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References from Altered striatal long-term potentiation in the eIF4E-TG mouse model of autism spectrum disorder. Local targets link to admitted publications; unresolved targets remain external evidence.
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
10.1113/jphysiol.1973.sp010273 · 1973 · External reference
Fear conditioning induces associative long-term potentiation in the amygdala
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Experience-dependent modification of synaptic plasticity in visual cortex
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Long-Term Synaptic Depression in the Striatum: Physiological and Pharmacological Characterization
10.1523/jneurosci.12-11-04224.1992 · 1992 · External reference
Structural basis of long-term potentiation in single dendritic spines
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Locally dynamic synaptic learning rules in pyramidal neuron dendrites
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Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
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Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
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Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells
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Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits
10.1016/j.neuron.2018.04.008 · 2018 · External reference
Endogenous ACh enhances striatal NMDA-responses via M1-like muscarinic receptors and PKC activation
1998 · External reference
Coactivation of D1 and D2 dopamine receptors is required for long-term synaptic depression in the striatum
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Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus
10.1016/0304-3940(90)90382-j · 1990 · External reference
Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro
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Translational regulatory mechanisms in persistent forms of synaptic plasticity
10.1016/j.neuron.2004.09.013 · 2004 · External reference
A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity
10.1126/science.273.5280.1402 · 1996 · External reference
Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis
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Protein synthesis in entorhinal cortex and long-term potentiation in dentate gyrus
10.1002/1098-1063(2000)10:4<431::aid-hipo9>3.0.co;2-z · 2000 · External reference
A role for dendritic protein synthesis in hippocampal late LTP
10.1111/j.1460-9568.2003.03054.x · 2003 · External reference
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation
10.1038/s41593-019-0568-z · 2020 · External reference
Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism
10.1038/s41398-018-0335-z · 2019 · External reference
Dynamic Akt/mTOR signaling in children with autism spectrum disorder
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Valproic acid exposure sequentially activates Wnt and mTOR pathways in rats
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Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
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Dysregulation of mTOR signaling in fragile X syndrome
10.1523/jneurosci.3696-09.2010 · 2010 · External reference
Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice
10.1016/j.celrep.2023.112901 · 2023 · External reference
Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
10.1101/gad.1110003 · 2003 · External reference
The Autistic Neuron: Troubled Translation?
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Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome
10.1523/jneurosci.1496-08.2008 · 2008 · External reference
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations
10.1136/jmg.2004.024646 · 2005 · External reference
Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines
10.1016/j.brainres.2006.02.044 · 2006 · External reference
Mechanism of valproic acid-induced dendritic spine and synaptic impairment in the prefrontal cortex for causing core autistic symptoms in mice
2022 · External reference
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
10.1073/pnas.94.10.5401 · 1997 · External reference
Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome
10.1002/ajmg.a.30709 · 2005 · External reference
Abnormal development of dendritic spines in FMR1 knock-out mice
10.1523/jneurosci.21-14-05139.2001 · 2001 · External reference
Deletion of FMR1 in purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in fragile X syndrome
10.1016/j.neuron.2005.07.005 · 2005 · External reference
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
10.1038/nn1566 · 2005 · External reference
Analysis of neocortex in three males with the fragile X syndrome
10.1002/ajmg.1320410306 · 1991 · External reference
Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: A quantitative examination
10.1002/1096-8628(20010115)98:2<161::aid-ajmg1025>3.0.co;2-b · 2001 · External reference
The GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome
10.4161/15384101.2014.989114 · 2015 · External reference
Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala
10.1152/jn.00597.2013 · 2014 · External reference
Altered synaptic plasticity in a mouse model of fragile X mental retardation
10.1073/pnas.122205699 · 2002 · External reference
Impaired presynaptic long-term potentiation in the anterior cingulate cortex of Fmr1 knock-out mice
10.1523/jneurosci.2644-14.2015 · 2015 · External reference
Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency
10.1006/mcne.2001.1085 · 2002 · External reference
Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex
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Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex
10.1016/j.nbd.2011.12.028 · 2012 · External reference
Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis
10.1152/jn.00449.2010 · 2010 · External reference
Bi-directional changes in synaptic plasticity induced at corticostriatal synapses in vitro
10.1007/s002210000523 · 2000 · External reference
Bridging the gap between striatal plasticity and learning
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Input- and cell-type-specific endocannabinoid-dependent LTD in the striatum
10.1016/j.celrep.2014.12.005 · 2015 · External reference
Postsynaptic endocannabinoid release is critical to long-term depression in the striatum
10.1038/nn832 · 2002 · External reference
Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum
10.1523/jneurosci.2959-05.2005 · 2005 · External reference
Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum
10.1038/s41467-022-28950-0 · 2022 · External reference
Dopamine receptor activation is required for corticostriatal spike-timing-dependent plasticity
10.1523/jneurosci.4402-07.2008 · 2008 · External reference
mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity
10.1038/s41467-021-26131-z · 2021 · External reference
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
10.1038/s41380-021-01245-4 · 2021 · External reference
Corticostriatal Transmission Is Selectively Enhanced in Striatonigral Neurons with Postnatal Loss of Tsc1
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Neurofibromin regulates corticostriatal inhibitory networks during working memory performance
10.1073/pnas.1004829107 · 2010 · External reference
Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning
10.1016/j.celrep.2021.109511 · 2021 · External reference
Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome
10.1016/j.neuron.2023.03.008 · 2023 · External reference
Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome
10.1038/ncomms2045 · 2012 · External reference
Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD
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Impaired dopamine release and synaptic plasticity in the striatum of Parkin-/- mice
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EIF4E eukaryotic translation initiation factor 4E
2025 · External reference
Deregulation of EIF4E: A novel mechanism for autism
10.1136/jmg.2009.066852 · 2009 · External reference
Autism-related deficits via dysregulated eIF4E-dependent translational control
10.1038/nature11628 · 2013 · External reference
The Overexpression of eIF4E Decreases Oxytocin Levels and Induces Social Cognitive Behavioral Disorders in Mice
10.1523/eneuro.0387-24.2024 · 2024 · External reference
Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders
10.1016/j.celrep.2024.114997 · 2024 · External reference
Postnatal reduction of eIF4E overexpression in D1-SPNs ameliorates KCNQ dysfunction, hyperexcitability and ASD-like behaviours
10.1007/s00018-026-06115-2 · 2026 · External reference
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
10.1038/nature11782 · 2013 · External reference
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
2020 · External reference
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
10.1038/nature09965 · 2011 · External reference
The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones
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Convergence of cortical and thalamic input to direct and indirect pathway medium spiny neurons in the striatum
10.1007/s00429-013-0601-z · 2014 · External reference
N-methyl-D-aspartate (NMDA) receptor composition modulates dendritic spine morphology in striatal medium spiny neurons
10.1074/jbc.m112.347427 · 2012 · External reference
Functional comparison of corticostriatal and thalamostriatal postsynaptic responses in striatal neurons of the mouse
2018 · External reference
Corticostriatal and thalamostriatal synapses have distinctive properties
10.1523/jneurosci.0435-08.2008 · 2008 · External reference
A comprehensive excitatory input map of the striatum reveals novel functional organization
10.7554/elife.19103 · 2016 · External reference
Differential innervation of direct- and indirect-pathway striatal projection neurons
10.1016/j.neuron.2013.05.014 · 2013 · External reference
The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities
10.1016/j.celrep.2019.12.095 · 2020 · External reference
The DMC-Behavior Platform: An Open-Source Framework for Auditory-Guided Perceptual Decision-Making in Head-Fixed Mice
10.1523/eneuro.0457-24.2025 · 2025 · External reference
The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus
10.1523/jneurosci.2423-05.2005 · 2005 · External reference
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism
10.1172/jci87997 · 2017 · External reference
NMDA-dependent facilitation of corticostriatal plasticity by the amygdala
10.1073/pnas.0609831104 · 2007 · External reference
The alpha-2δ-1–NMDA Receptor Coupling is Essential for Corticostriatal Long-Term Potentiation and is Involved in Learning and Memory
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A Ca2+ threshold for induction of spike-timing-dependent depression in the mouse striatum
10.1523/jneurosci.3206-11.2011 · 2011 · External reference
State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons
10.1016/j.neuron.2004.10.013 · 2004 · External reference
Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons
10.1111/ejn.13287 · 2017 · External reference
Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome
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Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B â ’/â ’ mice
10.1038/nn.4260 · 2016 · External reference
Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome
10.1523/jneurosci.0937-07.2007 · 2007 · External reference
Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors
10.1016/j.cell.2014.04.045 · 2014 · External reference
Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models
10.1038/s41398-018-0155-1 · 2018 · External reference
Atypically diffuse functional connectivity between caudate nuclei and cerebral cortex in autism
10.1186/1744-9081-2-34 · 2006 · External reference
Aberrant striatal functional connectivity in children with autism
10.1016/j.biopsych.2010.10.029 · 2011 · External reference
Frontostriatal deficits in fragile X syndrome: Relation to FMR1 gene expression
10.1073/pnas.0304544101 · 2004 · External reference
Connectivity-based parcellation reveals distinct cortico-striatal connectivity fingerprints in Autism Spectrum Disorder
10.1016/j.neuroimage.2017.02.019 · 2018 · External reference
Repetitive behaviors in autism are linked to imbalance of corticostriatal connectivity: A functional connectivity MRI study
10.1093/scan/nsx129 · 2018 · External reference
Fronto-striatal dysfunction and potential compensatory mechanisms in male adolescents with fragile X syndrome
10.1002/hbm.20406 · 2007 · External reference
Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder
2017 · External reference
Bidirectional activity-dependent plasticity at corticostriatal synapses
10.1523/jneurosci.4476-05.2005 · 2005 · External reference
Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity
10.1126/science.1160575 · 2008 · External reference
Functional state of corticostriatal synapses determines their expression of short- and long-term plasticity
10.1002/1098-2396(20001201)38:3<271::aid-syn6>3.0.co;2-a · 2000 · External reference
Striatal Plasticity and Basal Ganglia Circuit Function
10.1016/j.neuron.2008.11.005 · 2008 · External reference
Long-term Potentiation in the Striatum is Unmasked by Removing the Voltage-dependent Magnesium Block of NMDA Receptor Channels
10.1111/j.1460-9568.1992.tb00119.x · 1992 · External reference
In vivo activity-dependent plasticity at cortico-striatal connections: Evidence for physiological long-term potentiation
10.1073/pnas.94.13.7036 · 1997 · External reference
Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors
10.1523/jneurosci.17-12-04536.1997 · 1997 · External reference
Coordinated expression of dopamine receptors in neostriatal medium spiny neurons
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Role of Ca2+ in striatal LTD and LTP
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Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
10.1073/pnas.0702717104 · 2007 · External reference
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
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PINK1 deficiency enhances autophagy and mitophagy induction
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The mRNA 5′ cap-binding protein eIF4E and control of cell growth
10.1016/s0955-0674(98)80150-6 · 1998 · External reference
Dopamine-dependent plasticity of corticostriatal synapses
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Unilateral dopamine denervation blocks corticostriatal LTP
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Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity
10.1113/jphysiol.2010.188466 · 2010 · External reference
Essential role of presynaptic NMDA receptors in activity-dependent BDNF secretion and corticostriatal LTP
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Functional and structural deficits at accumbens synapses in a mouse model of Fragile X
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Short-term and long-term plasticity at corticostriatal synapses: Implications for learning and memory
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The role of the dorsal striatum in reward and decision-making
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Sensitivity to theta-burst timing permits LTP in dorsal striatal adult brain slice
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Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
10.1038/nn.2261 · 2009 · External reference
The acquisition of goal-directed actions generates opposing plasticity in direct and indirect pathways in dorsomedial striatum
10.1523/jneurosci.0313-14.2014 · 2014 · External reference
Striatal direct and indirect pathway neurons differentially control the encoding and updating of goal-directed learning
10.7554/elife.58544 · 2020 · External reference
Local D2- To D1-neuron transmodulation updates goal-directed learning in the striatum
10.1126/science.aaz5751 · 2020 · External reference
Lateralized nigrostriatal dopamine pathway activation promotes early reversal learning
10.3389/fnbeh.2025.1703094 · 2025 · External reference
Dorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning
10.1038/s41386-020-0612-4 · 2020 · External reference
Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
10.1038/s41467-019-13396-8 · 2019 · External reference
High-performance calcium sensors for imaging activity in neuronal populations and microcompartments
10.1038/s41592-019-0435-6 · 2019 · External reference
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
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Stimfit: Quantifying electrophysiological data with Python
10.3389/fninf.2014.00016 · 2014 · External reference
Demon Voltammetry and Analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures
10.1016/j.jneumeth.2011.03.001 · 2011 · External reference
An Improved BAC Transgenic Fluorescent Reporter Line for Sensitive and Specific Identification of Striatonigral Medium Spiny Neurons
10.3389/fnsys.2011.00032 · 2011 · External reference
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
10.1038/nature02033 · 2003 · External reference
Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
2018 · External reference
AMP-activated protein kinase slows D2 dopamine autoreceptor desensitization in substantia nigra neurons
10.1016/j.neuropharm.2019.107705 · 2019 · External reference
Long-term synaptic depression in the striatum: physiological and pharmacological characterization
10.1523/jneurosci.12-11-04224.1992 · 1992 · External reference
D1 receptor activation enhances evoked discharge in neostriatal medium spiny neurons by modulating an L-type Ca2+ conductance
10.1523/jneurosci.17-09-03334.1997 · 1997 · External reference
Detection of spontaneous synaptic events with an optimally scaled template
10.1016/s0006-3495(97)78062-7 · 1997 · External reference
High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy
10.1038/nprot.2011.389 · 2011 · External reference
Dendritic Spines Shape Analysis-Classification or Clusterization? Perspective
10.3389/fnsyn.2020.00031 · 2020 · External reference
Acute physiological stress promotes clustering of synaptic markers and alters spine morphology in the hippocampus
10.1371/journal.pone.0079077 · 2013 · External reference
Dendritic spines: structure, dynamics and regulation
10.1038/35104061 · 2001 · External reference
Age-related behavioural and striatal dysfunctions in Shank3ΔC/ΔC mouse model of autism spectrum disorder
10.1111/ejn.15919 · 2023 · External reference