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References from Mailuoning oral liquid alleviates permanent ischemic stroke by targeting CCR5 to modulate microglial polarization and PI3K/AKT/mTOR axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Neuroinflammation and peripheral immunity: focus on ischemic stroke
10.1016/j.intimp.2023.110332 · 2023 · External reference
10.1161/strokeaha.118.022606
10.1161/strokeaha.118.022606 · 2019 · External reference
Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke
10.4103/1673-5374.392889 · 2025 · External reference
Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo
10.1016/j.jep.2021.113943 · 2021 · External reference
Microglial responses after ischemic stroke and intracerebral hemorrhage
10.1155/2013/746068 · 2013 · External reference
Shaping neuronal fate: functional heterogeneity of direct microglia-neuron interactions
10.1016/j.neuron.2020.11.007 · 2021 · External reference
Microglia: immune and non-immune functions
10.1016/j.immuni.2021.09.014 · 2021 · External reference
CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury
10.1016/j.cell.2019.01.044 · 2019 · External reference
CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia
10.1016/j.intimp.2020.106577 · 2020 · External reference
Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury
10.1016/j.expneurol.2021.113604 · 2021 · External reference
Low-dose maraviroc, an antiretroviral drug, attenuates the infiltration of T cells into the central nervous system and protects the nigrostriatum in hemiparkinsonian monkeys
10.4049/jimmunol.1800587 · 2019 · External reference
CCR5-Δ32 polymorphism: a possible protective factor for post-stroke depressive symptoms
10.1503/jpn.200197 · 2021 · External reference
Network pharmacology analysis and experimental validation of tectoridin in the treatment of ischemic stroke by inhibiting apoptosis and regulating inflammation
10.3390/ijms26041402 · 2025 · External reference
Piperine ameliorates ischemic stroke-induced brain injury in rats by regulating the PI3K/AKT/mTOR pathway
10.1016/j.jep.2022.115309 · 2022 · External reference
Erjingpill bionic cerebrospinal fluid alleviates LPS-induced inflammatory response in BV2 cells by inhibiting glycolysis via mTOR
10.1016/j.jep.2024.118412 · 2024 · External reference
6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation
10.1186/s12974-016-0543-5 · 2016 · External reference
Mailuoning oral liquid ameliorates vasculitis in thromboangiitis obliterans rats via inactivating cGAS-STING-IRF3 and TLR4-MAPKs/NF-κB signaling pathways
2024 · External reference
Mailuoning oral liquid attenuates convalescent cerebral ischemia by inhibiting AMPK/mTOR-associated apoptosis and promoting CREB/BDNF-mediated neuroprotection
10.1016/j.jep.2023.116731 · 2023 · External reference
A comprehensive quality evaluation strategy of Mailuoning oral liquid based on fingerprint, qualitative and quantitative analyses
10.1016/j.jpba.2023.115497 · 2023 · External reference
Targeted characterization and guided isolation of chemical components in Scrophulariae Radix based on LC-MS
10.1016/j.jpba.2023.115569 · 2023 · External reference
Quality control of Lonicerae Japonicae Flos and Lonicerae Flos of the assistant drugs in Mailuning oral liquid
2025 · External reference
Albiflorin alleviates neuroinflammation of rats after MCAO via PGK1/Nrf2/HO-1 signaling pathway
10.1016/j.intimp.2024.112439 · 2024 · External reference
Neuroinflammation in acute ischemic and hemorrhagic stroke
10.1007/s11910-023-01282-2 · 2023 · External reference
Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms
10.1002/ptr.8033 · 2024 · External reference
Mailuoning for acute ischaemic stroke
2015 · External reference
Protective effect of mailuoning injection on cerebral ischemia/reperfusion injury in rats and its mechanism
2014 · External reference
Exploring efficacy of Chinese medicine injection for promoting blood circulation and removing blood stasis in treatment of acute cerebral infarction based on two complex network analysis methods
2021 · External reference
The pharmacological actions of Mai Luoning oral liquid against cerebral ischemia, pharmaceutical and clinical
2004 · External reference
Effect of Mailuoning injection on 8-iso-prostaglandin F2 alpha and superoxide dismutase in rabbits with extremity ischemia-reperfusion injury
10.1016/j.jss.2014.06.008 · 2014 · External reference
The protective effects of Mai-Luo-Ning injection against LPS-induced acute lung injury via the TLR4/NF-κB signalling pathway
10.1016/j.phymed.2022.154290 · 2022 · External reference
Effect of Mailuoning injectable powder on experimental vascular occlusion angeitides in rats
2008 · External reference
The role of thrombin in brain injury after hemorrhagic and ischemic stroke
10.1007/s12975-020-00855-4 · 2021 · External reference
Benzydamine attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting cathepsins
10.1016/j.intimp.2024.113824 · 2025 · External reference
Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
10.1111/j.1750-3639.2000.tb00247.x · 2000 · External reference
Depletion of iNOS-positive inflammatory cells decelerates neuronal degeneration and alleviates cerebral ischemic damage by suppressing the inflammatory response
10.1016/j.freeradbiomed.2022.02.008 · 2022 · External reference
Monocyte-related cytokines/chemokines in cerebral ischemic stroke
10.1111/cns.14368 · 2023 · External reference
MKEY, a peptide inhibitor of CXCL4-CCL5 heterodimer formation, protects against stroke in mice
10.1161/jaha.116.003615 · 2016 · External reference
Monocyte transmodulation: the next novel therapeutic approach in overcoming ischemic stroke?
2020 · External reference
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
10.1016/j.neuron.2023.04.006 · 2023 · External reference
Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+T lymphocytes
10.1016/j.neuron.2022.12.009 · 2023 · External reference
CCR5 activation promotes NLRP1-dependent neuronal pyroptosis via CCR5/PKA/CREB pathway after intracerebral hemorrhage
10.1161/strokeaha.120.033285 · 2021 · External reference
Gnetupendin a protects against ischemic stroke through activating the PI3K/AKT/mTOR-dependent autophagy pathway
10.1016/j.phymed.2024.156233 · 2024 · External reference
Promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT/mTOR pathway
10.1016/j.phymed.2024.155817 · 2024 · External reference
International union of pharmacology committee on receptor nomenclature and drug classification. XXXVIII. Update on terms and symbols in quantitative pharmacology
10.1124/pr.55.4.4 · 2003 · External reference
Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks
10.1371/journal.pcbi.1000197 · 2008 · External reference
The implications of target saturation for the use of drug-target residence time
2018 · External reference
Phytochemicals as regulators of microglia/macrophages activation in cerebral ischemia
10.1016/j.phrs.2021.105419 · 2021 · External reference
Healing the heart naturally: the role of bioactive phytocompounds in cardiovascular therapeutics
10.1016/j.phymed.2026.158084 · 2026 · External reference
Quercetin targets the Ccl4-Ccr5 axis to relieve neuropathic pain after spinal cord injury
10.1063/5.0253463 · 2025 · External reference
Mechanism of quercetin alleviating postherpetic neuralgia in rats by inhibiting MIP-1α/CCR1/CCR5 signaling pathway
2024 · External reference
Non-psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors-, endocannabinoids-, and NF-κB-mediated signaling
10.1002/ptr.7458 · 2022 · External reference
MYCN-mediated pyroptosis and inflammation in the molecular mechanism of MicroRNA-202-3P promote functional recovery in spinal cord injury
10.1016/j.intimp.2025.115349 · 2025 · External reference
RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells
10.1186/s12974-018-1195-4 · 2018 · External reference
CCL5/RANTES signaling in inflammation dysregulation after mild traumatic brain injury
10.1186/s12929-025-01203-0 · 2026 · External reference
Novel association between E3 ubiquitin ligase MARCH8 and glucose transporter Glut1 in intracerebral hemorrhage
10.1016/j.intimp.2025.114798 · 2025 · External reference
Intranasal administration of geniposide-baicalin treats ischemic stroke reperfusion conjugated with pneumonia by inhibiting HMGB1-mediated pyroptosis via NLRP3/Caspase-1/GSDMD pathway
10.1016/j.intimp.2026.116642 · 2026 · External reference