References

Cancer statistics, 2022

2022 · External reference

Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the united states

10.1158/0008-5472.can-14-0155 · 2014 · External reference

Pancreatic cancer: A review

10.1001/jama.2021.13027 · 2021 · External reference

A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer

10.1056/nejmoa032295 · 2004 · External reference

Effect of chemoradiotherapy vs chemotherapy on survival in patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine with or without erlotinib: The lap07 randomized clinical trial

10.1001/jama.2016.4324 · 2016 · External reference

Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: An eastern cooperative oncology group trial

10.1200/jco.2011.34.8904 · 2011 · External reference

Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: Results of the dutch randomized phase iii preopanc trial

10.1200/jco.19.02274 · 2020 · External reference

The role of tgf-beta/smad4 signaling in cancer

10.7150/ijbs.23230 · 2018 · External reference

10.1056/nejmra1404198

10.1056/nejmra1404198 · 2014 · External reference

Cancer Genome Atlas Research N. Integrated genomic characterization of pancreatic ductal adenocarcinoma

2017 · External reference

Whole genomes redefine the mutational landscape of pancreatic cancer

10.1038/nature14169 · 2015 · External reference

Genomic analyses identify molecular subtypes of pancreatic cancer

10.1038/nature16965 · 2016 · External reference

Dpc4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer

10.1200/jco.2008.17.7188 · 2009 · External reference

Smad4 gene mutations are associated with poor prognosis in pancreatic cancer

10.1158/1078-0432.ccr-09-0227 · 2009 · External reference

Prognostic value of smad4 in pancreatic cancer: A meta-analysis

10.1016/j.tranon.2015.11.007 · 2016 · External reference

Smad4 loss correlates with higher rates of local and distant failure in pancreatic adenocarcinoma patients receiving adjuvant chemoradiation

10.1097/mpa.0000000000000985 · 2018 · External reference

Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma

10.1002/cncr.33038 · 2020 · External reference

Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: A randomized controlled trial

10.1001/jama.299.9.1019 · 2008 · External reference

Altered gemcitabine and nab-paclitaxel scheduling improves therapeutic efficacy compared with standard concurrent treatment in preclinical models of pancreatic cancer

10.1158/1078-0432.ccr-20-1422 · 2021 · External reference

Nonparametric estimation from incomplete observations

10.1080/01621459.1958.10501452 · 1958 · External reference

Evaluation of survival data and two new rank order statistics arising in its consideration

1966 · External reference

Unresolved reference

External reference

A class of k-sample tests for comparing the cumulative incidence of a competing risk

10.1214/aos/1176350951 · 1988 · External reference

10.1111/j.2517-6161.1972.tb00899.x

10.1111/j.2517-6161.1972.tb00899.x · External reference

A proportional hazards model for the subdistribution of a competing risk

10.1080/01621459.1999.10474144 · 1999 · External reference

Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia

10.1053/j.gastro.2011.12.042 · 2012 · External reference

Pancreatic cancer biology and genetics from an evolutionary perspective

10.1038/nrc.2016.66 · 2016 · External reference

Association of alterations in main driver genes with outcomes of patients with resected pancreatic ductal adenocarcinoma

10.1001/jamaoncol.2017.3420 · 2018 · External reference

Expression of smad2 and smad4 in cervical cancer: Absent nuclear smad4 expression correlates with poor survival

10.1038/modpathol.2008.62 · 2008 · External reference

Smad4 alteration associates with invasive-front pathological markers and poor prognosis in colorectal cancer

10.1111/his.13805 · 2019 · External reference

Pancreatic cancer

10.1016/s0140-6736(16)00141-0 · 2016 · External reference

Clinical outcome and expression of mutant p53, p16, and smad4 in lung adenocarcinoma: A prospective study

10.1186/s12957-015-0502-0 · 2015 · External reference

Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells

10.3748/wjg.v22.i9.2678 · 2016 · External reference

Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts

10.1158/0008-5472.can-07-3127 · 2007 · External reference

Structural and functional analysis of smad4 gene promoter in malignant pancreatic and colorectal tissues: Detection of two novel polymorphic nucleotide repeats

10.1016/j.canep.2010.10.002 · 2011 · External reference

Inactivation of smad4 tumor suppressor gene during gastric carcinoma progression

10.1158/1078-0432.ccr-06-1467 · 2007 · External reference

Dpc4, a candidate tumor suppressor gene at human chromosome 18q21.1

10.1126/science.271.5247.350 · 1996 · External reference

Loss of dpc4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma

10.3748/wjg.v9.i12.2764 · 2003 · External reference

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

10.1101/gad.1478706 · 2006 · External reference

Kras(g12d) and smad4/dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas

10.1016/j.ccr.2007.01.017 · 2007 · External reference

The smad4 protein and prognosis of pancreatic ductal adenocarcinoma

2001 · External reference

Rhot1 and smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer

2012 · External reference

Vascular endothelial growth factor and dpc4 predict adjuvant therapy outcomes in resected pancreatic cancer

10.1016/j.gassur.2005.06.021 · 2005 · External reference

Immunohistochemically detected expression of 3 major genes (cdkn2a/p16, tp53, and smad4/dpc4) strongly predicts survival in patients with resectable pancreatic cancer

10.1097/sla.0b013e3182827a65 · 2013 · External reference

Smad4 genetic alterations predict a worse prognosis in patients with pancreatic ductal adenocarcinoma

10.1097/mpa.0b013e318247d6af · 2012 · External reference

Loss of smad4 staining in pre-operative cell blocks is associated with distant metastases following pancreaticoduodenectomy with venous resection for pancreatic cancer

10.1002/jso.23606 · 2014 · External reference

Locally advanced pancreatic cancer: Association between prolonged preoperative treatment and lymph-node negativity and overall survival

10.1001/jamasurg.2013.2690 · 2014 · External reference

Phase ii trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (t4) pancreatic adenocarcinoma: Correlation of smad4(dpc4) immunostaining with pattern of disease progression

10.1200/jco.2010.33.8038 · 2011 · External reference

Prognostic value of c-met expression in patients with pancreatic cancer receiving adjuvant and neoadjuvant chemoradiation therapy

10.1016/j.ijrobp.2017.10.030 · 2018 · External reference

Molecular subtypes of pancreatic cancer

10.1038/s41575-019-0109-y · 2019 · External reference