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References from Acacetin alleviates pyroptosis, inflammatory response, and oxidative stress in renal tubular epithelial cells caused by kidney stone via targeting GPR35. Local targets link to admitted publications; unresolved targets remain external evidence.
Kidney stone disease: risk factors, pathophysiology and management
10.1038/s41581-025-00990-x · 2025 · External reference
The role of the microbiome in kidney stone formation
10.1016/j.ijsu.2016.11.024 · 2016 · External reference
Disrupting crystal growth through molecular recognition: designer therapies for kidney stone prevention
10.1021/acs.accounts.1c00631 · 2022 · External reference
Mineralogy, geochemistry, and micromorphology of human kidney stones (urolithiasis) from Mersin, the southern Turkey
10.1007/s10653-023-01525-8 · 2023 · External reference
Randall’s plaque and calcium oxalate stone formation: role for immunity and inflammation
10.1038/s41581-020-00392-1 · 2021 · External reference
Application of metabolomics in urolithiasis: the discovery and usage of succinate
10.1038/s41392-023-01311-z · 2023 · External reference
The role of inflammation and ROS in CaOx kidney stones
10.1186/s40001-025-03469-4 · 2025 · External reference
Cell death-related molecules and targets in the progression of urolithiasis (review)
10.3892/ijmm.2024.5376 · 2024 · External reference
An update on the role of the inflammasomes in the pathogenesis of kidney diseases
10.1007/s00467-015-3153-z · 2016 · External reference
Mechanism and regulation of NLRP3 Inflammasome activation
10.1016/j.tibs.2016.09.002 · 2016 · External reference
Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro
10.1016/j.phymed.2021.153562 · 2021 · External reference
Pyroptosis and redox balance in kidney diseases
10.1089/ars.2020.8243 · 2021 · External reference
Systematic review of the nuclear factor erythroid 2-related factor 2 (NRF2) system in human chronic kidney disease: alterations, interventions and relation to morbidity
10.1093/ndt/gfab031 · 2022 · External reference
Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment
10.1038/s41420-025-02491-z · 2025 · External reference
Klotho inhibits the formation of calcium oxalate stones by regulating the Keap1-Nrf2-ARE signaling pathway
10.1007/s11255-022-03398-9 · 2023 · External reference
Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation
10.1016/j.freeradbiomed.2023.07.013 · 2023 · External reference
Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress
10.1016/j.bbi.2019.02.009 · 2019 · External reference
Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35
10.3389/fimmu.2022.1019365 · 2022 · External reference
Activation of GPR35 by kynurenic acid inhibits IL-1β secretion in macrophages during CR-hvKP-induced pneumonia
10.1016/j.intimp.2025.114416 · 2025 · External reference
Acacetin prevents renal damage induced by Streptozotocin via altering the NF-κB/ASC/NLRP3 and AMPK/SIRT1 pathways in mice
10.1002/bab.2753 · 2025 · External reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings
10.1021/acs.jcim.1c00203 · 2021 · External reference
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay
10.1126/scitranslmed.aau3174 · 2019 · External reference
Calcium-sensing receptor: evidence and hypothesis for its role in nephrolithiasis
10.1007/s00240-018-1096-0 · 2019 · External reference
Functional analysis reveals calcium-sensing receptor gene regulating cell-cell junction in renal tubular epithelial cells
10.1007/s11255-024-03948-3 · 2024 · External reference
Mechanistic studies of ca(2+)-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation
10.1038/s41598-025-91460-8 · 2025 · External reference
CAV1 unveils a novel therapeutic target for nephrolithiasis by modulating CaSR and ER stress
10.1016/j.bbadis.2025.167751 · 2025 · External reference
Determining the true burden of kidney stone disease
10.1038/s41581-020-0320-7 · 2020 · External reference
Kidney stone recurrence among children and adolescents
10.1016/j.juro.2016.07.090 · 2017 · External reference
Kidney stone prevention
10.1016/j.advnut.2023.03.002 · 2023 · External reference
Medical management of kidney stones: AUA guideline
10.1016/j.juro.2014.05.006 · 2014 · External reference
Targeting the NLRP3 inflammasome for calcium oxalate stones: pathophysiology and emerging pharmacological interventions
10.3389/fphys.2025.1614438 · 2025 · External reference
Quercetin inhibits calcium oxalate crystallization and growth but promotes crystal aggregation and invasion
10.1016/j.crfs.2023.100650 · 2024 · External reference
10.1016/j.jep.2014.10.013
10.1016/j.jep.2014.10.013 · External reference
Application potential of Lysimachia christinae Hance polysaccharides in kidney stone prevention/treatment: a multidimensional comparison between ultrasonic-assisted extraction and hot water extraction
10.1016/j.ultsonch.2025.107720 · 2026 · External reference
Lysimachia christinae Hance aqueous extract ameliorates renal injury in kidney stone rats and calcium oxalate crystal-induced oxidative stress in HK-2 cells via inhibiting the PI3K/Akt/mTOR pathway
2026 · External reference
Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis
2014 · External reference
VDR activation attenuates renal tubular epithelial cell ferroptosis by regulating Nrf2/HO-1 signaling pathway in diabetic nephropathy
10.4028/b-wjqrp6 · 2024 · External reference
Network pharmacology-based study on the mechanism of ShenKang injection in diabetic kidney disease through Keap1/Nrf2/ho-1 signaling pathway
10.1016/j.phymed.2023.154915 · 2023 · External reference
Inhibitory effect of Incarvillea diffusa Royle extract in the formation of calcium oxalate nephrolithiasis by regulating ROS-induced Nrf2/HO-1 pathway in rats
10.1016/j.jep.2023.117619 · 2024 · External reference
Gallic acid ameliorates calcium oxalate crystal-induced renal injury via upregulation of Nrf2/HO-1 in the mouse model of stone formation
10.1016/j.phymed.2022.154429 · 2022 · External reference
Acacetin as a natural cardiovascular therapeutic: mechanisms and preclinical evidence
2025 · External reference
Acacetin is a promising drug candidate for cardiovascular diseases
10.1142/s0192415x24500654 · 2024 · External reference
Acacetin attenuates renal damage-induced by ischemia-reperfusion with declining apoptosis and oxidative stress in mice
10.4103/ijpvm.ijpvm_512_18 · 2020 · External reference
Renal protection by acacetin in streptozotocin-induced diabetic nephropathy via TLR4/NF-κB pathway modulation in rats
10.17219/acem/192225 · 2025 · External reference
Acacetin ameliorates pressure overload-induced cardiac remodeling by targeting USP10 and inhibiting maladaptive cardiomyocyte autophagy
10.1016/j.phymed.2025.156588 · 2025 · External reference
Dose translation from animal to human studies revisited
10.1096/fj.07-9574lsf · 2008 · External reference
Gallic acid induces osteoblast differentiation and alleviates inflammatory response through GPR35/GSK3β/β-catenin signaling pathway in human periodontal ligament cells
10.1111/jre.13208 · 2024 · External reference
Ferroptosis, necroptosis, and pyroptosis in calcium oxalate crystal-induced kidney injury
10.1016/j.bbadis.2025.167791 · 2025 · External reference
Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion
10.1172/jci63679 · 2013 · External reference
Engineered macrophage membrane-coated nanoparticles attenuate calcium oxalate nephrocalcinosis-induced kidney injury by reducing oxidative stress and pyroptosis
10.1016/j.actbio.2025.02.021 · 2025 · External reference
Regulating the balance between GSDMD-mediated pyroptosis and CHMP4B-dependent cell repair attenuates calcium oxalate kidney stone formation
10.7150/ijbs.105415 · 2025 · External reference