Research graph
References from A stromal β-defensin, DEFB124, contributes to cutaneous host defense against Staphylococcus aureus. Local targets link to admitted publications; unresolved targets remain external evidence.
Antimicrobial peptides
10.1016/j.cub.2015.11.017 · 2016 · External reference
The immunology of host defence peptides: beyond antimicrobial activity
10.1038/nri.2016.29 · 2016 · External reference
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
10.1038/nm1616 · 2007 · External reference
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
10.1126/science.1104742 · 2004 · External reference
Defensins: antimicrobial peptides of innate immunity
10.1038/nri1180 · 2003 · External reference
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection
10.1016/j.immuni.2022.06.021 · 2022 · External reference
Human Beta-Defensin 3 Induces Maturation of Human Langerhans Cell–Like Dendritic Cells: An Antimicrobial Peptide that Functions as an Endogenous Adjuvant
10.1038/jid.2012.319 · 2013 · External reference
Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling
10.1126/scitranslmed.abp9675 · 2022 · External reference
Discovery of five conserved β-defensin gene clusters using a computational search strategy
10.1073/pnas.042692699 · 2002 · External reference
Expression of antimicrobial peptides in cutaneous infections after skin surgery
10.1111/j.1365-2133.2010.09781.x · 2010 · External reference
Epithelial antimicrobial defence of the skin and intestine
10.1038/nri3228 · 2012 · External reference
The Novel Human β-Defensin 114 Regulates Lipopolysaccharide (LPS)-mediated Inflammation and Protects Sperm from Motility Loss∗
10.1074/jbc.m112.411884 · 2013 · External reference
Production and characterization of recombinant human beta-defensin DEFB120
10.1002/psc.2611 · 2014 · External reference
A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility
10.1126/scitranslmed.3002289 · 2011 · External reference
Distinct Roles of IL-4, IL-13, and IL-22 in Human Skin Barrier Dysfunction and Atopic Dermatitis
10.1111/all.70060 · 2026 · External reference
Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
10.4049/jimmunol.171.6.3262 · 2003 · External reference
Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship
10.1016/j.tim.2017.11.008 · 2018 · External reference
Staphylococcus aureus: The Bug Behind the Itch in Atopic Dermatitis
10.1016/j.jid.2024.01.001 · 2024 · External reference
Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis
10.1016/j.immuni.2015.03.014 · 2015 · External reference
Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation
10.1073/pnas.2309243121 · 2024 · External reference
Expression of antimicrobial peptides in atopic dermatitis and possible immunoregulatory functions
10.1097/aci.0b013e328364ddfd · 2013 · External reference
Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression
10.1016/j.jid.2016.05.127 · 2016 · External reference
Competition between skin antimicrobial peptides and commensal bacteria in type 2 inflammation enables survival of S. aureus
10.1016/j.celrep.2023.112494 · 2023 · External reference
Crisaborole and atopic dermatitis skin biomarkers: An intrapatient randomized trial
10.1016/j.jaci.2019.06.047 · 2019 · External reference
Oral Janus kinase/SYK inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in patients with atopic dermatitis
10.1016/j.jaci.2019.07.013 · 2019 · External reference
Atopic dermatitis displays stable and dynamic skin transcriptome signatures
10.1016/j.jaci.2020.06.012 · 2021 · External reference
Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab
10.1016/j.jaci.2018.07.028 · 2019 · External reference
Genevestigator V3: A Reference Expression Database for the Meta-Analysis of Transcriptomes
10.1155/2008/420747 · 2008 · External reference
Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract
10.1152/physiolgenomics.00104.2005 · 2005 · External reference
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis
10.1101/gr.131029.111 · 2012 · External reference
UniProt: the Universal Protein Knowledgebase in 2025
2024 · External reference
UCSF ChimeraX: Tools for structure building and analysis
10.1002/pro.4792 · 2023 · External reference
Dermcidin: a novel human antibiotic peptide secreted by sweat glands
10.1038/ni732 · 2001 · External reference
Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo
10.4049/jimmunol.174.12.8003 · 2005 · External reference
The Proteome of Hand Eczema Assessed by Tape Stripping
10.1016/j.jid.2022.12.024 · 2023 · External reference
Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers
10.2337/db20-0188 · 2020 · External reference
Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging
10.18632/aging.100755 · 2015 · External reference
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19
2021 · External reference
Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells
10.4111/kju.2014.55.6.417 · 2014 · External reference
Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21
10.1111/cas.13815 · 2018 · External reference
Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis
10.1016/s0888-7543(02)00034-4 · 2003 · External reference
Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation
10.1186/s12964-024-01637-3 · 2024 · External reference
Dermal adipocytes protect against invasive Staphylococcus aureus skin infection
10.1126/science.1260972 · 2015 · External reference
Staphylococcus aureus in atopic dermatitis: How a common bacterium exploits and drives disease
10.1016/j.jaci.2025.12.1009 · 2026 · External reference
Immunity against Staphylococcus aureus cutaneous infections
10.1038/nri3010 · 2011 · External reference
IL-4 and IL-13 Negatively Regulate TNF-α- and IFN-γ-Induced β-Defensin Expression through STAT-6, Suppressor of Cytokine Signaling (SOCS)-1, and SOCS-31
10.4049/jimmunol.179.2.984 · 2007 · External reference
Interleukin-17A (IL-17A) and IL-17F Are Critical for Antimicrobial Peptide Production and Clearance of Staphylococcus aureus Nasal Colonization
10.1128/iai.00596-16 · 2016 · External reference
Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment
10.1016/j.jaci.2023.05.026 · 2023 · External reference
Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection
10.1038/sj.gt.3302472 · 2005 · External reference
Staphylococcus aureus Susceptibility to Innate Antimicrobial Peptides, β-Defensins and CAP18, Expressed by Human Keratinocytes
10.1128/iai.71.7.3730-3739.2003 · 2003 · External reference
Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes
10.1038/srep37639 · 2016 · External reference
The short proline-rich antibacterial peptide family
10.1007/s00018-002-8493-8 · 2002 · External reference
Mechanisms and regulation of defensins in host defense
10.1038/s41392-023-01553-x · 2023 · External reference
Atopic Dermatitis like mouse model using early inoculation of patient-derived S. aureus together with MC903
10.1016/j.xjidi.2025.100436 · 2026 · External reference
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
10.1038/35023079 · 2000 · External reference
Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis
10.1016/j.jaci.2020.01.042 · 2020 · External reference
Fibroblast-derived CCL2 orchestrates immune responses and defends against Staphylococcus aureus skin infection
10.1038/s41423-026-01442-7 · 2026 · External reference
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts
10.1126/sciimmunol.ads0519 · 2025 · External reference
Jalview Version 2--a multiple sequence alignment editor and analysis workbench
10.1093/bioinformatics/btp033 · 2009 · External reference
APD3: the antimicrobial peptide database as a tool for research and education
10.1093/nar/gkv1278 · 2015 · External reference
Dermal fibroblasts respond to interleukin-4 and 13 and promote T-cell recruitment in atopic dermatitis
10.1172/jci196108 · 2026 · External reference
UCSF ChimeraX: Tools for structure building and analysis
10.1002/pro.4792 · ExternalCitation · doi-reference
Production and characterization of recombinant human beta-defensin DEFB120
10.1002/psc.2611 · ExternalCitation · doi-reference
The short proline-rich antibacterial peptide family
10.1007/s00018-002-8493-8 · ExternalCitation · doi-reference
Competition between skin antimicrobial peptides and commensal bacteria in type 2 inflammation enables survival of S. aureus
10.1016/j.celrep.2023.112494 · ExternalCitation · doi-reference
Antimicrobial peptides
10.1016/j.cub.2015.11.017 · ExternalCitation · doi-reference
Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis
10.1016/j.immuni.2015.03.014 · ExternalCitation · doi-reference
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection
10.1016/j.immuni.2022.06.021 · ExternalCitation · doi-reference
Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab
10.1016/j.jaci.2018.07.028 · ExternalCitation · doi-reference
Crisaborole and atopic dermatitis skin biomarkers: An intrapatient randomized trial
10.1016/j.jaci.2019.06.047 · ExternalCitation · doi-reference
Oral Janus kinase/SYK inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in patients with atopic dermatitis
10.1016/j.jaci.2019.07.013 · ExternalCitation · doi-reference
Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis
10.1016/j.jaci.2020.01.042 · ExternalCitation · doi-reference
Atopic dermatitis displays stable and dynamic skin transcriptome signatures
10.1016/j.jaci.2020.06.012 · ExternalCitation · doi-reference
Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment
10.1016/j.jaci.2023.05.026 · ExternalCitation · doi-reference
Staphylococcus aureus in atopic dermatitis: How a common bacterium exploits and drives disease
10.1016/j.jaci.2025.12.1009 · ExternalCitation · doi-reference
Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression
10.1016/j.jid.2016.05.127 · ExternalCitation · doi-reference
The Proteome of Hand Eczema Assessed by Tape Stripping
10.1016/j.jid.2022.12.024 · ExternalCitation · doi-reference
Staphylococcus aureus: The Bug Behind the Itch in Atopic Dermatitis
10.1016/j.jid.2024.01.001 · ExternalCitation · doi-reference
Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship
10.1016/j.tim.2017.11.008 · ExternalCitation · doi-reference
Atopic Dermatitis like mouse model using early inoculation of patient-derived S. aureus together with MC903
10.1016/j.xjidi.2025.100436 · ExternalCitation · doi-reference
Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis
10.1016/s0888-7543(02)00034-4 · ExternalCitation · doi-reference
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
10.1038/35023079 · ExternalCitation · doi-reference
Human Beta-Defensin 3 Induces Maturation of Human Langerhans Cell–Like Dendritic Cells: An Antimicrobial Peptide that Functions as an Endogenous Adjuvant
10.1038/jid.2012.319 · ExternalCitation · doi-reference
Dermcidin: a novel human antibiotic peptide secreted by sweat glands
10.1038/ni732 · ExternalCitation · doi-reference
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
10.1038/nm1616 · ExternalCitation · doi-reference
The immunology of host defence peptides: beyond antimicrobial activity
10.1038/nri.2016.29 · ExternalCitation · doi-reference
Defensins: antimicrobial peptides of innate immunity
10.1038/nri1180 · ExternalCitation · doi-reference
Immunity against Staphylococcus aureus cutaneous infections
10.1038/nri3010 · ExternalCitation · doi-reference
Epithelial antimicrobial defence of the skin and intestine
10.1038/nri3228 · ExternalCitation · doi-reference
Mechanisms and regulation of defensins in host defense
10.1038/s41392-023-01553-x · ExternalCitation · doi-reference
Fibroblast-derived CCL2 orchestrates immune responses and defends against Staphylococcus aureus skin infection
10.1038/s41423-026-01442-7 · ExternalCitation · doi-reference
Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection
10.1038/sj.gt.3302472 · ExternalCitation · doi-reference
Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes
10.1038/srep37639 · ExternalCitation · doi-reference
Discovery of five conserved β-defensin gene clusters using a computational search strategy
10.1073/pnas.042692699 · ExternalCitation · doi-reference
Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation
10.1073/pnas.2309243121 · ExternalCitation · doi-reference
The Novel Human β-Defensin 114 Regulates Lipopolysaccharide (LPS)-mediated Inflammation and Protects Sperm from Motility Loss∗
10.1074/jbc.m112.411884 · ExternalCitation · doi-reference
Jalview Version 2--a multiple sequence alignment editor and analysis workbench
10.1093/bioinformatics/btp033 · ExternalCitation · doi-reference
APD3: the antimicrobial peptide database as a tool for research and education
10.1093/nar/gkv1278 · ExternalCitation · doi-reference
Expression of antimicrobial peptides in atopic dermatitis and possible immunoregulatory functions
10.1097/aci.0b013e328364ddfd · ExternalCitation · doi-reference
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis
10.1101/gr.131029.111 · ExternalCitation · doi-reference
Distinct Roles of IL-4, IL-13, and IL-22 in Human Skin Barrier Dysfunction and Atopic Dermatitis
10.1111/all.70060 · ExternalCitation · doi-reference
Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21
10.1111/cas.13815 · ExternalCitation · doi-reference
Expression of antimicrobial peptides in cutaneous infections after skin surgery
10.1111/j.1365-2133.2010.09781.x · ExternalCitation · doi-reference
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
10.1126/science.1104742 · ExternalCitation · doi-reference
Dermal adipocytes protect against invasive Staphylococcus aureus skin infection
10.1126/science.1260972 · ExternalCitation · doi-reference
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts
10.1126/sciimmunol.ads0519 · ExternalCitation · doi-reference
A common mutation in the defensin DEFB126 causes impaired sperm function and subfertility
10.1126/scitranslmed.3002289 · ExternalCitation · doi-reference
Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling
10.1126/scitranslmed.abp9675 · ExternalCitation · doi-reference
Interleukin-17A (IL-17A) and IL-17F Are Critical for Antimicrobial Peptide Production and Clearance of Staphylococcus aureus Nasal Colonization
10.1128/iai.00596-16 · ExternalCitation · doi-reference
Staphylococcus aureus Susceptibility to Innate Antimicrobial Peptides, β-Defensins and CAP18, Expressed by Human Keratinocytes
10.1128/iai.71.7.3730-3739.2003 · ExternalCitation · doi-reference
Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract
10.1152/physiolgenomics.00104.2005 · ExternalCitation · doi-reference
Genevestigator V3: A Reference Expression Database for the Meta-Analysis of Transcriptomes
10.1155/2008/420747 · ExternalCitation · doi-reference
Dermal fibroblasts respond to interleukin-4 and 13 and promote T-cell recruitment in atopic dermatitis
10.1172/jci196108 · ExternalCitation · doi-reference
Single-cell and spatial transcriptomic investigation reveals the spatiotemporal specificity of the beta-defensin gene family during mouse sperm maturation
10.1186/s12964-024-01637-3 · ExternalCitation · doi-reference
Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging
10.18632/aging.100755 · ExternalCitation · doi-reference
Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers
10.2337/db20-0188 · ExternalCitation · doi-reference
Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
10.4049/jimmunol.171.6.3262 · ExternalCitation · doi-reference
Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo
10.4049/jimmunol.174.12.8003 · ExternalCitation · doi-reference
IL-4 and IL-13 Negatively Regulate TNF-α- and IFN-γ-Induced β-Defensin Expression through STAT-6, Suppressor of Cytokine Signaling (SOCS)-1, and SOCS-31
10.4049/jimmunol.179.2.984 · ExternalCitation · doi-reference
Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells
10.4111/kju.2014.55.6.417 · ExternalCitation · doi-reference
