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References from Tautomeric asymmetric self–inhibition: an underexploited pH–dependent strategy to enhance berberrubine solubility. Local targets link to admitted publications; unresolved targets remain external evidence.
Cocrystal engineering-based strategies for enhancing the permeability of poorly permeable APIs
10.1021/acs.cgd.5c00755 · 2025 · External reference
Recent advances in coamorphous systems of natural active pharmaceutical ingredients: preparations, characterizations, and applications
10.1021/acsomega.5c03834 · 2025 · External reference
Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures in zebrafish
10.1007/s11481-019-09902-w · 2020 · External reference
Cocrystal of berberine with its metabolite: a new strategy to improve the physicochemical properties of berberine
2025 · External reference
The hypoglycemic effect of berberine and berberrubine involves modulation of intestinal farnesoid X receptor signaling pathway and inhibition of hepatic gluconeogenesis
10.1124/dmd.120.000215 · 2021 · External reference
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and Jak2/Stat3 signaling pathway
10.1016/j.ejphar.2021.174592 · 2021 · External reference
Integrated metabolomics and molecular docking reveal berberrubine inhibits thrombosis by regulating the vitamin K catalytic cycle in mice
10.1016/j.ejphar.2022.175436 · 2023 · External reference
Berberine and inflammatory bowel disease: a concise review
10.1016/j.phrs.2016.09.041 · 2016 · External reference
Antinociceptive effect of berberine on visceral hypersensitivity in rats
10.3748/wjg.v19.i28.4582 · 2013 · External reference
Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice
10.1016/j.lfs.2007.08.003 · 2007 · External reference
Unusual tautomerism of methyl allophanate: selective crystallization of the minor component via hydrogen-bond network
2025 · External reference
Mechanistic insights into tautomerism-induced crystal growth self-inhibition informed by kinetics modeling
10.1002/aic.70175 · 2026 · External reference
Tautomerism and rotamerism of favipiravir and halogenated analogues in solution and in the solid state
10.1021/acs.joc.3c00777 · 2023 · External reference
Keto-enol tautomerism in the development of new drugs
2024 · External reference
A study of the tautomerism of β-dicarbonyl compounds with special emphasis on curcuminoids
10.1016/j.tet.2008.06.065 · 2008 · External reference
Bent keto form of curcumin, preferential stabilization of enol by piperine, and isomers of curcumin cyclodextrin complexes: insights from ion mobility mass spectrometry
10.1021/acs.analchem.7b05231 · 2018 · External reference
Investigating stability and tautomerization of gossypol—a spectroscopy study
10.3390/molecules24071286 · 2019 · External reference
Hyperforin: a natural lead compound with multiple pharmacological activities
10.1016/j.phytochem.2022.113526 · 2023 · External reference
Tautomerism induces bending and twisting of biogenic crystals
10.1073/pnas.2426814122 · 2025 · External reference
Growth “self-inhibition” of irbesartan desmotrope: surface intra-annular tautomer inter-conversion is the culprit
10.1039/d3cc06170a · 2024 · External reference
Tautomerism unveils a self-inhibition mechanism of crystallization
10.1038/s41467-023-35924-3 · 2023 · External reference
Berberrubine, an attractive derivative of berberine with multiple pharmacological activities
10.1016/j.arabjc.2024.106045 · 2025 · External reference
Structural simplification of berberine to obtain novel antifungal isoquinoline derivatives against phytopathogenic fungi
10.1021/acs.jafc.5c04811 · 2025 · External reference
Nanoparticle-based oral delivery of berberine attenuates high-fat diet-induced hepatic steatosis in mice: insights from integrated hepatic metabolomic and transcriptomic analyses
10.1021/acs.jafc.5c15040 · 2026 · External reference
Sensitive analysis and pharmacokinetic study of berberrubine using LC-MS/MS
2017 · External reference
Combined analytical approaches to define biodistribution and biological activity of semi-synthetic berberrubine, the active metabolite of natural berberine
10.1007/s00216-018-0884-2 · 2018 · External reference
The fluorescence properties of protoberberine and tetrahydroprotoberberine alkaloids
10.1135/cccc19763157 · 1976 · External reference
Syntheses and absorption spectra of some compounds with the berbine structure
10.1135/cccc19763654 · 1976 · External reference
Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects
10.1021/np400607k · 2014 · External reference
Resonance driven regioselective demethylation of berberine. Microwave assisted synthesis of berberrubine and its assessment as fluorescent chemosensor for alkanes
10.1016/j.tet.2015.06.098 · 2015 · External reference
Is your Henderson–Hasselbalch calculation of buffer pH correct?
10.1021/acs.jchemed.2c01203 · 2023 · External reference
In vitro dissolution profile comparison—statistics and analysis of the similarity factor, f2
10.1023/a:1011976615750 · 1998 · External reference
Understanding and designing tailor-made additives for controlling nucleation: case study of p-aminobenzoic acid crystallizing from ethanolic solutions
10.1021/acs.cgd.0c01209 · 2021 · External reference
Molecular modifiers reveal a mechanism of pathological crystal growth inhibition
10.1038/nature19062 · 2016 · External reference
Is lactic acid a misunderstood trigger of gout attack for a century?
10.1016/j.colsurfb.2024.113913 · 2024 · External reference
Effect of dimer formation on the growth cessation of polar organic crystals
10.1021/cg0498103 · 2006 · External reference
Accurate DFT-D3 calculations in a small basis set
10.1021/acs.jctc.7b00365 · 2017 · External reference
Unresolved reference
2009 · External reference
In situ kinetic observations on crystal nucleation and growth
10.1021/acs.chemrev.1c01067 · 2022 · External reference
Mechanisms of nucleation and growth of nanoparticles in solution
10.1021/cr400544s · 2014 · External reference
Role of additives in crystal nucleation from solutions: a review
10.1021/acs.cgd.1c00776 · 2022 · External reference
A new perspective on crystal nucleation: a classical view on non-classical nucleation
10.1021/acs.cgd.3c01078 · 2024 · External reference
Mechanistic insights into tautomerism-induced crystal growth self-inhibition informed by kinetics modeling
10.1002/aic.70175 · ExternalCitation · doi-reference
Combined analytical approaches to define biodistribution and biological activity of semi-synthetic berberrubine, the active metabolite of natural berberine
10.1007/s00216-018-0884-2 · ExternalCitation · doi-reference
Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures in zebrafish
10.1007/s11481-019-09902-w · ExternalCitation · doi-reference
Berberrubine, an attractive derivative of berberine with multiple pharmacological activities
10.1016/j.arabjc.2024.106045 · ExternalCitation · doi-reference
Is lactic acid a misunderstood trigger of gout attack for a century?
10.1016/j.colsurfb.2024.113913 · ExternalCitation · doi-reference
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and Jak2/Stat3 signaling pathway
10.1016/j.ejphar.2021.174592 · ExternalCitation · doi-reference
Integrated metabolomics and molecular docking reveal berberrubine inhibits thrombosis by regulating the vitamin K catalytic cycle in mice
10.1016/j.ejphar.2022.175436 · ExternalCitation · doi-reference
Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice
10.1016/j.lfs.2007.08.003 · ExternalCitation · doi-reference
Berberine and inflammatory bowel disease: a concise review
10.1016/j.phrs.2016.09.041 · ExternalCitation · doi-reference
Hyperforin: a natural lead compound with multiple pharmacological activities
10.1016/j.phytochem.2022.113526 · ExternalCitation · doi-reference
A study of the tautomerism of β-dicarbonyl compounds with special emphasis on curcuminoids
10.1016/j.tet.2008.06.065 · ExternalCitation · doi-reference
Resonance driven regioselective demethylation of berberine. Microwave assisted synthesis of berberrubine and its assessment as fluorescent chemosensor for alkanes
10.1016/j.tet.2015.06.098 · ExternalCitation · doi-reference
Bent keto form of curcumin, preferential stabilization of enol by piperine, and isomers of curcumin cyclodextrin complexes: insights from ion mobility mass spectrometry
10.1021/acs.analchem.7b05231 · ExternalCitation · doi-reference
Understanding and designing tailor-made additives for controlling nucleation: case study of p-aminobenzoic acid crystallizing from ethanolic solutions
10.1021/acs.cgd.0c01209 · ExternalCitation · doi-reference
Role of additives in crystal nucleation from solutions: a review
10.1021/acs.cgd.1c00776 · ExternalCitation · doi-reference
A new perspective on crystal nucleation: a classical view on non-classical nucleation
10.1021/acs.cgd.3c01078 · ExternalCitation · doi-reference
Cocrystal engineering-based strategies for enhancing the permeability of poorly permeable APIs
10.1021/acs.cgd.5c00755 · ExternalCitation · doi-reference
In situ kinetic observations on crystal nucleation and growth
10.1021/acs.chemrev.1c01067 · ExternalCitation · doi-reference
Structural simplification of berberine to obtain novel antifungal isoquinoline derivatives against phytopathogenic fungi
10.1021/acs.jafc.5c04811 · ExternalCitation · doi-reference
Nanoparticle-based oral delivery of berberine attenuates high-fat diet-induced hepatic steatosis in mice: insights from integrated hepatic metabolomic and transcriptomic analyses
10.1021/acs.jafc.5c15040 · ExternalCitation · doi-reference
Is your Henderson–Hasselbalch calculation of buffer pH correct?
10.1021/acs.jchemed.2c01203 · ExternalCitation · doi-reference
Accurate DFT-D3 calculations in a small basis set
10.1021/acs.jctc.7b00365 · ExternalCitation · doi-reference
Tautomerism and rotamerism of favipiravir and halogenated analogues in solution and in the solid state
10.1021/acs.joc.3c00777 · ExternalCitation · doi-reference
Recent advances in coamorphous systems of natural active pharmaceutical ingredients: preparations, characterizations, and applications
10.1021/acsomega.5c03834 · ExternalCitation · doi-reference
Effect of dimer formation on the growth cessation of polar organic crystals
10.1021/cg0498103 · ExternalCitation · doi-reference
Mechanisms of nucleation and growth of nanoparticles in solution
10.1021/cr400544s · ExternalCitation · doi-reference
Berberine and its metabolites: relationship between physicochemical properties and plasma levels after administration to human subjects
10.1021/np400607k · ExternalCitation · doi-reference
In vitro dissolution profile comparison—statistics and analysis of the similarity factor, f2
10.1023/a:1011976615750 · ExternalCitation · doi-reference
Molecular modifiers reveal a mechanism of pathological crystal growth inhibition
10.1038/nature19062 · ExternalCitation · doi-reference
Tautomerism unveils a self-inhibition mechanism of crystallization
10.1038/s41467-023-35924-3 · ExternalCitation · doi-reference
Growth “self-inhibition” of irbesartan desmotrope: surface intra-annular tautomer inter-conversion is the culprit
10.1039/d3cc06170a · ExternalCitation · doi-reference
Tautomerism induces bending and twisting of biogenic crystals
10.1073/pnas.2426814122 · ExternalCitation · doi-reference
The hypoglycemic effect of berberine and berberrubine involves modulation of intestinal farnesoid X receptor signaling pathway and inhibition of hepatic gluconeogenesis
10.1124/dmd.120.000215 · ExternalCitation · doi-reference
The fluorescence properties of protoberberine and tetrahydroprotoberberine alkaloids
10.1135/cccc19763157 · ExternalCitation · doi-reference
Syntheses and absorption spectra of some compounds with the berbine structure
10.1135/cccc19763654 · ExternalCitation · doi-reference
Investigating stability and tautomerization of gossypol—a spectroscopy study
10.3390/molecules24071286 · ExternalCitation · doi-reference
Antinociceptive effect of berberine on visceral hypersensitivity in rats
10.3748/wjg.v19.i28.4582 · ExternalCitation · doi-reference
