Research graph
References from Aire is a cell-intrinsic regulator of natural IgM-secreting cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Autoimmune Polyendocrine Syndromes
10.1056/nejmra1713301 · 2018 · External reference
Projection of an immunological self shadow within the thymus by the aire protein
10.1126/science.1075958 · 2002 · External reference
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
10.1093/hmg/11.4.397 · 2002 · External reference
Autoimmune regulator and self-tolerance - molecular and clinical aspects
10.1111/imr.12419 · 2016 · External reference
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
10.1038/ni723 · 2001 · External reference
Aire
10.1146/annurev.immunol.25.022106.141532 · 2009 · External reference
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
10.1038/nri2450 · 2008 · External reference
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
10.1084/jem.20092144 · 2010 · External reference
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
10.1084/jem.20080046 · 2008 · External reference
The cellular mechanism of Aire control of T cell tolerance
10.1016/j.immuni.2005.07.005 · 2005 · External reference
Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes
10.4049/jimmunol.0804133 · 2009 · External reference
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
10.1084/jem.20102327 · 2011 · External reference
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
10.1182/blood-2010-06-286393 · 2011 · External reference
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice
10.4049/jimmunol.174.4.1862 · 2005 · External reference
Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines
10.1084/jem.20091669 · 2010 · External reference
AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies
10.1016/j.cell.2016.06.024 · 2016 · External reference
Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease
10.4049/jimmunol.1701318 · 2018 · External reference
Deletional tolerance mediated by extrathymic Aire-expressing cells
10.1126/science.1159407 · 2008 · External reference
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4+ T cells
10.1016/j.immuni.2013.08.005 · 2013 · External reference
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium
10.1126/sciimmunol.abl5053 · 2021 · External reference
Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens
10.3389/fimmu.2018.02902 · 2018 · External reference
Aire-expressing ILC3-like cells in the lymph node display potent APC features
10.1084/jem.20181430 · 2019 · External reference
Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans
10.1038/s41590-022-01247-6 · 2022 · External reference
A wave of Thetis cells imparts tolerance to food antigens early in life
10.1126/science.adp0535 · 2025 · External reference
PRDM16-dependent antigen-presenting cells induce tolerance to gut antigens
10.1038/s41586-025-08982-4 · 2025 · External reference
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens
10.1016/j.cell.2025.03.020 · 2025 · External reference
RORγt eTACs mediate oral tolerance and Treg induction
10.1084/jem.20250573 · 2025 · External reference
RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells
10.1073/pnas.2417308122 · 2025 · External reference
The emerging family of RORγt+ antigen-presenting cells
10.1038/s41577-023-00906-5 · 2024 · External reference
Thetis cells: regulators of intestinal immune tolerance
10.1016/j.coi.2025.102570 · 2025 · External reference
Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction
10.1016/j.immuni.2015.05.013 · 2015 · External reference
B cells differentiate in human thymus and express AIRE
10.1016/j.jaci.2016.09.044 · 2017 · External reference
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4
10.1038/s41586-024-07079-8 · 2024 · External reference
Antigen presentation for central tolerance induction
10.1038/s41577-024-01076-8 · 2025 · External reference
Type III interferon drives thymic B cell activation and regulatory T cell generation
10.1073/pnas.2220120120 · 2023 · External reference
Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance
10.1016/j.celrep.2016.09.011 · 2016 · External reference
Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells
10.1038/ni.3154 · 2015 · External reference
Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance
10.1038/ni.1874 · 2010 · External reference
A new staining protocol for detection of murine antibody-secreting plasma cell subsets by flow cytometry
10.1002/eji.201747019 · 2017 · External reference
IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes
10.4049/jimmunol.1900285 · 2019 · External reference
B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production
10.3389/fimmu.2016.00324 · 2016 · External reference
Sterile inflammation: sensing and reacting to damage
10.1038/nri2873 · 2010 · External reference
B-1 B cells: development, selection, natural autoantibody and leukemia
10.1016/j.coi.2006.07.010 · 2006 · External reference
TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses
10.4049/jimmunol.178.12.7779 · 2007 · External reference
TNF receptor family signaling in the development and functions of medullary thymic epithelial cells
10.3389/fimmu.2012.00278 · 2012 · External reference
B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling
10.1016/j.coi.2007.04.008 · 2007 · External reference
Efficient In Vitro Plasma Cell Differentiation by B Cell Receptor Activation and Cytokine Stimulation
10.4110/in.2024.24.e35 · 2024 · External reference
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia
10.1101/gr.171645.113 · 2014 · External reference
Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells
10.4049/jimmunol.1500558 · 2015 · External reference
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells
10.1016/j.immuni.2018.06.007 · 2018 · External reference
AIRE regulates T-cell-independent B-cell responses through BAFF
10.1073/pnas.0808205105 · 2008 · External reference
A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire
10.1002/eji.201747267 · 2018 · External reference
Testing gene function early in the B cell lineage in mb1-cre mice
10.1073/pnas.0605944103 · 2006 · External reference
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells
10.1182/blood-2006-10-049767 · 2007 · External reference
Natural IgM antibodies against oxidation-specific epitopes
10.1007/s10875-010-9396-3 · 2010 · External reference
Innate sensing of oxidation-specific epitopes in health and disease
10.1038/nri.2016.63 · 2016 · External reference
Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells
10.1016/j.celrep.2016.02.027 · 2016 · External reference
Autoantibody Profiling in Ulcerative Colitis: Identification of Early Immune Signatures and Disease-Associated Antigens for Improved Diagnosis and Monitoring
10.3390/ijms26094086 · 2025 · External reference
Functional Analysis of Autoantibody Signatures in Rheumatoid Arthritis
10.3390/molecules27041452 · 2022 · External reference
Validation of a murine proteome-wide phage display library for identification of autoantibody specificities
10.1172/jci.insight.174976 · 2023 · External reference
Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes
10.1038/nri3383 · 2013 · External reference
The importance of natural IgM: scavenger, protector and regulator
10.1038/nri2849 · 2010 · External reference
Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells
10.4049/jimmunol.171.10.5406 · 2003 · External reference
Regulation of B1 cell migration by signals through Toll-like receptors
10.1084/jem.20061041 · 2006 · External reference
Division and differentiation of natural antibody-producing cells in mouse spleen
10.1073/pnas.0700001104 · 2007 · External reference
Cracking the BAFF code
10.1038/nri2572 · 2009 · External reference
B cell maturation antigen (BCMA) is dispensable for the survival of long-lived plasma cells
10.1038/s41467-025-62530-2 · 2025 · External reference
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
10.1084/jem.20070795 · 2007 · External reference
Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation
10.4049/jimmunol.181.8.5225 · 2008 · External reference
AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH
10.1016/j.bbrc.2012.05.057 · 2012 · External reference
Aire’s partners in the molecular control of immunological tolerance
10.1016/j.cell.2009.12.030 · 2010 · External reference
DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity
10.1016/j.bbamcr.2007.09.003 · 2008 · External reference
The double life of a B-1 cell: self-reactivity selects for protective effector functions
10.1038/nri2901 · 2011 · External reference
CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity
10.4049/jimmunol.0902711 · 2010 · External reference
Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice
10.4049/jimmunol.1403139 · 2015 · External reference
Role of B-1a cells in autoimmunity
10.1016/j.autrev.2005.10.007 · 2006 · External reference
Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq
10.7554/elife.55053 · 2020 · External reference
Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties
10.1084/jem.20132203 · 2014 · External reference
TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
10.1038/s41586-025-09421-0 · 2025 · External reference
Altered B cell homeostasis and Toll-like receptor 9-driven response in patients affected by autoimmune polyglandular syndrome Type 1: Altered B cell phenotype and dysregulation of the B cell function in APECED patients
10.1016/j.imbio.2016.09.001 · 2017 · External reference
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
10.1038/ni1444 · 2007 · External reference
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
10.1038/360225a0 · 1992 · External reference
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation
10.1016/1074-7613(94)90095-7 · 1994 · External reference
Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression
10.1016/s1074-7613(00)80681-0 · 1996 · External reference
Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms
10.1016/j.immuni.2008.05.016 · 2008 · External reference
Cell-based ELISpot protocol to detect and quantify antigen-specific antibody-secreting cells in murine whole-organ single-cell suspensions
10.1016/j.xpro.2025.103797 · 2025 · External reference
miR-148a controls metabolic programming and survival of mature CD19-negative plasma cells in mice
10.1002/eji.202048993 · 2021 · External reference
Determining immunoglobulin-specific B cell receptor repertoire of murine splenocytes by next-generation sequencing
10.1016/j.xpro.2022.101277 · 2022 · External reference
Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data
10.1093/bioinformatics/btv359 · 2015 · External reference
IMGT® tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS
10.1007/978-1-61779-842-9_32 · 2012 · External reference
Cloning and expression of murine Ig genes from single B cells
10.1016/j.jim.2009.08.009 · 2009 · External reference
