Research graph
References from Glucose-deprived tumor microenvironment activates AMP-activated protein kinase to drive adoptively transferred T helper 9 cell senescence. Local targets link to admitted publications; unresolved targets remain external evidence.
Dynamics and specificities of T cells in cancer immunotherapy
10.1038/s41568-023-00560-y · 2023 · External reference
Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox
10.1016/j.immuni.2021.11.015 · 2021 · External reference
CD4+ T cells in cancer
10.1038/s43018-023-00521-2 · 2023 · External reference
CAR T cell immunotherapy for human cancer
10.1126/science.aar6711 · 2018 · External reference
Driving CAR T-cells forward
10.1038/nrclinonc.2016.36 · 2016 · External reference
CAR T cell combination therapies to treat cancer
10.1016/j.ccell.2024.07.002 · 2024 · External reference
Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
10.1056/nejmoa1407222 · 2014 · External reference
Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study
10.1016/s0140-6736(21)00933-8 · 2021 · External reference
CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?
10.1016/j.ymthe.2020.09.015 · 2020 · External reference
CAR-T therapy in solid tumors
10.1016/j.ccell.2025.03.019 · 2025 · External reference
CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn
10.1038/s41571-023-00832-4 · 2023 · External reference
How the ageing microenvironment influences tumour progression
10.1038/s41568-019-0222-9 · 2019 · External reference
Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors
10.1038/s41467-023-40850-5 · 2023 · External reference
Metabolic challenges and interventions in CAR T cell therapy
10.1126/sciimmunol.abq3016 · 2023 · External reference
Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche
10.1016/j.cell.2022.03.033 · 2022 · External reference
Metabolic barriers to cancer immunotherapy
10.1038/s41577-021-00541-y · 2021 · External reference
Metabolic programming and immune suppression in the tumor microenvironment
10.1016/j.ccell.2023.01.009 · 2023 · External reference
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
10.1038/s41571-019-0203-7 · 2019 · External reference
Cell-programmed nutrient partitioning in the tumour microenvironment
10.1038/s41586-021-03442-1 · 2021 · External reference
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
10.1016/j.cell.2015.08.016 · 2015 · External reference
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
10.1016/j.cmet.2016.12.018 · 2017 · External reference
TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
10.1038/ni.2920 · 2014 · External reference
IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3- effector T cells
10.1038/ni.1677 · 2008 · External reference
Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells
10.1016/j.ccell.2021.09.011 · 2021 · External reference
Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors
10.1016/j.ccell.2018.05.004 · 2018 · External reference
Th9 cells promote antitumor immune responses in vivo
10.1172/jci65459 · 2012 · External reference
Tumor-specific IL-9–producing CD8+Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers
10.1073/pnas.1317431111 · 2014 · External reference
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells
10.1038/nm.2856 · 2012 · External reference
Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8+ T cells activate host CD4+ T cells to control tumors with antigen loss
10.1038/s43018-025-00935-0 · 2025 · External reference
A reappraisal of IL-9 in inflammation and cancer
10.1016/j.mucimm.2024.10.003 · 2025 · External reference
IL-9-producing T cells: potential players in allergy and cancer
10.1038/s41577-020-0396-0 · 2020 · External reference
Cellular sources and immune functions of interleukin-9
10.1038/nri2848 · 2010 · External reference
Th9 cells, new players in adaptive immunity
10.1016/j.it.2013.10.004 · 2014 · External reference
The development and in vivo function of T helper 9 cells
10.1038/nri3824 · 2015 · External reference
Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
10.1038/s41467-020-19672-2 · 2020 · External reference
BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy
10.1084/jem.20202144 · 2021 · External reference
Loss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy
10.1038/s41590-025-02235-2 · 2025 · External reference
Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment
10.1038/s41423-019-0344-8 · 2019 · External reference
Hallmarks of T cell aging
10.1038/s41590-021-00927-z · 2021 · External reference
Aging, Cellular Senescence, and Cancer
10.1146/annurev-physiol-030212-183653 · 2013 · External reference
Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
10.1136/jitc-2022-005020 · 2022 · External reference
Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors
10.3389/fimmu.2025.1484303 · 2025 · External reference
Ageing, immune fitness and cancer
10.1038/s41568-025-00858-z · 2025 · External reference
Chemoradiotherapy-induced ACKR2+ tumor cells drive CD8+ T cell senescence and cervical cancer recurrence
2024 · External reference
Tumor extracellular vesicle–derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming
10.1126/scitranslmed.adm7269 · 2025 · External reference
Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy
10.1126/scitranslmed.aaz6314 · 2021 · External reference
TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence
10.15252/emmm.201403918 · 2014 · External reference
Senescent T cells: a potential biomarker and target for cancer therapy
10.1016/j.ebiom.2021.103409 · 2021 · External reference
Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
10.1172/jci133679 · 2020 · External reference
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging
10.1016/j.immuni.2024.01.001 · 2024 · External reference
AMPK: restoring metabolic homeostasis over space and time
10.1016/j.molcel.2021.08.015 · 2021 · External reference
Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells
10.1016/j.immuni.2016.05.009 · 2016 · External reference
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival
10.1016/j.cmet.2016.03.008 · 2016 · External reference
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
10.1016/j.immuni.2010.07.014 · 2010 · External reference
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
10.1038/ni.1867 · 2010 · External reference
The non-canonical NF-κB pathway in immunity and inflammation
10.1038/nri.2017.52 · 2017 · External reference
Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation
10.1016/j.immuni.2021.02.003 · 2021 · External reference
AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
10.1016/j.tcb.2015.10.013 · 2016 · External reference
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
10.1016/j.molcel.2008.03.003 · 2008 · External reference
Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation
10.1074/jbc.m403286200 · 2004 · External reference
Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling
10.1038/s43018-024-00768-3 · 2024 · External reference
Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells
10.1016/j.ccell.2022.09.013 · 2022 · External reference
Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity
10.1038/s43587-024-00746-5 · 2024 · External reference
PPAR-γ regulates the effector function of human T helper 9 cells by promoting glycolysis
10.1038/s41467-023-38233-x · 2023 · External reference
Human “TH9” cells are a subpopulation of PPAR-γ+ TH2 cells
10.1126/sciimmunol.aat5943 · 2019 · External reference
AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
10.1016/j.molcel.2017.05.032 · 2017 · External reference
AMPK: positive and negative regulation, and its role in whole-body energy homeostasis
10.1016/j.ceb.2014.09.004 · 2015 · External reference
The role of AMPK in T cell metabolism and function
10.1016/j.coi.2017.04.004 · 2017 · External reference
AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
10.1016/j.cmet.2020.01.015 · 2020 · External reference
Glutamine suppresses senescence and promotes autophagy through glycolysis inhibition-mediated AMPKα lactylation in intervertebral disc degeneration
10.1038/s42003-024-06000-3 · 2024 · External reference
The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
10.1016/j.immuni.2014.12.030 · 2015 · External reference
The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity
10.1016/j.molcel.2025.08.035 · 2025 · External reference
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
10.1038/s41586-024-08348-2 · 2024 · External reference
Non-canonical NF-κB signaling pathway
10.1038/cr.2010.177 · 2010 · External reference
Identification and Characterization of a Novel MAP Kinase Kinase Kinase, MLTK
10.1074/jbc.m008595200 · 2001 · External reference
ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains
10.1016/j.molcel.2020.03.021 · 2020 · External reference
The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
10.1016/j.molcel.2024.10.044 · 2024 · External reference
The ribotoxic stress response drives UV-mediated cell death
10.1016/j.cell.2024.05.018 · 2024 · External reference
Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate
10.1016/j.cell.2020.06.006 · 2020 · External reference
ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging
10.1126/science.adf3208 · 2023 · External reference
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome
10.1126/science.abl6324 · 2022 · External reference
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma
10.1038/s41586-025-09489-8 · 2025 · External reference
IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy
10.1016/j.immuni.2025.10.024 · 2025 · External reference
IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy
10.1016/j.immuni.2025.10.021 · 2025 · External reference
Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production
10.1016/j.immuni.2018.05.008 · 2018 · External reference
Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
10.1038/s41467-019-08585-4 · 2019 · External reference
AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
10.1016/j.molcel.2022.10.026 · 2022 · External reference
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
10.7554/elife.44235 · 2019 · External reference
