Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from RhoA through its various effectors mediate mitochondrial fragmentation in polycystic kidney disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Polycystic kidney disease
10.1038/s41572-018-0047-y · 2018 · External reference
Physiologic mechanisms underlying polycystic kidney disease
10.1152/physrev.00018.2024 · 2025 · External reference
Autosomal Dominant Polycystic Kidney Disease: A Review
10.1001/jama.2025.0310 · 2025 · External reference
Mechanisms of Cyst Development in Polycystic Kidney Disease
10.1053/j.akdh.2023.03.001 · 2023 · External reference
Inflammation and Fibrosis in Polycystic Kidney Disease
10.1007/978-3-319-51436-9_12 · 2017 · External reference
Polycystic Kidney Disease and Renal Fibrosis
10.1007/978-981-13-8871-2_5 · 2019 · External reference
A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease
10.1101/gad.315127.118 · 2018 · External reference
Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling
10.1172/jci.insight.135385 · 2020 · External reference
Myocardin-Related Transcription Factor Mediates Epithelial Fibrogenesis in Polycystic Kidney Disease
10.3390/cells13110984 · 2024 · External reference
Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3
10.1083/jcb.200906155 · 2010 · External reference
Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFbeta-regulated Smad3
10.1038/ncomms11642 · 2016 · External reference
Profibrotic epithelial phenotype: a central role for MRTF and TAZ
10.1038/s41598-019-40764-7 · 2019 · External reference
MRTF: Basic Biology and Role in Kidney Disease
10.3390/ijms22116040 · 2021 · External reference
Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression
10.1096/fj.201901739rr · 2020 · External reference
A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed
10.1038/s41598-018-20856-6 · 2018 · External reference
Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease
10.1016/j.ebiom.2016.01.027 · 2016 · External reference
Metabolism and mitochondria in polycystic kidney disease research and therapy
10.1038/s41581-018-0051-1 · 2018 · External reference
The pathobiology of polycystic kidney disease from a metabolic viewpoint
10.1038/s41581-019-0183-y · 2019 · External reference
Metabolic reprogramming and the role of mitochondria in polycystic kidney disease
10.1016/j.cellsig.2019.109495 · 2020 · External reference
The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion
10.1038/s41467-023-37449-1 · 2023 · External reference
Metabolic reprogramming in polycystic kidney disease and other renal ciliopathies
10.1038/s44321-025-00239-x · 2025 · External reference
The Mitochondrial Ca(2+) import complex is altered in ADPKD
10.1016/j.ceca.2021.102501 · 2022 · External reference
Polycystin 2 regulates mitochondrial Ca(2+) signaling, bioenergetics, and dynamics through mitofusin 2
10.1126/scisignal.aat7397 · 2019 · External reference
The multiple links between actin and mitochondria
10.1038/s41580-023-00613-y · 2023 · External reference
Mitochondrial fission - changing perspectives for future progress
10.1242/jcs.263640 · 2025 · External reference
Rho signaling research: history, current status and future directions
10.1002/1873-3468.13087 · 2018 · External reference
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2
10.1126/science.1228360 · 2013 · External reference
A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division
10.7554/elife.08828 · 2015 · External reference
Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites
10.7554/elife.11553 · 2015 · External reference
INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division
10.1083/jcb.201709111 · 2018 · External reference
The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2
10.1016/j.devcel.2010.04.001 · 2010 · External reference
Formins as effector proteins of Rho GTPases
10.4161/sgtp.29513 · 2014 · External reference
Regulation of formin INF2 and its alteration in INF2-linked inherited disorders
10.1007/s00018-024-05499-3 · 2024 · External reference
Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling
10.1681/asn.2012080834 · 2013 · External reference
Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis
10.1096/fj.202100067r · 2021 · External reference
Molecular mechanisms of mitochondrial dynamics
10.1038/s41580-024-00785-1 · 2025 · External reference
RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria
10.1038/s41418-022-01032-w · 2022 · External reference
A mitochondrial delicacy: dynamin-related protein 1 and mitochondrial dynamics
10.1152/ajpcell.00042.2018 · 2018 · External reference
Parkin suppresses Drp1-independent mitochondrial division
10.1016/j.bbrc.2016.05.038 · 2016 · External reference
Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
10.1038/s41467-020-14885-x · 2020 · External reference
Endotoxemia Engages the RhoA Kinase Pathway to Impair Cardiac Function By Altering Cytoskeleton, Mitochondrial Fission, and Autophagy
10.1089/ars.2015.6421 · 2016 · External reference
TNF-alpha induces Drp1-mediated mitochondrial fragmentation during inflammatory cardiomyocyte injury
2018 · External reference
RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes
10.1016/j.cellsig.2018.06.012 · 2018 · External reference
Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1
10.1111/j.1749-6632.2010.05629.x · 2010 · External reference
Posttranslational modifications of mitochondrial fission and fusion proteins in cardiac physiology and pathophysiology
10.1152/ajpcell.00523.2018 · 2019 · External reference
Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission
10.1016/j.cub.2005.02.064 · 2005 · External reference
Formin proteins: a domain-based approach
10.1016/j.tibs.2005.04.014 · 2005 · External reference
Mechanisms of formin-mediated actin assembly and dynamics
10.1007/s12551-018-0468-6 · 2018 · External reference
Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly
10.1016/j.chembiol.2009.10.006 · 2009 · External reference
The DIAPH3 linker specifies a beta-actin network that maintains RhoA and Myosin-II at the cytokinetic furrow
10.1038/s41467-024-49427-2 · 2024 · External reference
The formin mDia2 stabilizes microtubules independently of its actin nucleation activity
10.1083/jcb.200709029 · 2008 · External reference
Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2)
10.1073/pnas.1017010108 · 2011 · External reference
An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells
10.1091/mbc.e15-07-0489 · 2016 · External reference
The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization
10.1091/mbc.02-06-0092 · 2002 · External reference
Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1
10.1074/jbc.m411605200 · 2005 · External reference
Enhancement of mDia2 activity by Rho-kinase-dependent phosphorylation of the diaphanous autoregulatory domain
10.1042/bj20101700 · 2011 · External reference
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells
10.1016/s0165-6147(00)01596-0 · 2001 · External reference
A role for myosin II in mammalian mitochondrial fission
10.1016/j.cub.2013.12.032 · 2014 · External reference
Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge
10.1042/bj20021559 · 2003 · External reference
Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na+-K+-2Cl- cotransporter?
10.1152/ajpcell.00631.2004 · 2005 · External reference
Revisiting the gene mutations and protein profile of WT 9-12: An autosomal dominant polycystic kidney disease cell line
10.1111/gtc.13129 · 2024 · External reference
Determinants and outcomes of mitochondrial dynamics
10.1016/j.molcel.2023.02.012 · 2023 · External reference
Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes
10.1016/j.redox.2020.101660 · 2020 · External reference
Inhibition of Mitochondrial Dynamics by Mitochondrial Division Inhibitor-1 Suppresses Cell Migration and Metastatic Markers in Colorectal Cancer HCT116 Cells
10.2147/jep.s510578 · 2025 · External reference
Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA
10.1074/jbc.m114.547596 · 2014 · External reference
Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission
10.1016/j.jbc.2023.103067 · 2023 · External reference
Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling
10.1016/j.freeradbiomed.2024.05.019 · 2024 · External reference
Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif
10.1371/journal.pone.0008045 · 2009 · External reference
Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
10.1038/s41419-024-06448-5 · 2024 · External reference
Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease
10.1128/mcb.00337-17 · 2017 · External reference
Reactive Oxygen Species in Cystic Kidney Disease
2024 · External reference
Decoupling shear stress and pressure effects in the biomechanics of autosomal dominant polycystic kidney disease using a perfused kidney-on-chip
10.1016/j.actbio.2025.03.022 · 2025 · External reference
Ketamine Induces Mitochondrial Fission and Dysfunction in Cervical Cancer Cells via RhoA-Dependent DRP-1 Activation
10.1002/jbt.70500 · 2025 · External reference
Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission
10.3389/fcell.2025.1481756 · 2025 · External reference
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
10.1074/jbc.275.5.3577 · 2000 · External reference
Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation
10.1016/j.cellsig.2012.11.001 · 2013 · External reference
Actin(g) on mitochondria - a role for cofilin1 in neuronal cell death pathways
10.1515/hsz-2019-0120 · 2019 · External reference
Cofilin(s) and Mitochondria: Function Beyond Actin Dynamics
10.3390/ijms26094094 · 2025 · External reference
Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission
10.1038/cddis.2017.448 · 2017 · External reference
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia
10.1083/jcb.145.5.1009 · 1999 · External reference
A common cofilin activity cycle in invasive tumor cells and inflammatory cells
10.1242/jcs.031146 · 2009 · External reference
ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis
10.1186/s13046-020-01545-7 · 2020 · External reference
Mitochondrial translocation of cofilin is an early step in apoptosis induction
10.1038/ncb1070 · 2003 · External reference
Mitochondrial fission and mitophagy depend on cofilin-mediated actin depolymerization activity at the mitochondrial fission site
10.1038/s41388-017-0064-4 · 2018 · External reference
Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission
10.1083/jcb.201404050 · 2015 · External reference
Inverted formins: A subfamily of atypical formins
10.1002/cm.21409 · 2017 · External reference
Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors
10.1242/jcs.234435 · 2019 · External reference
Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
10.1016/j.cub.2022.02.058 · 2022 · External reference
Ultrastructure and dynamics of the actin-myosin II cytoskeleton during mitochondrial fission
10.1038/s41556-019-0313-6 · 2019 · External reference
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase
10.1152/physrev.00023.2003 · 2003 · External reference
Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions
10.4161/sgtp.29846 · 2014 · External reference
Distinct fission signatures predict mitochondrial degradation or biogenesis
10.1038/s41586-021-03510-6 · 2021 · External reference
Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis
10.1002/jcp.21051 · 2007 · External reference
SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission
10.1083/jcb.202406017 · 2025 · External reference
RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether
10.1038/s41467-025-66138-4 · 2025 · External reference
Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease
10.1016/j.devcel.2005.12.005 · 2006 · External reference
Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus
10.1172/jci21753 · 2004 · External reference
Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling
10.1093/hmg/ddn208 · 2008 · External reference
Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction
10.1016/j.jbc.2023.105158 · 2023 · External reference
Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis
10.1038/s41419-019-2218-5 · 2020 · External reference
ROS-Drp1-mitophagy feedback loop regulates myogenic differentiation via actin cytoskeleton remodeling-mediated MRTF-A/SRF axis
10.1080/13510002.2025.2536400 · 2025 · External reference
Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway
10.1091/mbc.e06-07-0602 · 2007 · External reference
TGF-beta1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism
10.1074/jbc.m117.780502 · 2017 · External reference
Regulation of the RhoA exchange factor GEF-H1 by profibrotic stimuli through a positive feedback loop involving RhoA, MRTF, and Sp1
10.1152/ajpcell.00088.2024 · 2024 · External reference
Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli
2025 · External reference
Folding latency of fluorescent proteins affects the mitochondrial localization of fusion proteins
10.1247/csf.19028 · 2019 · External reference
Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas
10.1074/jbc.275.13.9725 · 2000 · External reference
An optogenetic tool for the activation of endogenous diaphanous-related formins induces thickening of stress fibers without an increase in contractility
10.1002/cm.21115 · 2013 · External reference
Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator
10.1038/s41467-017-01231-x · 2017 · External reference
Force-dependent activation of actin elongation factor mDia1 protects the cytoskeleton from mechanical damage and promotes stress fiber repair
10.1016/j.devcel.2021.11.004 · 2021 · External reference
The diaphanous inhibitory domain/diaphanous autoregulatory domain interaction is able to mediate heterodimerization between mDia1 and mDia2
10.1074/jbc.m703834200 · 2007 · External reference
Regulation of polycystin-1 function by calmodulin binding
10.1371/journal.pone.0161525 · 2016 · External reference