Research graph
References from Rapamycin attenuates ferroptotic stress and improves macrophage efferocytosis in experimental atherosclerosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Optimal medical Management of Atherosclerotic Intracranial Stenosis
10.1161/strokeaha.123.043633 · 2024 · External reference
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
10.1038/s41392-022-00955-7 · 2022 · External reference
Intracranial atherosclerotic Stenoses: pathophysiology, epidemiology, risk factors and current therapy options
10.1007/s12325-020-01291-4 · 2020 · External reference
Through the layers: how macrophages drive atherosclerosis across the vessel wall
10.1172/jci157011 · 2022 · External reference
Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets
10.1038/s41569-023-00957-0 · 2024 · External reference
The clearance of dead cells by efferocytosis
10.1038/s41580-020-0232-1 · 2020 · External reference
From inflammation to targeted therapy: leveraging neutrophil, platelet, RBC, and macrophage biology for nanocarrier in atherosclerosis
10.1007/s11883-026-01394-3 · 2026 · External reference
Efferocytosis in atherosclerosis
10.1038/s41569-024-01037-7 · 2024 · External reference
NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK/PI3K/AKT pathway
10.1016/j.redox.2023.102763 · 2023 · External reference
Interplay between efferocytosis and atherosclerosis
10.1016/j.acvd.2023.07.007 · 2023 · External reference
Ferroptosis: a potential target of macrophages in plaque vulnerability
10.1515/biol-2022-0722 · 2023 · External reference
The mechanisms of ferroptosis and its role in atherosclerosis
10.1016/j.biopha.2023.116112 · 2024 · External reference
Interaction between macrophages and ferroptosis
10.1038/s41419-022-04775-z · 2022 · External reference
Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction
10.1172/jci159498 · 2023 · External reference
Myeloid cell PKM2 deletion enhances efferocytosis and reduces atherosclerosis
10.1161/circresaha.121.320704 · 2022 · External reference
Intercellular mitochondrial transfer and mitochondrial transplantation in cardiovascular disease
2026 · External reference
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
10.1038/nchembio.2079 · 2016 · External reference
Focused update on intracranial atherosclerosis: introduction, highlights, and knowledge gaps
10.1161/strokeaha.123.045513 · 2024 · External reference
Comparison of drug-coated balloon with conventional balloon for angioplasty in symptomatic intracranial atherosclerotic stenosis
10.1136/jnis-2022-019685 · 2023 · External reference
First-in-human experience of sirolimus coated balloon for symptomatic intracranial artery stenosis
10.1136/jnis-2023-021177 · 2025 · External reference
A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association
10.1161/01.cir.92.5.1355 · 1995 · External reference
Is uric acid a true antioxidant? Identification of uric acid oxidation products and their biological effects
10.1080/13510002.2025.2498105 · 2025 · External reference
SPTBN2 suppresses ferroptosis in NSCLC cells by facilitating SLC7A11 membrane trafficking and localization
10.1016/j.redox.2024.103039 · 2024 · External reference
Gasdermin D mediates host cell death but not interleukin-1β secretion in mycobacterium tuberculosis-infected macrophages
10.1038/s41420-021-00716-5 · 2021 · External reference
Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis
10.1172/jci145275 · 2021 · External reference
CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis
10.1172/jci94735 · 2017 · External reference
Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE−/− mice
10.1186/s12951-024-02463-y · 2024 · External reference
In vitro assessment of efferocytic capacity of human macrophages using flow cytometry
10.21769/bioprotoc.4903 · 2023 · External reference
The Caspase-1-EGR4 axis regulates macrophage repolarization in acute myeloid leukemia cells
10.1038/s41598-026-41381-x · 2026 · External reference
Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications
10.1016/j.cell.2022.06.003 · 2022 · External reference
Ferroptosis: molecular mechanisms and health implications
10.1038/s41422-020-00441-1 · 2021 · External reference
Mediation of Ferroptosis suppressor protein 1 expression via 4-Hydroxy-2-Nonenal accumulation contributes to acquisition of resistance to apoptosis and Ferroptosis in diffuse large B-cell lymphoma
10.1016/j.labinv.2024.102027 · 2024 · External reference
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants
10.1007/s00204-024-03696-4 · 2024 · External reference
Targeting ferroptosis opens new avenues for the development of novel therapeutics
10.1038/s41392-023-01606-1 · 2023 · External reference
MMP9 drives ferroptosis by regulating GPX4 and iron signaling
10.1016/j.isci.2024.110622 · 2024 · External reference
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
10.1038/s41392-024-01969-z · 2024 · External reference
Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation
10.1038/s41467-024-46971-9 · 2024 · External reference
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
10.1038/s41467-017-02733-4 · 2018 · External reference
LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress
10.1038/s41419-025-07394-6 · 2025 · External reference
MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice
10.1038/s41467-024-53006-w · 2024 · External reference
Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression
10.1016/j.jbc.2024.105637 · 2024 · External reference
Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
10.1016/j.celrep.2022.111941 · 2023 · External reference
Endogenous SOD2 (superoxide dismutase) regulates platelet-dependent thrombin generation and thrombosis during aging
10.1161/atvbaha.121.317735 · 2023 · External reference
HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis
10.1016/j.devcel.2024.12.011 · 2025 · External reference
MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis
10.1172/jci90520 · 2017 · External reference
MFG-E8 promotes tendon-bone healing by regualting macrophage efferocytosis and M2 polarization after anterior cruciate ligament reconstruction
10.1016/j.jot.2022.04.002 · 2022 · External reference
Astragaloside IV alleviates H2O2-induced mitochondrial dysfunction and inhibits mitophagy via PI3K/AKT/mTOR pathway
10.1155/cdr/9549175 · 2025 · External reference
SHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation
2024 · External reference
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con a induced autoimmune liver injury
10.1186/s12964-025-02075-5 · 2025 · External reference
CD147 Sparks atherosclerosis by driving M1 phenotype and impairing Efferocytosis
10.1161/circresaha.123.323223 · 2024 · External reference
cGAS mediates inflammation by polarizing macrophages to M1 phenotype via the mTORC1 pathway
10.4049/jimmunol.2200351 · 2023 · External reference
Kushenol O regulates GALNT7/NF-κB axis-mediated macrophage M2 polarization and Efferocytosis in papillary thyroid carcinoma
10.1016/j.phymed.2025.156373 · 2025 · External reference
The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation
10.1111/imr.13214 · 2023 · External reference
Vascular smooth muscle cell phenotypic switching in atherosclerosis
10.1016/j.heliyon.2024.e37727 · 2024 · External reference
Phenotypic switching of vascular smooth muscle cells in atherosclerosis
10.1161/jaha.123.031121 · 2023 · External reference
Shedding new light on atherosclerosis therapeutics: nanomedicines targeting atherosclerotic immune microenvironment
10.1016/j.engmed.2024.100043 · 2024 · External reference
An atorvastatin/Ferrostatin-1 Codelivered hybrid exosome/liposome system for combinational Ferroptosis inhibition, inflammation suppression, Efferocytosis promotion, and macrophage reprogramming in atherosclerosis treatment
10.1021/acsami.5c07617 · 2025 · External reference
IRF5 siRNA Nanoimmunotherapy: restoring macrophage Efferocytosis in atherosclerosis
10.1161/circulationaha.125.075352 · 2025 · External reference
First we eat, then we do everything else: the dynamic metabolic regulation of efferocytosis
10.1016/j.cmet.2021.08.001 · 2021 · External reference
Macrophage phenotypes in atherosclerosis
10.1111/imr.12218 · 2014 · External reference
Crosstalk between macrophages and vascular smooth muscle cells in atherosclerotic plaque stability
10.1161/atvbaha.121.316233 · 2022 · External reference
CXCL16 promotes macrophage-driven inflammation and vascular smooth muscle cell phenotypic switching during carotid plaque destabilization
10.1016/j.intimp.2026.116848 · 2026 · External reference
Targeting glycoprotein VI (GPVI) in cancer: mechanistic insights and therapeutic strategies to suppress metastasis and thrombosis
10.1186/s12645-026-00375-0 · 2026 · External reference
When GPVI Goes rogue: pathogenesis and therapeutic horizons in ITP
10.1017/erm.2026.10047 · 2026 · External reference
The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics
10.1007/s00395-024-01033-5 · 2024 · External reference
Autophagy inhibition and ferroptosis activation during atherosclerosis: hypoxia-inducible factor 1α inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages
10.1016/j.biopha.2023.114333 · 2023 · External reference
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
10.1016/j.chembiol.2022.10.006 · 2022 · External reference
A compendium of kinetic modulatory profiles identifies ferroptosis regulators
10.1038/s41589-021-00751-4 · 2021 · External reference
mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
2021 · External reference
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis
10.1073/pnas.2017152117 · 2020 · External reference
Cellular degradation systems in ferroptosis
10.1038/s41418-020-00728-1 · 2021 · External reference
The tumor-platelet-immune Interface: driving metastasis, pre-metastatic niche formation and therapeutic vulnerabilities
10.1017/erm.2026.10043 · 2026 · External reference
Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
10.1038/s41392-024-01840-1 · 2024 · External reference
Macrophage profiling in atherosclerosis: understanding the unstable plaque
10.1007/s00395-023-01023-z · 2024 · External reference
Macrophages in atherosclerosis: a dynamic balance
10.1038/nri3520 · 2013 · External reference
Macrophage polarization, metabolic reprogramming, and inflammatory effects in ischemic heart disease
2022 · External reference
DRug-coated balloon for endovascular treatment of sYmptOmatic intracraNial stenotic disease (DR. BEYOND): the protocol of a multicentre randomised trial
10.1136/svn-2024-003259 · 2025 · External reference
Platelet–neutrophil cooperation in premetastatic niche formation: from NETosis and stromal conditioning to nanotherapeutic interception
10.1186/s12645-026-00423-9 · 2026 · External reference
Guided immunotherapy for residual solid tumor: integrating platelets and CAR T cells to reduce post-surgical recurrence
10.1186/s40364-026-00957-5 · 2026 · External reference
Nanodrug-based modulation of platelet–leukocyte interactions in ovarian cancer: a new frontier in targeted therapy
10.1186/s12645-025-00340-3 · 2025 · External reference
