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References from MED26 facilitates Mediator-Pol II complex assembly and promotes nuclear stress body formation during heat stress. Local targets link to admitted publications; unresolved targets remain external evidence.
Role of the heat shock response and molecular chaperones in oncogenesis and cell death
10.1093/jnci/92.19.1564 · 2000 · External reference
HSF1: Guardian of Proteostasis in Cancer
10.1016/j.tcb.2015.10.011 · 2016 · External reference
Heat shock proteins function as signaling molecules to mediate neuron-glia communication in C. elegans during aging
10.1038/s41593-025-01989-0 · 2025 · External reference
Regulation of heat shock transcription factors and their roles in physiology and disease
10.1038/nrm.2017.73 · 2018 · External reference
Regulation of the members of the mammalian heat shock factor family
10.1111/j.1742-4658.2010.07828.x · 2010 · External reference
A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock
10.1091/mbc.e09-07-0639 · 2010 · External reference
HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator
10.1128/mcb.17.1.469 · 1997 · External reference
Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions
10.1038/s41467-024-47601-0 · 2024 · External reference
Regulation of heat shock factor trimer formation: role of a conserved leucine zipper
10.1126/science.8421783 · 1993 · External reference
Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock
10.1038/s41556-022-00846-7 · 2022 · External reference
Repression motif in HSF1 regulated by phosphorylation
10.1016/j.cellsig.2023.110813 · 2023 · External reference
Molecular mechanisms of heat shock factor 1 regulation
10.1016/j.tibs.2021.10.004 · 2022 · External reference
Structures of heat shock factor trimers bound to DNA
10.1016/j.isci.2021.102951 · 2021 · External reference
Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure
10.1016/j.bbrc.2019.06.061 · 2019 · External reference
Stress-induced transcription of satellite III repeats
10.1083/jcb.200306104 · 2004 · External reference
Satellite RNAs: emerging players in subnuclear architecture and gene regulation
10.15252/embj.2023114331 · 2023 · External reference
Nuclear stress bodies
10.1101/cshperspect.a000695 · 2010 · External reference
Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression
10.1016/j.celrep.2022.111784 · 2022 · External reference
LncRNA-dependent nuclear stress bodies promote intron retention through SR protein phosphorylation
10.15252/embj.2019102729 · 2020 · External reference
m(6) A modification of HSATIII lncRNAs regulates temperature-dependent splicing
10.15252/embj.2021107976 · 2021 · External reference
A Phase Separation Model for Transcriptional Control
10.1016/j.cell.2017.02.007 · 2017 · External reference
Enhancer Features that Drive Formation of Transcriptional Condensates
10.1016/j.molcel.2019.07.009 · 2019 · External reference
Organization and regulation of gene transcription
10.1038/s41586-019-1517-4 · 2019 · External reference
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
10.1016/j.cell.2018.10.042 · 2018 · External reference
Coactivator condensation at super-enhancers links phase separation and gene control
10.1126/science.aar3958 · 2018 · External reference
Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response
10.1016/j.molcel.2022.10.013 · 2022 · External reference
An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II
10.1016/j.molcel.2024.06.006 · 2024 · External reference
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
10.1038/nrg2901 · 2010 · External reference
Transcription regulation by the Mediator complex
10.1038/nrm.2017.115 · 2018 · External reference
Structure, function, and activator-induced conformations of the CRSP coactivator
10.1126/science.1065249 · 2002 · External reference
Activator-Mediator binding regulates Mediator-cofactor interactions
10.1073/pnas.0914215107 · 2010 · External reference
Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator
10.1128/mcb.25.6.2117-2129.2005 · 2005 · External reference
MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription
10.1016/j.molcel.2005.05.015 · 2005 · External reference
Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors
10.1073/pnas.0606379103 · 2006 · External reference
Human mediator subunit MED26 functions as a docking site for transcription elongation factors
10.1016/j.cell.2011.06.005 · 2011 · External reference
MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex
10.1038/ncomms6941 · 2015 · External reference
MED26-containing Mediator may orchestrate multiple transcription processes through organization of nuclear bodies
10.1002/bies.202200178 · 2023 · External reference
Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16
10.1074/jbc.m112.449553 · 2013 · External reference
Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock
10.1016/s1097-2765(01)00296-9 · 2001 · External reference
Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module
10.1128/mcb.23.4.1358-1367.2003 · 2003 · External reference
Differential requirement of MED14/17 recruitment for activation of heat inducible genes
10.1111/nph.17119 · 2021 · External reference
MED12 interacts with the heat-shock transcription factor HSF1 and recruits CDK8 to promote the heat-shock response in mammalian cells
10.1002/1873-3468.14139 · 2021 · External reference
The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells
10.1002/1873-3468.14617 · 2023 · External reference
The 3' Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies' association with histone locus bodies
10.1038/s41467-022-30632-w · 2022 · External reference
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
10.1038/s41467-020-18377-w · 2020 · External reference
Proximity labeling in mammalian cells with TurboID and split-TurboID
10.1038/s41596-020-0399-0 · 2020 · External reference
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses
10.1016/j.cell.2025.05.003 · 2025 · External reference
Functional partitioning of transcriptional regulators by patterned charge blocks
10.1016/j.cell.2022.12.013 · 2023 · External reference
How multisite phosphorylation impacts the conformations of intrinsically disordered proteins
10.1371/journal.pcbi.1008939 · 2021 · External reference
Post-translational modification of human heat shock factors and their functions: a recent update by proteomic approach
10.1021/pr201151a · 2012 · External reference
The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development
10.1073/pnas.1002981108 · 2011 · External reference
MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation
10.1038/s42003-021-01930-8 · 2021 · External reference
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function
10.1101/gad.1767009 · 2009 · External reference
Evidence for Multiple Mediator Complexes in Yeast Independently Recruited by Activated Heat Shock Factor
10.1128/mcb.00005-16 · 2016 · External reference
The Role of Med15 Sequence Features in Transcription Factor Interactions
10.1080/10985549.2024.2436672 · 2025 · External reference
Real-time visualization of reconstituted transcription reveals RNAPII activation mechanisms at single promoters
10.1016/j.celrep.2025.116251 · 2025 · External reference
Eukaryotic gene transcription with purified components
10.1016/0076-6879(83)01039-3 · 1983 · External reference
