation
10.1186/s13073-025-01452-6 · 2025 · External reference
Beyond multiple mechanisms and a unique drug: defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies
2016 · External reference
Crippling of Kruppel (-like factor 2) by bad flow portends a miRky day for endothelial function
10.1161/circulationaha.111.043299 · 2011 · External reference
PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations
10.1007/s10143-014-0597-8 · 2015 · External reference
AKT-ing via microRNA
10.4161/cc.9.16.12634 · 2010 · External reference
Cellular processes underlying cerebral cavernous malformations: autophagy as another point of view
10.1080/15548627.2015.1125073 · 2016 · External reference
mTORC1 signaling in brain endothelial progenitors contributes to CCM pathogenesis
10.1161/circresaha.123.324015 · 2024 · External reference
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations
10.1093/brain/awad104 · 2023 · External reference
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
10.1038/s41586-021-03562-8 · 2021 · External reference
TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice
10.1186/s12974-020-01853-x · 2020 · External reference
ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension
10.1016/j.vph.2015.03.017 · 2015 · External reference
ROCK2 regulates microglia proliferation and neuronal survival after traumatic brain injury
10.1016/j.bbi.2024.01.004 · 2024 · External reference
miR-101a-3p/ROCK2 axis regulates neuronal injury in Parkinson's disease models
10.18632/aging.205836 · 2024 · External reference
The roles of ROCK2/CBS-H(2)S pathway in the cerebral ischemia/reperfusion injury
10.1016/j.ijbiomac.2025.144399 · 2025 · External reference
Epileptic seizure as a presenting symptom of cerebrotendinous xanthomatosis
10.1111/j.1528-1157.1991.tb04705.x · 1991 · External reference
Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis
10.1093/hmg/ddu153 · 2014 · External reference
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease
10.1161/strokeaha.111.625467 · 2012 · External reference
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
10.1038/11056 · 1999 · External reference
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells
10.2353/ajpath.2008.070076 · 2008 · External reference
Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations
10.1136/jnnp.71.2.188 · 2001 · External reference
CCM3 loss-induced lymphatic defect is mediated by the augmented VEGFR3-ERK1/2 signaling
10.1161/atvbaha.121.316707 · 2021 · External reference
Limiting inflammation-the negative regulation of NF-kappaB and the NLRP3 inflammasome
10.1038/ni.3772 · 2017 · External reference
Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations
10.1111/jcmm.12022 · 2013 · External reference
Non-coding RNA-targeted therapy: a state-of-the-art review
10.3390/ijms25073630 · 2024 · External reference
Molecular pathogenesis of ischemic and hemorrhagic strokes: background and therapeutic approaches
10.3390/ijms25126297 · 2024 · External reference
Novel therapeutic mechanisms and strategies for intracerebral hemorrhage: focusing on exosomes
10.2147/ijn.s473611 · 2024 · External reference
Genomic variants disrupt miRNA-mRNA regulation
10.1002/cbdv.202200623 · 2022 · External reference
miRNA dysregulation in traumatic brain injury and epilepsy: a systematic review to identify putative biomarkers for post-traumatic epilepsy
10.1007/s11011-023-01172-z · 2023 · External reference
Astrocyte-derived extracellular vesicular miR-143-3p dampens autophagic degradation of endothelial adhesion molecules and promotes neutrophil transendothelial migration after acute brain injury
2024 · External reference
Noncoding RNAs and intracerebral hemorrhage
10.2174/1871527318666190204102604 · 2019 · External reference
Genome-wide sequencing reveals microRNAs downregulated in cerebral cavernous malformations
10.1007/s12031-017-0880-6 · 2017 · External reference
Biological disturbance of MiR-425 and its application prospects in cardiovascular diseases
10.3389/fcell.2025.1593241 · 2025 · External reference
Downregulation of long noncoding RNA SNHG7 protects against inflammation and apoptosis in Parkinson's disease model by targeting the miR-425-5p/TRAF5/NF-kappaB axis
10.1002/jbt.22867 · 2021 · External reference
Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3
10.1016/j.toxlet.2016.04.023 · 2016 · External reference
Editome landscape of CCM-derived endothelial cells
10.1080/15476286.2022.2091306 · 2022 · External reference
Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27
10.1182/blood-2012-12-473017 · 2013 · External reference
miR-27a-5p inhibits acute rejection of liver transplantation in rats by inducing M2 polarization of Kupffer cells through the PI3K/Akt pathway
10.1016/j.cyto.2022.156085 · 2023 · External reference
MiR-27a targeting PIK3R3 regulates the proliferation and apoptosis of sheep hair follicle stem cells
10.3390/ani13010141 · 2022 · External reference
Inhibiting miR-27a and miR-142-5p attenuate nonalcoholic fatty liver disease by regulating Nrf2 signaling pathway
10.1002/iub.2221 · 2020 · External reference
MiR-27a alleviates osteoarthritis in rabbits via inhibiting inflammation
2019 · External reference
Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice
10.1371/journal.pbio.3000734 · 2020 · External reference
miR-126-3p is essential for CXCL12-induced angiogenesis
10.1111/jcmm.16460 · 2021 · External reference
Brain vitamin D(3)-auto/paracrine system in relation to structural, neurophysiological, and behavioral disturbances associated with glucocorticoid-induced neurotoxicity
10.3389/fncel.2023.1133400 · 2023 · External reference
MicroRNA miR-126 attenuates brain injury in septic rats via NF-kappaB signaling pathway
10.1080/21655979.2021.1937905 · 2021 · External reference
MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium
10.1038/srep45284 · 2017 · External reference
MicroRNA-126-3p attenuates intracerebral hemorrhage-induced blood-brain barrier disruption by regulating VCAM-1 expression
10.3389/fnins.2019.00866 · 2019 · External reference
A systematic review of microRNAs in hemorrhagic neurovascular disease: cerebral cavernous malformations as a paradigm
10.3390/ijms26083794 · 2025 · External reference
miR-126 regulates angiogenic signaling and vascular integrity
10.1016/j.devcel.2008.07.008 · 2008 · External reference
An insight into the microRNAs associated with arteriovenous and cavernous malformations of the brain
10.3390/cells10061373 · 2021 · External reference
The let-7 family of microRNAs
10.1016/j.tcb.2008.07.007 · 2008 · External reference
let-7 microRNAs: their role in cerebral and cardiovascular diseases, inflammation, cancer, and their regulation
10.3390/biomedicines9060606 · 2021 · External reference
Let-7 in cardiovascular diseases, heart development and cardiovascular differentiation from stem cells
10.3390/ijms141123086 · 2013 · External reference
Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis
10.2337/db16-1405 · 2017 · External reference
Induction of let-7d-5p miRNA modulates aortic smooth muscle inflammatory signaling and phenotypic switching
10.1016/j.atherosclerosis.2024.117573 · 2024 · External reference
miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions
10.1038/jcbfm.2015.154 · 2015 · External reference
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
10.1126/scitranslmed.aaw3521 · 2019 · External reference
Blocking signalopathic events to treat cerebral cavernous malformations
10.1016/j.molmed.2020.03.003 · 2020 · External reference
Impairment of tight junctions and glucose transport in endothelial cells of human cerebral cavernous malformations
10.1097/nen.0b013e31821bc40e · 2011 · External reference
MiR-128-3p - a gray eminence of the human central nervous system
10.1016/j.omtn.2024.102141 · 2024 · External reference
miR-128-3p inhibits apoptosis and inflammation in LPS-induced sepsis by targeting TGFBR2
10.1515/med-2021-0222 · 2021 · External reference
Circulating plasma miRNA homologs in mice and humans reflect familial cerebral cavernous malformation disease
10.1007/s12975-022-01050-3 · 2023 · External reference
Lifetime risk of first symptomatic ICH or seizure in familial cerebral cavernous malformations: a multicenter patient data analysis
10.1212/wnl.0000000000213798 · 2025 · External reference
Prevalence, genetic and clinical characteristics in first-degree relatives of patients with familial cerebral cavernous malformations in China
10.1136/svn-2023-003004 · 2025 · External reference
Genetics of cerebral cavernous malformations: current status and future prospects
2015 · External reference
miR-21 coordinates tumor growth and modulates KRIT1 levels
10.1016/j.bbrc.2013.07.031 · 2013 · External reference
HIF-1alpha and VEGF immunophenotypes as potential biomarkers in the prognosis and evaluation of treatment efficacy of atherosclerosis: a systematic review of the literature
10.31083/fbl27004 · 2025 · External reference
circ_2858 helps blood-brain barrier disruption by increasing VEGFA via sponging miR-93-5p during Escherichia coli meningitis
10.1016/j.omtn.2020.09.034 · 2020 · External reference
SnoRNA and lncSNHG: advances of nucleolar small RNA host gene transcripts in anti-tumor immunity
10.3389/fimmu.2023.1143980 · 2023 · External reference
Genetic associations and regulation of expression indicate an independent role for 14q32 snoRNAs in human cardiovascular disease
10.1093/cvr/cvy309 · 2019 · External reference
U8 variants on the brain: a small nucleolar RNA and human disease
10.1080/15476286.2022.2048563 · 2022 · External reference
Decoding the molecular script of 2'-O-ribomethylation: implications across CNS disorders
10.1016/j.heliyon.2024.e39036 · 2024 · External reference
Genome-wide sequencing reveals small nucleolar RNAs downregulated in cerebral cavernous malformations
10.1007/s10571-018-0602-9 · 2018 · External reference
Integrated lncRNA function upon genomic and epigenomic regulation
10.1016/j.molcel.2022.05.027 · 2022 · External reference
Revealing protein-lncRNA interaction
10.1093/bib/bbv031 · 2016 · External reference
Toward understanding non-coding RNA roles in intracranial aneurysms and subarachnoid hemorrhage
10.1515/tnsci-2017-0010 · 2017 · External reference
Altered expression of long noncoding RNAs in blood after ischemic stroke and proximity to putative stroke risk loci
10.1161/strokeaha.116.013869 · 2016 · External reference
Transcriptome-wide profiling of cerebral cavernous malformations patients reveal important long noncoding RNA molecular signatures
10.1038/s41598-019-54845-0 · 2019 · External reference
Dysregulated hemostasis and immunothrombosis in cerebral cavernous malformations
10.3390/ijms232012575 · 2022 · External reference
Polymorphisms in genes related to oxidative stress and inflammation: emerging links with the pathogenesis and severity of Cerebral Cavernous Malformation disease
10.1016/j.freeradbiomed.2021.06.021 · 2021 · External reference
Circulating lncRNAs remark expression profile of cerebrovascular malformation endothelial cells
10.1096/fj.202504229r · 2026 · External reference
Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance
10.1038/s41467-021-26420-7 · 2021 · External reference
Vis-a-vis: a focus on genetic features of cerebral cavernous malformations and brain arteriovenous malformations pathogenesis
10.1007/s10072-018-3674-x · 2019 · External reference
MiRNA-190 exerts neuroprotective effects against ischemic stroke through Rho/Rho-kinase pathway
10.1007/s00424-020-02490-2 · 2021 · External reference
Present insights into the progress in gene therapy delivery systems for central nervous system diseases
10.1016/j.ijpharm.2024.125069 · 2025 · External reference
A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases
10.15252/emmm.201506078 · 2016 · External reference
Lipid nanoparticle-mediated delivery of microRNA-124 reduces neuroinflammation
10.1016/j.biomaterials.2025.123589 · 2026 · External reference
CircRNA and miRNA expression profiles during remote ischemic postconditioning attenuate brain ischemia/reperfusion injury
10.1016/j.brainresbull.2022.04.006 · 2022 · External reference
CircRNA_0003307 promoted brain microvascular endothelial cell angiogenesis, invasion, and migration in cerebral ischemia-reperfusion injury: potential involvement of miRNA-191-5p/CDK6 pathway
10.1016/j.neuroscience.2024.09.025 · 2024 · External reference
Surgery for cerebral cavernous malformations: a systematic review and meta-analysis
10.1007/s10143-021-01591-5 · 2022 · External reference
Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): an international, multicentric study
10.1038/s41598-024-77140-z · 2024 · External reference
Long-term outcomes of gamma knife radiosurgery for cerebral cavernous malformations: 10 years and beyond
10.3346/jkms.2024.39.e229 · 2024 · External reference
Bleeding risk of cerebral cavernous malformations in patients on statin and antiplatelet medication: a cohort study
10.1227/neu.0000000000002480 · 2023 · External reference
Could propranolol be beneficial in adult cerebral cavernous malformations?
10.1007/s10143-018-01074-0 · 2019 · External reference
Single-cell transcriptome profiling reveals dynamic cell populations and immune infiltration in cerebral cavernous malformation
2025 · External reference
Single-cell sequencing insights into the transcriptional landscape of cerebral cavernous malformations
10.1007/s10456-025-10011-x · 2025 · External reference
Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma
10.1038/s43856-023-00265-1 · 2023 · External reference
Overview of cerebral cavernous malformations: comparison of treatment approaches
10.1136/jnnp-2021-328658 · 2022 · External reference
Natural history of cerebral cavernous malformations
10.1016/b978-0-444-63640-9.00021-7 · 2017 · External reference