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References from Brain-derived neurotrophic factor in diabetes: A promising target for cognitive restoration. Local targets link to admitted publications; unresolved targets remain external evidence.
Brain-derived neurotrophic factor and its clinical implications
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Brain-derived neurotrophic factor alleviates diabetes mellitus-accelerated atherosclerosis by promoting M2 polarization of macrophages through repressing the STAT3 pathway
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Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism
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New insights in the biology of BDNF synthesis and release: implications in CNS function
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New insights in the biology of BDNF synthesis and release: implications in CNS function
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Activity-dependent dendritic release of BDNF and biological consequences
10.1007/s12035-009-8050-7 · 2009 · External reference
Metabotropic glutamate receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca2+ wave-dependent activation of SK and TRPC channels
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Presynaptic ryanodine receptor-activated calmodulin kinase II increases vesicle mobility and potentiates neuropeptide release
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Mechanisms and regulation of neurotrophin synthesis and secretion
2016 · External reference
Exploring the impact of exercise-induced BDNF on neuroplasticity in neurodegenerative and neuropsychiatric conditions
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Evidence for the contribution of BDNF-TrkB signal strength in neurogenesis: An organotypic study
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Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
10.1016/j.expneurol.2004.11.016 · 2005 · External reference
The lighter side of BDNF
10.1152/ajpregu.00776.2010 · 2011 · External reference
BDNF function and intracellular signaling in neurons
2010 · External reference
Impact and mechanisms of action of BDNF on neurological disorders, cancer, and cardiovascular diseases
10.1111/cns.70138 · 2024 · External reference
Regulation of BDNF-TrkB signaling and potential therapeutic strategies for Parkinson’s disease
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Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation
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P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation
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TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury
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Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning
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BDNF-induced TrkB activation down-regulates the K+–Cl− cotransporter KCC2 and impairs neuronal Cl− extrusion
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Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury
10.4103/1673-5374.198964 · 2017 · External reference
Brain-derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection
2017 · External reference
Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-γ signaling for glutamate release via a glutamate transporter
10.1073/pnas.0800888106 · 2009 · External reference
Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF–TrkB–PI3K/Akt signaling pathway
10.1007/s11064-012-0871-5 · 2012 · External reference
PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression
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Translational control by MAPK signaling in long-term synaptic plasticity and memory
10.1016/s0092-8674(04)00115-1 · 2004 · External reference
The mechanism of phospholipase C-γ1 regulation
10.1038/emm.2000.18 · 2000 · External reference
Endogenous brain-derived neurotrophic factor triggers fast calcium transients at synapses in developing dendrites
10.1523/jneurosci.3590-06.2007 · 2007 · External reference
Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor
10.1038/nature03477 · 2005 · External reference
Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release
10.1074/jbc.m508157200 · 2006 · External reference
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
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Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage
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Exploring the various aspects of brain-derived neurotropic factor (BDNF) in diabetes mellitus
10.2174/1871527319666201014125642 · 2021 · External reference
Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons
10.1074/jbc.m207232200 · 2003 · External reference
Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice
10.1002/dmrr.290 · 2002 · External reference
Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control
10.1210/en.2008-1184 · 2009 · External reference
Characteristics of BDNF-induced weight loss
10.1016/0014-4886(95)90045-4 · 1995 · External reference
Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr (db)/lepr (db) mice
10.2337/diabetes.48.3.588 · 1999 · External reference
Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice
10.1016/s0026-0495(00)90988-0 · 2000 · External reference
Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
10.1007/s00125-006-0537-4 · 2007 · External reference
Inflammation and insulin resistance
10.1172/jci29069 · 2006 · External reference
Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
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Increased frequency of NGF in sera of rheumatoid arthritis and systemic lupus erythematosus patients
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Brain-derived neurotrophic factor expression ex vivo in obesity
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Plasma brain-derived neurotrophic factor in hemodialysis patients
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Antidiabetic effect of brain-derived neurotrophic factor and its association with inflammation in type 2 diabetes mellitus
10.1155/2017/2823671 · 2017 · External reference
Serum brain-derived neurotrophic factor and platelet activation evaluated by soluble P-selectin and soluble CD-40-ligand in patients with acute myocardial infarction
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Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus
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Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice
10.1006/bbrc.1997.7220 · 1997 · External reference
Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto–Kakizaki rats
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Streptozotocin produces oxidative stress, inflammation and decreases BDNF concentrations to induce apoptosis of RIN5F cells and type 2 diabetes mellitus in Wistar rats
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Effect of metformin on Schwann cells under hypoxia condition
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Impact of impaired cerebral blood flow autoregulation on cognitive impairment
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Hippocampal neuronal apoptosis in type 1 diabetes
10.1016/s0006-8993(02)02887-1 · 2002 · External reference
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10.1016/j.jns.2004.09.019 · 2004 · External reference
Impaired cerebral blood flow in type 2 diabetes mellitus–A comparative study with subjective cognitive decline, vascular dementia and Alzheimer’s disease subjects
10.1016/j.nicl.2020.102302 · 2020 · External reference
Consistent effects of hypoglycemia on cognitive function in people with or without diabetes
10.2337/dc21-2502 · 2022 · External reference
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Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
10.1002/hipo.20470 · 2008 · External reference
Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans
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The many faces of insulin-like peptide signalling in the brain
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Communication between patients, peers, and care providers through a mobile health intervention supporting medication-assisted treatment for opioid use disorder
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A simple role for BDNF in learning and memory?
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Brain-derived neurotrophic factor and neuropsychiatric disorders
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Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients
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Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
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2008 · External reference
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TrkB-mediated neuroprotective and antihypoxic properties of brain-derived neurotrophic factor
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Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
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An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus
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Cognitive impairment and BDNF serum levels
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Brain-Derived Neurotrophic Factor and Diabetes
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Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: relationship to glucose metabolism and biomarkers of insulin resistance
10.1016/j.clinbiochem.2008.03.003 · 2008 · External reference
Association between cognition and peripheral brain-derived neurotrophic factor in a sample of normal adults in Kano, Nigeria
10.4103/njbcs.njbcs_46_17 · 2019 · External reference
BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?
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Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation
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Effect of brain derived neurotrophic factor, in relation to diet and lifestyle factors, for prevention of neuropsychiatric and vascular diseases and diabetes
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Potential role of insulin on the pathogenesis of depression
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Targeting Altered Mitochondrial Biogenesis in the Brain of Diabetic Rats: Potential Effect of Pioglitazone and Exendin-4
2019 · External reference
Pharmacological inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study
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Celecoxib alleviates memory deficits by downregulation of COX-2 expression and upregulation of the BDNF-TrkB signaling pathway in a diabetic rat model
10.1007/s12031-017-0922-0 · 2017 · External reference
Deferoxamine regulates neuroinflammation and oxidative stress in rats with diabetes-induced cognitive dysfunction
10.1007/s10787-019-00665-7 · 2019 · External reference
Ameliorative Effect of Berberine on Neonatally Induced Type 2 Diabetic Neuropathy via Modulation of BDNF, IGF-1, PPAR-γ, and AMPK Expressions
10.1177/1559325819862449 · 2019 · External reference
Irisin regulates the expression of BDNF and glycometabolism in diabetic rats
2019 · External reference
The role of sigma-1 receptor and brain-derived neurotrophic factor in the development of diabetes and comorbid depression in streptozotocin-induced diabetic rats
10.1007/s00213-016-4209-x · 2016 · External reference
Rolipram-induced improvement of cognitive function correlates with changes in hippocampal CREB phosphorylation, BDNF and Arc protein levels
10.1016/j.neulet.2015.09.023 · 2016 · External reference
Docosahexaenoic acid modulates brain-derived neurotrophic factor via GPR40 in the brain and alleviates diabesity-associated learning and memory deficits in mice
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Chromium picolinate attenuates cognitive deficit in ICV-STZ rat paradigm of sporadic Alzheimer’s-like dementia via targeting neuroinflammatory and IRS-1/PI3K/AKT/GSK-3β pathway
10.1007/s10787-019-00681-7 · 2020 · External reference
The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway
10.1007/s00213-019-05379-w · 2020 · External reference
Dihydromyricetin improves type 2 diabetes-induced cognitive impairment via suppressing oxidative stress and enhancing brain-derived neurotrophic factor-mediated neuroprotection in mice
10.1093/abbs/gmy003 · 2018 · External reference
(p-ClPhSe) 2 modulates hippocampal BDNF/TrkB signaling and reverses memory impairment induced by diabetes in mice
10.1016/j.pnpbp.2019.109660 · 2019 · External reference
The effect of cilostazol on hippocampal memory and oxidative stress biomarkers in rat model of diabetes mellitus
10.1016/j.brainres.2019.03.025 · 2019 · External reference
Effect of vitamin D supplementation on CREB-TrkB-BDNF pathway in the hippocampus of diabetic rats
2020 · External reference
Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression
10.1016/j.neurobiolaging.2014.09.028 · 2015 · External reference
Apigenin modulates hippocampal CREB-BDNF signaling in high fat, high fructose diet-fed rats
10.1016/j.jff.2020.103898 · 2020 · External reference
Effect of glucagon-like peptide-1 analogue; Exendin-4, on cognitive functions in type 2 diabetes mellitus; possible modulation of brain derived neurotrophic factor and brain Visfatin
10.1016/j.brainresbull.2018.02.002 · 2018 · External reference
Effects of noopept on cognitive functions and pubertal process in rats with diabetes
10.1016/j.lfs.2019.116698 · 2019 · External reference
NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia
10.1016/j.phrs.2019.01.035 · 2019 · External reference
Intermittent administration of brain-derived neurotrophic factor (BDNF) ameliorates glucose metabolism and prevents pancreatic exhaustion in diabetic mice
10.1263/jbb.105.395 · 2008 · External reference
ERα and/or ERβ activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice
10.1016/j.expneurol.2018.09.002 · 2019 · External reference
Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia
10.1016/j.physbeh.2018.12.012 · 2019 · External reference
Naringin ameliorates cognitive deficits in streptozotocin-induced diabetic rats
2016 · External reference
Impact of diabetes on cognitive function and brain structure
10.1111/nyas.12807 · 2015 · External reference
The association between diabetes mellitus and depression
2016 · External reference
Decreased Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Patients with Alzheimer's Disease (AD): A Systematic Review and Meta-Analysis
10.3390/ijms20020257 · 2019 · External reference
Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial
10.1155/2018/7169583 · 2018 · External reference
Impact of prolonged neuromuscular electrical stimulation on metabolic profile and cognition-related blood parameters in type 2 diabetes: A randomized controlled cross-over trial
10.1016/j.diabres.2018.05.032 · 2018 · External reference
Reduced Serum Levels of Brain-Derived Neurotrophic Factor Are Related to Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes Mellitus
10.1159/000493275 · 2018 · External reference
Oxidative stress-mediated influence of plasma DPP4 activity to BDNF ratio on mild cognitive impairment in elderly type 2 diabetic patients: results from the GDMD study in China
10.1016/j.metabol.2018.03.014 · 2018 · External reference
Low BDNF is associated with cognitive deficits in patients with type 2 diabetes
10.1007/s00213-012-2942-3 · 2013 · External reference
Strong Association of Serum GSK-3β/BDNF Ratio with Mild Cognitive Impairment in Elderly Type 2 Diabetic Patients
10.2174/1567205016666190827112546 · 2019 · External reference
Brain-derived neurotrophic factor, insulin like growth factor-1 and inflammatory cytokine responses to continuous and intermittent exercise in patients with type 1 diabetes
10.1016/j.diabres.2018.08.018 · 2018 · External reference
Pinoresinol diglucoside mitigates streptozotocin-induced cognitive decline in rats by regulating neurotransmitters, apoptosis and cytokines-NF-κB/BDNF/CREB/caspase-3 pathway: Molecular docking study
10.1016/j.lmot.2026.102242 · 2026 · External reference
Neuroprotective and Cognitive Benefits of a Ketogenic Diet in a Type 2 Diabetes Rat Model
10.1007/s12035-025-05328-z · 2026 · External reference
BDNF Levels and Cognitive Function in Patients with Type 2 Diabetes Treated with SGLT2 Inhibitors
10.14235/bas.galenos.2024.38268 · 2025 · External reference
Semaglutide and high-intensity interval exercise attenuate cognitive impairment in type 2 diabetic mice via BDNF modulation
10.3390/brainsci15050480 · 2025 · External reference
Effect of exogenous β-hydroxybutyrate on BDNF signaling, cognition, and amyloid precursor protein processing in humans with T2D and insulin-resistant rodents
10.1152/ajpcell.00867.2024 · 2025 · External reference
Elderberry diet improved cognitive functions, increased long-term potentiation and BDNF expression, and decreased astrogliosis in rats with diabetic cognitive impairments
10.1007/s13205-025-04564-3 · 2025 · External reference
Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes
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Subchronic effects of HgCl2 on cognitive function and central inflammation in type 2 diabetic rats: involvement of BDNF and acetylcholinesterase
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Mitigating hyperglycemia-induced learning and memory impairment: insulin combined with lemon peel essential oil effects on hippocampal oxidative stress, neuroinflammation, and BDNF expression in type 1 diabetic rats
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High intensity interval training and selenium nanoparticles protect hippocampal neurons and enhance cognitive function in diabetic rats
10.1038/s41598-025-07441-4 · 2025 · External reference