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References from The mechanism of vascular injury caused by polystyrene microplastics: Involving ferroptosis and metabolomics. Local targets link to admitted publications; unresolved targets remain external evidence.
Trends of cause-specific cardiovascular disease mortality in China, 2009-2019: a nationwide longitudinal study
2025 · External reference
Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study
10.1016/j.jacc.2020.11.010 · 2020 · External reference
Research progress in endothelial cell injury and repair
2022 · External reference
Microplastics in our diet: A growing concern for human health
10.1016/j.scitotenv.2025.178882 · 2025 · External reference
Lung hazards of microplastics and their toxicological mechanisms
10.1016/j.envpol.2025.127149 · 2025 · External reference
Landmark study links microplastics to serious health problems
2024 · External reference
Microplastics and Nanoplastics in Atheromas and Cardiovascular Events
10.1056/nejmoa2309822 · 2024 · External reference
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
10.1038/s41569-022-00735-4 · 2023 · External reference
Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease
10.1080/15548627.2025.2481126 · 2025 · External reference
Ferroptosis: Death by Lipid Peroxidation
10.1016/j.tcb.2015.10.014 · 2016 · External reference
The cell biology of acute myocardial ischemia
10.1146/annurev.me.42.020191.001301 · 1991 · External reference
Catalytic deconstruction of waste polyethylene with ethylene to form propylene
10.1126/science.add1088 · 2022 · External reference
Dynamic crosslinking compatibilizes immiscible mixed plastics
10.1038/s41586-023-05858-3 · 2023 · External reference
Polystyrene microplastics cause cardiac fibrosis by activating Wnt/β-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats
10.1016/j.envpol.2020.115025 · 2020 · External reference
PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
10.1186/s11658-025-00838-z · 2025 · External reference
Nanoplastic-induced vascular endothelial injury and coagulation dysfunction in mice
10.1016/j.scitotenv.2022.161271 · 2023 · External reference
Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet
10.1186/s12933-020-01000-z · 2020 · External reference
Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart
10.1172/jci152308 · 2022 · External reference
EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression
10.1038/s41401-022-00923-5 · 2023 · External reference
Linking endothelial dysfunction with endothelial cell activation
10.1172/jci66843 · 2013 · External reference
Diet-induced obesity promotes endothelial cell desensitization to VEGF-A and permanent islet vessel dysfunction in mice
10.1172/jci177601 · 2025 · External reference
A potent fluorescent probe for HOCl with dual NIR emissions: Achieving the early diagnosis of polystyrene microplastics-induced liver injury involved in ferroptosis
10.1016/j.jhazmat.2025.138087 · 2025 · External reference
Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryos
10.1016/j.envpol.2024.124022 · 2024 · External reference
Adverse effect of polystyrene microplastics (PS-MPs) on tube formation and viability of human umbilical vein endothelial cells
10.1016/j.fct.2021.112356 · 2021 · External reference
Ferroptosis involved in inhaled polystyrene microplastics leaded myocardial fibrosis through HIF-ROS-SLC7A11/GPX4 Pathway
10.1016/j.jes.2025.04.059 · 2026 · External reference
Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets
10.1038/s41569-023-00957-0 · 2024 · External reference
Ferroptosis in health and disease
10.1016/j.redox.2024.103211 · 2024 · External reference
Ferroptosis: molecular mechanisms and health implications
10.1038/s41422-020-00441-1 · 2021 · External reference
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
10.1016/j.cell.2022.06.003 · 2022 · External reference
Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis
10.1002/tox.24387 · 2024 · External reference
Peptide Extract from Apricot Kernels Mitigates Damage in Human Aortic Endothelial Cells Induced by Polystyrene Microplastics through the Inhibition of the NLRP3 Signaling Pathway
10.2174/0109298665410365251118113915 · 2026 · External reference
Safety and efficacy of a novel ANGPTL4 inhibitory antibody for lipid lowering: results from phase 1 and phase 1b/2a clinical studies
10.1016/s0140-6736(25)00825-6 · 2025 · External reference
A comparative study in healthy and diabetic mice followed the exposure of polystyrene microplastics: Differential lipid metabolism and inflammation reaction
10.1016/j.ecoenv.2022.114031 · 2022 · External reference
The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis
10.3389/fphar.2024.1336369 · 2024 · External reference
Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro
10.1016/j.redox.2018.08.005 · 2018 · External reference
Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites
10.1080/19490976.2024.2374608 · 2024 · External reference
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition
10.1038/s41556-023-01314-6 · 2024 · External reference
Ferroptosis: when metabolism meets cell death
10.1152/physrev.00031.2024 · 2025 · External reference
Role of Mitochondria in Ferroptosis
10.1016/j.molcel.2018.10.042 · 2019 · External reference
Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target
10.1186/s43556-026-00420-9 · 2026 · External reference
Cellular metabolism: A key player in cancer ferroptosis
10.1002/cac2.12519 · 2024 · External reference
Ferroptosis of Endothelial Cells in Vascular Diseases
10.3390/nu14214506 · 2022 · External reference
Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism
10.1186/s12989-023-00560-8 · 2023 · External reference
A systematic review and quality assessment of estimated daily intake of microplastics through food
10.1515/reveh-2024-0111 · 2024 · External reference
Effects of Microplastic (MP) Exposure at Environmentally Relevant Doses on the Structure, Function, and Transcriptome of the Kidney in Mice
10.3390/molecules28207104 · 2023 · External reference
Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice
10.1016/j.ecoenv.2023.114848 · 2023 · External reference
Polystyrene microplastics induced female reproductive toxicity in mice
10.1016/j.jhazmat.2021.127629 · 2022 · External reference
Polystyrene nanoplastics and cadmium co-exposure aggravated cardiomyocyte damage in mice by regulating PANoptosis pathway
10.1016/j.envpol.2024.123713 · 2024 · External reference
Male reproductive toxicity of polystyrene microplastics: Study on the endoplasmic reticulum stress signaling pathway
10.1016/j.fct.2022.113577 · 2023 · External reference
Defining mitochondrial protein functions through deep multiomic profiling
10.1038/s41586-022-04765-3 · 2022 · External reference
Metabolites released from apoptotic cells act as tissue messengers
10.1038/s41586-020-2121-3 · 2020 · External reference
LRP1 is a master regulator of tau uptake and spread
10.1038/s41586-020-2156-5 · 2020 · External reference
Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation
10.1038/s41467-024-54296-w · 2024 · External reference
Size-dependent effects of microplastics on intestinal microbiome for Perna viridis
10.1016/j.jhazmat.2024.134658 · 2024 · External reference
Polymers of micro(nano) plastic in household tap water of the Barcelona Metropolitan Area
10.1016/j.watres.2022.118645 · 2022 · External reference
Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2
10.1016/j.envpol.2021.117904 · 2021 · External reference
Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin E signaling to promote inflammation post-spinal cord injury
10.1186/s12974-023-02848-0 · 2023 · External reference
Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
10.1021/tx00026a012 · 1992 · External reference
Synergies of dibutyl phthalate on high-fat diet can aggravate cardiac fibrosis/dysfunction and the protective effects of vitamin E and salidroside: A molecular toxicological study in Sprague-Dawley rats
10.1016/j.ecoenv.2025.118708 · 2025 · External reference
Cellular metabolism: A key player in cancer ferroptosis
10.1002/cac2.12519 · ExternalCitation · doi-reference
Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis
10.1002/tox.24387 · ExternalCitation · doi-reference
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
10.1016/j.cell.2022.06.003 · ExternalCitation · doi-reference
A comparative study in healthy and diabetic mice followed the exposure of polystyrene microplastics: Differential lipid metabolism and inflammation reaction
10.1016/j.ecoenv.2022.114031 · ExternalCitation · doi-reference
Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice
10.1016/j.ecoenv.2023.114848 · ExternalCitation · doi-reference
Synergies of dibutyl phthalate on high-fat diet can aggravate cardiac fibrosis/dysfunction and the protective effects of vitamin E and salidroside: A molecular toxicological study in Sprague-Dawley rats
10.1016/j.ecoenv.2025.118708 · ExternalCitation · doi-reference
Polystyrene microplastics cause cardiac fibrosis by activating Wnt/β-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats
10.1016/j.envpol.2020.115025 · ExternalCitation · doi-reference
Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2
10.1016/j.envpol.2021.117904 · ExternalCitation · doi-reference
Polystyrene nanoplastics and cadmium co-exposure aggravated cardiomyocyte damage in mice by regulating PANoptosis pathway
10.1016/j.envpol.2024.123713 · ExternalCitation · doi-reference
Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryos
10.1016/j.envpol.2024.124022 · ExternalCitation · doi-reference
Lung hazards of microplastics and their toxicological mechanisms
10.1016/j.envpol.2025.127149 · ExternalCitation · doi-reference
Adverse effect of polystyrene microplastics (PS-MPs) on tube formation and viability of human umbilical vein endothelial cells
10.1016/j.fct.2021.112356 · ExternalCitation · doi-reference
Male reproductive toxicity of polystyrene microplastics: Study on the endoplasmic reticulum stress signaling pathway
10.1016/j.fct.2022.113577 · ExternalCitation · doi-reference
Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study
10.1016/j.jacc.2020.11.010 · ExternalCitation · doi-reference
Ferroptosis involved in inhaled polystyrene microplastics leaded myocardial fibrosis through HIF-ROS-SLC7A11/GPX4 Pathway
10.1016/j.jes.2025.04.059 · ExternalCitation · doi-reference
Polystyrene microplastics induced female reproductive toxicity in mice
10.1016/j.jhazmat.2021.127629 · ExternalCitation · doi-reference
Size-dependent effects of microplastics on intestinal microbiome for Perna viridis
10.1016/j.jhazmat.2024.134658 · ExternalCitation · doi-reference
A potent fluorescent probe for HOCl with dual NIR emissions: Achieving the early diagnosis of polystyrene microplastics-induced liver injury involved in ferroptosis
10.1016/j.jhazmat.2025.138087 · ExternalCitation · doi-reference
Role of Mitochondria in Ferroptosis
10.1016/j.molcel.2018.10.042 · ExternalCitation · doi-reference
Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro
10.1016/j.redox.2018.08.005 · ExternalCitation · doi-reference
Ferroptosis in health and disease
10.1016/j.redox.2024.103211 · ExternalCitation · doi-reference
Nanoplastic-induced vascular endothelial injury and coagulation dysfunction in mice
10.1016/j.scitotenv.2022.161271 · ExternalCitation · doi-reference
Microplastics in our diet: A growing concern for human health
10.1016/j.scitotenv.2025.178882 · ExternalCitation · doi-reference
Ferroptosis: Death by Lipid Peroxidation
10.1016/j.tcb.2015.10.014 · ExternalCitation · doi-reference
Polymers of micro(nano) plastic in household tap water of the Barcelona Metropolitan Area
10.1016/j.watres.2022.118645 · ExternalCitation · doi-reference
Safety and efficacy of a novel ANGPTL4 inhibitory antibody for lipid lowering: results from phase 1 and phase 1b/2a clinical studies
10.1016/s0140-6736(25)00825-6 · ExternalCitation · doi-reference
Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
10.1021/tx00026a012 · ExternalCitation · doi-reference
EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression
10.1038/s41401-022-00923-5 · ExternalCitation · doi-reference
Ferroptosis: molecular mechanisms and health implications
10.1038/s41422-020-00441-1 · ExternalCitation · doi-reference
Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation
10.1038/s41467-024-54296-w · ExternalCitation · doi-reference
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition
10.1038/s41556-023-01314-6 · ExternalCitation · doi-reference
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
10.1038/s41569-022-00735-4 · ExternalCitation · doi-reference
Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets
10.1038/s41569-023-00957-0 · ExternalCitation · doi-reference
Metabolites released from apoptotic cells act as tissue messengers
10.1038/s41586-020-2121-3 · ExternalCitation · doi-reference
LRP1 is a master regulator of tau uptake and spread
10.1038/s41586-020-2156-5 · ExternalCitation · doi-reference
Defining mitochondrial protein functions through deep multiomic profiling
10.1038/s41586-022-04765-3 · ExternalCitation · doi-reference
Dynamic crosslinking compatibilizes immiscible mixed plastics
10.1038/s41586-023-05858-3 · ExternalCitation · doi-reference
Microplastics and Nanoplastics in Atheromas and Cardiovascular Events
10.1056/nejmoa2309822 · ExternalCitation · doi-reference
Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease
10.1080/15548627.2025.2481126 · ExternalCitation · doi-reference
Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites
10.1080/19490976.2024.2374608 · ExternalCitation · doi-reference
Catalytic deconstruction of waste polyethylene with ethylene to form propylene
10.1126/science.add1088 · ExternalCitation · doi-reference
The cell biology of acute myocardial ischemia
10.1146/annurev.me.42.020191.001301 · ExternalCitation · doi-reference
Ferroptosis: when metabolism meets cell death
10.1152/physrev.00031.2024 · ExternalCitation · doi-reference
Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart
10.1172/jci152308 · ExternalCitation · doi-reference
Diet-induced obesity promotes endothelial cell desensitization to VEGF-A and permanent islet vessel dysfunction in mice
10.1172/jci177601 · ExternalCitation · doi-reference
Linking endothelial dysfunction with endothelial cell activation
10.1172/jci66843 · ExternalCitation · doi-reference
PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
10.1186/s11658-025-00838-z · ExternalCitation · doi-reference
Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet
10.1186/s12933-020-01000-z · ExternalCitation · doi-reference
Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin E signaling to promote inflammation post-spinal cord injury
10.1186/s12974-023-02848-0 · ExternalCitation · doi-reference
Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism
10.1186/s12989-023-00560-8 · ExternalCitation · doi-reference
Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target
10.1186/s43556-026-00420-9 · ExternalCitation · doi-reference
A systematic review and quality assessment of estimated daily intake of microplastics through food
10.1515/reveh-2024-0111 · ExternalCitation · doi-reference
Peptide Extract from Apricot Kernels Mitigates Damage in Human Aortic Endothelial Cells Induced by Polystyrene Microplastics through the Inhibition of the NLRP3 Signaling Pathway
10.2174/0109298665410365251118113915 · ExternalCitation · doi-reference
The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis
10.3389/fphar.2024.1336369 · ExternalCitation · doi-reference
Effects of Microplastic (MP) Exposure at Environmentally Relevant Doses on the Structure, Function, and Transcriptome of the Kidney in Mice
10.3390/molecules28207104 · ExternalCitation · doi-reference
Ferroptosis of Endothelial Cells in Vascular Diseases
10.3390/nu14214506 · ExternalCitation · doi-reference
