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References from A systematic transcriptomic atlas and predictive framework for metabolite-driven T cell state transitions. Local targets link to admitted publications; unresolved targets remain external evidence.
Gut microbiota, metabolites and host immunity
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The role of gut microbial metabolites in the T cell lifecycle
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Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer
10.1038/s41467-021-24331-1 · 2021 · External reference
Gut-derived metabolites drive Th17 cell pathogenicity in multiple sclerosis
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Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration
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Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation
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Inosine induces stemness features in CAR-T cells and enhances potency
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Modulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells
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Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses
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Highly multiplexed design of an allosteric transcription factor to sense new ligands
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DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery
10.1021/acschembio.1c00920 · 2022 · External reference
DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery
10.1038/s41467-018-06500-x · 2018 · External reference
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2025 · External reference
Transfer learning enables predictions in network biology
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Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines
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Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes
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Cellular metabolism regulates the differentiation and function of T-cell subsets
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Nutrient allocation fuels T cell-mediated immunity
10.1016/j.cmet.2025.09.008 · 2025 · External reference
STAT3 Role in T-Cell Memory Formation
10.3390/ijms23052878 · 2022 · External reference
Transcriptional programing of T cell metabolism by STAT family transcription factors
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10.1016/j.cmet.2017.06.016 · 2017 · External reference
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Hormesis: Path and Progression to Significance
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Unravelling the pathogenesis of inflammatory bowel disease
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A strategy for liver selective NRF2 induction via cytochrome P450-activated prodrugs with low activity in hypoxia
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Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: inhibition of microglial neurotoxicity
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Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice
10.4049/jimmunol.1701734 · 2018 · External reference
The Aryl Hydrocarbon Receptor (AHR) as a Potential Target for the Control of Intestinal Inflammation: Insights from an Immune and Bacteria Sensor Receptor
10.1007/s12016-020-08789-3 · 2020 · External reference
Activation of the aryl hydrocarbon receptor inhibits the development of experimental autoimmune pancreatitis through IL-22-mediated signaling pathways
10.1093/cei/uxad040 · 2023 · External reference
Folic acid intervention changes liver Foxp3 methylation and ameliorates the damage caused by Th17/Treg imbalance after long-term alcohol exposure
10.1039/d1fo04267j · 2022 · External reference
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
10.1038/s41467-021-22173-5 · 2021 · External reference
Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro
10.4049/jimmunol.173.5.3186 · 2004 · External reference
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor
10.1016/j.immuni.2007.04.017 · 2007 · External reference
Aromatic microbial metabolite hippuric acid enhances inflammatory responses in macrophages via TLR-MyD88 signaling and lipid remodeling
10.1016/j.celrep.2025.116749 · 2026 · External reference
Cytokines in inflammatory bowel disease
10.1038/nri3661 · 2014 · External reference
m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways
10.1038/nature23450 · 2017 · External reference
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10.1093/bioinformatics/btt656 · 2014 · External reference
The Sequence Alignment/Map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
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10.1038/s41596-024-01020-z · 2024 · External reference
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10.1038/nmeth.4463 · 2017 · External reference
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Reversed graph embedding resolves complex single-cell trajectories
10.1038/nmeth.4402 · 2017 · External reference
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2024 · External reference
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10.1093/bioinformatics/btab711 · 2022 · External reference
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2025 · External reference
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Neuraminidase 1 promotes renal fibrosis development in male mice
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Twelve years of SAMtools and BCFtools
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