Research graph
References from FoxO transcription factors coordinate the urea cycle and gluconeogenesis by controlling Ass1. Local targets link to admitted publications; unresolved targets remain external evidence.
Amino Acid Nutrition and Metabolism in Health and Disease
10.3390/nu11112623 · 2019 · External reference
A nutrigenomics view of protein intake: Macronutrient, bioactive peptides, and protein turnover
10.1016/b978-0-12-398397-8.00003-4 · 2012 · External reference
Amino acid metabolism in health and disease
10.1038/s41392-023-01569-3 · 2023 · External reference
Amino Acid Catabolism: An Overlooked Area of Metabolism
10.3390/nu15153378 · 2023 · External reference
Amino acid metabolism, transport and signaling in the liver revisited
10.1016/j.bcp.2022.115074 · 2022 · External reference
Amino acid profiles of young adults differ by sex, body mass index and insulin resistance
10.1016/j.numecd.2018.01.001 · 2018 · External reference
Unresolved reference
2015 · External reference
Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans
10.1152/physrev.1992.72.2.419 · 1992 · External reference
Metabolic evidence for adaptation to a high protein diet in rats
10.1093/jn/131.1.91 · 2001 · External reference
Roles of malate and aspartate in gluconeogenesis in various physiological and pathological states
10.1016/j.metabol.2023.155614 · 2023 · External reference
Interrelationships between ureogenesis and gluconeogensis in perfused rat liver
10.1016/0304-4165(93)90010-6 · 1993 · External reference
Variations produced by food differences in the concentration of arginase in the livers of white rats
10.1016/s0021-9258(18)73652-1 · 1939 · External reference
Data mining approaches for understanding of regulation of expression of the urea cycle genes
2018 · External reference
Regulation of enzymes of the urea cycle and arginine metabolism
10.1146/annurev.nutr.22.110801.140547 · 2002 · External reference
The urea cycle: Teaching intermediary metabolism in a physiological setting
10.1002/bmb.2003.494031050249 · 2003 · External reference
Adaptive characteristics of urea cycle enzymes in the rat
10.1016/s0021-9258(18)93943-8 · 1962 · External reference
Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver
10.1016/s0021-9258(19)73959-3 · 1962 · External reference
Effects of insulin and glucose on urea synthesis in normal man, independent of pancreatic hormone secretion
10.1016/s0168-8278(05)80317-4 · 1994 · External reference
Effects of growth hormone and insulin-like growth factor-I singly and in combination on in vivo capacity of urea synthesis, gene expression of urea cycle enzymes, and organ nitrogen contents in rats
10.1002/hep.510250429 · 1997 · External reference
Glucose and Insulin Differently Regulate Gluconeogenic and Ureagenic Gene Expression
10.3177/jnsv.71.46 · 2025 · External reference
Transcriptional regulation of genes for ornithine cycle enzymes
10.1042/bj3120649 · 1995 · External reference
Protein turnover, ureagenesis and gluconeogenesis
10.1024/0300-9831/a000064 · 2011 · External reference
Amino acid ingestion and glucose metabolism—a review
10.1002/iub.375 · 2010 · External reference
Fasting hormones synergistically induce amino acid catabolism genes to promote gluconeogenesis
10.1016/j.jcmgh.2021.04.017 · 2021 · External reference
Unresolved reference
2010 · External reference
Understanding the interrelationship between the synthesis of urea and gluconeogenesis by formulating an overall balanced equation
10.1152/advan.00180.2016 · 2017 · External reference
Unresolved reference
1914 · External reference
Untersuchungen uber die Harnstoffbildung im Tierkörper
10.1007/bf01757657 · 1932 · External reference
The role of citric acid in intermediate metabolism in animal tissues
10.1016/0014-5793(80)80564-3 · 1980 · External reference
Regulation of gluconeogenesis by Krüppel-like factor 15
10.1016/j.cmet.2007.03.002 · 2007 · External reference
Krüppel-like factors: three fingers in many pies
10.1074/jbc.r100043200 · 2001 · External reference
Sp1-and Krüppel-like transcription factors
10.1186/gb-2003-4-2-206 · 2003 · External reference
Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity
10.1016/j.phrs.2017.12.018 · 2018 · External reference
Klf15 orchestrates circadian nitrogen homeostasis
10.1016/j.cmet.2012.01.020 · 2012 · External reference
High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways
10.1016/j.bbrc.2021.10.027 · 2021 · External reference
KLF15 enables rapid switching between lipogenesis and gluconeogenesis during fasting
10.1016/j.celrep.2016.07.069 · 2016 · External reference
Role of Krüppel-like factor 15 in PEPCK gene expression in the liver
10.1016/j.bbrc.2004.12.096 · 2005 · External reference
FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin
10.1016/j.isci.2021.103446 · 2021 · External reference
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
10.1111/acel.12427 · 2016 · External reference
Therapeutic strategies targeting FOXO transcription factors
10.1038/s41573-020-0088-2 · 2021 · External reference
FOXOs: signalling integrators for homeostasis maintenance
10.1038/nrm3507 · 2013 · External reference
Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins
10.1074/jbc.m004898200 · 2000 · External reference
Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity
10.1074/jbc.m003616200 · 2000 · External reference
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
10.1038/nature01667 · 2003 · External reference
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
10.1016/j.cmet.2007.08.006 · 2007 · External reference
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
2006 · External reference
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression
10.1074/jbc.m600272200 · 2006 · External reference
FoxO transcription factors regulate urea cycle through Ass1
10.1016/j.bbrc.2024.150594 · 2024 · External reference
Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis
10.1371/journal.pone.0074340 · 2013 · External reference
Dynamics of complex feedback architectures in metabolic pathways
10.1016/j.automatica.2018.10.046 · 2019 · External reference
Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver
10.1371/journal.pbio.2006249 · 2018 · External reference
Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit
10.1074/jbc.m109.096107 · 2010 · External reference
GR-KLF15 pathway controls hepatic lipogenesis during fasting
10.1111/febs.16957 · 2024 · External reference
Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex
10.1002/1873-3468.13328 · 2019 · External reference
Genome-wide screening of upstream transcription factors using an expression library
10.12688/f1000research.27532.2 · 2021 · External reference
Biological robustness
10.1038/nrg1471 · 2004 · External reference
Argininosuccinate synthase: at the center of arginine metabolism
2010 · External reference
Argininosuccinate synthetase from the urea cycle to the citrulline–NO cycle
10.1046/j.1432-1033.2003.03559.x · 2003 · External reference
Synergistic activation of a human promoter in vivo by transcription factor Sp1
1991 · External reference
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
10.1016/s0092-8674(00)80595-4 · 1999 · External reference
FoxO1 as a tissue-specific therapeutic target for type 2 diabetes
10.3389/fendo.2023.1286838 · 2023 · External reference
Hepatic transcriptional responses to fasting and feeding
10.1101/gad.348340.121 · 2021 · External reference
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
10.1038/ncomms6190 · 2014 · External reference
Genetic compensation: A phenomenon in search of mechanisms
10.1371/journal.pgen.1006780 · 2017 · External reference
The recent advances and future perspectives of genetic compensation studies in the zebrafish model
10.1016/j.gendis.2021.12.003 · 2023 · External reference
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
10.1172/jci119746 · 1997 · External reference
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis
10.1016/j.ymgme.2010.05.004 · 2010 · External reference
Unresolved reference
2006 · External reference
Current Understanding of Pathogenic Mechanisms and Disease Models of Citrin Deficiency
10.1002/jimd.70021 · 2025 · External reference
Aspartate-glutamate carrier 2 (citrin): a role in glucose and amino acid metabolism in the liver
10.5483/bmbrep.2023-0052 · 2023 · External reference
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy
10.1073/pnas.0701981104 · 2007 · External reference
Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene
10.1074/jbc.m005353200 · 2000 · External reference
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression
10.1016/j.bbrc.2007.08.165 · 2007 · External reference
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lepob/Lepob mice
10.1074/jbc.m201584200 · 2002 · External reference
p53 Activation in adipocytes of obese mice
10.1074/jbc.m302364200 · 2003 · External reference
p53 involvement in the pathogenesis of fatty liver disease
10.1074/jbc.m400884200 · 2004 · External reference
Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex
10.1002/1873-3468.13328 · ExternalCitation · doi-reference
The urea cycle: Teaching intermediary metabolism in a physiological setting
10.1002/bmb.2003.494031050249 · ExternalCitation · doi-reference
Effects of growth hormone and insulin-like growth factor-I singly and in combination on in vivo capacity of urea synthesis, gene expression of urea cycle enzymes, and organ nitrogen contents in rats
10.1002/hep.510250429 · ExternalCitation · doi-reference
Amino acid ingestion and glucose metabolism—a review
10.1002/iub.375 · ExternalCitation · doi-reference
Current Understanding of Pathogenic Mechanisms and Disease Models of Citrin Deficiency
10.1002/jimd.70021 · ExternalCitation · doi-reference
Untersuchungen uber die Harnstoffbildung im Tierkörper
10.1007/bf01757657 · ExternalCitation · doi-reference
The role of citric acid in intermediate metabolism in animal tissues
10.1016/0014-5793(80)80564-3 · ExternalCitation · doi-reference
Interrelationships between ureogenesis and gluconeogensis in perfused rat liver
10.1016/0304-4165(93)90010-6 · ExternalCitation · doi-reference
A nutrigenomics view of protein intake: Macronutrient, bioactive peptides, and protein turnover
10.1016/b978-0-12-398397-8.00003-4 · ExternalCitation · doi-reference
Dynamics of complex feedback architectures in metabolic pathways
10.1016/j.automatica.2018.10.046 · ExternalCitation · doi-reference
Role of Krüppel-like factor 15 in PEPCK gene expression in the liver
10.1016/j.bbrc.2004.12.096 · ExternalCitation · doi-reference
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression
10.1016/j.bbrc.2007.08.165 · ExternalCitation · doi-reference
High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways
10.1016/j.bbrc.2021.10.027 · ExternalCitation · doi-reference
FoxO transcription factors regulate urea cycle through Ass1
10.1016/j.bbrc.2024.150594 · ExternalCitation · doi-reference
Amino acid metabolism, transport and signaling in the liver revisited
10.1016/j.bcp.2022.115074 · ExternalCitation · doi-reference
KLF15 enables rapid switching between lipogenesis and gluconeogenesis during fasting
10.1016/j.celrep.2016.07.069 · ExternalCitation · doi-reference
Regulation of gluconeogenesis by Krüppel-like factor 15
10.1016/j.cmet.2007.03.002 · ExternalCitation · doi-reference
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
10.1016/j.cmet.2007.08.006 · ExternalCitation · doi-reference
Klf15 orchestrates circadian nitrogen homeostasis
10.1016/j.cmet.2012.01.020 · ExternalCitation · doi-reference
The recent advances and future perspectives of genetic compensation studies in the zebrafish model
10.1016/j.gendis.2021.12.003 · ExternalCitation · doi-reference
FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin
10.1016/j.isci.2021.103446 · ExternalCitation · doi-reference
Fasting hormones synergistically induce amino acid catabolism genes to promote gluconeogenesis
10.1016/j.jcmgh.2021.04.017 · ExternalCitation · doi-reference
Roles of malate and aspartate in gluconeogenesis in various physiological and pathological states
10.1016/j.metabol.2023.155614 · ExternalCitation · doi-reference
Amino acid profiles of young adults differ by sex, body mass index and insulin resistance
10.1016/j.numecd.2018.01.001 · ExternalCitation · doi-reference
Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity
10.1016/j.phrs.2017.12.018 · ExternalCitation · doi-reference
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis
10.1016/j.ymgme.2010.05.004 · ExternalCitation · doi-reference
Variations produced by food differences in the concentration of arginase in the livers of white rats
10.1016/s0021-9258(18)73652-1 · ExternalCitation · doi-reference
Adaptive characteristics of urea cycle enzymes in the rat
10.1016/s0021-9258(18)93943-8 · ExternalCitation · doi-reference
Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver
10.1016/s0021-9258(19)73959-3 · ExternalCitation · doi-reference
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
10.1016/s0092-8674(00)80595-4 · ExternalCitation · doi-reference
Effects of insulin and glucose on urea synthesis in normal man, independent of pancreatic hormone secretion
10.1016/s0168-8278(05)80317-4 · ExternalCitation · doi-reference
Protein turnover, ureagenesis and gluconeogenesis
10.1024/0300-9831/a000064 · ExternalCitation · doi-reference
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
10.1038/nature01667 · ExternalCitation · doi-reference
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
10.1038/ncomms6190 · ExternalCitation · doi-reference
Biological robustness
10.1038/nrg1471 · ExternalCitation · doi-reference
FOXOs: signalling integrators for homeostasis maintenance
10.1038/nrm3507 · ExternalCitation · doi-reference
Amino acid metabolism in health and disease
10.1038/s41392-023-01569-3 · ExternalCitation · doi-reference
Therapeutic strategies targeting FOXO transcription factors
10.1038/s41573-020-0088-2 · ExternalCitation · doi-reference
Transcriptional regulation of genes for ornithine cycle enzymes
10.1042/bj3120649 · ExternalCitation · doi-reference
Argininosuccinate synthetase from the urea cycle to the citrulline–NO cycle
10.1046/j.1432-1033.2003.03559.x · ExternalCitation · doi-reference
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy
10.1073/pnas.0701981104 · ExternalCitation · doi-reference
Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity
10.1074/jbc.m003616200 · ExternalCitation · doi-reference
Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins
10.1074/jbc.m004898200 · ExternalCitation · doi-reference
Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene
10.1074/jbc.m005353200 · ExternalCitation · doi-reference
Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit
10.1074/jbc.m109.096107 · ExternalCitation · doi-reference
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lepob/Lepob mice
10.1074/jbc.m201584200 · ExternalCitation · doi-reference
p53 Activation in adipocytes of obese mice
10.1074/jbc.m302364200 · ExternalCitation · doi-reference
p53 involvement in the pathogenesis of fatty liver disease
10.1074/jbc.m400884200 · ExternalCitation · doi-reference
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression
10.1074/jbc.m600272200 · ExternalCitation · doi-reference
Krüppel-like factors: three fingers in many pies
10.1074/jbc.r100043200 · ExternalCitation · doi-reference
Metabolic evidence for adaptation to a high protein diet in rats
10.1093/jn/131.1.91 · ExternalCitation · doi-reference
Hepatic transcriptional responses to fasting and feeding
10.1101/gad.348340.121 · ExternalCitation · doi-reference
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
10.1111/acel.12427 · ExternalCitation · doi-reference
GR-KLF15 pathway controls hepatic lipogenesis during fasting
10.1111/febs.16957 · ExternalCitation · doi-reference
Regulation of enzymes of the urea cycle and arginine metabolism
10.1146/annurev.nutr.22.110801.140547 · ExternalCitation · doi-reference
Understanding the interrelationship between the synthesis of urea and gluconeogenesis by formulating an overall balanced equation
10.1152/advan.00180.2016 · ExternalCitation · doi-reference
Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans
10.1152/physrev.1992.72.2.419 · ExternalCitation · doi-reference
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
10.1172/jci119746 · ExternalCitation · doi-reference
Sp1-and Krüppel-like transcription factors
10.1186/gb-2003-4-2-206 · ExternalCitation · doi-reference
Genome-wide screening of upstream transcription factors using an expression library
10.12688/f1000research.27532.2 · ExternalCitation · doi-reference
Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver
10.1371/journal.pbio.2006249 · ExternalCitation · doi-reference
Genetic compensation: A phenomenon in search of mechanisms
10.1371/journal.pgen.1006780 · ExternalCitation · doi-reference
Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis
10.1371/journal.pone.0074340 · ExternalCitation · doi-reference
Glucose and Insulin Differently Regulate Gluconeogenic and Ureagenic Gene Expression
10.3177/jnsv.71.46 · ExternalCitation · doi-reference
FoxO1 as a tissue-specific therapeutic target for type 2 diabetes
10.3389/fendo.2023.1286838 · ExternalCitation · doi-reference
Amino Acid Nutrition and Metabolism in Health and Disease
10.3390/nu11112623 · ExternalCitation · doi-reference
Amino Acid Catabolism: An Overlooked Area of Metabolism
10.3390/nu15153378 · ExternalCitation · doi-reference
Aspartate-glutamate carrier 2 (citrin): a role in glucose and amino acid metabolism in the liver
10.5483/bmbrep.2023-0052 · ExternalCitation · doi-reference
