Research graph
References from Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle fiber-type gene expression. Local targets link to admitted publications; unresolved targets remain external evidence.
Exercise and Type 2 Diabetes
10.2337/dc10-9990 · 2010 · External reference
Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
10.2337/dc09-s302 · 2009 · External reference
Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation
10.1001/archinte.164.8.892 · 2004 · External reference
Insulin Resistance and Type 2 Diabetes
10.2337/db12-0073 · 2012 · External reference
The effect of exercise on skeletal muscle glucose uptake in type 2 diabetes: An epigenetic perspective
10.1016/j.metabol.2015.09.013 · 2015 · External reference
Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake
10.1002/j.2040-4603.2020.tb00136.x · 2020 · External reference
Effects of Exercise and Aging on Skeletal Muscle
10.1101/cshperspect.a029785 · 2018 · External reference
Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training
10.3390/nu11102432 · 2019 · External reference
Different effects on human skeletal myosin heavy chain isoform expression: strength vs. combination training
10.1152/japplphysiol.00830.2002 · 1985 · External reference
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
10.1038/s41467-019-13869-w · 2020 · External reference
Muscle Fiber Type Transitions with Exercise Training: Shifting Perspectives
10.3390/sports9090127 · 2021 · External reference
Skeletal muscle cell-specific differences in type 2 diabetes
10.1007/s00018-022-04265-7 · 2022 · External reference
Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes
10.2337/diacare.29.04.06.dc05-1854 · 2006 · External reference
Slow-Twitch Fiber Proportion in Skeletal Muscle Correlates With Insulin Responsiveness
10.1210/jc.2012-3876 · 2013 · External reference
Skeletal muscle fiber type: using insights from muscle developmental biology to dissect targets for susceptibility and resistance to muscle disease
10.1002/wdev.230 · 2016 · External reference
Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes
10.1038/srep43775 · 2017 · External reference
Relationship between insulin sensitivity and gene expression in human skeletal muscle
10.1186/s12902-021-00687-9 · 2021 · External reference
The genetic regulatory signature of type 2 diabetes in human skeletal muscle
10.1038/ncomms11764 · 2016 · External reference
Gene Expression Profile in Skeletal Muscle of Type 2 Diabetes and the Effect of Insulin Treatment
10.2337/diabetes.51.6.1913 · 2002 · External reference
Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle
10.1073/pnas.1814263116 · 2019 · External reference
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
10.1038/ng1180 · 2003 · External reference
From bulk, single-cell to spatial RNA sequencing
10.1038/s41368-021-00146-0 · 2021 · External reference
RNA-sequencing from single nuclei
10.1073/pnas.1319700110 · 2013 · External reference
Perspectives on single-nucleus RNA sequencing in different cell types and tissues
10.4132/jptm.2022.12.19 · 2023 · External reference
Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
10.1038/s41467-020-15816-6 · 2020 · External reference
Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise
10.1101/gr.280051.124 · 2025 · External reference
The skeletal muscle response to high-intensity training assessed by single-nucleus RNA-sequencing is blunted in individuals with type 2 diabetes
10.1113/jp288368 · 2025 · External reference
Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
10.1007/bf00280883 · 1985 · External reference
Cardiorespiratory fitness in aging men and women: the DR’s EXTRA study
10.1111/j.1600-0838.2010.01127.x · 2011 · External reference
Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study
10.2337/diabetes.54.1.158 · 2005 · External reference
Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction
10.1056/nejm199406023302201 · 1994 · External reference
Unresolved reference
2006 · External reference
The threshold value for identifying insulin resistance (HOMA-IR) in an admixed adolescent population: A hyperglycemic clamp validated study
2022 · External reference
Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation
2024 · External reference
Extensive differential gene expression and regulation by sex in human skeletal muscle
2025 · External reference
RNA-Enrich: a cut-off free functional enrichment testing method for RNA-seq with improved detection power
10.1093/bioinformatics/btv694 · 2016 · External reference
Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence
10.1155/2021/7796727 · 2021 · External reference
Skeletal muscle fiber composition may modify the effect of nutrition on body composition in young females
10.1016/j.numecd.2022.12.027 · 2023 · External reference
Muscle fiber phenotype: a culprit of abnormal metabolism and function in skeletal muscle of humans with obesity
10.1152/ajpendo.00190.2023 · 2023 · External reference
Comparison of the contributions of the nuclear and cytoplasmic compartments to global gene expression in human cells
10.1186/1471-2164-8-340 · 2007 · External reference
Exporting RNA from the nucleus to the cytoplasm
10.1038/nrm2255 · 2007 · External reference
Control of mammalian gene expression by selective mRNA export
10.1038/nrm4010 · 2015 · External reference
Changes in chromatin accessibility are not concordant with transcriptional changes for single-factor perturbations
10.15252/msb.202210979 · 2022 · External reference
Age-related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk
10.1161/circresaha.118.312806 · 2018 · External reference
Diabetes and Altered Glucose Metabolism with Aging
10.1016/j.ecl.2013.02.010 · 2013 · External reference
Physical activity in aging: Comparison among young, aged, and nonagenarian individuals
10.1152/japplphysiol.90450.2008 · 2008 · External reference
A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging
10.1186/s13395-015-0059-1 · 2015 · External reference
Required Sample Size to Detect the Mediated Effect
10.1111/j.1467-9280.2007.01882.x · 2007 · External reference
Unresolved reference
2022 · External reference
On the Dependency of Cellular Protein Levels on mRNA Abundance
10.1016/j.cell.2016.03.014 · 2016 · External reference
Correlation of mRNA and protein in complex biological samples
10.1016/j.febslet.2009.10.036 · 2009 · External reference
Analysis of protein isoforms: can we do it better?
10.1002/pmic.201200161 · 2012 · External reference
Transcriptional Regulation and Its Misregulation in Disease
10.1016/j.cell.2013.02.014 · 2013 · External reference
The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions
2010 · External reference
GENCODE: The reference human genome annotation for The ENCODE Project
10.1101/gr.135350.111 · 2012 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Compendium of Physical Activities: a second update of codes and MET values
10.1249/mss.0b013e31821ece12 · 2011 · External reference
STARsolo: accurate, fast and versatile mapping/quantification of single-cell and single-nucleus RNA-seq data. 2021
2021 · External reference
Fast and accurate short read alignment with Burrows-Wheeler transform
10.1093/bioinformatics/btp324 · 2009 · External reference
Decontamination of ambient RNA in single-cell RNA-seq with DecontX
10.1186/s13059-020-1950-6 · 2020 · External reference
Jointly Defining Cell Types from Multiple Single-Cell Datasets Using LIGER
10.1038/s41596-020-0391-8 · 2020 · External reference
Iterative single-cell multi-omic integration using online learning
10.1038/s41587-021-00867-x · 2021 · External reference
Regulation of the Nucleosome Repeat Length In Vivo by the DNA Sequence, Protein Concentrations and Long-Range Interactions
10.1371/journal.pcbi.1003698 · 2014 · External reference
Model-based Analysis of ChIP-Seq (MACS)
10.1186/gb-2008-9-9-r137 · 2008 · External reference
Unresolved reference
2002 · External reference
scATAC-seq generates more accurate and complete regulatory maps than bulk ATAC-seq
10.1038/s41598-025-87351-7 · 2025 · External reference
