Research graph
References from Emerging nanomedicine upshot: Reprogramming cellular dormancy for tissue regeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
Multicellular transcriptional analysis of mammalian heart regeneration
10.1161/circulationaha.117.028252 · 2017 · External reference
Comparative regenerative mechanisms across different mammalian tissues. NPJ
2018 · External reference
Mammals fail to regenerate organs when wound contraction drives scar formation. NPJ
2021 · External reference
In vivo partial cellular reprogramming enhances liver plasticity and regeneration
10.1016/j.celrep.2022.110730 · 2022 · External reference
An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury
10.1016/j.neuron.2021.10.007 · 2022 · External reference
The struggle to make CNS axons regenerate: why has it been so difficult?
10.1007/s11064-019-02844-y · 2020 · External reference
Immunological considerations and challenges for regenerative cellular therapies
10.1038/s42003-021-02237-4 · 2021 · External reference
The future of regenerative medicine: cell therapy using pluripotent stem cells and acellular therapies based on extracellular vesicles
10.3390/cells10020240 · 2021 · External reference
Challenges and strategies for improving the regenerative effects of mesenchymal stromal cell-based therapies
10.3390/ijms18102087 · 2017 · External reference
Application of dendrimer-based nanosensors in immunodiagnosis
10.1016/j.colsurfb.2021.112174 · 2022 · External reference
Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives
10.1186/s12951-025-03448-1 · 2025 · External reference
Extracellular vesicles as bioactive nanotherapeutics: an emerging paradigm for regenerative medicine
10.7150/thno.72812 · 2022 · External reference
Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury
10.4103/1673-5374.335830 · 2022 · External reference
3D-printed manganese dioxide incorporated scaffold promotes osteogenic-angiogenic coupling for refractory bone defect by remodeling osteo-regenerative microenvironment
2025 · External reference
Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders
10.1093/icb/icq022 · 2010 · External reference
Metabolic changes during cardiac regeneration in the axolotl
2025 · External reference
Endocardial notch signaling promotes cardiomyocyte proliferation in the regenerating zebrafish heart through Wnt pathway antagonism
10.1016/j.celrep.2018.12.048 · 2019 · External reference
Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances
2025 · External reference
Notch, and TGF-β pathways impinge on hedgehog signaling complexity: an open window on cancer
10.3389/fgene.2019.00711 · 2019 · External reference
The multiple interactions of RUNX with the hippo–YAP pathway
10.3390/cells10112925 · 2021 · External reference
Acute inflammation stimulates a regenerative response in the neonatal mouse heart
10.1038/cr.2015.110 · 2015 · External reference
Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration
10.7554/elife.92519 · 2024 · External reference
Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish
10.15252/embr.201949752 · 2020 · External reference
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart
10.7554/elife.50163 · 2019 · External reference
The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response
10.1016/j.cell.2014.03.032 · 2014 · External reference
Regulation of chromatin organization during animal regeneration
10.1186/s13619-023-00162-x · 2023 · External reference
Epigenetic regulation of satellite cell fate during skeletal muscle regeneration
10.1186/s13395-020-00259-w · 2021 · External reference
Mechanism of non-coding RNA regulation of DNMT3A
10.1186/s13072-025-00574-w · 2025 · External reference
Regeneration alters open chromatin and cis-regulatory landscape of erythroid precursors
10.1101/gr.279949.124 · 2025 · External reference
MicroRNAs: a neoteric approach to understand pathogenesis, diagnose, and treat myocardial infarction
10.1097/fjc.0000000000001141 · 2021 · External reference
MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression
10.1038/cddis.2015.239 · 2015 · External reference
Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease
10.1038/ncomms6288 · 2014 · External reference
Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration
10.1007/s00441-016-2431-9 · 2016 · External reference
Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition. Front Cell
2023 · External reference
Extracellular matrix stiffness—The central cue for skin fibrosis
10.3389/fmolb.2023.1132353 · 2023 · External reference
Extracellular matrix stiffness regulates microvascular stability by controlling endothelial paracrine signaling to determine pericyte fate
10.1161/atvbaha.123.319119 · 2023 · External reference
Immunology of acute and chronic wound healing
10.3390/biom11050700 · 2021 · External reference
Macrophages are required for neonatal heart regeneration
10.1172/jci72181 · 2014 · External reference
High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration
10.1002/reg2.95 · 2018 · External reference
Mitochondrial aerobic respiration is activated during hair follicle stem cell differentiation, and its dysfunction retards hair regeneration
10.7717/peerj.1821 · 2016 · External reference
PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
10.1007/s13238-019-0618-z · 2019 · External reference
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
10.1073/pnas.1003428107 · 2010 · External reference
Targeting macrophage polarization for reinstating homeostasis following tissue damage
10.3390/ijms25137278 · 2024 · External reference
Learning from mother nature: innovative tools to boost endogenous repair of critical or difficult-to-heal large tissue defects. front bioeng
2017 · External reference
Stem cell therapies in clinical trials: progress and challenges
10.1016/j.stem.2015.06.007 · 2015 · External reference
Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ
2019 · External reference
Gene therapy for regenerative medicine
10.3390/pharmaceutics15030856 · 2023 · External reference
Nanocarrier-based systems for targeted delivery: current challenges and future directions
2025 · External reference
Modulating the tumor microenvironment to enhance tumor nanomedicine delivery
10.3389/fphar.2017.00952 · 2017 · External reference
miRNA in cardiac development and regeneration
10.1186/s13619-021-00077-5 · 2021 · External reference
MiRNA transfection via poly(amidoamine)-based delivery vector prevents hypoxia/reperfusion-induced cardiomyocyte apoptosis
10.2217/nnm-2019-0363 · 2020 · External reference
Chemically modified microRNA delivery via DNA tetrahedral frameworks for dental pulp regeneration
10.1186/s12951-024-02393-9 · 2024 · External reference
Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
2016 · External reference
Delivery of therapeutic miRNAs using nanoscale zeolitic imidazolate framework for accelerating vascularized bone regeneration
10.1016/j.cej.2021.132867 · 2022 · External reference
Plasmid encoding mirna-200C delivered by Caco3-based nanoparticles enhances rat alveolar bone formation
10.2217/nnm-2022-0151 · 2022 · External reference
Itraconazole and difluorinated-curcumin containing chitosan nanoparticle loaded hydrogel for amelioration of onychomycosis
10.3390/biomimetics7040206 · 2022 · External reference
Valproic acid-labeled chitosan nanoparticles promote recovery of neuronal injury after spinal cord injury
2020 · External reference
Sustained release of valproic acid loaded on chitosan nanoparticles within hybrid of alginate/chitosan hydrogel with/without stem cells in regeneration of spinal cord injury
10.1007/s40204-022-00209-3 · 2023 · External reference
Self-assembling scaffolds epigenetically reactivate and electroactively guide neuronal regeneration to restore central neural circuits
10.1038/s41467-026-72397-6 · 2026 · External reference
mPPTMP195 nanoparticles enhance fracture recovery through HDAC4 nuclear translocation inhibition
2024 · External reference
Unresolved reference
2021 · External reference
Transient naive reprogramming corrects hiPS cells functionally and epigenetically
10.1038/s41586-023-06424-7 · 2023 · External reference
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
10.1038/s41467-020-15174-3 · 2020 · External reference
Cellular reprogramming and epigenetic rejuvenation. Clin
2021 · External reference
Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain
10.1038/s41413-025-00416-1 · 2025 · External reference
Tenofovir-tethered gold nanoparticles as a novel multifunctional long-acting anti-HIV therapy to overcome deficient drug delivery-: an in vivo proof of concept
10.1186/s12951-022-01750-w · 2023 · External reference
Gold nanoparticles modulate macrophage polarization to promote skeletal muscle regeneration
2025 · External reference
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 · External reference
Fibroblast growth factor 2 conjugated superparamagnetic iron oxide nanoparticles (FGF2-SPIONs) ameliorate hepatic stellate cells activation in vitro and acute liver injury in vivo
10.1016/j.jconrel.2020.09.041 · 2020 · External reference
Antifibrotic and pro-regenerative effects of SMAD3 siRNA and collagen I mRNA-loaded lipid nanoparticles in human tenocytes
10.1021/acsanm.4c02996 · 2024 · External reference
Macrophage plasticity: signaling pathways, tissue repair, and regeneration
2024 · External reference
Collagenase-mediated extracellular matrix targeting for enhanced drug penetration and therapeutic efficacy in nanoscale delivery systems for cancer therapy
10.1186/s12951-025-03815-y · 2025 · External reference
Microenvironment-responsive nanomedicines: a promising direction for tissue regeneration
2024 · External reference
Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries
2026 · External reference
Extracellular matrix sheet modified with VEGF-loaded nanoparticles for bladder regeneration
10.1038/s41427-022-00442-z · 2022 · External reference
Nanoparticle-mediated TGF-β release from microribbon-based hydrogels accelerates stem cell-based cartilage formation in vivo
10.1007/s10439-020-02522-z · 2020 · External reference
Nanomedicines against mitochondrial dysfunction-induced metabolic diseases
10.1002/advs.202514522 · 2025 · External reference
Mitochondria-targeted nanoparticles with whole-course-repair efficacy in therapy of myocardial ischemia reperfusion injury
2025 · External reference
Mitochondria-targeted ROS scavenger JP4-039 improves cardiac function in a post-myocardial infarction animal model and induces angiogenesis in vitro
10.1371/journal.pone.0320703 · 2025 · External reference
ROS-responsive thioketal nanoparticles delivering system for targeted ulcerative colitis therapy with potent HDAC6 inhibitor, tubastatin a
10.1016/j.ejps.2024.106856 · 2024 · External reference
Biomedical application of reactive oxygen species–responsive nanocarriers in cancer
2020 · External reference
Reactive oxygen species-based biomaterials for regenerative medicine and tissue engineering applications. front bioeng
2021 · External reference
Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair
2023 · External reference
Dual-responsive multi-functional silica nanoparticles with repaired mitochondrial functions for efficient alleviation of spinal cord injury
10.1002/exp.70012 · 2025 · External reference
Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
10.4103/1673-5374.208546 · 2017 · External reference
10.1126/sciadv.adl0372
10.1126/sciadv.adl0372 · External reference
Remotely temporal scheduled macrophage phenotypic transition enables optimized immunomodulatory bone regeneration
10.1002/smll.202203680 · 2022 · External reference
Exosome-guided phenotypic switch of M1 to M2 macrophages for cutaneous wound healing
10.1002/advs.201900513 · 2019 · External reference
Osteoimmunomodulatory nanoparticles for bone regeneration
10.3390/nano13040692 · 2023 · External reference
Advanced immunomodulatory biomaterials for therapeutic applications
10.1002/adhm.202304496 · 2025 · External reference
Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis
10.1186/s12951-021-01128-4 · 2021 · External reference
Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes
2022 · External reference
Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury
10.1073/pnas.1820276116 · 2019 · External reference
In vivo amelioration of age-associated hallmarks by partial reprogramming
10.1016/j.cell.2016.11.052 · 2016 · External reference
Epigenetic modifications as therapeutic targets
10.1038/nbt.1678 · 2010 · External reference
Macrophages in tissue repair, regeneration, and fibrosis
10.1016/j.immuni.2016.02.015 · 2016 · External reference
The ethical implications of tissue engineering for regenerative purposes: a systematic review
10.1089/ten.teb.2022.0033 · 2023 · External reference
ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts
10.1016/j.stemcr.2021.05.005 · 2021 · External reference
The ethics of regenerative medicine
10.1007/s42977-021-00075-3 · 2021 · External reference
A robust pH-sensitive unimolecular dendritic nanocarrier that enables targeted anti-cancer drug delivery via GLUT transporters
10.1016/j.colsurfb.2018.07.053 · 2018 · External reference
Engineering precision nanoparticles for drug delivery
10.1038/s41573-020-0090-8 · 2021 · External reference
Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases
10.1038/s41419-019-1453-0 · 2019 · External reference
The use of peptides, aptamers, and variable domains of heavy chain only antibodies in tissue engineering and regenerative medicine
10.1016/j.actbio.2023.07.045 · 2023 · External reference
GLUT1 transporter-facilitated solid lipid nanoparticles loaded with anti-cancer therapeutics for ovarian cancer targeting
10.1016/j.ijpharm.2023.122894 · 2023 · External reference
Cell membrane-coated nanoparticles for precision medicine: a comprehensive review of coating techniques for tissue-specific therapeutics
10.3390/ijms25042071 · 2024 · External reference
Controlling the biodistribution and clearance of nanomedicines
10.1038/s44222-023-00138-1 · 2024 · External reference
Regulatory safety evaluation of nanomedical products: key issues to refine
10.1007/s13346-022-01208-4 · 2022 · External reference
Nonclinical regulatory immunotoxicity testing of nanomedicinal products: proposed strategy and possible pitfalls
10.1002/wnan.1633 · 2020 · External reference
Hemocompatibility studies in nanotoxicology: hemolysis or eryptosis? (a review)
10.1016/j.tiv.2024.105814 · 2024 · External reference
Genotoxicity testing of nanomaterials
10.1002/wnan.1833 · 2022 · External reference
Organ-on-chip platforms for nanoparticle toxicity and efficacy assessment: advancing beyond traditional in vitro and in vivo models
2025 · External reference
Beyond extracellular vesicle (EV) hype: practical solutions and remaining hurdles in EV research, manufacturing, and clinical translation
10.1002/advs.202521913 · 2026 · External reference
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A translational framework to DELIVER nanomedicines to the clinic
10.1038/s41565-024-01754-7 · 2024 · External reference
