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References from Gut microbiota - γδT cells axis: mechanisms of immunoregulation and therapeutic opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
Intestinal aging-related immune dysfunction: mechanisms and interventions
2025 · External reference
The role of the gut microbiota in the relationship between diet and human health
10.1146/annurev-physiol-031522-092054 · 2023 · External reference
Influence of microbiota on tumor immunotherapy
10.7150/ijbs.91771 · 2024 · External reference
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
10.1038/s41586-019-1237-9 · 2019 · External reference
Gut microbiota-derived metabolites as key actors in inflammatory bowel disease
10.1038/s41575-019-0258-z · 2020 · External reference
Gut microbiota and renal fibrosis: novel mechanistic insights and therapeutic potential
2026 · External reference
Gut microbial-derived metabolites: key players in kidney disease and renal fibrosis
10.7150/ijbs.133969 · 2026 · External reference
TGF-β controls development of TCRγδ+CD8αα+ intestinal intraepithelial lymphocytes
10.1038/s41421-023-00542-2 · 2023 · External reference
Biological characteristics of γδT cells and application in tumor immunotherapy
2022 · External reference
The intestinal γδ T cells: functions in the gut and in the distant organs
2023 · External reference
Gut microbiota-derived short-chain fatty acids regulate group 3 innate lymphoid cells in HCC
10.1002/hep.32449 · 2023 · External reference
Immunotherapy resistance in MASLD-related hepatocellular carcinoma: special immune microenvironment and gut microbiota
10.7150/ijbs.117394 · 2025 · External reference
Gut microbiota in human metabolic health and disease
10.1038/s41579-020-0433-9 · 2021 · External reference
Gut microbiome and health: mechanistic insights
10.1136/gutjnl-2021-326789 · 2022 · External reference
Comparing mouse and human tissue-resident γδ T cells
10.3389/fimmu.2022.891687 · 2022 · External reference
γδ T cells: origin and fate, subsets, diseases and immunotherapy
10.1038/s41392-023-01653-8 · 2023 · External reference
What we know and what we don’t know about the function of γδ T cells
10.1002/eji.70058 · 2025 · External reference
Calcined lotus leaf-derived carbon dots: enhanced hemostasis, anti-inflammatory, immunomodulatory properties for ulcerative colitis management
2026 · External reference
Surfing on the waves of the human γδ T cell ontogenic sea
10.1111/imr.13184 · 2023 · External reference
Double-edged sword: γδ T cells in mucosal homeostasis and disease
10.1038/s12276-023-00985-3 · 2023 · External reference
Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells
10.1038/s41565-024-01722-1 · 2024 · External reference
Nurturing the phenotype: environmental signals and transcriptional regulation of intestinal γδ T cells
10.1002/eji.202451076 · 2024 · External reference
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice
10.1038/s41590-023-01710-y · 2024 · External reference
CAR-γδ T cells: a new paradigm of programmable innate immune sentinels and their systemic applications in cancer and beyond
10.3389/fimmu.2025.1735763 · 2025 · External reference
From host defense to metabolic signatures: unveiling the role of γδ T cells in bacterial infections
10.3390/biom14020225 · 2024 · External reference
γδT cells, a key subset of T cell for cancer immunotherapy
10.3389/fimmu.2025.1562188 · 2025 · External reference
Analysis of the components of mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) and its regulation of γδ T-cell function
10.1186/s11658-024-00585-7 · 2024 · External reference
Γδ T cells and allergic diseases
10.1007/s12016-023-08966-0 · 2023 · External reference
Gamma delta T cells in cancer therapy: from tumor recognition to novel treatments
2024 · External reference
Modulation of lytic molecules restrain serial killing in γδ T lymphocytes
10.1038/s41467-023-41634-7 · 2023 · External reference
Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells
10.1038/s41586-023-06525-3 · 2023 · External reference
Γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection
10.3390/v16030425 · 2024 · External reference
TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells
10.1038/s41419-024-06994-y · 2024 · External reference
Γδ T cells in skin inflammation
10.1615/critrevimmunol.2022047288 · 2022 · External reference
Mesenchymal stem cell-secreted KGF ameliorates acute lung injury via the Gab1/ERK/NF-κB signaling axis
10.1186/s11658-025-00757-z · 2025 · External reference
Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes
10.1016/j.immuni.2023.01.023 · 2023 · External reference
Neutrophils mediate protection against colitis and carcinogenesis by controlling bacterial invasion and IL-22 production by γδ T cells
10.1158/2326-6066.cir-23-0295 · 2024 · External reference
Akkermansia muciniphila- and pathogenic bacteria-derived endotoxins differently regulate human dendritic cell generation and γδ T lymphocyte activation
10.3390/biom14121571 · 2024 · External reference
IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia
10.3389/fimmu.2023.1156842 · 2023 · External reference
Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent manner
10.1016/j.isci.2023.108453 · 2023 · External reference
Phospholipid metabolites of the gut microbiota promote hypoxia-induced intestinal injury via CD1d-dependent γδ T cells
10.1080/19490976.2022.2096994 · 2022 · External reference
Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation
10.1038/s41598-023-35097-5 · 2023 · External reference
Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota
10.1038/s12276-023-01088-9 · 2023 · External reference
Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance
10.1186/s40168-023-01478-1 · 2023 · External reference
Mapping the T cell repertoire to a complex gut bacterial community
10.1038/s41586-023-06431-8 · 2023 · External reference
Propionate functions as a feeding-state-dependent regulatory metabolite to counter pro-inflammatory signaling linked to nutrient load and obesity
10.1093/jleuko/qiae006 · 2024 · External reference
Interplay between microbiota and γδ T cells: insights into immune homeostasis and neuro-immune interactions
10.3390/ijms25031747 · 2024 · External reference
Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease
10.3389/fendo.2023.1169624 · 2023 · External reference
Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells
10.1016/j.celrep.2021.109332 · 2021 · External reference
Butyrate suppresses mucosal inflammation in inflammatory bowel disease primarily through HDAC3 inhibition in monocytes and macrophages
10.1111/febs.70289 · 2025 · External reference
Microbial short chain fatty acids: effective histone deacetylase inhibitors in immune regulation (review)
2026 · External reference
Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
10.1016/j.imbio.2021.152126 · 2021 · External reference
How bile acids and the microbiota interact to shape host immunity
10.1038/s41577-024-01057-x · 2024 · External reference
Ileitis promotes MASLD progression via bile acid modulation and enhanced TGR5 signaling in ileal CD8+ T cells
2024 · External reference
10.1002/advs.202412071
10.1002/advs.202412071 · External reference
Dietary indoles influence the AHR-RORγt Axis and mucosal immune homeostasis in ART-treated SIV infection
10.1172/jci.insight.201258 · 2026 · External reference
Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease
10.3389/fcell.2023.1228283 · 2023 · External reference
Local γδ T cells: translating promise to practice in cancer immunotherapy
10.1038/s41416-023-02303-0 · 2023 · External reference
Gram-positive bacteria cell wall peptidoglycan polymers activate human dendritic cells to produce IL-23 and IL-1β and promote TH17 cell differentiation
10.3390/microorganisms11010173 · 2023 · External reference
Promoting intestinal antimicrobial defense and microbiome symbiosis contributes to IL-22-mediated protection against alcoholic hepatitis in mice
10.3389/fimmu.2023.1289356 · 2023 · External reference
Interleukin-22 (IL-22) enhanced the mucosal barrier and inhibited the invasion of Salmonella enterica in human induced pluripotent stem cell-derived small intestinal epithelial cells
10.1093/femsle/fnae006 · 2024 · External reference
Regulation of Bacteroides acidifaciens by the aryl hydrocarbon receptor in IL-22-producing immune cells has sex-dependent consequential impact on colitis
10.3389/fimmu.2024.1444045 · 2024 · External reference
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span
10.1126/sciimmunol.adn3954 · 2024 · External reference
IL-17: balancing protective immunity and pathogenesis
10.1155/2023/3360310 · 2023 · External reference
TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice
10.1111/imm.13685 · 2023 · External reference
A binary module for microbiota-mediated regulation of γδ17 cells, hallmarked by microbiota-driven expression of programmed cell death protein 1
10.1016/j.celrep.2023.112951 · 2023 · External reference
γδT cells in IBD: beneficial or detrimental?
10.1111/imm.70012 · 2025 · External reference
Hyperactivation and enhanced cytotoxicity of reduced CD8+ gamma delta T cells in the intestine of patients with Crohn's disease correlates with disease activity
10.1186/s12865-024-00606-2 · 2024 · External reference
Intestinal barrier impairment, preservation, and repair: An update
10.3390/nu16203494 · 2024 · External reference
Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice
10.1016/j.bbi.2024.01.214 · 2024 · External reference
Crosstalk between the microbiota and intestinal γδ T cell compartments in health and IBD
10.1080/19490976.2025.2604908 · 2026 · External reference
Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease
10.1126/science.adh0301 · 2023 · External reference
The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease
10.1038/s41392-023-01697-w · 2023 · External reference
Metformin suppresses gammadelta T17 cell differentiation alleviating DSS-induced colitis
10.1007/s12026-025-09601-0 · 2025 · External reference
Ketogenic diet exacerbates DSS-induced colitis through a β-hydroxybutyrate-Thomasclavelia spiroformis-γδ17 T cell axis in mice
2026 · External reference
Tumor-infiltrating gamma delta T-cells reveal exhausted subsets with remarkable heterogeneity in colorectal cancer
10.1002/ijc.34669 · 2023 · External reference
Systematic analysis of human colorectal cancer scRNA-seq revealed limited pro-tumoral IL-17 production potential in gamma delta T cells
10.1016/j.neo.2024.101072 · 2024 · External reference
Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue
10.1038/s42255-019-0160-6 · 2020 · External reference
Mechanisms of γδ T cell accumulation in visceral adipose tissue with aging
2023 · External reference
γδ T cells regulate the intestinal response to nutrient sensing
10.1126/science.aba8310 · 2021 · External reference
High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production
10.1016/j.celrep.2023.112713 · 2023 · External reference
γδ T cells in diabetes mellitus: dual roles and therapeutic implications
2025 · External reference
Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis
10.1038/s41586-024-08131-3 · 2024 · External reference
Glucose metabolism controls human γδ T-cell-mediated tumor immunosurveillance in diabetes
10.1038/s41423-022-00894-x · 2022 · External reference
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
10.1038/s41590-023-01447-8 · 2023 · External reference
IL-17A-producing γδ T cells: a novel target in stroke immunotherapy
10.1002/eji.202451067 · 2024 · External reference
Pathogenic Th17 cells are a potential therapeutic target for tacrolimus in AChR-myasthenia gravis patients
10.1016/j.jneuroim.2024.578464 · 2024 · External reference
Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis
10.1186/s12985-023-02205-w · 2023 · External reference
Structures of human γδ T cell receptor-CD3 complex
10.1038/s41586-024-07439-4 · 2024 · External reference
10.1038/s41467-023-41938-8
10.1038/s41467-023-41938-8 · External reference
Biological variability of human intraepithelial lymphocytes throughout the human gastrointestinal tract in health and coeliac disease
10.1111/eci.14304 · 2024 · External reference
Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor
10.3389/fimmu.2023.1056267 · 2023 · External reference
Distinct, age-dependent TLR7/8 signaling responses in porcine gamma-delta T cells
10.1016/j.molimm.2023.06.012 · 2023 · External reference
Protein expression of TLR2, TLR4, and TLR9 on monocytes in TB, HIV, and TB/HIV
10.1155/2024/9399524 · 2024 · External reference
Direct costimulatory effect of TLR3 ligand poly(I:C) on human gamma delta T lymphocytes
10.4049/jimmunol.176.3.1348 · 2006 · External reference
PRDM16 regulates γδT17 cell differentiation via controlling type 17 program and lipid-dependent cell fitness
2023 · External reference
Activation of human γδ T cells: modulation by toll-like receptor 8 ligands and role of monocytes
10.3390/cells9030713 · 2020 · External reference
γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors
10.1038/s43018-023-00589-w · 2023 · External reference
Natural γδT17 cell development and functional acquisition is governed by the mTORC2-c-Maf-controlled mitochondrial fission pathway
2023 · External reference
TCR signaling and cellular metabolism regulate the capacity of murine epidermal γδ T cells to rapidly produce IL-13 but not IFN-γ
10.3389/fimmu.2024.1361139 · 2024 · External reference
Metabolic sensing and control in mitochondria
10.1016/j.molcel.2023.02.016 · 2023 · External reference
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions
10.1038/s42255-025-01276-z · 2025 · External reference
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism
10.1038/s41467-021-24755-9 · 2021 · External reference
Microbial metabolites and gut immunology
10.1146/annurev-immunol-090222-102035 · 2024 · External reference
Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood
10.1038/s41467-023-41630-x · 2023 · External reference
Phosphoantigen recognition by Vγ9Vδ2 T cells
10.1002/eji.202451068 · 2024 · External reference
Inulin prebiotic reinforces host cancer immunosurveillance via ɣδ T cell activation
10.3389/fimmu.2023.1104224 · 2023 · External reference
Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice
10.1038/s41467-024-46983-5 · 2024 · External reference
Drivers and determinants of strain dynamics following fecal microbiota transplantation
10.1038/s41591-022-01913-0 · 2022 · External reference
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases
10.1038/s41591-022-01964-3 · 2022 · External reference
Upregulation of intestinal barrier function in mice with DSS-induced colitis by a defined bacterial consortium is associated with expansion of IL-17A producing gamma delta T cells
2017 · External reference
Past, present, and future of microbiome-based therapies
10.20517/mrr.2023.80 · 2024 · External reference
Donor composition and fiber promote strain engraftment in a randomized controlled trial of fecal microbiota transplant for ulcerative colitis
10.1016/j.medj.2025.100707 · 2025 · External reference
Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect
10.1038/s41467-025-56375-y · 2025 · External reference
An optimized cultivation method for future in vivo application of γδ T cells
10.3389/fimmu.2023.1185564 · 2023 · External reference
A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice
10.1038/s41590-024-01834-9 · 2024 · External reference
Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model
2024 · External reference
Phase I study of zoledronic acid combined with escalated doses of interleukine-2 for early in vivo generation of Vγ9Vδ2 T-cells after haploidentical stem cell transplant with posttransplant cyclophosphamide
10.1002/ajh.27191 · 2024 · External reference
Vγ9Vδ2 T-cell immunotherapy in blood cancers: ready for prime time?
10.3389/fimmu.2023.1167443 · 2023 · External reference
TNFR2+ regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing γδ T cells in the lung
2023 · External reference
JAK inhibitors for inflammatory bowel disease: recent advances
10.1136/flgastro-2023-102400 · 2024 · External reference
Differential properties of Janus kinase inhibitors in the treatment of immune-mediated inflammatory diseases
2023 · External reference