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References from Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
10.1002/j.1460-2075.1992.tb05481.x · 1992 · External reference
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
10.1073/pnas.192461099 · 2002 · External reference
A new member of the immunoglobulin superfamily—CTLA-4
10.1038/328267a0 · 1987 · External reference
Enhancement of antitumor immunity by CTLA-4 blockade
10.1126/science.271.5256.1734 · 1996 · External reference
Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors
10.1016/j.intimp.2018.06.001 · 2018 · External reference
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
10.1158/2159-8290.cd-18-0367 · 2018 · External reference
Improved survival with ipilimumab in patients with metastatic melanoma
10.1056/nejmoa1003466 · 2010 · External reference
Nivolumab in previously untreated melanoma without BRAF mutation
10.1056/nejmoa1412082 · 2015 · External reference
Pembrolizumab for Early Triple-Negative Breast Cancer
10.1056/nejmoa1910549 · 2020 · External reference
Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer
10.1056/nejmoa2202809 · 2022 · External reference
The Lymphatic System in Disease Processes and Cancer Progression
10.1146/annurev-bioeng-112315-031200 · 2016 · External reference
Lymph node – an organ for T-cell activation and pathogen defense
10.1111/imr.12399 · 2016 · External reference
Progression of Metastasis through Lymphatic System
10.3390/cells10030627 · 2021 · External reference
Solid stress impairs lymphocyte infiltration into lymph-node metastases
10.1038/s41551-021-00766-1 · 2021 · External reference
Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes
10.1084/jem.20221847 · 2023 · External reference
Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
10.1016/j.cell.2022.04.019 · 2022 · External reference
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
10.1038/s41467-020-17046-2 · 2020 · External reference
Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice
10.1126/science.aal3662 · 2018 · External reference
Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice
10.1126/science.aal3622 · 2018 · External reference
Lymph node ratio is an independent prognostic factor in gastric cancer after curative resection (R0) regardless of the examined number of lymph nodes
10.1097/coc.0b013e318246b4e9 · 2013 · External reference
The Lymph Node Ratio Is an Independent Prognostic Factor in Pancreatic Cancer Patients Who Receive Curative Resection Followed by Adjuvant Chemotherapy
10.21873/anticanres.12801 · 2018 · External reference
Lymph node ratio as a prognostic factor in head and neck cancer patients
10.1186/s13014-015-0490-9 · 2015 · External reference
Prognostic information from sentinel lymph node biopsy in patients with thick melanoma
10.1001/archsurg.2010.115 · 2010 · External reference
The lymph node ratio as prognostic factor in node-positive breast cancer
10.1016/j.radonc.2003.10.015 · 2004 · External reference
The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes
10.1016/j.ccell.2020.09.001 · 2020 · External reference
The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes
10.1016/j.cell.2022.09.020 · 2022 · External reference
Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial
10.1016/s1470-2045(15)70122-1 · 2015 · External reference
Local delivery of low-dose anti-CTLA-4 to the melanoma lymphatic basin leads to systemic Treg reduction and effector T cell activation
10.1126/sciimmunol.abn8097 · 2022 · External reference
Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma
10.1056/nejmoa1613210 · 2017 · External reference
Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy
10.1172/jci.insight.124507 · 2018 · External reference
Chemotherapy but Not the Tumor Draining Lymph Nodes Determine the Immunotherapy Response in Secondary Tumors
10.1016/j.isci.2020.101056 · 2020 · External reference
Multi-scale characterization of tumor-draining lymph nodes in resectable lung cancer treated with neoadjuvant immune checkpoint inhibitors
10.1016/j.ebiom.2022.104265 · 2022 · External reference
Effect of lymph node dissection and adjuvant therapy in patients with sentinel node+ melanoma: An observational multicenter study
10.1200/jco.2023.41.16_suppl.e21569 · 2023 · External reference
Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes
10.1016/j.immuni.2022.07.019 · 2022 · External reference
Same yet different—how lymph node heterogeneity affects immune responses
10.1038/s41577-023-00965-8 · 2024 · External reference
Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin
10.1126/science.8171322 · 1994 · External reference
Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness
10.4049/jimmunol.155.4.1685 · 1995 · External reference
Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration
1995 · External reference
The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes
10.1038/ni.3101 · 2015 · External reference
Assessing breast lymphoedema following breast cancer treatment using indocyanine green lymphography
10.1007/s10549-020-05661-y · 2020 · External reference
A new indocyanine green fluorescence lymphography protocol for diagnostic assessment of lower limb lymphoedema
10.1016/j.bjps.2022.08.017 · 2022 · External reference
Lymphatic mapping after previous breast surgery
10.1016/j.breast.2011.10.007 · 2012 · External reference
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks
10.1016/j.immuni.2023.06.020 · 2023 · External reference
Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer
10.1126/sciimmunol.adf4726 · 2025 · External reference
Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy
10.1126/scitranslmed.aay3575 · 2020 · External reference
Tumor-draining lymph nodes are survival niches that support T cell priming against lymphatic transported tumor antigen and effects of immune checkpoint blockade in TNBC
10.1007/s00262-020-02792-5 · 2021 · External reference
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition
10.1097/coc.0000000000000239 · 2016 · External reference
Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma
10.1200/jco.21.02229 · 2022 · External reference
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy
10.1016/j.immuni.2018.12.021 · 2019 · External reference
Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma
10.1056/nejmoa2211437 · 2023 · External reference
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses
10.1126/scitranslmed.abd8636 · 2021 · External reference
Exit Strategies: S1P Signaling and T Cell Migration
10.1016/j.it.2015.10.005 · 2015 · External reference
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
10.1038/nri3298 · 2012 · External reference
Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs
10.1146/annurev-immunol-020711-075011 · 2012 · External reference
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
10.1111/j.1600-6143.2004.00476.x · 2004 · External reference
A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC
10.1038/s43018-022-00450-6 · 2022 · External reference
The tumor-draining lymph node as a reservoir for systemic immune surveillance
10.1016/j.trecan.2023.09.006 · 2024 · External reference
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue
10.1084/jem.20210749 · 2022 · External reference
Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma
10.1056/nejmoa1709030 · 2017 · External reference
Adjuvant nivolumab versus ipilimumab in resected stage IIIB-C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trial
10.1016/s1470-2045(20)30494-0 · 2020 · External reference
Adjuvant Therapy of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Patients With Resected Stage IIIB-D or Stage IV Melanoma (CheckMate 915)
10.1200/jco.22.00533 · 2023 · External reference
Growth and Immune Evasion of Lymph Node Metastasis
10.3389/fonc.2018.00036 · 2018 · External reference
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
10.1016/j.cell.2023.02.021 · 2023 · External reference
Altered lymphatic drainage patterns in re-operative sentinel lymph node biopsy for ipsilateral breast tumor recurrence
10.1186/s13014-019-1367-0 · 2019 · External reference
Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment
10.3389/fimmu.2018.03059 · 2018 · External reference
Role of tertiary lymphoid organs in the regulation of immune responses in the periphery
10.1007/s00018-022-04388-x · 2022 · External reference
The lymphoid system: a review of species differences
10.1293/tox.2016-0075 · 2017 · External reference
Immune Checkpoint Inhibitors for Lung Cancer Treatment: A Review
10.3390/jcm9051362 · 2020 · External reference
Latest evidence on immune checkpoint inhibitors in metastatic colorectal cancer: A 2022 update
10.1016/j.critrevonc.2022.103663 · 2022 · External reference
Graph Theory for Modeling and Analysis of the Human Lymphatic System
10.3390/math8122236 · 2020 · External reference
Network Modeling of Murine Lymphatic System
10.3390/a16030168 · 2023 · External reference
THE LYMPH SYSTEM IN MICE
1964 · External reference
Anatomy and nomenclature of murine lymph nodes: Descriptive study and nomenclatory standardization in BALB/cAnNCrl mice
10.1016/j.jim.2006.01.022 · 2006 · External reference
Lymph node mapping in the mouse
10.1016/j.jim.2007.11.012 · 2008 · External reference
Lymphatic Territories (Lymphosomes) in the Rat: An Anatomical Study for Future Lymphatic Research
10.1097/prs.0000000000003776 · 2017 · External reference
HIV-Associated Intramammary Lymphadenopathy
10.1111/j.1524-4741.2007.00401.x · 2007 · External reference
Quantification of lymph nodes in selective neck dissection
10.1097/00005537-199903000-00005 · 1999 · External reference
Three-dimensional visualization of skin lymphatic drainage patterns of the head and neck
10.1002/hed.21089 · 2009 · External reference
Functional anatomy of the lymphatics draining the skin: a detailed statistical analysis
10.1111/j.1469-7580.2009.01183.x · 2010 · External reference
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection
10.1016/0026-2862(89)90074-5 · 1989 · External reference
Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation
10.1016/s0021-9290(99)00125-6 · 1999 · External reference
Unresolved reference
2009 · External reference
Exercising and Compression Mechanism in the Treatment of Lymphedema
2021 · External reference
Diagnosis and Management of Obesity-Induced Lymphedema
10.1097/prs.0000000000002258 · 2016 · External reference
Exercise-Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart
10.1111/acel.70043 · 2025 · External reference
Regulation of Lymphatic Function in Obesity
10.3389/fphys.2020.00459 · 2020 · External reference
Lymphedema and Obesity
10.1101/cshperspect.a041176 · 2022 · External reference
