Research graph
References from Emerging role of cGAS-STING in the pathogenesis of allergic diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Global research trends in chronic Care for Comorbid Allergic Diseases: a web of science bibliometric review (1999-2024)
10.1007/s11882-025-01238-1 · 2025 · External reference
Urban allergic diseases are exacerbated by adverse environmental factors
10.1021/acs.est.5c09233 · 2025 · External reference
Pathogenesis of allergic diseases and implications for therapeutic interventions
2023 · External reference
Tissue-resident Th2 cells in type 2 immunity and allergic diseases
10.1111/imr.70006 · 2025 · External reference
Roles of follicular helper and regulatory T cells in allergic diseases and allergen immunotherapy
10.1111/all.14639 · 2021 · External reference
IgE in allergic diseases
10.1111/imr.70057 · 2025 · External reference
Cytokine-targeting biologics for allergic diseases
10.1016/j.anai.2018.01.009 · 2018 · External reference
Allergic diseases: from bench to clinic - contribution of the discovery of interleukin-5
10.1016/j.cyto.2016.11.011 · 2017 · External reference
Type 2 immunity in allergic diseases
10.1038/s41423-025-01261-2 · 2025 · External reference
The multiple roles of mite allergens in allergic diseases
10.1097/aci.0000000000000573 · 2019 · External reference
Role of the cGAS-STING pathway in systemic and organ-specific diseases
10.1038/s41581-022-00589-6 · 2022 · External reference
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
10.1038/s41392-022-01252-z · 2022 · External reference
The cGAS-STING pathway as a therapeutic target in inflammatory diseases
10.1038/s41577-021-00524-z · 2021 · External reference
Role of respiratory epithelial cells in allergic diseases
10.3390/cells11091387 · 2022 · External reference
Epithelial barrier theory: the role of Exposome, microbiome, and barrier function in allergic diseases
10.4168/aair.2023.15.6.705 · 2023 · External reference
Pyroptosis, gasdermins and allergic diseases
10.1111/all.16236 · 2024 · External reference
Balance of apoptotic cell death and survival in allergic diseases
10.1016/j.micinf.2014.07.004 · 2014 · External reference
Mitochondrial and nuclear mitochondrial variants in allergic diseases
10.4168/aair.2020.12.5.877 · 2020 · External reference
STING activation in alveolar macrophages and group 2 innate lymphoid cells suppresses IL-33-driven type 2 immunopathology
10.1172/jci.insight.143509 · 2021 · External reference
Cyclic-di-GMP induces STING-dependent ILC2 to ILC1 shift during innate type 2 lung inflammation
10.3389/fimmu.2021.618807 · 2021 · External reference
House dust mite-induced asthma causes oxidative damage and DNA double-strand breaks in the lungs
10.1016/j.jaci.2016.02.017 · 2016 · External reference
Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles
10.1016/j.mrrev.2014.09.001 · 2014 · External reference
Mitotic progression following DNA damage enables pattern recognition within micronuclei
10.1038/nature23470 · 2017 · External reference
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
10.1038/nature12306 · 2013 · External reference
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
10.1016/j.celrep.2013.05.009 · 2013 · External reference
Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
10.1016/j.cell.2013.04.046 · 2013 · External reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · 2013 · External reference
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
10.1126/science.1229963 · 2013 · External reference
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
10.1016/j.molcel.2013.05.022 · 2013 · External reference
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
10.1038/nature07317 · 2008 · External reference
STING is a direct innate immune sensor of cyclic di-GMP
10.1038/nature10429 · 2011 · External reference
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
10.1016/j.immuni.2008.09.003 · 2008 · External reference
10.1146/annurev-immunol-101721-032910
10.1146/annurev-immunol-101721-032910 · External reference
cGAS-STING and autophagy: crosstalk, molecular mechanisms, and targeted therapy
10.1007/s00204-025-04206-w · 2026 · External reference
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
10.1038/ncb3586 · 2017 · External reference
cGAS/STING signalling pathway in senescence and oncogenesis
10.1016/j.semcancer.2024.08.007 · 2024 · External reference
Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis
10.1128/spectrum.00781-25 · 2025 · External reference
Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy
2025 · External reference
10.1007/s00204-025-04150-9
10.1007/s00204-025-04150-9 · External reference
cGAS-STING signaling in cell death: mechanisms of action and implications in pathologies
10.1002/eji.202350386 · 2023 · External reference
Intersection of immune signaling and cell death: the bidirectional regulatory mechanism of STING pathway and Ferroptosis
10.1016/j.autrev.2025.103877 · 2025 · External reference
Targeting cGAS-STING signaling and cell death modes in cancer and autoimmune diseases
10.1016/j.cytogfr.2025.07.004 · 2025 · External reference
The activation of cGAS-STING pathway offers novel therapeutic opportunities in cancers
2025 · External reference
cGAS-STING and neurodegenerative diseases: a molecular crosstalk and therapeutic perspective
10.1016/j.intimp.2025.114902 · 2025 · External reference
Unraveling the cGAS-STING pathway in Alzheimer’s disease: a new frontier in neuroinflammation and therapeutic strategies
10.1016/j.neuroscience.2025.04.001 · 2025 · External reference
The neuroimmune nexus: unraveling the role of the mtDNA-cGAS-STING signal pathway in Alzheimer's disease
10.1186/s13024-025-00815-2 · 2025 · External reference
Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles
10.1038/s41573-019-0043-2 · 2019 · External reference
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases
10.1016/j.arr.2025.102691 · 2025 · External reference
cGAS-STING targeting offers a novel therapeutic paradigm in cardiovascular diseases
10.1016/j.ejps.2025.107137 · 2025 · External reference
cGAS-STING targeting offers therapy choice in lung diseases
10.1186/s13062-025-00611-4 · 2025 · External reference
Targeting cGAS-STING: modulating the immune landscape of hepatic diseases
2025 · External reference
cGAS-STING: mechanisms and therapeutic opportunities
10.1007/s11427-024-2808-3 · 2025 · External reference
Rebalancing redox homeostasis: a pivotal regulator of the cGAS-STING pathway in autoimmune diseases
10.1016/j.autrev.2025.103823 · 2025 · External reference
Therapeutic targeting the cGAS-STING pathway associated with protein and gene: An emerging and promising novel strategy for aging-related neurodegenerative disease
10.1016/j.intimp.2025.114679 · 2025 · External reference
CMPK2 promotes NLRP3 inflammasome activation via mtDNA-STING pathway in house dust mite-induced allergic rhinitis
10.1002/ctm2.70180 · 2025 · External reference
PM2.5 exacerbates house dust mite-induced allergic rhinitis via STING-mediated nasal epithelial barrier disruption
10.3389/fimmu.2026.1752415 · 2026 · External reference
Airway epithelial cGAS is critical for induction of experimental allergic airway inflammation
10.4049/jimmunol.1900869 · 2020 · External reference
Allergens abrogate antiinflammatory DNA effects and unmask macrophage-driven neutrophilic asthma via ILC2/STING/TNF-α signaling
10.1172/jci187907 · 2025 · External reference
Birch pollen allergen-induced dsDNA release activates cGAS-STING signaling and type 2 immune response in mice
10.1016/j.isci.2025.112324 · 2025 · External reference
BLOC1S1 control of vacuolar organelle fidelity modulates murine TH2 cell immunity and allergy susceptibility
10.1111/all.16461 · 2025 · External reference
Inhibition of the ATP synthase c subunit ameliorates HDM/LPS-induced inflammatory responses in asthmatic bronchial epithelial cells by blocking the mPTP-mtDNA-cGAS-STING axis
10.1186/s12931-025-03299-2 · 2025 · External reference
PVC Nanoplastics exposure exacerbates asthma through R-loop accumulation and subsequent STING activation in macrophages
2025 · External reference
STING-dependent induction of neutrophilic asthma exacerbation in response to house dust mite
10.1111/all.16369 · 2025 · External reference
The asthma risk gene, GSDMB, promotes mitochondrial DNA-induced ISGs expression
2024 · External reference
Up-regulation of HSP90α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway
10.1016/j.intimp.2024.111917 · 2024 · External reference
Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signaling after nuclear DNA damage
10.1016/j.molcel.2018.07.034 · 2018 · External reference
DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity
10.1016/j.immuni.2015.01.012 · 2015 · External reference
Mitochondrial dysfunction due to myeloid TFAM loss limits senolytic efficacy in allergic airway inflammation
2026 · External reference
LncRNA NONMMUT051252 promotes atopic dermatitis via the miR-141-5p/USP14/cGAS-STING axis and ferroptosis
10.1016/j.abb.2026.110974 · 2026 · External reference
Panax notoginseng extract alleviates atopic dermatitis-like skin inflammation associated with suppression of the cGAS-STING pathway
10.3389/fphar.2026.1859988 · 2026 · External reference
Sodium butyrate ameliorates atopic dermatitis-induced inflammation by inhibiting HDAC3-mediated STAT1 and NF-κB pathway
10.1007/s10753-023-01955-7 · 2024 · External reference
Tackling allergic airway inflammation with organic sheet-like nanoplatforms by targeted elimination of epithelial small extracellular vesicles
2025 · External reference
STING/RANTES pathway in airway epithelium enhances Der p1-induced airway inflammation
10.1111/all.16173 · 2024 · External reference
Paeoniflorin inhibits degranulation of mast cells through suppressing the cGAS/STING signaling pathway
2025 · External reference
Nucleic acid sensor STING drives remodeling and its inhibition enhances steroid responsiveness in chronic obstructive pulmonary disease
10.1371/journal.pone.0284061 · 2023 · External reference
STING targeting in lung diseases
10.3390/cells11213483 · 2022 · External reference
Linarin protects against asthma-induced airway epithelial ferroptosis and inflammation via ALDH2 regulation
2025 · External reference
Study on the mechanism of artesunate in modulating AR epithelial injury and Th2-type inflammatory status
10.2147/jir.s513760 · 2025 · External reference
Treatment with human placental extracts inhibits allergic rhinitis by modulating AMPK/SHP1/SHP2/STING signaling
10.3892/mmr.2025.13548 · 2025 · External reference
Qufeng xuanbi formula attenuates HDM-induced allergic asthma by targeting the STING/HIF-1α/glycolysis axis
10.1016/j.jep.2026.122134 · 2026 · External reference
Therapeutic effects of chlorogenic acid on allergic rhinitis through TLR4/MAPK/NF-κB pathway modulation
10.17305/bb.2024.11582 · 2025 · External reference
