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miRNA-29a inhibits atherosclerotic plaque formation by mediating macrophage autophagy via PI3K/AKT/mTOR pathway

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Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage-specific Fas-induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics

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Distinct types of regulated cell death in atherosclerosis

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Formyl peptide receptor 1 and its antagonist T0080 in atherosclerosis

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HCC-1 accelerates atherosclerosis by inducing endothelial cell and macrophage Pyroptosis and serves as an early diagnostic biomarker

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NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice

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Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency

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RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis

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Macrophage death in atherosclerosis: potential role in calcification

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Neutralization of IL-33 ameliorates septic myocardial injury through anti-inflammatory, anti-oxidative, and anti-apoptotic by regulating the NF-κB/STAT3/SOCS3 signaling pathway

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CD147 Sparks atherosclerosis by driving M1 phenotype and impairing Efferocytosis

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Multiplex imaging for cell phenotyping of early human atherosclerosis

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Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis

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Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis

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Cyclophilin D induces necrotic core formation by mediating mitochondria-associated macrophage death in advanced atherosclerotic lesions

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Protective functions of liver X receptor α in established vulnerable plaques: involvement of regulating endoplasmic reticulum-mediated macrophage apoptosis and Efferocytosis

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Iron, lipid peroxidation, and ferroptosis play pathogenic roles in atherosclerosis

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Sphingosine 1-phosphate receptor 1signaling in macrophages reduces atherosclerosis in LDL receptor-deficient mice

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PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis

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PM(2.5) aggravates the lipid accumulation, mitochondrial damage and apoptosis in macrophage foam cells

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Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis

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Hypoxia-inducible factor-1 as targets for neuroprotection: from ferroptosis to Parkinson’s disease

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Autophagy inhibition and ferroptosis activation during atherosclerosis: hypoxia-inducible factor 1alpha inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages

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Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis

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Nicotine induces macrophage pyroptosis via LINC01272/miR-515/KLF6 axis

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Pyroptosis in cardiovascular diseases: pumping gasdermin on the fire

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Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder

10.1186/s10020-023-00656-z · 2023 · External reference

Editorial: Inflammasomes: cornerstone of immunity

10.3389/fcell.2022.888378 · 2022 · External reference

Macrophage-derived GSDMD plays an essential role in atherosclerosis and cross talk between macrophages via the mitochondria-STING-IRF3/NF-κB Axis

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Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo

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Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the NF-κB pathway and ameliorates atherosclerosis

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GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis

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Guizhitongluo tablet inhibits atherosclerosis and foam cell formation through regulating Piezo1/NLRP3 mediated macrophage pyroptosis

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Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome

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HHcy induces Pyroptosis and atherosclerosis via the lipid raft-mediated NOX-ROS-NLRP3 Inflammasome pathway in apoE(−/−) mice

10.3390/cells11152438 · 2022 · External reference

Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis

10.1007/s13105-021-00811-2 · 2021 · External reference

Caspase-11-Gasdermin D-mediated Pyroptosis is involved in the pathogenesis of atherosclerosis

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Fufang Zhenzhu Tiaozhi (FTZ) suppression of macrophage pyroptosis: key to stabilizing rupture-prone plaques

10.1016/j.jep.2024.117705 · 2024 · External reference

Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis

10.1186/s10020-023-00753-z · 2024 · External reference

Macrophage histone lactylation in atherosclerosis progression: mechanisms, predictive models, and therapeutic potential of Ruan Jian Qing Mai formula

10.1016/j.lfs.2025.123777 · 2025 · External reference

TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling

10.1016/j.expneurol.2023.114599 · 2024 · External reference

Knockdown of TRIM8 protects HK-2 cells against hypoxia/reoxygenation-induced injury by inhibiting oxidative stress-mediated apoptosis and pyroptosis via PI3K/Akt signal pathway

10.2147/dddt.s333372 · 2021 · External reference

TRIM64 promotes ox-LDL-induced foam cell formation, pyroptosis, and inflammation in THP-1-derived macrophages by activating a feedback loop with NF-κB via IκBα ubiquitination

10.1007/s10565-022-09768-4 · 2023 · External reference

IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome

10.1016/j.intimp.2020.106800 · 2020 · External reference

LncRNA H19 mitigates oxidized low-density lipoprotein induced Pyroptosis via Caspase-1 in raw 264.7 cells

10.1007/s10753-021-01511-1 · 2021 · External reference

Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis

2023 · External reference

Roles of pyroptosis in atherosclerosis pathogenesis

10.1016/j.biopha.2023.115369 · 2023 · External reference

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

10.1038/s41467-020-20141-z · 2020 · External reference

E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1

10.1172/jci186509 · 2025 · External reference

Retinoic acid receptor alpha (RARα) in macrophages protects from diet-induced atherosclerosis in mice

10.3390/cells11203186 · 2022 · External reference

FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE(−/−) mice atherosclerosis

10.1038/s41374-021-00679-2 · 2022 · External reference

PFKFB3 gene deletion in endothelial cells inhibits intraplaque angiogenesis and lesion formation in a murine model of venous bypass grafting

10.1007/s10456-021-09816-3 · 2022 · External reference

Lactate supports a metabolic-epigenetic link in macrophage polarization

10.1126/sciadv.abi8602 · 2021 · External reference

Pyruvate carboxylase in macrophages aggravates atherosclerosis by regulating metabolism reprogramming to promote inflammatory responses through the hypoxia-inducible factor-1 signaling pathway

2025 · External reference

miR-369-3p ameliorates diabetes-associated atherosclerosis by regulating macrophage succinate-GPR91 signalling

10.1093/cvr/cvae102 · 2024 · External reference

Imaging Immunometabolism in atherosclerosis

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Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis

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Targeted autophagy disruption reveals the central role of macrophage iron metabolism in systemic iron homeostasis

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Macrophage P2Y12 regulates iron transport and its inhibition protects against atherosclerosis

10.1016/j.jare.2024.12.019 · 2024 · External reference

Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis

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The G2A receptor controls polarization of macrophage by determining their localization within the inflamed tissue

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Macrophage junctional adhesion molecule-like (JAML) protein promotes NLRP3 inflammasome activation in the development of atherosclerosis

10.1038/s41418-025-01489-5 · 2025 · External reference

Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms

10.1093/eurheartj/ehab660 · 2021 · External reference

Human macrophage long intergenic noncoding RNA, SIMALR, suppresses inflammatory macrophage apoptosis via NTN1 (Netrin-1)

2022 · External reference

M1/M2 macrophage-targeted nanotechnology and PROTAC for the treatment of atherosclerosis

10.1016/j.lfs.2024.122811 · 2024 · External reference

Decellularized amnion membrane triggers macrophage polarization for desired host immune response

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Immunomodulatory scaffolds derived from lymph Node extracellular matrices

10.1021/acsami.1c02542 · 2021 · External reference

Histone deacetylase 3: a potential therapeutic target for atherosclerosis

10.14336/ad.2021.1116 · 2022 · External reference

A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis

10.1016/j.immuni.2025.01.003 · 2025 · External reference

Macrophage KDM2A promotes atherosclerosis via regulating FYN and inducing inflammatory response

10.7150/ijbs.102675 · 2025 · External reference

MiR-195-3p alleviates homocysteine-mediated atherosclerosis by targeting IL-31 through its epigenetics modifications

10.1111/acel.13485 · 2021 · External reference

Exploration of N6-Methyladenosine profiles of mRNAs and the function of METTL3 in atherosclerosis

10.3390/cells11192980 · 2022 · External reference

Innate immune memory in monocytes and macrophages: the potential therapeutic strategies for atherosclerosis

10.3390/cells11244072 · 2022 · External reference

Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis

10.1016/j.apsb.2021.12.014 · 2022 · External reference

Targeted intervention of natural medicinal active ingredients and traditional Chinese medicine on epigenetic modification: possible strategies for prevention and treatment of atherosclerosis

10.1016/j.phymed.2023.155139 · 2024 · External reference

Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases

2024 · External reference

Engineered M2 macrophage-derived extracellular vesicles with platelet membrane fusion for targeted therapy of atherosclerosis

2024 · External reference

Gene-engineered cerium-exosomes mediate atherosclerosis therapy through remodeling of the inflammatory microenvironment and DNA damage repair

10.1002/smll.202404463 · 2024 · External reference

Developing therapeutically enhanced extracellular vesicles for atherosclerosis therapy

10.1002/adhm.202404398 · 2025 · External reference

Clinical cases of biventricular arrhythmogenic cardiomyopathy with a variant in the DES gene

10.1097/re9.0000000000000006 · 2025 · External reference

Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury

10.1016/j.biopha.2024.116224 · 2024 · External reference

NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development

10.1186/s12964-025-02296-8 · 2025 · External reference

Exosomes in atherosclerosis: convergence on macrophages

10.7150/ijbs.71862 · 2022 · External reference

Stem cell-derived exosome delivery systems for treating atherosclerosis: the new frontier of stem cell therapy

2025 · External reference

Recent advances in anti-atherosclerosis and potential therapeutic targets for nanomaterial-derived drug formulations

2023 · External reference

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect

10.1186/s12951-022-01720-2 · 2022 · External reference

The novel GSDMD inhibitor GI-Y2 exerts antipyroptotic effects to reduce atherosclerosis

10.1002/ctm2.70263 · 2025 · External reference

Metal-organic framework-based nanoplatforms for synergistic anti-atherosclerosis therapy by regulating the PI3K/AKT/MSR1 pathway in macrophages

10.1039/d4nr04058a · 2025 · External reference

Development of a CD163-targeted PET radiotracer that images resident macrophages in atherosclerosis

10.2967/jnumed.123.266910 · 2024 · External reference

Tailoring zinc ferrite nanoparticle surface coating for macrophage-affinity magnetic resonance imaging of atherosclerosis

10.1021/acsami.3c17212 · 2024 · External reference

Targeting macrophages with multifunctional nanoparticles to detect and prevent atherosclerotic cardiovascular disease

10.1093/cvr/cvae099 · 2024 · External reference

Surface-modified nanotherapeutics targeting atherosclerosis

10.1039/d2bm00660j · 2022 · External reference

Epsin Nanotherapy regulates cholesterol transport to fortify atheroma regression

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Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype

10.1016/j.ecoenv.2021.113112 · 2022 · External reference

Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis

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