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References from Interplay between semi-continuous blending and continuous twin-screw wet granulation: impact of blend uniformity on CQAs of low-dose granules. Local targets link to admitted publications; unresolved targets remain external evidence.
Development of a blending design space model to control blend uniformity in a mini-batch direct compression line
10.1016/j.powtec.2025.120675 · 2025 · External reference
Continuous feeding of low-dose apis via periodic micro dosing
10.1016/j.ijpharm.2016.05.033 · 2016 · External reference
In-line nir spectroscopy for comprehensive process understanding of semi-continuous blending in continuous production of low-dose formulations
10.1016/j.ijpharm.2025.125622 · 2025 · External reference
Continuous twin screw wet granulation of low-dose formulations: Impact of process variables and api/binder addition methods on granule quality attributes
10.1016/j.ijpharm.2026.126684 · 2026 · External reference
10.1016/j.xphs.2019.06.023
10.1016/j.xphs.2019.06.023 · External reference
Continuous manufacturing of homogeneous ultralow-dose granules by twin-screw wet granulation
10.3311/ppch.14972 · 2020 · External reference
Studying the api distribution of controlled release formulations produced via continuous twin-screw wet granulation: Influence of matrix former, filler and process parameters
10.3390/pharmaceutics16030341 · 2024 · External reference
Twin screw wet granulation: influence of formulation parameters on granule properties and growth behavior
10.1016/j.powtec.2012.04.035 · 2013 · External reference
10.1002/cem.686
10.1002/cem.686 · External reference
Unresolved reference
2016 · External reference
Integrated twin-screw wet granulation, continuous vibrational fluid drying and milling: A fully continuous powder-to-granule line
10.1016/j.ijpharm.2020.120126 · 2021 · External reference
Linking process variables to residence time distribution in a hybrid flowsheet model for continuous direct compression
10.1016/j.cherd.2019.10.026 · 2020 · External reference
Recommendations for the assessment of blend and content uniformity: Modifications to withdrawn fda draft stratified sampling guidance
10.1007/s12247-014-9207-0 · 2015 · External reference
Twin screw wet granulation: influence of formulation parameters on granule properties and growth behavior
10.1016/j.powtec.2012.04.035 · 2013 · External reference
Unresolved reference
2020 · External reference
Process intensification using a semi-continuous mini-blender to support continuous direct compression processing
10.1016/j.powtec.2023.118844 · 2023 · External reference
Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing semi-continuous mini-blending
2024 · External reference
Measurement of residence time distributions and material tracking on three continuous manufacturing lines
10.1016/j.ijpharm.2019.03.058 · 2019 · External reference
Enhanced blend uniformity and flowability of low drug loaded fine api blends via dry coating: The effect of mixing time and excipient size
10.1016/j.ijpharm.2023.122722 · 2023 · External reference
Investigating the effects of mixing dynamics on twin-screw granule quality attributes via the development of a physics-based process map
10.3390/pharmaceutics16040456 · 2024 · External reference
Mechanistic understanding of the effects of process and design parameters on the mixing dynamics in continuous twin-screw granulation
10.1016/j.powtec.2021.05.071 · 2021 · External reference
Experimental investigation of granule size and shape dynamics in twin-screw granulation
10.1016/j.ijpharm.2014.09.020 · 2014 · External reference
Mixing and transport during pharmaceutical twin-screw wet granulation: Experimental analysis via chemical imaging
10.1016/j.ejpb.2014.04.004 · 2014 · External reference
10.1007/s12247-015-9215-8
10.1007/s12247-015-9215-8 · External reference
Twin screw wet granulation: The study of a continuous twin screw granulator using positron emission particle tracking (pept) technique
10.1016/j.ejpb.2012.04.011 · 2012 · External reference
High potency active pharmaceutical ingredients (hpapis) the fastest growing market segment in the pharmaceutical industry
2010 · External reference
Unresolved reference
2021 · External reference
Unresolved reference
External reference
Continuous twin screw granulation: Robustness of lactose/mcc-based formulations
2020 · External reference
10.3390/pharmaceutics13050668
10.3390/pharmaceutics13050668 · External reference
Continuous twin screw granulation: Influence of process and formulation variables on granule quality attributes of model formulations
2020 · External reference
Continuous twin screw granulation: A complex interplay between formulation properties, process settings and screw design
10.1016/j.ijpharm.2019.119004 · 2020 · External reference
10.1007/978-94-6351-086-8
10.1007/978-94-6351-086-8 · External reference
Managing api raw material variability during continuous twin-screw wet granulation
10.1016/j.ijpharm.2019.03.012 · 2019 · External reference
In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet granulation and its use in process development
10.1016/j.ijpharm.2020.119451 · 2020 · External reference
Unresolved reference
External reference
Continuous twin screw granulation: Influence of process variables on granule and tablet quality
10.1016/j.ejpb.2012.05.010 · 2012 · External reference
Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using nir chemical imaging
10.1016/j.ejpb.2013.10.012 · 2014 · External reference
In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding
10.1016/j.ijpharm.2017.07.045 · 2017 · External reference
10.1007/978-94-015-9580-3
10.1007/978-94-015-9580-3 · External reference