Research graph
References from Trop-1/EpCAM Thr115 is a driver of hyperproliferative cell repair and of severe lung damage in COVID-19. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review
10.1001/jama.2020.12839 · 2020 · External reference
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
10.1001/jamainternmed.2020.0994 · 2020 · External reference
Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy
10.1001/jamainternmed.2020.3539 · 2020 · External reference
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
10.1056/nejmoa2020283 · 2020 · External reference
Genetic mechanisms of critical illness in COVID-19
10.1038/s41586-020-03065-y · 2021 · External reference
Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
10.1016/j.ajhg.2021.05.017 · 2021 · External reference
Mapping the human genetic architecture of COVID-19
10.1038/s41586-021-03767-x · 2021 · External reference
Whole-genome sequencing reveals host factors underlying critical COVID-19
10.1038/s41586-022-04576-6 · 2022 · External reference
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
10.1126/science.abd4570 · 2020 · External reference
Presence of Genetic Variants Among Young Men With Severe COVID-19
10.1001/jama.2020.13719 · 2020 · External reference
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study
10.7554/elife.67569 · 2021 · External reference
Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19
10.3389/fimmu.2021.719115 · 2021 · External reference
Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males
10.1016/j.ebiom.2021.103246 · 2021 · External reference
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males
10.1080/15548627.2021.1995152 · 2022 · External reference
SELP Asp603Asn and severe thrombosis in COVID-19 males
10.1186/s13045-021-01136-9 · 2021 · External reference
Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients
10.1038/s41435-021-00157-1 · 2022 · External reference
Severe COVID-19 in Hospitalized Carriers of Single CFTR Pathogenic Variants
10.3390/jpm11060558 · 2021 · External reference
Gain- and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes
10.3390/cells11244096 · 2022 · External reference
Trop-1 are conserved growth stimulatory molecules that mark early stages of tumor progression
10.1002/cncr.22785 · 2007 · External reference
Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA
1989 · External reference
Human Trop-2 is a tumor-associated calcium signal transducer
10.1002/(sici)1097-0215(19980529)76:5<671::aid-ijc10>3.0.co;2-7 · 1998 · External reference
Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions
10.1128/mcb.21.7.2570-2580.2001 · 2001 · External reference
Post-Mendelian Genetic Model in COVID-19
10.26502/fccm.92920232 · 2021 · External reference
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
10.1007/s00439-021-02397-7 · 2022 · External reference
Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization
10.1159/000056891 · 2001 · External reference
Cell adhesion molecules, signal transduction and cell growth
10.1016/s0955-0674(99)00045-9 · 1999 · External reference
Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule
10.1083/jcb.125.2.437 · 1994 · External reference
Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM)
10.1074/jbc.m115.662700 · 2015 · External reference
EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion
10.1038/s41598-018-31482-7 · 2018 · External reference
Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins
10.1083/jcb.139.5.1337 · 1997 · External reference
Carcinoma-associated 38-kD membrane glycoprotein MH 99/KS 1/4 is related to proliferation and age of transformed epithelial cell lines
10.1111/1523-1747.ep12384258 · 1994 · External reference
Expression of 38-kD cell-surface glycoprotein in transformed human keratinocyte cell lines, basal cell carcinomas, and epithelial germs
10.1111/1523-1747.ep12873988 · 1990 · External reference
KSA antigen Ep-CAM mediates cell-cell adhesion of pancreatic epithelial cells: morphoregulatory roles in pancreatic islet development
10.1083/jcb.140.6.1519 · 1998 · External reference
Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver
10.1002/(sici)1096-9896(199906)188:2<201::aid-path339>3.0.co;2-8 · 1999 · External reference
Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast
10.1111/j.1432-0436.1998.00201.x · 1998 · External reference
Expression of the homophilic adhesion molecule, Ep-CAM, in the mammalian germ line
10.1530/jrf.0.1160379 · 1999 · External reference
Monoclonal antibody 9C4 recognizes epithelial cellular adhesion molecule, a cell surface antigen expressed in early steps of erythropoiesis
10.1016/s0301-472x(02)00798-1 · 2002 · External reference
Ep-CAM overexpression in breast cancer as a predictor of survival
10.1016/s0140-6736(00)03312-2 · 2000 · External reference
Results of the central data analysis
1991 · External reference
Prospective identification of tumorigenic breast cancer cells
10.1073/pnas.0530291100 · 2003 · External reference
Biochemical and immunological characterization of the human carcinoma-associated antigen MH 99/KS 1/4
10.1002/ijc.2910550619 · 1993 · External reference
Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
10.1172/jci88428 · 2017 · External reference
The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation
10.1038/sj.onc.1207610 · 2004 · External reference
EpCAM-associated claudin-7 supports lymphatic spread and drug resistance in rat pancreatic cancer
10.1002/ijc.28085 · 2013 · External reference
A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression
10.1158/1541-7786.mcr-06-0384 · 2007 · External reference
Metastasis-association of the rat ortholog of the human epithelial glycoprotein antigen EGP314
10.1038/sj.onc.1202542 · 1999 · External reference
Murine monoclonal antibodies raised against human non-small cell carcinoma of the lung: specificity and tumor targeting
1990 · External reference
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
10.1016/0092-8674(87)90646-5 · 1987 · External reference
mTrop1/Epcam knockout mice develop congenital tufting enteropathy through dysregulation of intestinal E-cadherin/beta-catenin
10.1371/journal.pone.0049302 · 2012 · External reference
Trop-2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis
10.1016/j.neo.2021.03.006 · 2021 · External reference
Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study
10.1016/s1473-3099(20)30434-5 · 2020 · External reference
EpCAM Expression is an Indicator of Increased Incidence of Relapse in p53-Positive Breast Cancer
2013 · External reference
Association of the 323/A3 surface glycoprotein with tumor characteristics and behavior in human breast cancer
1990 · External reference
Prognostic significance of Ep-CAM AND Her-2/neu overexpression in invasive breast cancer
10.1002/ijc.10270 · 2002 · External reference
A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population
10.1007/s10549-010-1094-6 · 2011 · External reference
Abandoning the Notion of Non-Small Cell Lung Cancer
10.1016/j.molmed.2019.04.012 · 2019 · External reference
The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung
10.1053/hp.2000.6711 · 2000 · External reference
Immunochemical characterization of two antigens recognized by new monoclonal antibodies against human colon carcinoma
10.4049/jimmunol.136.4.1497 · 1986 · External reference
Crystal structure and its bearing towards an understanding of key biological functions of EpCAM
10.1038/ncomms5764 · 2014 · External reference
Current View on EpCAM Structural Biology
10.3390/cells9061361 · 2020 · External reference
EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome
10.1002/humu.23688 · 2019 · External reference
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
10.1056/nejmoa1913948 · 2021 · External reference
Predicting deleterious amino acid substitutions
10.1101/gr.176601 · 2001 · External reference
EpCAM is involved in maintenance of the murine embryonic stem cell phenotype
10.1002/stem.97 · 2009 · External reference
Trop-2, Na(+)/K(+) ATPase, CD9, PKCalpha, cofilin assemble a membrane signaling super-complex that drives colorectal cancer growth and invasion
10.1038/s41388-022-02220-1 · 2022 · External reference
DNA methylation prevents the amplification of TROP1, a tumor-associated cell surface antigen gene
10.1073/pnas.91.13.5833 · 1994 · External reference
DNA methylation prevents transfection of genes for specific surface antigens
10.1073/pnas.85.22.8391 · 1988 · External reference
Large, recursive membrane platforms are associated to Trop-1, Trop-2, and protein kinase signaling for cell growth
10.1091/mbc.e24-06-0267 · 2025 · External reference
The tumor antigen EpCAM: tetraspanins and the tight junction protein claudin-7, new partners, new functions
10.2741/3121 · 2008 · External reference
The tetraspanin CD9 inhibits the proliferation and tumorigenicity of human colon carcinoma cells
10.1002/ijc.22902 · 2007 · External reference
Molecular subtyping of breast cancer from traditional tumor marker profiles using parallel clustering methods
10.1158/1078-0432.ccr-05-0763 · 2006 · External reference
The Trop-2 signalling network in cancer growth
10.1038/onc.2012.151 · 2013 · External reference
Adaptive immune cells are necessary for SARS-CoV-2-induced pathology
10.1126/sciadv.adg5461 · 2024 · External reference
Tolerogenic Dendritic Cells Induce Apoptosis-Independent T Cell Hyporesponsiveness of SARS-CoV-2-Specific T Cells in an Antigen-Specific Manner
10.3390/ijms232315201 · 2022 · External reference
The relationship between elastin cross linking and alveolar wall rupture in human pulmonary emphysema
10.1152/ajplung.00284.2022 · 2023 · External reference
On liquid diffusion
10.1080/14786445508641925 · 1855 · External reference
How does oxygen diffuse from capillaries to tissue mitochondria? Barriers and pathways
10.1113/jp278815 · 2021 · External reference
O(2) permeability of lipid bilayers is low, but increases with membrane cholesterol
10.1007/s00018-021-03974-9 · 2021 · External reference
An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung
10.1126/science.ado5561 · 2024 · External reference
Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo
10.1073/pnas.1117674109 · 2012 · External reference
Expression of Ep-CAM shifts the state of cadherin-mediated adhesions from strong to weak
10.1016/s0014-4827(02)00045-9 · 2003 · External reference
Nuclear signalling by tumour-associated antigen EpCAM
10.1038/ncb1824 · 2009 · External reference
Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
10.1016/j.immuni.2007.08.015 · 2007 · External reference
EpCAM Signaling Promotes Tumor Progression and Protein Stability of PD-L1 through the EGFR Pathway
10.1158/0008-5472.can-20-1264 · 2020 · External reference
Trop-2 Induces Tumor Growth Through AKT and Determines Sensitivity to AKT Inhibitors
10.1158/1078-0432.ccr-15-1701 · 2016 · External reference
