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References from Stable reconstruction of the breviscapine biosynthetic pathway enables accumulation of a putative scutellarin-related product and reshapes endogenous metabolism in tobacco. Local targets link to admitted publications; unresolved targets remain external evidence.
Structural and mechanistic themes in glycoconjugate biosynthesis at membrane interfaces
10.1016/j.sbi.2019.03.013 · 2019 · External reference
Hierarchical metabolic engineering for rewiring cellular metabolism
10.1093/femsre/fuaf047 · 2025 · External reference
Metabolic Engineering Strategies for Flavonoid Biosynthesis in Saccharomyces cerevisiae: Current Advances and Future Perspectives
10.1002/bit.70248 · 2026 · External reference
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits
10.1039/d0np00092b · 2021 · External reference
Advances in Engineering Nucleotide Sugar Metabolism for Natural Product Glycosylation in Saccharomyces cerevisiae
10.1021/acssynbio.3c00737 · 2024 · External reference
Monoterpene biosynthesis potential of plant subcellular compartments
10.1111/nph.13629 · 2016 · External reference
Metabolism and pharmacological mechanisms of active ingredients in Erigeron breviscapus
10.2174/1389200221666201217093255 · 2021 · External reference
Secondary Metabolite Plasticity in Eclipta prostrata (L.) L.(Asteraceae) under Environmental and Biological Stressors
10.1021/acsomega.5c08697 · 2025 · External reference
Nucleotide sugars and glycosyltransferases for synthesis of cell wall matrix polysaccharides
10.1016/s0981-9428(00)00167-4 · 2000 · External reference
Engineering Nicotiana benthamiana as a platform for natural product biosynthesis
10.1016/j.pbi.2024.102611 · 2024 · External reference
Cytochrome P450 enzymes in the generation of commercial products
10.1038/nrd792 · 2002 · External reference
Biosynthetic pathway for bioactive tetrahydroxyflavanone 7-O-glucuronides in Scutellaria barbata
10.1016/j.bioorg.2026.110292 · 2026 · External reference
Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana
10.1111/pbi.70232 · 2026 · External reference
High quality genome of Erigeron breviscapus provides a reference for herbal plants in Asteraceae
10.1111/1755-0998.13257 · 2021 · External reference
A simple and general method for transferring genes into plants
10.1126/science.227.4691.1229 · 1985 · External reference
Analysis of the transcriptome of Erigeron breviscapus uncovers putative scutellarin and chlorogenic acids biosynthetic genes and genetic markers
10.1371/journal.pone.0100357 · 2014 · External reference
Advances in UDP-glycosyltransferases from medicinal plants: discovery, catalytic mechanism, engineering and biosynthetic application
10.3390/metabo16060402 · 2026 · External reference
Engineering scutellarin biosynthesis in Artemisia annua
10.1007/s00299-025-03471-4 · 2025 · External reference
The relationships between chemical and genetic differentiation and environmental factors across the distribution of Erigeron breviscapus (Asteraceae)
2013 · External reference
Design of a redox-proficient Escherichia coli for screening terpenoids and modifying cytochrome P450s
10.1038/s41929-023-01049-5 · 2023 · External reference
Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches
10.1038/s41467-018-02883-z · 2018 · External reference
Total synthesis of scutellarin and apigenin 7-O-β-d-glucuronide
10.1016/j.carres.2019.02.005 · 2019 · External reference
Complete biosynthesis of QS-21 in engineered yeast
10.1038/s41586-024-07345-9 · 2024 · External reference
Lime-assisted cultivation of Erigeron breviscapus: enhancing plant biomass production and scutellarin content in cadmium-contaminated soil
10.1007/s11368-024-03912-9 · 2024 · External reference
Biotechnological production of flavonoids: an update on plant metabolic engineering, microbial host selection, and genetically encoded biosensors
10.1002/biot.201900432 · 2020 · External reference
Engineering metabolism in Nicotiana species: a promising future
10.1016/j.tibtech.2020.11.012 · 2021 · External reference
Synergies between synthetic biology and metabolic engineering
10.1038/nbt.1937 · 2011 · External reference
Engineering cellular metabolism
10.1016/j.cell.2016.02.004 · 2016 · External reference
CYP450: A crucial player in active ingredient biosynthesis in medicinal plants
10.1097/st9.0000000000000090 · 2025 · External reference
10.21203/rs.3.rs-7396768/v1
10.21203/rs.3.rs-7396768/v1 · External reference
Yeast metabolic engineering for the production of pharmaceutically important secondary metabolites
10.1007/s00253-020-10587-y · 2020 · External reference
Engineering plant cytochrome P450s for enhanced synthesis of natural products: past achievements and future perspectives
10.1016/j.xplc.2019.100012 · 2020 · External reference
Plant-based engineering for production of high-valued natural products
10.1039/d2np00017b · 2022 · External reference
Synthetic biology approaches for the production of flavonoids
2025 · External reference
Flavonoid production: current trends in plant metabolic engineering and de novo microbial production
10.3390/metabo13010124 · 2023 · External reference
Current understanding of the pathways of flavonoid biosynthesis in model and crop plants
10.1093/jxb/erx177 · 2017 · External reference
Nature's laboratory: plant metabolic engineering methods using phenylpropanoids as a case study
10.1186/s13068-025-02684-9 · 2025 · External reference
Metabolic engineering of Yarrowia lipolytica for scutellarin production
10.1016/j.synbio.2022.05.009 · 2022 · External reference
Breviscapine: A review on its phytochemistry, pharmacokinetics and therapeutic effects
10.1142/s0192415x21500646 · 2021 · External reference
Advances in chemical constituents, clinical applications, pharmacology, pharmacokinetics and toxicology of Erigeron breviscapus
2021 · External reference
Advances in pharmacology, biosynthesis, and metabolic engineering of Scutellaria-specialized metabolites
10.1080/07388551.2022.2149386 · 2024 · External reference
Distinct nitrogen forms shape flavonoid biosynthesis and gene–Metabolite networks in Erigeron breviscapus
10.3390/agronomy15030755 · 2025 · External reference
Engineering the expression of plant secondary metabolites-genistein and scutellarin through an efficient transient production platform in Nicotiana benthamiana L.
10.3389/fpls.2022.994792 · 2022 · External reference
Cloning and bioinformation analysis of flavone synthase II gene of Erigeron breviscapus
2013 · External reference
Systematic Metabolic Engineering and Fermentation Optimization of Yarrowia lipolytica for High-Yield Production of Scutellarin
10.1021/acs.jafc.6c00867 · 2026 · External reference
Metabolic engineering of Yarrowia lipolytica for high-level production of scutellarin
10.1016/j.biortech.2023.129421 · 2023 · External reference
Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato
10.1038/ncomms9635 · 2015 · External reference
Advances in ethnopharmacology, phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions
10.53388/tmr20240514001 · 2025 · External reference
Biotechnological production of flavonoids: an update on plant metabolic engineering, microbial host selection, and genetically encoded biosensors
10.1002/biot.201900432 · ExternalCitation · doi-reference
Metabolic Engineering Strategies for Flavonoid Biosynthesis in Saccharomyces cerevisiae: Current Advances and Future Perspectives
10.1002/bit.70248 · ExternalCitation · doi-reference
Yeast metabolic engineering for the production of pharmaceutically important secondary metabolites
10.1007/s00253-020-10587-y · ExternalCitation · doi-reference
Engineering scutellarin biosynthesis in Artemisia annua
10.1007/s00299-025-03471-4 · ExternalCitation · doi-reference
Lime-assisted cultivation of Erigeron breviscapus: enhancing plant biomass production and scutellarin content in cadmium-contaminated soil
10.1007/s11368-024-03912-9 · ExternalCitation · doi-reference
Biosynthetic pathway for bioactive tetrahydroxyflavanone 7-O-glucuronides in Scutellaria barbata
10.1016/j.bioorg.2026.110292 · ExternalCitation · doi-reference
Metabolic engineering of Yarrowia lipolytica for high-level production of scutellarin
10.1016/j.biortech.2023.129421 · ExternalCitation · doi-reference
Total synthesis of scutellarin and apigenin 7-O-β-d-glucuronide
10.1016/j.carres.2019.02.005 · ExternalCitation · doi-reference
Engineering cellular metabolism
10.1016/j.cell.2016.02.004 · ExternalCitation · doi-reference
Engineering Nicotiana benthamiana as a platform for natural product biosynthesis
10.1016/j.pbi.2024.102611 · ExternalCitation · doi-reference
Structural and mechanistic themes in glycoconjugate biosynthesis at membrane interfaces
10.1016/j.sbi.2019.03.013 · ExternalCitation · doi-reference
Metabolic engineering of Yarrowia lipolytica for scutellarin production
10.1016/j.synbio.2022.05.009 · ExternalCitation · doi-reference
Engineering metabolism in Nicotiana species: a promising future
10.1016/j.tibtech.2020.11.012 · ExternalCitation · doi-reference
Engineering plant cytochrome P450s for enhanced synthesis of natural products: past achievements and future perspectives
10.1016/j.xplc.2019.100012 · ExternalCitation · doi-reference
Nucleotide sugars and glycosyltransferases for synthesis of cell wall matrix polysaccharides
10.1016/s0981-9428(00)00167-4 · ExternalCitation · doi-reference
Systematic Metabolic Engineering and Fermentation Optimization of Yarrowia lipolytica for High-Yield Production of Scutellarin
10.1021/acs.jafc.6c00867 · ExternalCitation · doi-reference
Secondary Metabolite Plasticity in Eclipta prostrata (L.) L.(Asteraceae) under Environmental and Biological Stressors
10.1021/acsomega.5c08697 · ExternalCitation · doi-reference
Advances in Engineering Nucleotide Sugar Metabolism for Natural Product Glycosylation in Saccharomyces cerevisiae
10.1021/acssynbio.3c00737 · ExternalCitation · doi-reference
Synergies between synthetic biology and metabolic engineering
10.1038/nbt.1937 · ExternalCitation · doi-reference
Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato
10.1038/ncomms9635 · ExternalCitation · doi-reference
Cytochrome P450 enzymes in the generation of commercial products
10.1038/nrd792 · ExternalCitation · doi-reference
Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches
10.1038/s41467-018-02883-z · ExternalCitation · doi-reference
Complete biosynthesis of QS-21 in engineered yeast
10.1038/s41586-024-07345-9 · ExternalCitation · doi-reference
Design of a redox-proficient Escherichia coli for screening terpenoids and modifying cytochrome P450s
10.1038/s41929-023-01049-5 · ExternalCitation · doi-reference
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits
10.1039/d0np00092b · ExternalCitation · doi-reference
Plant-based engineering for production of high-valued natural products
10.1039/d2np00017b · ExternalCitation · doi-reference
Advances in pharmacology, biosynthesis, and metabolic engineering of Scutellaria-specialized metabolites
10.1080/07388551.2022.2149386 · ExternalCitation · doi-reference
Hierarchical metabolic engineering for rewiring cellular metabolism
10.1093/femsre/fuaf047 · ExternalCitation · doi-reference
Current understanding of the pathways of flavonoid biosynthesis in model and crop plants
10.1093/jxb/erx177 · ExternalCitation · doi-reference
CYP450: A crucial player in active ingredient biosynthesis in medicinal plants
10.1097/st9.0000000000000090 · ExternalCitation · doi-reference
High quality genome of Erigeron breviscapus provides a reference for herbal plants in Asteraceae
10.1111/1755-0998.13257 · ExternalCitation · doi-reference
Monoterpene biosynthesis potential of plant subcellular compartments
10.1111/nph.13629 · ExternalCitation · doi-reference
Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana
10.1111/pbi.70232 · ExternalCitation · doi-reference
A simple and general method for transferring genes into plants
10.1126/science.227.4691.1229 · ExternalCitation · doi-reference
Breviscapine: A review on its phytochemistry, pharmacokinetics and therapeutic effects
10.1142/s0192415x21500646 · ExternalCitation · doi-reference
Nature's laboratory: plant metabolic engineering methods using phenylpropanoids as a case study
10.1186/s13068-025-02684-9 · ExternalCitation · doi-reference
Analysis of the transcriptome of Erigeron breviscapus uncovers putative scutellarin and chlorogenic acids biosynthetic genes and genetic markers
10.1371/journal.pone.0100357 · ExternalCitation · doi-reference
10.21203/rs.3.rs-7396768/v1
10.21203/rs.3.rs-7396768/v1 · ExternalCitation · doi-reference
Metabolism and pharmacological mechanisms of active ingredients in Erigeron breviscapus
10.2174/1389200221666201217093255 · ExternalCitation · doi-reference
Engineering the expression of plant secondary metabolites-genistein and scutellarin through an efficient transient production platform in Nicotiana benthamiana L.
10.3389/fpls.2022.994792 · ExternalCitation · doi-reference
Distinct nitrogen forms shape flavonoid biosynthesis and gene–Metabolite networks in Erigeron breviscapus
10.3390/agronomy15030755 · ExternalCitation · doi-reference
Flavonoid production: current trends in plant metabolic engineering and de novo microbial production
10.3390/metabo13010124 · ExternalCitation · doi-reference
Advances in UDP-glycosyltransferases from medicinal plants: discovery, catalytic mechanism, engineering and biosynthetic application
10.3390/metabo16060402 · ExternalCitation · doi-reference
Advances in ethnopharmacology, phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions
10.53388/tmr20240514001 · ExternalCitation · doi-reference
