Research graph
References from Chronic sleep deprivation promotes atherosclerosis via NFIL3/RORγt Axis mediated Th17/Treg imbalance, targeting IL-17A attenuates disease progression. Local targets link to admitted publications; unresolved targets remain external evidence.
Lifestyle factors and high-risk atherosclerosis: pathways and mechanisms beyond traditional risk factors
10.1177/2047487319869400 · 2020 · External reference
Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK biobank
10.1093/eurheartj/ehab170 · 2021 · External reference
Association of Sleep Duration and Quality with Subclinical Atherosclerosis
10.1016/j.jacc.2018.10.060 · 2019 · External reference
Healthy sleep score changes and incident cardiovascular disease in European prospective community-based cohorts
10.1093/eurheartj/ehad657 · 2023 · External reference
Sleep irregularity and subclinical markers of cardiovascular disease: the multi-ethnic study of atherosclerosis
10.1161/jaha.122.027361 · 2023 · External reference
Broken sleep predicts hardened blood vessels
10.1371/journal.pbio.3000726 · 2020 · External reference
Role of sleep deprivation in immune-related disease risk and outcomes
10.1038/s42003-021-02825-4 · 2021 · External reference
Impact of sleep deprivation on monocyte subclasses and function
10.1093/jimmun/vkae016 · 2025 · External reference
Sleep deprivation promotes endothelial inflammation and Atherogenesis by reducing Exosomal miR-182-5p
10.1161/atvbaha.123.319026 · 2023 · External reference
Sleep modulates haematopoiesis and protects against atherosclerosis
10.1038/s41586-019-0948-2 · 2019 · External reference
Sleep deprivation and NLRP3 inflammasome: is there a causal relationship?
10.3389/fnins.2022.1018628 · 2022 · External reference
The changing landscape of atherosclerosis
10.1038/s41586-021-03392-8 · 2021 · External reference
Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond
10.1093/eurheartj/ehad304 · 2023 · External reference
The treg/th17 imbalance in patients with obstructive sleep apnoea syndrome
10.1155/2012/815308 · 2012 · External reference
Treg/Th17 balance in stable CAD patients with different stages of coronary atherosclerosis
10.1016/j.atherosclerosis.2014.10.088 · 2015 · External reference
HFD aggravated the arthritis and atherosclerosis by altering the intestinal status and gut microbiota
10.1186/s10020-024-01014-3 · 2024 · External reference
Research progress on Th17 and T regulatory cells and their cytokines in regulating atherosclerosis
2022 · External reference
10.1155/2020/8821029
10.1155/2020/8821029 · External reference
Anti-atherosclerosis effect of Angong Niuhuang pill via regulating Th17/Treg immune balance and inhibiting chronic inflammatory on ApoE(−/−) mice model of early and mid-term atherosclerosis
2019 · External reference
Interleukin-17-producing CD4(+) T cells promote inflammatory response and Foster disease progression in Hyperlipidemic patients and atherosclerotic mice
2021 · External reference
T cell subsets and functions in atherosclerosis
10.1038/s41569-020-0352-5 · 2020 · External reference
Adoptive transfer of CX3CR1 transduced-T regulatory cells improves homing to the atherosclerotic plaques and dampens atherosclerosis progression
10.1093/cvr/cvaa264 · 2021 · External reference
Sleep loss potentiates Th17-cell pathogenicity and promotes autoimmune uveitis
10.1002/ctm2.1250 · 2023 · External reference
Circadian immunity from bench to bedside: a practical guide
10.1172/jci175706 · 2024 · External reference
REV-ERBα regulates T(H)17 cell development and autoimmunity
10.1016/j.celrep.2018.11.101 · 2018 · External reference
TH17 cell differentiation is regulated by the circadian clock
10.1126/science.1243884 · 2013 · External reference
Recommendation on design, execution, and reporting of animal atherosclerosis studies: a scientific statement from the American Heart Association
10.1161/res.0000000000000169 · 2017 · External reference
Time-restricted feeding reduces atherosclerosis in LDLR KO mice but not in ApoE knockout mice
10.1161/atvbaha.124.320998 · 2024 · External reference
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice
10.1126/scitranslmed.ade6285 · 2023 · External reference
Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes
10.1038/s41467-024-45426-5 · 2024 · External reference
A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice
10.4049/jimmunol.1000116 · 2010 · External reference
Sangerbox 2: enhanced functionalities and update for a comprehensive clinical bioinformatics data analysis platform
10.1002/imt2.238 · 2024 · External reference
Rhythms of life: circadian disruption and brain disorders across the lifespan
10.1038/s41583-018-0088-y · 2019 · External reference
Emerging role of E4BP4/NFIL3 in metabolic homeostasis
10.1016/j.metabol.2025.156390 · 2025 · External reference
Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications
10.3389/fimmu.2025.1697854 · 2025 · External reference
Prolonged periods of shallow sleep are associated with diabetic carotid atherosclerosis
10.1186/s40001-025-02923-7 · 2025 · External reference
Sleep health: reciprocal regulation of sleep and innate immunity
10.1038/npp.2016.148 · 2017 · External reference
NFIL3/E4BP4 is a key transcription factor for CD8α+ dendritic cell development
10.1182/blood-2010-07-295873 · 2011 · External reference
Neuroinflammation, sleep, and circadian rhythms
10.3389/fcimb.2022.853096 · 2022 · External reference
Sleep-wake behavior and responses to sleep deprivation and immune challenge of protein kinase RNA-activated knockout mice
10.1016/j.bbi.2024.07.027 · 2024 · External reference
Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice
10.1016/j.bbi.2020.01.001 · 2020 · External reference
Chronic sleep deprivation promotes experimental autoimmune uveitis through STAT1 phosphorylation, ISG15 expression and enhanced pathogenicity of macrophages
10.1016/j.intimp.2025.114556 · 2025 · External reference
The sleep-immune crosstalk in health and disease
10.1152/physrev.00010.2018 · 2019 · External reference
Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis
10.1038/s41584-023-00997-3 · 2023 · External reference
The immune system in atherosclerosis
10.1038/ni.2001 · 2011 · External reference
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
10.1038/s41577-021-00584-1 · 2022 · External reference
Inflammation, immunity, and infection in Atherothrombosis: JACC review topic of the week
10.1016/j.jacc.2018.08.1043 · 2018 · External reference
The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage
10.1038/s41590-019-0445-7 · 2019 · External reference
Differential regulation of lineage-determining transcription factor expression in innate lymphoid cell and adaptive T helper cell subsets
2022 · External reference
NFIL3/Tim3 axis regulates effector Th1 inflammation in COPD mice
10.3389/fimmu.2024.1482213 · 2024 · External reference
Secukinumab, an interleukin-17A inhibitor, in ankylosing spondylitis
10.1056/nejmoa1505066 · 2015 · External reference
Efficacy and safety of intravenous Secukinumab in patients with active axial Spondyloarthritis: results from a randomized, placebo-controlled, phase 3 study
10.1002/art.42993 · 2025 · External reference
Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial
10.1016/s0140-6736(17)32814-3 · 2018 · External reference
Inhibition of interleukin-1β and reduction in Atherothrombotic cardiovascular events in the CANTOS trial
10.1016/j.jacc.2020.08.011 · 2020 · External reference
