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References from Zebrafish larvae reveal early neuropathology and host responses to nervous necrosis virus. Local targets link to admitted publications; unresolved targets remain external evidence.
Orange-spotted grouper IFNh response to NNV or MSRV and its potential antiviral activities
10.1016/j.fsi.2023.109345 · 2024 · External reference
Binding kinetics of grouper nervous necrosis viruses with functionalized antimicrobial peptides by nanomechanical detection
10.1016/j.bios.2011.10.003 · 2012 · External reference
Dual-CRISPR/Cas12a-assisted RT-RAA visualization system for rapid on-site detection of nervous necrosis virus (NNV)
10.1016/j.aca.2024.343469 · 2025 · External reference
Nectin1 is a pivotal host factor involved in attachment and entry of red-spotted grouper nervous necrosis virus in the early stages of the viral life cycle
10.1128/jvi.00901-24 · 2024 · External reference
Establishment of a new intestinal cell line from the grouper (Epinephelus coioides) for aquatic virus pathogenesis
10.1016/j.aquaculture.2022.738771 · 2023 · External reference
Detection of nervous necrosis virus RGNNV genotype in pearl gentian grouper (Epinephelus lanceolatus♂ × E. fuscoguttatus♀) fry imported to Thailand
10.1016/j.aquaculture.2022.738659 · 2022 · External reference
Nervous necrosis virus modulation of European sea bass (Dicentrarchus labrax, L.) immune genes and transcriptome towards establishment of virus carrier state
10.3390/ijms242316613 · 2023 · External reference
Interspecies transmission between Solea senegalensis and Sparus aurata of reassortant nervous necrosis virus (NNV) strains and effect of stress on the outcome of the infection
10.1016/j.aquaculture.2021.737519 · 2022 · External reference
Transcriptomic analysis of fish hosts responses to nervous necrosis virus
10.3390/pathogens11020201 · 2022 · External reference
Two cytokine receptor family B (CRFB) members in orange-spotted grouper Epinephelus coioides, EcCRFB3 and EcCRFB4, negatively regulate interferon immune responses to assist nervous necrosis virus replication
10.1016/j.fsi.2024.109718 · 2024 · External reference
Influence of viral re-infection on head kidney transcriptome of nervous necrosis virus-resistant and -susceptible European sea bass (Dicentrarchus labrax, L.)
10.3390/v17020230 · 2025 · External reference
Zebrafish as a model organism for neurodegenerative disease
10.3389/fnmol.2022.940484 · 2022 · External reference
Importance of the pig as a human biomedical model
10.1126/scitranslmed.abd5758 · 2021 · External reference
Animal models of diabetic microvascular complications: Relevance to clinical features
10.1016/j.biopha.2021.112305 · 2022 · External reference
Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development
10.1016/j.devcel.2023.11.001 · 2023 · External reference
Modelling viral infections using zebrafish: Innate immune response and antiviral research
10.1016/j.antiviral.2016.12.013 · 2017 · External reference
Modeling virus-induced inflammation in zebrafish: A balance between infection control and excessive inflammation
10.3389/fimmu.2021.636623 · 2021 · External reference
Linking virus discovery to immune responses visualized during zebrafish infections
10.1016/j.cub.2020.04.031 · 2020 · External reference
Establishment of an LMBV-infection model in zebrafish larvae and its application in studying virus-host interactions
10.1016/j.aquaculture.2024.741280 · 2024 · External reference
A robust human norovirus replication model in zebrafish larvae
10.1371/journal.ppat.1008009 · 2019 · External reference
Recapitulation of retinal damage in zebrafish larvae infected with Zika virus
10.3390/cells11091457 · 2022 · External reference
Color-Flu fluorescent reporter influenza A viruses allow for in vivo studies of innate immune function in zebrafish
10.3390/v16010155 · 2024 · External reference
Evaluation of zebrafish (Danio rerio) as an animal model for the viral infections of fish
10.1111/jfd.12994 · 2019 · External reference
Pathogenicity study of covert mortality nodavirus (CMNV) infection in zebrafish model
10.1016/j.aquaculture.2021.737378 · 2022 · External reference
Zebrafish (Danio rerio) as a model for the study of vaccination against viral haemorrhagic septicemia virus (VHSV)
10.1016/j.vaccine.2006.05.015 · 2006 · External reference
Screening of freshwater fish species for their susceptibility to a betanodavirus
10.3354/dao01841 · 2007 · External reference
Zebrafish as a vertebrate model for studying nodavirus infections
10.3389/fimmu.2022.863096 · 2022 · External reference
Mortality caused by bath exposure of zebrafish (Danio rerio) larvae to nervous necrosis virus is limited to the fourth day postfertilization
10.1128/aem.04175-14 · 2015 · External reference
Mortality due to viral nervous necrosis in zebrafish Danio rerio and goldfish Carassius auratus
10.3354/dao02605 · 2013 · External reference
Nervous necrosis virus capsid protein and protein A dynamically modulate the fish cGAS-mediated IFN signal pathway to facilitate viral evasion
10.1128/jvi.00686-24 · 2024 · External reference
Betanodavirus infections of teleost fish: A review
10.1046/j.1365-2761.2002.00350.x · 2002 · External reference
Understanding the interaction between betanodavirus and its host for the development of prophylactic measures for viral encephalopathy and retinopathy
10.1016/j.fsi.2016.03.033 · 2016 · External reference
Transcriptome analysis reveals the DNA replication genes response to Vibrio anguillarum and NNV infection in Jinhu grouper (Epinephelus fuscoguttatus♀ × Epinephelus tukula♂)
10.1016/j.cbd.2025.101421 · 2025 · External reference
Transcriptome analysis of genes responding to NNV infection in Asian seabass epithelial cells
10.1016/j.fsi.2016.04.029 · 2016 · External reference
The interferon response is involved in nervous necrosis virus acute and persistent infection in zebrafish infection model
10.1016/j.molimm.2007.07.018 · 2008 · External reference
Phase separation in innate immunity: Teleost IL6Ra's evolutionary leap against viruses
10.1016/j.ijbiomac.2025.147307 · 2025 · External reference
Interleukin-1β secreted from betanodavirus-infected microglia caused the death of neurons in giant grouper brains
10.1016/j.dci.2017.01.002 · 2017 · External reference
Single-cell RNA-seq landscape midbrain cell responses to red spotted grouper nervous necrosis virus infection
10.1371/journal.ppat.1009665 · 2021 · External reference
Functional analysis of a novel MHC-Iα genotype in orange-spotted grouper: Effects on Singapore grouper iridovirus (SGIV) replication and apoptosis
10.1016/j.fsi.2022.01.030 · 2022 · External reference
European sea bass brain DLB-1 cell line is susceptible to nodavirus: A transcriptomic study
10.1016/j.fsi.2018.11.024 · 2019 · External reference
A case report of interspecies transmission of nervous necrosis virus (NNV) between red seabream brood (Pagrus major) and juvenile Pacific cod (Gadus macrocephalus)
10.1016/j.aquaculture.2022.738798 · 2023 · External reference
Betanodavirus genotypes produce clinical signs and mortality in the shi drum (Umbrina cirrosa), and infective particles are isolated from the damaged brain
10.1016/j.aquaculture.2021.736777 · 2021 · External reference
Genes related to cell-mediated cytotoxicity and interferon response are induced in the retina of European sea bass upon intravitreal infection with nodavirus
10.1016/j.fsi.2018.01.034 · 2018 · External reference
Efficacy of live NNV immersion vaccine immunized at low temperature in sevenband grouper, Epinephelus septemfasciatus
10.1016/j.virusres.2020.198227 · 2021 · External reference
Ribosome profiling reveals translational upregulation of cellular oxidative phosphorylation mRNAs during vaccinia virus-induced host shutoff
10.1128/jvi.01858-16 · 2017 · External reference
Enhancement of autophagy can alleviate oxidative stress, inflammation, and apoptosis induced by ammonia stress in yellow catfish Pelteobagrus fulvidraco
10.1016/j.fsi.2024.109582 · 2024 · External reference
JAK-STAT pathway: A novel target to tackle viral infections
10.3390/v13122379 · 2021 · External reference
FOXO signaling pathway participates in oxidative stress-induced histone deacetylation
10.1080/10715762.2023.2190862 · 2023 · External reference
Fish Iridoviridae: Infection, vaccination and immune response
10.1186/s13567-024-01347-1 · 2024 · External reference
The antiviral role of largemouth bass STING against iridovirus infection
10.1016/j.fsi.2024.109480 · 2024 · External reference
Spring viraemia of carp virus modulates p53 expression using two distinct mechanisms
10.1371/journal.ppat.1007695 · 2019 · External reference
Acute infection of viral pathogens and their innate immune escape
10.3389/fmicb.2021.672026 · 2021 · External reference
RGNNV-induced cell cycle arrest at G1/S phase enhanced viral replication via p53-dependent pathway in GS cells
10.1016/j.virusres.2018.06.011 · 2018 · External reference
Unresolved reference
2000 · External reference
Protein A from orange-spotted nervous necrosis virus triggers type I interferon production in fish cells
10.1016/j.fsi.2018.05.006 · 2018 · External reference
Cell culture isolation of piscine neuropathy nodavirus from juvenile sea bass, Dicentrarchus labrax
10.1099/0022-1317-77-9-2067 · 1996 · External reference
Structural analysis and insertion study reveal the ideal sites for surface displaying foreign peptides on a betanodavirus-like particle
10.1186/s13567-015-0294-9 · 2016 · External reference
ZNFX1 functions as a compensatory dsRNA recognition receptor to exert antiviral effect in orange-spotted grouper
10.1371/journal.ppat.1013652 · 2025 · External reference
The first case of infectious spleen and kidney necrosis virus (ISKNV) infection in aquarium-maintained mandarin fish, Siniperca chuatsi (Basilewsky), in Japan
10.1111/jfd.12134 · 2014 · External reference
CNS-derived glia ensheath peripheral nerves and mediate motor root development
10.1038/nn2025 · 2008 · External reference