Research graph
References from Cucurbitacin B attenuates LPS-induced skeletal muscle atrophy by inhibiting JAK2/STAT3 and suppressing proteasome activity. Local targets link to admitted publications; unresolved targets remain external evidence.
Skeletal muscle regulates metabolism via interorgan crosstalk: roles in health and disease
10.1016/j.jamda.2016.04.019 · 2016 · External reference
Integrating mechanisms of exacerbated atrophy and other adverse skeletal muscle impact in COPD
10.3389/fphys.2022.861617 · 2022 · External reference
TLR13 contributes to skeletal muscle atrophy by increasing insulin resistance in chronic kidney disease
10.1111/cpr.13181 · 2022 · External reference
Skeletal muscle disorders as risk factors for type 2 diabetes
10.1016/j.mce.2025.112466 · 2025 · External reference
Pathophysiological mechanisms and emerging therapeutic strategies for muscle wasting: an integrative review
10.3389/fphys.2025.1674892 · 2025 · External reference
Molecular mechanisms of skeletal muscle atrophy: clinical challenges and future therapeutic strategies
10.1016/j.bcp.2026.117913 · 2026 · External reference
Morroniside ameliorates inflammatory skeletal muscle atrophy via inhibiting canonical and non-canonical NF-κB and regulating protein synthesis/degradation
10.3389/fphar.2022.1056460 · 2022 · External reference
Beef peptides mitigate skeletal muscle atrophy in C2C12 myotubes through protein degradation, protein synthesis, and the oxidative stress pathway
10.1039/d3fo03911k · 2024 · External reference
Insulin-like growth factor-1 (IGF-1) promotes myoblast proliferation and skeletal muscle growth of embryonic chickens via the PI3K/Akt signalling pathway
10.1002/cbin.10466 · 2015 · External reference
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
10.1038/ncb1101-1014 · 2001 · External reference
Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle
10.1172/jci146415 · 2021 · External reference
Regulation of dendritic cell function by insulin/IGF-1/PI3K/Akt signaling through klotho expression
10.1080/10799893.2016.1247862 · 2017 · External reference
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
10.1038/s41467-020-20123-1 · 2021 · External reference
Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signaling
10.3389/fendo.2026.1788603 · 2026 · External reference
An integrated drug repositioning analysis identifies rosiglitazone as a treatment for sarcopenia
10.1038/s42003-026-09595-x · 2026 · External reference
Biomarkers of skeletal muscle atrophy based on atrogenes evaluation: a systematic review and meta-analysis study
10.3390/ijms26083516 · 2025 · External reference
Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse
10.1164/rccm.200910-1487oc · 2011 · External reference
Forkhead box O signaling pathway in skeletal muscle atrophy
10.1016/j.ajpath.2022.09.003 · 2022 · External reference
Parthenolide attenuates skeletal muscle atrophy through regulation of protein homeostasis and inhibition of inflammation, FASEB journal : official publication of the Federation of American Societies for
2026 · External reference
CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy
10.1080/15548627.2023.2288528 · 2024 · External reference
Neuregulin-1β alleviates sepsis-induced skeletal muscle atrophy by inhibiting autophagy via AKT/mTOR signaling pathway in rats
10.1097/shk.0000000000001860 · 2022 · External reference
Maduramicin ammonium impairs autophagic flux through activating AMPK-mediated eIF2α-ATF4 endoplasmic reticulum stress pathway in skeletal muscle
10.1002/jsfa.14071 · 2025 · External reference
Corylifol a ameliorates muscle atrophy by inhibiting TAOK1/p38-MAPK/FoxO3 pathway in cancer cachexia
10.1002/jcsm.13288 · 2023 · External reference
Advances in research on cell models for skeletal muscle atrophy
2023 · External reference
Keratocan improves muscle wasting in sarcopenia by promoting skeletal muscle development and fast-twitch fibre synthesis
2025 · External reference
PI3K/AKT/FOXO3a pathway induces muscle atrophy by ubiquitin-proteasome system and autophagy system in COPD rat model
10.1007/s12013-024-01232-w · 2024 · External reference
Inhibition of peritendinous adhesion through targeting JAK2-STAT3 signaling pathway: the therapeutic potential of AG490
2024 · External reference
Triptolide prevents LPS-induced skeletal muscle atrophy via inhibiting NF-κB/TNF-α and regulating protein synthesis/degradation pathway
10.1111/bph.15472 · 2021 · External reference
Cucurbitacin B alleviates DSS-induced experimental colitis by targeting ZNF70 to suppress the NLRP3/STAT3 signaling axis
10.1007/s10787-025-01898-5 · 2025 · External reference
Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction
2024 · External reference
Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation
10.1002/jcsm.13381 · 2024 · External reference
Bu-Yang decoction attenuates OVX-induced sarcopenia by upregulating CXCR4 to suppress GPX4-mediated ferroptosis
10.1016/j.jep.2025.120166 · 2025 · External reference
Emodin attenuates estrogen-deficient sarcopenia by suppressing CYP1B1 to restore CD36-driven fatty acid handling in muscle stem cells
10.1016/j.intimp.2025.116028 · 2026 · External reference
Salidroside mitigates sepsis-induced myocarditis in rats by regulating IGF-1/PI3K/Akt/GSK-3β signaling
10.1007/s10753-015-0200-7 · 2015 · External reference
Unresolved reference
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Cordycepin ameliorates lipopolysaccharide-challenged C2C12 myotube shrinkage by regulating sodium channel kinetics and inhibiting the protein degradation pathway
10.1016/j.intimp.2026.117172 · 2026 · External reference
Atrophic C2C12 myotubes activate inflammatory response of macrophages in vitro
10.3390/cells14050317 · 2025 · External reference
Inflammation: roles in skeletal muscle atrophy
2022 · External reference
Cucurbitacin B alleviates DSS-induced ulcerative colitis by improving gut microbiota disorder in C57BL/6 mice
10.1186/s13568-025-01922-5 · 2025 · External reference
Exploring the effect and mechanism of cucurbitacin B on cholestatic liver injury based on network pharmacology and experimental verification
10.1016/j.jep.2023.117584 · 2024 · External reference
Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice
10.1177/03946320251348715 · 2025 · External reference
Ghrelin attenuates skeletal-muscle atrophy by regulating muscle protein degradation and lung inflammation in aged male mice with lipopolysaccharide-induced lung injury
10.1016/j.peptides.2026.171478 · 2026 · External reference
