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References from Predicting pharmaceutical powder segregation from particle property disparity and blend flowability. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Prediction of porosity from particle scale interactions: surface modification of fine cohesive powders
10.1016/j.powtec.2014.01.006 · 2014 · External reference
The relationship between attractive interparticle forces and bulk behaviour in dry and uncharged fine powders
10.1080/17461390500402657 · 2005 · External reference
Characterization of particle and bulk level cohesion reduction of surface modified fine aluminum powders
10.1016/j.colsurfa.2010.03.015 · 2010 · External reference
A concise treatise on model-based enhancements of cohesive powder properties via dry particle coating
10.1016/j.apt.2022.103836 · 2022 · External reference
Underpinning mechanistic understanding of the segregation phenomena of pharmaceutical blends using a near-infrared (NIR) spectrometer embedded segregation tester
10.1016/j.ejps.2020.105516 · 2020 · External reference
Detailed accounts of segregation mechanisms and the evolution of pharmaceutical blend segregation analysis: a review
10.1016/j.ijpharm.2024.124739 · 2024 · External reference
Morphological, packing, flow and tableting properties of new avicel types
10.3109/03639049509048132 · 1995 · External reference
Modelling size segregation of granular materials: the roles of segregation, advection and diffusion
10.1017/jfm.2013.680 · 2014 · External reference
Percolation of a fine particle in static granular beds
10.1103/physreve.107.014903 · 2023 · External reference
Quantification of segregation potential for polydisperse, cohesive, multi-component powders and prediction of tablet die-filling performance - a methodology for practical testing, re-formulation and process design
10.1016/j.powtec.2015.04.037 · 2015 · External reference
Particle-size and-density segregation in granular free-surface flows
10.1017/jfm.2015.438 · 2015 · External reference
Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles
10.1016/j.ijpharm.2011.05.070 · 2011 · External reference
Passivation of high-surface-energy sites of milled ibuprofen crystals via dry coating for reduced cohesion and improved flowability
10.1002/jps.23589 · 2013 · External reference
Assessing powder segregation potential by near infrared (NIR) spectroscopy and correlating segregation tendency to tabletting performance
10.1016/j.powtec.2012.05.021 · 2013 · External reference
Development of an improved fluidization segregation tester: for use with pharmaceutical powders
2006 · External reference
Improving blend content uniformity via dry particle coating of micronized drug powders
10.1016/j.ejps.2017.04.012 · 2017 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Regimes of segregation and mixing in combined size and density granular systems: an experimental study
10.1007/s10035-005-0198-x · 2005 · External reference
Particle size-based segregation of pharmaceutical powders in a vertical chute with a closed bottom: an experimental evaluation
10.1016/j.powtec.2015.03.021 · 2015 · External reference
Blend segregation in tablets manufacturing and its effect on drug content uniformity—a review
10.3390/pharmaceutics13111909 · 2021 · External reference
Prediction of inter-particle adhesion force from surface energy and surface roughness
10.1163/016942410x525623 · 2011 · External reference
Predicting segregation of bimodal particle mixtures using the flow properties of bulk solids
1996 · External reference
Review of new segregation tester method by Dr. Kerry Johanson, P.E
10.1016/j.powtec.2014.02.021 · 2014 · External reference
New mass flow limiting lines based on segregation pattern and magnitude
10.1016/j.powtec.2019.08.079 · 2019 · External reference
Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: the effect of mixing time and excipient size
10.1016/j.ijpharm.2023.122722 · 2023 · External reference
Novel methodology to assess and predict segregation risk in a continuous direct compression via mini-batch blending process
10.1016/j.ijpharm.2026.126888 · 2026 · External reference
Effect of aspect ratio of ellipsoidal particles on segregation of a binary mixture in a rotating drum
10.1016/j.powtec.2023.118682 · 2023 · External reference
Assessing predictability of packing porosity and bulk density enhancements after dry coating of pharmaceutical powders
10.1016/j.powtec.2020.09.037 · 2021 · External reference
Selection of silica type and amount for flowability enhancements via dry coating: contact mechanics based predictive approach
10.1007/s11095-023-03561-6 · 2023 · External reference
Applications of NIR in early stage formulation development: part I. Semi-quantitative blend uniformity and content uniformity analyses by reflectance NIR without calibration models
10.1016/j.ijpharm.2007.03.040 · 2007 · External reference
Novel powder property-based indices for predicting segregation risk in multicomponent pharmaceutical blends
10.1016/j.ijpharm.2025.125990 · 2025 · External reference
Particle size segregation promoted by powder flow in confined space: the die filling process case
10.1016/j.powtec.2014.04.023 · 2014 · External reference
Micro-modeling of cohesive mixing processes
10.1016/j.powtec.2003.08.042 · 2003 · External reference
Unresolved reference
2009 · External reference
Influence of formulation composition and processing on the content uniformity of low-dose tablets manufactured at kilogram scale
10.1080/10837450902832885 · 2009 · External reference
Powder technology in the pharmaceutical industry: the need to catch up fast
10.1016/s0032-5910(01)00482-x · 2002 · External reference
Diminished segregation in continuous powder mixing
10.1016/j.powtec.2016.11.038 · 2017 · External reference
Mixing and segregation of granular material
10.1146/annurev.fluid.32.1.55 · 2000 · External reference
Predicting powder blend flowability from individual constituent properties using machine learning
10.1007/s11095-025-03855-x · 2025 · External reference
A predictive model based on key particle properties for segregation of free-flowing powder blends measured using near-infrared spectroscopy
10.1016/j.ijpharm.2026.126921 · 2026 · External reference
Ibuprofen crystals with optimized properties
10.1016/s0378-5173(02)00294-6 · 2002 · External reference
Powders and bulk solids: behavior, characterization, storage and flow
2008 · External reference
Assessment of segregation potential of powder blends
10.1080/10837450701556834 · 2007 · External reference
Methods for minimizing segregation: a review
10.1080/02726350490501420 · 2004 · External reference
Segregation quantification of two-component particulate mixtures: effect of particle size, density, shape, and surface texture
10.1080/02726350701783977 · 2007 · External reference
Comparison of three different dry coating devices for fine API bulk property enhancements: the effect of device intensities and processing parameters
10.1016/j.ijpharm.2025.126116 · 2025 · External reference
Enhancing drug processibility through dry coating: comparison at lab and pilot scales
10.1016/j.ijpharm.2025.125724 · 2025 · External reference
Mechanistic prediction of powder flowability through Bond number: model calibration and estimation of flow enhancement after dry coating
10.1016/j.ijpharm.2026.126902 · 2026 · External reference
Contact mechanics models for surface engineering of fine powders: a review connecting particle adhesion to bulk properties through Bond number
2026 · External reference
10.1146/annurev-chembioeng-060718-030122
10.1146/annurev-chembioeng-060718-030122 · External reference
The segregation of particulate materials. A review
10.1016/0032-5910(76)80053-8 · 1976 · External reference
10.1098/rspa.2015.0856
10.1098/rspa.2015.0856 · External reference
Evaluation of particle density effect for mixing behavior in a rotating drum mixer by DEM simulation
10.1016/j.apt.2015.12.013 · 2016 · External reference
Effect of non-sphericity of a narrow-sized binary mixture on mixing in convective vibrated packed bed using discrete element method
10.1016/j.powtec.2023.118600 · 2023 · External reference
Passivation of high-surface-energy sites of milled ibuprofen crystals via dry coating for reduced cohesion and improved flowability
10.1002/jps.23589 · ExternalCitation · doi-reference
Regimes of segregation and mixing in combined size and density granular systems: an experimental study
10.1007/s10035-005-0198-x · ExternalCitation · doi-reference
Selection of silica type and amount for flowability enhancements via dry coating: contact mechanics based predictive approach
10.1007/s11095-023-03561-6 · ExternalCitation · doi-reference
Predicting powder blend flowability from individual constituent properties using machine learning
10.1007/s11095-025-03855-x · ExternalCitation · doi-reference
The segregation of particulate materials. A review
10.1016/0032-5910(76)80053-8 · ExternalCitation · doi-reference
Evaluation of particle density effect for mixing behavior in a rotating drum mixer by DEM simulation
10.1016/j.apt.2015.12.013 · ExternalCitation · doi-reference
A concise treatise on model-based enhancements of cohesive powder properties via dry particle coating
10.1016/j.apt.2022.103836 · ExternalCitation · doi-reference
Characterization of particle and bulk level cohesion reduction of surface modified fine aluminum powders
10.1016/j.colsurfa.2010.03.015 · ExternalCitation · doi-reference
Improving blend content uniformity via dry particle coating of micronized drug powders
10.1016/j.ejps.2017.04.012 · ExternalCitation · doi-reference
Underpinning mechanistic understanding of the segregation phenomena of pharmaceutical blends using a near-infrared (NIR) spectrometer embedded segregation tester
10.1016/j.ejps.2020.105516 · ExternalCitation · doi-reference
Applications of NIR in early stage formulation development: part I. Semi-quantitative blend uniformity and content uniformity analyses by reflectance NIR without calibration models
10.1016/j.ijpharm.2007.03.040 · ExternalCitation · doi-reference
Simultaneous micronization and surface modification for improvement of flow and dissolution of drug particles
10.1016/j.ijpharm.2011.05.070 · ExternalCitation · doi-reference
Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: the effect of mixing time and excipient size
10.1016/j.ijpharm.2023.122722 · ExternalCitation · doi-reference
Detailed accounts of segregation mechanisms and the evolution of pharmaceutical blend segregation analysis: a review
10.1016/j.ijpharm.2024.124739 · ExternalCitation · doi-reference
Enhancing drug processibility through dry coating: comparison at lab and pilot scales
10.1016/j.ijpharm.2025.125724 · ExternalCitation · doi-reference
Novel powder property-based indices for predicting segregation risk in multicomponent pharmaceutical blends
10.1016/j.ijpharm.2025.125990 · ExternalCitation · doi-reference
Comparison of three different dry coating devices for fine API bulk property enhancements: the effect of device intensities and processing parameters
10.1016/j.ijpharm.2025.126116 · ExternalCitation · doi-reference
Novel methodology to assess and predict segregation risk in a continuous direct compression via mini-batch blending process
10.1016/j.ijpharm.2026.126888 · ExternalCitation · doi-reference
Mechanistic prediction of powder flowability through Bond number: model calibration and estimation of flow enhancement after dry coating
10.1016/j.ijpharm.2026.126902 · ExternalCitation · doi-reference
A predictive model based on key particle properties for segregation of free-flowing powder blends measured using near-infrared spectroscopy
10.1016/j.ijpharm.2026.126921 · ExternalCitation · doi-reference
Micro-modeling of cohesive mixing processes
10.1016/j.powtec.2003.08.042 · ExternalCitation · doi-reference
Assessing powder segregation potential by near infrared (NIR) spectroscopy and correlating segregation tendency to tabletting performance
10.1016/j.powtec.2012.05.021 · ExternalCitation · doi-reference
Prediction of porosity from particle scale interactions: surface modification of fine cohesive powders
10.1016/j.powtec.2014.01.006 · ExternalCitation · doi-reference
Review of new segregation tester method by Dr. Kerry Johanson, P.E
10.1016/j.powtec.2014.02.021 · ExternalCitation · doi-reference
Particle size segregation promoted by powder flow in confined space: the die filling process case
10.1016/j.powtec.2014.04.023 · ExternalCitation · doi-reference
Particle size-based segregation of pharmaceutical powders in a vertical chute with a closed bottom: an experimental evaluation
10.1016/j.powtec.2015.03.021 · ExternalCitation · doi-reference
Quantification of segregation potential for polydisperse, cohesive, multi-component powders and prediction of tablet die-filling performance - a methodology for practical testing, re-formulation and process design
10.1016/j.powtec.2015.04.037 · ExternalCitation · doi-reference
Diminished segregation in continuous powder mixing
10.1016/j.powtec.2016.11.038 · ExternalCitation · doi-reference
New mass flow limiting lines based on segregation pattern and magnitude
10.1016/j.powtec.2019.08.079 · ExternalCitation · doi-reference
Assessing predictability of packing porosity and bulk density enhancements after dry coating of pharmaceutical powders
10.1016/j.powtec.2020.09.037 · ExternalCitation · doi-reference
Effect of non-sphericity of a narrow-sized binary mixture on mixing in convective vibrated packed bed using discrete element method
10.1016/j.powtec.2023.118600 · ExternalCitation · doi-reference
Effect of aspect ratio of ellipsoidal particles on segregation of a binary mixture in a rotating drum
10.1016/j.powtec.2023.118682 · ExternalCitation · doi-reference
Powder technology in the pharmaceutical industry: the need to catch up fast
10.1016/s0032-5910(01)00482-x · ExternalCitation · doi-reference
Ibuprofen crystals with optimized properties
10.1016/s0378-5173(02)00294-6 · ExternalCitation · doi-reference
Modelling size segregation of granular materials: the roles of segregation, advection and diffusion
10.1017/jfm.2013.680 · ExternalCitation · doi-reference
Particle-size and-density segregation in granular free-surface flows
10.1017/jfm.2015.438 · ExternalCitation · doi-reference
Methods for minimizing segregation: a review
10.1080/02726350490501420 · ExternalCitation · doi-reference
Segregation quantification of two-component particulate mixtures: effect of particle size, density, shape, and surface texture
10.1080/02726350701783977 · ExternalCitation · doi-reference
Assessment of segregation potential of powder blends
10.1080/10837450701556834 · ExternalCitation · doi-reference
Influence of formulation composition and processing on the content uniformity of low-dose tablets manufactured at kilogram scale
10.1080/10837450902832885 · ExternalCitation · doi-reference
The relationship between attractive interparticle forces and bulk behaviour in dry and uncharged fine powders
10.1080/17461390500402657 · ExternalCitation · doi-reference
10.1098/rspa.2015.0856
10.1098/rspa.2015.0856 · ExternalCitation · doi-reference
Percolation of a fine particle in static granular beds
10.1103/physreve.107.014903 · ExternalCitation · doi-reference
10.1146/annurev-chembioeng-060718-030122
10.1146/annurev-chembioeng-060718-030122 · ExternalCitation · doi-reference
Mixing and segregation of granular material
10.1146/annurev.fluid.32.1.55 · ExternalCitation · doi-reference
Prediction of inter-particle adhesion force from surface energy and surface roughness
10.1163/016942410x525623 · ExternalCitation · doi-reference
Morphological, packing, flow and tableting properties of new avicel types
10.3109/03639049509048132 · ExternalCitation · doi-reference
Blend segregation in tablets manufacturing and its effect on drug content uniformity—a review
10.3390/pharmaceutics13111909 · ExternalCitation · doi-reference
