Research graph
References from Deep brain stimulation mechanisms in comorbid pain and emotional dysregulation from animal models. Local targets link to admitted publications; unresolved targets remain external evidence.
An ACC-VTA-ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences
10.1038/s41593-023-01519-w · 2024 · External reference
Chronic pain-induced functional and structural alterations in the brain: A multi-modal meta-analysis
10.1016/j.jpain.2024.104740 · 2025 · External reference
Neuronal and Molecular Mechanisms Underlying Chronic Pain and Depression Comorbidity in the Paraventricular Thalamus
10.1523/jneurosci.1752-23.2024 · 2024 · External reference
Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice
10.1038/s41467-023-37968-x · 2023 · External reference
AQP4 mitigates chronic neuropathic pain-induced cognitive impairment in mice
10.1016/j.bbr.2022.114282 · 2023 · External reference
Cognitive and emotional control of pain and its disruption in chronic pain
10.1038/nrn3516 · 2013 · External reference
A neural circuit for comorbid depressive symptoms in chronic pain
10.1038/s41593-019-0468-2 · 2019 · External reference
The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic pain
10.1016/j.celrep.2023.113170 · 2023 · External reference
Neurochemical mechanisms of deep brain stimulation for depression in animal models
10.1016/j.euroneuro.2022.12.003 · 2023 · External reference
Early responses to deep brain stimulation in depression are modulated by anti-inflammatory drugs
10.1038/mp.2013.63 · 2014 · External reference
Orbitofrontal cortex-hippocampus potentiation mediates relief for depression: A randomized double-blind trial and TMS-EEG study
2023 · External reference
Neuromodulation for treatment-resistant depression: Functional network targets contributing to antidepressive outcomes
10.3389/fnhum.2023.1125074 · 2023 · External reference
Opportunities and challenges for the use of deep brain stimulation in the treatment of refractory major depression
10.1007/s44192-024-00062-9 · 2024 · External reference
Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain
10.1152/physrev.00040.2019 · 2021 · External reference
The association between pain-induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey
10.1113/jp282013 · 2021 · External reference
Spatial transcriptomics reveals the distinct organization of mouse prefrontal cortex and neuronal subtypes regulating chronic pain
10.1038/s41593-023-01455-9 · 2023 · External reference
VTA-NAc glutaminergic projection involves in the regulation of pain and pain-related anxiety
10.3389/fnmol.2022.1083671 · 2022 · External reference
A neuronal circuit for activating descending modulation of neuropathic pain
10.1038/s41593-019-0481-5 · 2019 · External reference
Persistent Activity of Metabotropic Glutamate Receptor 5 in the Periaqueductal Gray Constrains Emergence of Chronic Neuropathic Pain
10.1016/j.cub.2020.09.008 · 2020 · External reference
A common neuronal ensemble in nucleus accumbens regulates pain-like behaviour and sleep
10.1038/s41467-023-40450-3 · 2023 · External reference
Sex differences in amygdalohippocampal oscillations and neuronal activation in a rodent anxiety model and in response to infralimbic deep brain stimulation
10.3389/fnbeh.2023.1122163 · 2023 · External reference
Safety and feasibility of deep brain stimulation of the anterior cingulate and thalamus in chronic refractory neuropathic pain: a pilot and randomized study
10.1186/s10194-025-01967-8 · 2025 · External reference
The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson's disease
10.3389/fnins.2022.998932 · 2022 · External reference
Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states
10.1038/s41593-021-00811-x · 2021 · External reference
Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain
10.1007/s11427-023-2406-3 · 2024 · External reference
Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility
10.7554/elife.64567 · 2021 · External reference
Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses
10.1016/j.neuron.2025.01.002 · 2025 · External reference
Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption
10.1038/s41593-020-00772-7 · 2021 · External reference
Circuits and functions of the lateral habenula in health and in disease
10.1038/s41583-020-0292-4 · 2020 · External reference
Serotonin 5-HT(1B) receptors mediate the antidepressant- and anxiolytic-like effects of ventromedial prefrontal cortex deep brain stimulation in a mouse model of social defeat
10.1007/s00213-022-06259-6 · 2022 · External reference
Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms
10.1038/tp.2015.24 · 2015 · External reference
Increased dopamine receptor expression and anti-depressant response following deep brain stimulation of the medial forebrain bundle
10.1016/j.jad.2017.03.074 · 2017 · External reference
Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus
10.1523/jneurosci.1353-16.2016 · 2017 · External reference
Dorsal raphe projection inhibits the excitatory inputs on lateral habenula and alleviates depressive behaviors in rats
10.1007/s00429-018-1623-3 · 2018 · External reference
Number of serotonergic neurons in the subthalamic nucleus and globus pallidus internus could influence the effects of deep brain stimulation in Parkinson's disease
10.1002/ca.24207 · 2025 · External reference
Deep brain light stimulation effects on glutamate and dopamine concentration
10.1364/boe.6.000023 · 2015 · External reference
Deep brain stimulation of the dorsal raphe induces anxiolytic and panicolytic-like effects and alters serotonin immunoreactivity
10.1016/j.bbr.2023.114462 · 2023 · External reference
Deep brain stimulation improved depressive-like behaviors and hippocampal synapse deficits by activating the BDNF/mTOR signaling pathway
10.1016/j.bbr.2021.113709 · 2022 · External reference
Antidepressant actions of lateral habenula deep brain stimulation differentially correlate with CaMKII/GSK3/AMPK signaling locally and in the infralimbic cortex
10.1016/j.bbr.2016.02.039 · 2016 · External reference
Unraveling the Role of Astrocytes in Subthalamic Nucleus Deep Brain Stimulation in a Parkinson's Disease Rat Model
10.1007/s10571-019-00784-3 · 2020 · External reference
The combined depletion of monoamines alters the effectiveness of subthalamic deep brain stimulation
10.1016/j.nbd.2015.07.010 · 2015 · External reference
Deep Brain Stimulation for Chronic Pain
10.1016/j.nec.2022.02.013 · 2022 · External reference
Deep-brain stimulation for Parkinson's disease
10.1056/nejmct1208070 · 2012 · External reference
Deep Brain Stimulation for Obsessive-Compulsive Disorder and Depression
10.1146/annurev-neuro-110122-110434 · 2023 · External reference
Deep brain stimulation of thalamus for epilepsy
10.1016/j.nbd.2023.106045 · 2023 · External reference
Deep Brain Stimulation for Depression
10.1007/s13311-022-01270-3 · 2022 · External reference
Deep brain stimulation for chronic pain: mechanisms, clinical applications, limitations, and future directions
10.3389/fmed.2025.1683991 · 2025 · External reference
Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states
10.1016/j.neuron.2024.03.015 · 2024 · External reference
The Multifaceted Role of the Ventromedial Prefrontal Cortex in Emotion, Decision Making, Social Cognition, and Psychopathology
10.1016/j.biopsych.2017.10.030 · 2018 · External reference
The Role of Motivation in Cognitive Reappraisal for Depressed Patients
10.3389/fnhum.2017.00516 · 2017 · External reference
The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain
10.1155/2017/9724371 · 2017 · External reference
nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
10.1038/s41467-020-16198-5 · 2020 · External reference
A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex
10.1038/s41593-019-0429-9 · 2019 · External reference
Cholinergics contribute to the cellular mechanisms of deep brain stimulation applied in rat infralimbic cortex but not white matter
10.1016/j.euroneuro.2021.02.019 · 2021 · External reference
Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation
10.1016/j.ebiom.2015.06.023 · 2015 · External reference
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus
10.1021/acschemneuro.1c00546 · 2021 · External reference
Deep brain stimulation of ventromedial prefrontal cortex reverses depressive-like behaviors via BDNF/TrkB signaling pathway in rats
10.1016/j.lfs.2023.122222 · 2023 · External reference
Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat
10.1523/jneurosci.2383-13.2013 · 2013 · External reference
Effect of Deep Brain Stimulation of the ventromedial prefrontal cortex on the noradrenergic system in rats
10.1016/j.brs.2017.10.003 · 2018 · External reference
Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala
10.1038/s41380-023-02056-5 · 2023 · External reference
The nucleus accumbens: an interface between cognition, emotion, and action
10.1146/annurev-psych-010213-115159 · 2015 · External reference
Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway
10.1016/j.ynstr.2023.100566 · 2023 · External reference
Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders
10.1016/j.fmre.2024.06.009 · 2025 · External reference
Deep brain stimulation of the accumbens increases dopamine, serotonin, and noradrenaline in the prefrontal cortex
10.1111/jnc.12054 · 2012 · External reference
Dual Roles for Nucleus Accumbens Core Dopamine D1-Expressing Neurons Projecting to the Substantia Nigra Pars Reticulata in Limbic and Motor Control in Male Mice
10.1523/eneuro.0082-23.2023 · 2023 · External reference
The interhemispheric amygdala-accumbens circuit encodes negative valence in mice
10.1126/science.adp7520 · 2024 · External reference
The antidepressant effect of nucleus accumbens deep brain stimulation is mediated by parvalbumin-positive interneurons in the dorsal dentate gyrus
10.1016/j.ynstr.2022.100492 · 2022 · External reference
NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA
10.1038/s41380-024-02476-x · 2024 · External reference
The ATP Level in the Medial Prefrontal Cortex Regulates Depressive-like Behavior via the Medial Prefrontal Cortex-Lateral Habenula Pathway
10.1016/j.biopsych.2022.02.014 · 2022 · External reference
Deep brain stimulation in the lateral habenula reverses local neuronal hyperactivity and ameliorates depression-like behaviors in rats
10.1016/j.nbd.2023.106069 · 2023 · External reference
Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors
10.1016/j.cell.2025.04.010 · 2025 · External reference
Activation of the Lateral Habenula-Ventral Tegmental Area Neural Circuit Contributes to Postoperative Cognitive Dysfunction in Mice
10.1002/advs.202202228 · 2022 · External reference
The behavioral relevance of a modular organization in the lateral habenula
10.1016/j.neuron.2024.04.026 · 2024 · External reference
The inhibitory influence of the lateral habenula on midbrain dopamine cells: ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus
10.1002/cne.22561 · 2011 · External reference
Differential projections from the lateral habenula to the rostromedial tegmental nucleus and ventral tegmental area in the rat
10.1002/cne.22787 · 2012 · External reference
5HT(1B) receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula
10.1016/j.neuropharm.2014.01.046 · 2014 · External reference
Synaptic potentiation mediated by L-type voltage-dependent calcium channels mediates the antidepressive effects of lateral habenula stimulation
10.1016/j.neuroscience.2017.08.025 · 2017 · External reference
Burst firing in Output-Defined Parallel Habenula Circuit Underlies the Antidepressant Effects of Bright Light Treatment
2024 · External reference
Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression
10.1016/j.nicl.2022.102961 · 2022 · External reference
Closed-loop brain stimulation augments fear extinction in male rats
10.1038/s41467-023-39546-7 · 2023 · External reference
Deep brain stimulation of the “medial forebrain bundle”: a strategy to modulate the reward system and manage treatment-resistant depression
10.1038/s41380-021-01100-6 · 2022 · External reference
The medial forebrain bundle as a deep brain stimulation target for treatment resistant depression: A review of published data
10.1016/j.pnpbp.2014.12.003 · 2015 · External reference
Deep brain stimulation targeted at lateral hypothalamus-medial forebrain bundle reverses depressive-like symptoms and related cognitive deficits in rat: Role of serotoninergic system
10.1016/j.neuroscience.2024.07.052 · 2024 · External reference
Chronic brain stimulation rewarding experience ameliorates depression-induced cognitive deficits and restores aberrant plasticity in the prefrontal cortex
10.1016/j.brs.2019.01.020 · 2019 · External reference
Medial Forebrain Bundle Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Importance of BDNF and Inflammatory Cytokines
10.1007/s12035-018-1381-5 · 2019 · External reference
Subthalamic nucleus deep brain stimulation alleviates oxidative stress via mitophagy in Parkinson’s disease
10.1038/s41531-024-00668-4 · 2024 · External reference
Effects of Bilateral Subthalamic Nucleus Stimulation on Depressive Symptoms and Cerebral Glucose Metabolism in Parkinson's Disease: A (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computerized Tomography Study
2022 · External reference
High-frequency stimulation of the substantia nigra induces serotonin-dependent depression-like behavior in animal models
10.1016/j.biopsych.2012.07.032 · 2013 · External reference
High-frequency stimulation of the subthalamic nucleus induces a sustained inhibition of serotonergic system via loss of cell phenotype
10.1038/s41598-022-18294-6 · 2022 · External reference
Effects of repeated deep brain stimulation on depressive- and anxiety-like behavior in rats: comparing entopeduncular and subthalamic nuclei
10.1016/j.brs.2012.09.012 · 2013 · External reference
Behavioural and clinical biomarkers of the human bed nucleus of stria terminalis from direct neural recordings
10.1093/brain/awaf431 · 2026 · External reference
No Consistent Antidepressant Effects of Deep Brain Stimulation of the Bed Nucleus of the Stria Terminalis
10.3390/brainsci14050499 · 2024 · External reference
Therapeutic deep brain stimulation targeting BNST-NAc circuit driven large-scale brain networks in treatment-resistant depression
10.1038/s41398-025-03669-w · 2025 · External reference
Effects of deep brain stimulation on dopamine D2 receptor binding in patients with treatment-refractory depression
10.1016/j.jad.2024.04.082 · 2024 · External reference
Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression
2025 · External reference
Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning
10.1038/s41467-021-23311-9 · 2021 · External reference
Diffusion tensor imaging and neuromodulation: DTI as key technology for deep brain stimulation
10.1016/b978-0-12-404706-8.00011-5 · 2012 · External reference
