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References from A novel repurposing opportunity for valsartan: angiotensin II type 1 receptor blockade dampens muscle-to-brain sensitization in fibromyalgia by targeting lncRNA H19/miR-29a-3p, inflammatory mediators, AKT/CREB signaling, neurotrophic factors, and amyloid–Tau pathology. Local targets link to admitted publications; unresolved targets remain external evidence.
Neuroinflammatory and immunological aspects of fibromyalgia
10.3390/brainsci15020206 · 2025 · External reference
Mechanisms of disease: pain in fibromyalgia syndrome
10.1038/ncprheum0091 · 2006 · External reference
A systematic review and meta-analysis of the prevalence of small fibre impairment in patients with fibromyalgia
2022 · External reference
Fibromyalgia and inflammation: unrevealing the connection
10.3390/cells14040271 · 2025 · External reference
Role of inflammation in the pathogenesis and treatment of fibromyalgia
10.1007/s00296-019-04251-6 · 2019 · External reference
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma
10.2147/jpr.s128508 · 2017 · External reference
Microglial signalling mechanisms: cathepsin S and fractalkine
10.1016/j.expneurol.2011.09.012 · 2012 · External reference
Is fibromyalgia associated with a unique cytokine profile? a systematic review and meta-analysis
10.1093/rheumatology/keab146 · 2021 · External reference
Resistance training before hyperalgesia induction promotes analgesic effects through central and peripheral biomarker modulation in an experimental fibromyalgia-like model
10.3390/life15060849 · 2025 · External reference
Elevated tau and β-amyloid in the serum of fibromyalgia patients
10.1017/s1092852920002114 · 2022 · External reference
Lower circulating IGF-1 levels in fibromyalgia: meta-analysis highlighting potential pathogenic role
2025 · External reference
Gender influence on clinical manifestations, depressive symptoms and brain-derived neurotrophic factor (BDNF) serum levels in patients affected by fibromyalgia
10.1007/s10067-022-06133-y · 2022 · External reference
IGF-1R promotes pain-like behavior in rats with myofascial pain syndrome via the PI3K/AKT pathway
10.1038/s41598-025-12552-z · 2025 · External reference
Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines
10.1096/fj.06-7690com · 2007 · External reference
Brain-derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice
10.1096/fj.202402421r · 2025 · External reference
Ameliorative effect of nano-pregabalin in gastrocnemius muscle of gamma irradiated rats with an experimental model of fibromyalgia: Crosstalk of Sirt3, IL-1β and PARP1 pathways
10.1016/j.taap.2024.117037 · 2024 · External reference
LncRNA H19 via miR-29a-3p is involved in lung inflammation and pulmonary fibrosis induced by neodymium oxide
10.1016/j.ecoenv.2022.114173 · 2022 · External reference
LncRNA H19 drives proliferation of cardiac fibroblasts and collagen production via suppression of the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β axis
10.14348/molcells.2021.0066 · 2022 · External reference
Angiotensin-related peptides and their role in pain regulation
2023 · External reference
Fibromyalgia: a review of related polymorphisms and clinical relevance
10.1590/0001-3765202120210618 · 2021 · External reference
Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice
10.1016/j.ejphar.2021.173870 · 2021 · External reference
Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease
10.1097/j.pain.0000000000003159 · 2024 · External reference
Nociceptive and transcriptomic responses in a swine diabetic wound model treated with a topical angiotensin 1 receptor antagonist
10.1097/nnr.0000000000000704 · 2024 · External reference
Comparison of the efficacy of propranolol versus valsartan in the prevention of migraine: a randomized controlled trial
10.1016/j.pmn.2024.07.001 · 2025 · External reference
Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease
10.1172/jci31547 · 2007 · External reference
Valsartan: an angiotensin receptor blocker modulates BDNF expression and provides neuroprotection against cerebral ischemic reperfusion injury
10.1007/s12035-024-04237-x · 2024 · External reference
Long term metabolic effects of sacubitril/valsartan in non-diabetic and diabetic patients with heart failure reduced ejection fraction: a real life study
10.3389/fphys.2022.897109 · 2022 · External reference
AT1 receptor blockers increase insulin-like growth factor-I production by stimulating sensory neurons in spontaneously hypertensive rats
10.1016/j.trsl.2009.06.004 · 2009 · External reference
New insights into repurposing of renin-angiotensin system inhibitors against Alzheimer's disease
10.7324/japs.2024.194605 · 2025 · External reference
Fibromyalgia syndrome pain in men and women: a scoping review
2023 · External reference
Exercise training alleviates symptoms and cognitive decline in a reserpine-induced fibromyalgia model by activating hippocampal PGC-1α/FNDC5/BDNF pathway
10.1016/j.neuroscience.2024.05.012 · 2024 · External reference
Possible interaction of suramin with thalamic P2X receptors and NLRP3 inflammasome activation alleviates reserpine-induced fibromyalgia-like symptoms
10.1007/s11481-025-10207-4 · 2025 · External reference
Unresolved reference
2011 · External reference
Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II–induced cardiac hypertrophy and remodeling
10.1161/01.res.0000100665.67510.f5 · 2003 · External reference
Angiotensin II receptor Neprilysin inhibitor (LCZ696) compared to valsartan attenuates hepatotoxicity in STZ-induced hyperglycemic rats
10.7150/ijms.49373 · 2020 · External reference
Study of the possible effect of sacubitril/valsartan combination versus valsartan on the cognitive function in Alzheimer's disease model in rats
10.1177/03946320231161469 · 2023 · External reference
Coumestrol/hydroxypropyl-β-cyclodextrin association incorporated in hydroxypropyl methylcellulose hydrogel exhibits wound healing effect: in vitro and in vivo study
10.1016/j.ejps.2018.04.019 · 2018 · External reference
Assessment of mechanical allodynia in rats using the electronic von Frey test
10.21769/bioprotoc.1933 · 2016 · External reference
Modafinil ameliorated fibromyalgia syndrome in rats by modulating mast cells and microglia activation through dopamine/substance P/MRGPRX/histamine and PI3K/p-Akt/NF-κB Signaling pathways
10.1007/s11481-025-10194-6 · 2025 · External reference
Motor coordination and balance in rodents
10.1002/0471142301.ns0812s15 · 2001 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method
10.1006/meth.2001.1262 · 2001 · External reference
Unresolved reference
2019 · External reference
Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin
10.1093/toxsci/kfp166 · 2009 · External reference
Spinal AT1R contributes to neuroinflammation and neuropathic pain via NOX2-dependent redox signaling in microglia
10.1016/j.freeradbiomed.2024.12.004 · 2025 · External reference
AT1 receptors as mechanosensors
10.1016/j.coph.2010.11.003 · 2011 · External reference
Effect of subpressor dose of angiotensin II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells in the rat dorsal root ganglia
10.1007/s10571-013-9934-7 · 2013 · External reference
Effect of the AT₁ receptor antagonist losartan on diurnal variation in pain threshold in spontaneously hypertensive rats
10.1358/mf.2010.32.9.1529826 · 2010 · External reference
Effect of ramipril valsartan and candesartan on thermal and visceral pain in mice
10.3923/jpt.2007.533.541 · 2007 · External reference
Telmisartan inhibits hyperalgesia and inflammatory progression in a diabetic neuropathic pain model of Wistar rats
10.17712/nsj.2015.2.20140511 · 2015 · External reference
Losartan attenuates neuroinflammation and neuropathic pain in paclitaxel-induced peripheral neuropathy
10.1111/jcmm.15427 · 2020 · External reference
Long noncoding RNA H19 in the injured dorsal root ganglion contributes to peripheral nerve injury-induced pain hypersensitivity
2020 · External reference
LncRNA H19 modulates neuropathic pain through miR-141/GLI2 axis in chronic constriction injury (CCI) rats
10.1016/j.trim.2021.101526 · 2022 · External reference
An emerging potential therapeutic target for osteoporosis: LncRNA H19/miR-29a-3p axis
10.4081/ejh.2020.3155 · 2020 · External reference
Fascia: a missing link in our understanding of the pathology of fibromyalgia
10.1016/j.jbmt.2009.08.003 · 2010 · External reference
Profile of cerebrospinal microRNAs in fibromyalgia
10.1371/journal.pone.0078762 · 2013 · External reference
Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1β, interleukin-6, and tumor necrosis factor-α in regulating synaptic and neuronal activity in the superficial spinal cord
10.1523/jneurosci.3338-07.2008 · 2008 · External reference
Interleukin-6: an emerging regulator of pathological pain
10.1186/s12974-016-0607-6 · 2016 · External reference
Inhibition of chemokine CX3CL1 in spinal cord mediates the electroacupuncture-induced suppression of inflammatory pain
10.2147/jpr.s205987 · 2019 · External reference
CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting
2023 · External reference
MiR-29a-3p improves acute lung injury by reducing alveolar epithelial cell PANoptosis
10.14336/ad.2021.1023 · 2022 · External reference
The protective effect of angiotensin II type I receptor blocker (valsartan) on behavioral impairment, NLRP3, BDNF, and oxidative stress in the brain tissue of ovariectomized female rats
2024 · External reference
Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis
10.1016/j.ejphar.2017.06.032 · 2017 · External reference
Fractalkine/CX3CR1 signaling during neuropathic pain
10.3389/fncel.2014.00121 · 2014 · External reference
Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain
10.1007/s10571-008-9279-9 · 2008 · External reference
PI3K/Akt pathway is required for spinal central sensitization in neuropathic pain
10.1007/s10571-017-0541-x · 2018 · External reference
Endogenous PI3K/Akt and NMDAR act independently in the regulation of CREB activity in lumbosacral spinal cord in cystitis
10.1016/j.expneurol.2013.10.015 · 2013 · External reference
Expression of PTEN, Akt and CREB genes in trigeminal ganglia of intractable migraine
10.1016/j.slast.2025.100312 · 2025 · External reference
Unresolved reference
2023 · External reference
Differential regulation of intracisternally injected angiotensin II-induced mechanical allodynia and thermal hyperalgesia in rats
10.3390/biomedicines11123279 · 2023 · External reference
Angiotensin II type 1 receptor activation induces dorsal horn capillary constriction and pain hypersensitivity
10.1016/j.jpain.2025.105384 · 2025 · External reference
NF-κB and CREB are required for angiotensin II type 1 receptor upregulation in neurons
10.1371/journal.pone.0078695 · 2013 · External reference
IL-1β and TNFα cooperativity in regulating IL-6 expression in adipocytes depends on CREB binding and H3K14 acetylation
10.3390/cells10113228 · 2021 · External reference
Fractalkine is a key player in skeletal muscle metabolism and pathophysiology
10.1111/febs.70267 · 2025 · External reference
LCZ696 (sacubitril/valsartan) inhibits pulmonary hypertension induced right ventricular remodeling by targeting pyruvate dehydrogenase kinase 4
10.1016/j.biopha.2023.114569 · 2023 · External reference
Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells
10.1186/1471-2202-7-51 · 2006 · External reference
Carbonic anhydrase 12 protects endplate cartilage from degeneration regulated by IGF-1/PI3K/CREB signaling pathway
10.3389/fcell.2020.595969 · 2020 · External reference
Exosome-transported lncRNA H19 regulates insulin-like growth factor-1 via the H19/let-7a/insulin-like growth factor-1 receptor axis in ischemic stroke
10.4103/1673-5374.357901 · 2023 · External reference
Down-regulation of the non-coding RNA H19 and its derived miR-675 is concomitant with up-regulation of insulin-like growth factor receptor type 1 during neural-like differentiation of human bone marrow mesenchymal stem cells
10.1002/cbin.10960 · 2018 · External reference
Muscle-specific expression of IGF-1 blocks angiotensin II–induced skeletal muscle wasting
10.1172/jci22324 · 2005 · External reference
Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin?
10.1186/ar4187 · 2013 · External reference
Insulin-like growth factor-1 (IGF-1) related drugs in pain management
10.3390/ph16050760 · 2023 · External reference
Higher serum S100B and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia
10.1186/1744-8069-10-46 · 2014 · External reference
Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants
10.1016/j.jpsychires.2006.02.007 · 2007 · External reference
Comparison of the serum brain-derived neurotrophic factor (BDNF) between fibromyalgia and nociceptive pain groups; and effect of duloxetine on the BDNF level
10.1186/s12891-022-05369-8 · 2022 · External reference
BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle
10.1073/pnas.1900544116 · 2019 · External reference
Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice
10.1080/15548627.2021.1985257 · 2022 · External reference
Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
10.4196/kjpp.2017.21.4.361 · 2017 · External reference
Reduced TrkB expression results in precocious age-like changes in neuromuscular structure, neurotransmission, and muscle function
10.1152/japplphysiol.00070.2011 · 2011 · External reference
Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice
10.1016/j.pbb.2014.05.006 · 2014 · External reference
Angiotensin II receptor blockers attenuate lipopolysaccharide-induced memory impairment by modulation of NF-κB-mediated BDNF/CREB expression and apoptosis in spontaneously hypertensive rats
10.1007/s12035-017-0450-5 · 2018 · External reference
Novel therapeutic potential of angiotensin receptor 1 blockade in a rat model of diabetes-associated depression parallels altered BDNF signalling
10.1007/s00125-019-4888-z · 2019 · External reference
Efficacy of whole-body vibration training on brain-derived neurotrophic factor, clinical and functional outcomes, and quality of life in women with fibromyalgia syndrome: a randomized controlled trial
10.1155/2021/7593802 · 2021 · External reference
Role of sacubitril/valsartan in modulating diabetes mediated cognitive and neuronal impairment
10.1016/j.intimp.2025.114431 · 2025 · External reference
Candesartan but not ramipril pretreatment improves outcome after stroke and stimulates neurotrophin BNDF/TrkB system in rats
10.1097/hjh.0b013e3282f2dac9 · 2008 · External reference
TNF-α modulates cytokine and cytokine receptors in C2C12 myotubes
10.1016/s0304-3835(01)00717-0 · 2002 · External reference
Deficiency of muscle-generated brain-derived neurotrophic factor causes inflammatory myopathy through reactive oxygen species-mediated necroptosis and pyroptosis
10.1016/j.redox.2024.103418 · 2024 · External reference
Taking down the unindicted co-conspirators of amyloid β-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors
2013 · External reference
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
10.1073/pnas.0710263105 · 2008 · External reference
Systematic analysis of the cerebrospinal fluid proteome of fibromyalgia patients
10.1016/j.jprot.2018.04.014 · 2019 · External reference
CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia
10.2147/jpr.s215348 · 2019 · External reference
p38 MAPK is a major regulator of amyloid beta-induced IL-6 expression in human microglia
10.1007/s12035-022-02909-0 · 2022 · External reference
Aβ1–42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors
10.1016/j.neurobiolaging.2007.01.003 · 2008 · External reference
Alleviation of behavioral deficits, amyloid-β deposition, and mitochondrial structure damage associated with mitophagy upregulation in AD animal models via AAV9-IGF-1 treatment
10.1016/j.brainres.2023.148743 · 2024 · External reference
Central insulin-like growth factor-1 treatment enhances working and reference memory by reducing neuroinflammation and amyloid beta deposition in a rat model of sporadic Alzheimer's disease
10.3390/ph18040527 · 2025 · External reference
Renin-angiotensin-system increases phosphorylated tau and reactive oxygen species in human cortical neuron cell line
2022 · External reference
Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain
10.1111/j.1600-079x.2006.00343.x · 2006 · External reference
Network pharmacology-based study of the therapeutic mechanism of resveratrol for Alzheimer's disease
2021 · External reference
p35/Cdk5 pathway mediates soluble amyloid-β peptide-induced tau phosphorylation in vitro
10.1002/jnr.10299 · 2002 · External reference
Insulin-like growth factor 1 impact on Alzheimer's disease: role in inflammation, stress, and cognition
10.3390/cimb47040233 · 2025 · External reference
Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology
10.1038/srep46359 · 2017 · External reference
Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction
10.1007/s11011-021-00787-4 · 2021 · External reference
Azilsartan prevents central modulation of BDNF and PPARγ in Alzheimer's pathology through amyloidogenic and inflammatory pathways: experimental and computational evidence
2026 · External reference
Older adults taking AT1-receptor blockers exhibit reduced cerebral amyloid retention
10.3233/jad-150487 · 2016 · External reference