Research graph
References from Macrophage HDAC3 drives obesity and adipose tissue metabolic maladaptation through GDF3-mediated inflammation and chromatin remodeling. Local targets link to admitted publications; unresolved targets remain external evidence.
What we talk about when we talk about fat
10.1016/j.cell.2013.12.012 · 2014 · External reference
Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
10.1016/j.cell.2019.05.054 · 2019 · External reference
Economic impacts of overweight and obesity: current and future estimates for eight countries
2021 · External reference
Dietary “Beigeing” fat contains more phosphatidylserine and enhances mitochondrial function while counteracting obesity
10.34133/research.0492 · 2024 · External reference
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
10.1126/science.7678183 · 1993 · External reference
Adipose tissue-resident immune cells in obesity and type 2 diabetes
10.3389/fimmu.2019.01173 · 2019 · External reference
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
10.1038/nm.2002 · 2009 · External reference
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
10.1038/nature14115 · 2015 · External reference
SBP2 deficiency in adipose tissue macrophages drives insulin resistance in obesity
10.1126/sciadv.aav0198 · 2019 · External reference
Obesity is associated with macrophage accumulation in adipose tissue
10.1172/jci200319246 · 2003 · External reference
Metabolic dysfunction-associated steatohepatitis detected by neutrophilic crown-like structures in morbidly obese patients: a multicenter and clinicopathological study
10.34133/research.0382 · 2024 · External reference
Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
10.1172/jci123069 · 2019 · External reference
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation
10.1038/s41590-021-01023-y · 2021 · External reference
Integrative regulation of physiology by histone deacetylase 3
10.1038/s41580-018-0076-0 · 2019 · External reference
Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge
10.1038/nature22819 · 2017 · External reference
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
10.1038/nm.2744 · 2012 · External reference
Glucose regulation of adipose tissue browning by CBP/p300- and HDAC3-mediated reversible acetylation of CREBZF
10.1073/pnas.2318935121 · 2024 · External reference
Macrophage CREBZF orchestrates inflammatory response to potentiate insulin resistance and type 2 diabetes
2024 · External reference
Histone deacetylase 3 couples mitochondria to drive IL-1β-dependent inflammation by configuring fatty acid oxidation
10.1016/j.molcel.2020.08.015 · 2020 · External reference
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
10.1038/s41467-017-00182-7 · 2017 · External reference
Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders
10.1126/scitranslmed.ade8460 · 2023 · External reference
BAF60a deficiency in macrophage promotes diet-induced obesity and metabolic inflammation
2022 · External reference
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
10.1172/jci35847 · 2008 · External reference
Glutamine production by Glul promotes thermogenic adipocyte differentiation through Prdm9-mediated H3K4me3 and transcriptional reprogramming
10.2337/db23-0162 · 2023 · External reference
PDCD4 deficiency in hepatocytes exacerbates nonalcoholic steatohepatitis through enhanced MHC class II transactivator expression
10.1016/j.metabol.2024.156036 · 2024 · External reference
Histone deacetylase 3 couples mitochondria to drive IL-1beta-dependent inflammation by configuring fatty acid oxidation
10.1016/j.molcel.2020.08.015 · 2020 · External reference
Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome
10.1186/s43556-023-00158-8 · 2023 · External reference
Metabolically activated adipose tissue macrophages perform detrimental and beneficial functions during diet-induced obesity
10.1016/j.celrep.2017.08.096 · 2017 · External reference
Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 Inflammasome
10.1016/j.immuni.2016.09.008 · 2016 · External reference
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
10.1016/j.cmet.2014.08.010 · 2014 · External reference
Obesity and related consequences to ageing
10.1007/s11357-016-9884-3 · 2016 · External reference
Role of adipose tissue macrophages in obesity-related disorders
10.1084/jem.20211948 · 2022 · External reference
Adapting to obesity with adipose tissue inflammation
10.1038/nrendo.2017.90 · 2017 · External reference
Adipose tissue fibrosis in obesity: etiology and challenges
10.1146/annurev-physiol-060721-092930 · 2022 · External reference
Insulin regulates lipolysis and fat mass by upregulating growth/differentiation factor 3 in adipose tissue macrophages
10.2337/db17-1201 · 2018 · External reference
Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages
10.1172/jci.insight.143379 · 2021 · External reference
Novel cardiokine GDF3 predicts adverse fibrotic remodeling after myocardial infarction
10.1161/circulationaha.121.056272 · 2023 · External reference
A novel therapeutic approach to treating obesity through modulation of TGFβ signaling
10.1210/en.2012-1016 · 2012 · External reference
Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
2022 · External reference
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages
10.1073/pnas.1121131109 · 2012 · External reference
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
10.1038/nature10728 · 2012 · External reference
Unveiling adipose populations linked to metabolic health in obesity
2024 · External reference
Single-nucleus RNA sequencing reveals heterogeneity among multiple white adipose tissue depots
10.1093/lifemeta/load045 · 2023 · External reference
Causes, consequences, and treatment of metabolically unhealthy fat distribution
10.1016/s2213-8587(20)30110-8 · 2020 · External reference
Is it time to rethink the relationship between adipose inflammation and insulin resistance?
10.1172/jci184663 · 2024 · External reference
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
10.1172/jci200319451 · 2003 · External reference
Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance
10.1007/s00109-016-1385-4 · 2016 · External reference
Macrophage function in adipose tissue homeostasis and metabolic inflammation
10.1038/s41590-023-01479-0 · 2023 · External reference
Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through growth differentiation factor 3
10.1016/j.cmet.2020.08.016 · 2020 · External reference
PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease
10.1016/j.celrep.2025.116811 · 2026 · External reference
Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species
10.3389/fgene.2026.1771707 · 2026 · External reference
Lithospermic acid regulates macrophage polarization via AMPKα1 activation and ameliorates sepsis associated acute kidney injury in mice
10.1016/j.intimp.2025.115822 · 2026 · External reference
Nuclear mTOR signaling orchestrates transcriptional programs underlying cellular growth and metabolism
10.3390/cells13090781 · 2024 · External reference
Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance
10.1007/s00109-016-1385-4 · ExternalCitation · doi-reference
Obesity and related consequences to ageing
10.1007/s11357-016-9884-3 · ExternalCitation · doi-reference
What we talk about when we talk about fat
10.1016/j.cell.2013.12.012 · ExternalCitation · doi-reference
Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
10.1016/j.cell.2019.05.054 · ExternalCitation · doi-reference
Metabolically activated adipose tissue macrophages perform detrimental and beneficial functions during diet-induced obesity
10.1016/j.celrep.2017.08.096 · ExternalCitation · doi-reference
PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease
10.1016/j.celrep.2025.116811 · ExternalCitation · doi-reference
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
10.1016/j.cmet.2014.08.010 · ExternalCitation · doi-reference
Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through growth differentiation factor 3
10.1016/j.cmet.2020.08.016 · ExternalCitation · doi-reference
Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 Inflammasome
10.1016/j.immuni.2016.09.008 · ExternalCitation · doi-reference
Lithospermic acid regulates macrophage polarization via AMPKα1 activation and ameliorates sepsis associated acute kidney injury in mice
10.1016/j.intimp.2025.115822 · ExternalCitation · doi-reference
PDCD4 deficiency in hepatocytes exacerbates nonalcoholic steatohepatitis through enhanced MHC class II transactivator expression
10.1016/j.metabol.2024.156036 · ExternalCitation · doi-reference
Histone deacetylase 3 couples mitochondria to drive IL-1beta-dependent inflammation by configuring fatty acid oxidation
10.1016/j.molcel.2020.08.015 · ExternalCitation · doi-reference
Causes, consequences, and treatment of metabolically unhealthy fat distribution
10.1016/s2213-8587(20)30110-8 · ExternalCitation · doi-reference
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
10.1038/nature10728 · ExternalCitation · doi-reference
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
10.1038/nature14115 · ExternalCitation · doi-reference
Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge
10.1038/nature22819 · ExternalCitation · doi-reference
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
10.1038/nm.2002 · ExternalCitation · doi-reference
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
10.1038/nm.2744 · ExternalCitation · doi-reference
Adapting to obesity with adipose tissue inflammation
10.1038/nrendo.2017.90 · ExternalCitation · doi-reference
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
10.1038/s41467-017-00182-7 · ExternalCitation · doi-reference
Integrative regulation of physiology by histone deacetylase 3
10.1038/s41580-018-0076-0 · ExternalCitation · doi-reference
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation
10.1038/s41590-021-01023-y · ExternalCitation · doi-reference
Macrophage function in adipose tissue homeostasis and metabolic inflammation
10.1038/s41590-023-01479-0 · ExternalCitation · doi-reference
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages
10.1073/pnas.1121131109 · ExternalCitation · doi-reference
Glucose regulation of adipose tissue browning by CBP/p300- and HDAC3-mediated reversible acetylation of CREBZF
10.1073/pnas.2318935121 · ExternalCitation · doi-reference
Role of adipose tissue macrophages in obesity-related disorders
10.1084/jem.20211948 · ExternalCitation · doi-reference
Single-nucleus RNA sequencing reveals heterogeneity among multiple white adipose tissue depots
10.1093/lifemeta/load045 · ExternalCitation · doi-reference
SBP2 deficiency in adipose tissue macrophages drives insulin resistance in obesity
10.1126/sciadv.aav0198 · ExternalCitation · doi-reference
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
10.1126/science.7678183 · ExternalCitation · doi-reference
Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders
10.1126/scitranslmed.ade8460 · ExternalCitation · doi-reference
Adipose tissue fibrosis in obesity: etiology and challenges
10.1146/annurev-physiol-060721-092930 · ExternalCitation · doi-reference
Novel cardiokine GDF3 predicts adverse fibrotic remodeling after myocardial infarction
10.1161/circulationaha.121.056272 · ExternalCitation · doi-reference
Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages
10.1172/jci.insight.143379 · ExternalCitation · doi-reference
Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
10.1172/jci123069 · ExternalCitation · doi-reference
Is it time to rethink the relationship between adipose inflammation and insulin resistance?
10.1172/jci184663 · ExternalCitation · doi-reference
Obesity is associated with macrophage accumulation in adipose tissue
10.1172/jci200319246 · ExternalCitation · doi-reference
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
10.1172/jci200319451 · ExternalCitation · doi-reference
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
10.1172/jci35847 · ExternalCitation · doi-reference
Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome
10.1186/s43556-023-00158-8 · ExternalCitation · doi-reference
A novel therapeutic approach to treating obesity through modulation of TGFβ signaling
10.1210/en.2012-1016 · ExternalCitation · doi-reference
Insulin regulates lipolysis and fat mass by upregulating growth/differentiation factor 3 in adipose tissue macrophages
10.2337/db17-1201 · ExternalCitation · doi-reference
Glutamine production by Glul promotes thermogenic adipocyte differentiation through Prdm9-mediated H3K4me3 and transcriptional reprogramming
10.2337/db23-0162 · ExternalCitation · doi-reference
Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species
10.3389/fgene.2026.1771707 · ExternalCitation · doi-reference
Adipose tissue-resident immune cells in obesity and type 2 diabetes
10.3389/fimmu.2019.01173 · ExternalCitation · doi-reference
Nuclear mTOR signaling orchestrates transcriptional programs underlying cellular growth and metabolism
10.3390/cells13090781 · ExternalCitation · doi-reference
Metabolic dysfunction-associated steatohepatitis detected by neutrophilic crown-like structures in morbidly obese patients: a multicenter and clinicopathological study
10.34133/research.0382 · ExternalCitation · doi-reference
Dietary “Beigeing” fat contains more phosphatidylserine and enhances mitochondrial function while counteracting obesity
10.34133/research.0492 · ExternalCitation · doi-reference
