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References from VWA2 fuels colon cancer growth and immune evasion through Wnt/β-catenin signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
A comprehensive framework for early-onset colorectal cancer research
10.1016/s1470-2045(21)00588-x · 2022 · External reference
Colorectal cancer
10.1016/s0140-6736(19)32319-0 · 2019 · External reference
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
10.1007/s10555-023-10158-3 · 2024 · External reference
The Rise of Early-Onset Colorectal Cancer: Clinical Characteristics and Outcomes in a Young Patient Population
10.2147/cmar.s554044 · 2025 · External reference
Colorectal Cancer: Preoperative Evaluation and Staging
10.1016/j.soc.2021.12.001 · 2022 · External reference
AMACO is a component of the basement membrane-associated Fraser complex
10.1038/jid.2013.492 · 2014 · External reference
A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13
10.1182/blood-2010-11-321596 · 2011 · External reference
IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family
10.1196/annals.1337.024 · 2004 · External reference
Contribution of homozygous and compound heterozygous missense mutations in VWA2 to Alzheimer's disease
10.1016/j.neurobiolaging.2020.09.009 · 2021 · External reference
A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux
10.1371/journal.pone.0191224 · 2018 · External reference
Epigenetic and transcriptional dysregulation of VWA2 associated with a MYC-driven oncogenic program in colorectal cancer
10.1038/s41598-018-29378-7 · 2018 · External reference
Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review
10.1001/jama.2021.0106 · 2021 · External reference
Colorectal cancer surgery in octogenarians: real-world long-term results
10.1007/s00423-023-03201-y · 2023 · External reference
Predictive Factors for Anastomotic Leakage Following Colorectal Cancer Surgery: Where Are We and Where Are We Going?
10.3390/curroncol30030236 · 2023 · External reference
Recent Advances in the Treatment of Colorectal Cancer: A Review
10.1272/jnms.jnms.2022_89-310 · 2022 · External reference
Cancer statistics for American Indian and Alaska Native individuals, 2022: Including increasing disparities in early onset colorectal cancer
2023 · External reference
Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
10.1001/jama.2016.3332 · 2016 · External reference
Increasing Incidence of Early-Onset Colorectal Cancer
10.1056/nejmra2200869 · 2022 · External reference
Molecular pathological classification of colorectal cancer
10.1007/s00428-016-1956-3 · 2016 · External reference
Wnt/beta-catenin signalling: function, biological mechanisms, and therapeutic opportunities
10.1038/s41392-021-00762-6 · 2022 · External reference
Wnt/β-catenin signaling in cancers and targeted therapies
10.1038/s41392-021-00701-5 · 2021 · External reference
Targeting the Wnt/β-catenin signaling pathway in cancer
10.1186/s13045-020-00990-3 · 2020 · External reference
Wnt signaling in cancer
10.1038/onc.2016.304 · 2017 · External reference
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
10.1186/s13045-024-01563-4 · 2024 · External reference
Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
10.1186/s12943-022-01616-7 · 2022 · External reference
Tumor microenvironment as a therapeutic target in cancer
10.1016/j.pharmthera.2020.107753 · 2021 · External reference
Spatial profiling technologies illuminate the tumor microenvironment
10.1016/j.ccell.2023.01.010 · 2023 · External reference
The updated landscape of tumor microenvironment and drug repurposing
10.1038/s41392-020-00280-x · 2020 · External reference
Roles of macrophages in tumor development: a spatiotemporal perspective
10.1038/s41423-023-01061-6 · 2023 · External reference
CD8+ T cell exhaustion and cancer immunotherapy
2023 · External reference
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
10.1016/j.cell.2024.03.011 · 2024 · External reference
CD8+ T cell-based cancer immunotherapy
10.1186/s12967-024-05134-6 · 2024 · External reference
CAR-T Cell Therapy: the Efficacy and Toxicity Balance
10.1007/s11899-023-00687-7 · 2023 · External reference
