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References from Sonocavitation therapy for pancreatic cancer: Research progress, clinical application and future perspectives. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2023
2023 · External reference
Overview and countermeasures of cancer burden in China
10.1007/s11427-022-2240-6 · 2023 · External reference
Cancer statistics in Chinese older people, 2022: current burden, time trends, and comparisons with the US, Japan, and the Republic of Korea
10.1007/s11427-022-2218-x · 2023 · External reference
Pancreatic cancer: Advances and challenges
10.1016/j.cell.2023.02.014 · 2023 · External reference
Outcome of Pancreatic Surgery During the First 6 Years of a Mandatory Audit Within the Dutch Pancreatic Cancer Group
10.1097/sla.0000000000005628 · 2023 · External reference
Metastatic pancreatic cancer: Mechanisms and detection
10.3892/or.2021.8182 · 2021 · External reference
Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer
10.1053/j.gastro.2017.11.280 · 2018 · External reference
Reflections on depletion of tumor stroma in pancreatic cancer
10.1016/j.bbcan.2019.01.007 · 2019 · External reference
Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer
10.1158/1078-0432.ccr-15-2010 · 2016 · External reference
PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications
10.1186/s12943-020-01167-9 · 2020 · External reference
From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer
10.1038/s41571-019-0281-6 · 2020 · External reference
KRAS Inhibitors- yes but what next? Direct targeting of KRAS- vaccines, adoptive T cell therapy and beyond
10.1016/j.ctrv.2021.102309 · 2021 · External reference
Nimotuzumab Plus Gemcitabine for K-Ras Wild-Type Locally Advanced or Metastatic Pancreatic Cancer
10.1200/jco.22.02630 · 2023 · External reference
The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy
10.1016/s2468-1253(23)00207-8 · 2023 · External reference
Phase 2 study of ipilimumab, nivolumab, and tocilizumab combined with stereotactic body radiotherapy in patients with refractory pancreatic cancer (TRIPLE-R)
10.1016/j.ejca.2022.11.035 · 2023 · External reference
First-in-human study of oleclumab, a potent, selective anti-CD73 monoclonal antibody, alone or in combination with durvalumab in patients with advanced solid tumors
10.1007/s00262-023-03430-6 · 2023 · External reference
Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors
10.1136/jitc-2022-006136 · 2023 · External reference
Tumor tough, therapy smarter: Rethinking CAR-T for pancreatic cancer
10.1016/j.seminoncol.2025.152411 · 2025 · External reference
Application prospects of tumor vaccines for pancreatic cancer: From TAAs to TSAs and combination strategies
10.1016/j.seminoncol.2025.152399 · 2025 · External reference
Type I collagen deletion in αSMA(+) myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer
10.1016/j.ccell.2021.02.007 · 2021 · External reference
Characterization of the genomic landscape in large-scale Chinese patients with pancreatic cancer
10.1016/j.ebiom.2022.103897 · 2022 · External reference
Microbubbles in medical imaging: current applications and future directions
10.1038/nrd1417 · 2004 · External reference
Mechanical bioeffects of ultrasound
10.1146/annurev.bioeng.6.040803.140126 · 2004 · External reference
Ultrasound-Mediated Drug Delivery: Sonoporation Mechanisms, Biophysics, and Critical Factors
10.34133/2022/9807347 · 2022 · External reference
Ultrasonically triggered drug delivery: breaking the barrier
10.1016/j.colsurfb.2014.07.051 · 2014 · External reference
Sonoporation: Past, Present, and Future
10.1002/admt.202100885 · 2022 · External reference
Sonoporation: Underlying Mechanisms and Applications in Cellular Regulation
10.15212/bioi-2020-0028 · 2021 · External reference
Highlights in ultrasound-targeted microbubble destruction-mediated gene/drug delivery strategy for treatment of malignancies
10.1016/j.ijpharm.2021.121412 · 2022 · External reference
UTMD inhibit EMT of breast cancer through the ROS/miR-200c/ZEB1 axis
10.1038/s41598-020-63653-w · 2020 · External reference
Hydralazine loaded nanodroplets combined with ultrasound-targeted microbubble destruction to induce pyroptosis for tumor treatment
10.1186/s12951-024-02453-0 · 2024 · External reference
Ultrasound-Targeted Microbubble Destruction: Modulation in the Tumor Microenvironment and Application in Tumor Immunotherapy
2022 · External reference
Ultrasound-targeted microbubble destruction remodels tumour microenvironment to improve immunotherapeutic effect
10.1038/s41416-022-02076-y · 2023 · External reference
Ultrasound-Targeted Microbubble Destruction (UTMD) for Localized Drug Delivery into Tumor Tissue
10.1016/j.irbm.2018.11.005 · 2019 · External reference
In Situ Micro–Nano Conversion Augmented Tumor-Localized Immunochemotherapy
10.1021/acsami.2c02490 · 2022 · External reference
Ultrasound-Mediated Destruction of LHRHa-Targeted and Paclitaxel-Loaded Lipid Microbubbles Induces Proliferation Inhibition and Apoptosis in Ovarian Cancer Cells
10.1021/mp4005244 · 2014 · External reference
Microbubbles used for contrast enhanced ultrasound and theragnosis: a review of principles to applications
10.1007/s13534-017-0016-5 · 2017 · External reference
Ultrasound mediated therapy: Recent progress and challenges in nanoscience
10.1016/j.nantod.2020.100949 · 2020 · External reference
Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: From theoretical considerations to practical applications
10.1016/j.jconrel.2016.09.026 · 2016 · External reference
Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft
10.1007/s11307-013-0672-5 · 2014 · External reference
Enhancing Nab-Paclitaxel Delivery Using Microbubble-Assisted Ultrasound in a Pancreatic Cancer Model
10.1021/acs.molpharmaceut.9b00416 · 2019 · External reference
Antitumor effect of VEGFR2-targeted microbubble destruction with gemcitabine using an endoscopic ultrasound probe: In vivo mouse pancreatic ductal adenocarcinoma model
10.1016/j.hbpd.2020.03.004 · 2020 · External reference
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors
10.1016/j.ultrasmedbio.2023.01.014 · 2023 · External reference
Ultrasound-targeted microbubble destruction improves the suppression and magnetic resonance imaging of pancreatic cancer with polyethyleneimine nanogels
10.7150/jca.93802 · 2024 · External reference
Sonoporation enhances liposome accumulation and penetration in tumors with low EPR
10.1016/j.jconrel.2016.02.021 · 2016 · External reference
Ultrasound-Mediated Microbubble Destruction (UMMD) Facilitates the Delivery of CA19-9 Targeted and Paclitaxel Loaded mPEG-PLGA-PLL Nanoparticles in Pancreatic Cancer
10.7150/thno.15164 · 2016 · External reference
Low-Intensity Focused Ultrasound Produces Immune Response in Pancreatic Cancer
10.1016/j.ultrasmedbio.2022.06.017 · 2022 · External reference
UTMD inhibits pancreatic cancer growth and metastasis by inducing macrophage polarization and vessel normalization
10.1016/j.biopha.2023.114322 · 2023 · External reference
Power-Doppler-based NH002 microbubble sonoporation with chemotherapy relieves hypoxia and enhances the efficacy of chemotherapy and immunotherapy for pancreatic tumors
10.1038/s41598-024-54432-y · 2024 · External reference
UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy
10.7150/thno.22834 · 2018 · External reference
Effect of acoustic cluster therapy (ACT®) combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer
10.1016/j.jconrel.2022.11.016 · 2022 · External reference
Ultrasound-stimulated Microbubbles for Treatment of Pancreatic Cancer Cells with Radiation and Nanoparticles: In vitro Study
10.4103/jmp.jmp_30_24 · 2024 · External reference
Gemcitabine loaded microbubbles for targeted chemo-sonodynamic therapy of pancreatic cancer
10.1016/j.jconrel.2018.04.018 · 2018 · External reference
An ultrasound responsive microbubble-liposome conjugate for targeted irinotecan-oxaliplatin treatment of pancreatic cancer
10.1016/j.ejpb.2020.10.012 · 2020 · External reference
Gemcitabine-loaded microbubble system for ultrasound imaging and therapy
10.1016/j.actbio.2021.05.046 · 2021 · External reference
Synthesis of a gemcitabine-modified phospholipid and its subsequent incorporation into a single microbubble formulation loaded with paclitaxel for the treatment of pancreatic cancer using ultrasound-targeted microbubble destruction
10.1016/j.ejpb.2021.05.018 · 2021 · External reference
Spatial-temporal-controlled NO gas and PARP1 siRNA delivery for alleviating the dilemma of deeper sonodynamic therapy in pancreatic cancer
10.1016/j.cej.2024.151775 · 2024 · External reference
Ultrasound-Responsive Microfluidic Microbubbles for Combination Tumor Treatment
2021 · External reference
Magnetically responsive microbubbles as delivery vehicles for targeted sonodynamic and antimetabolite therapy of pancreatic cancer
10.1016/j.jconrel.2017.07.040 · 2017 · External reference
Magnetic Targeting and Ultrasound Activation of Liposome–Microbubble Conjugate for Enhanced Delivery of Anticancer Therapies
10.1021/acsami.0c05308 · 2020 · External reference
Cascade Drug Delivery through Tumor Barriers of Pancreatic Cancer via Ultrasound in Combination with Functional Microbubbles
10.1021/acsbiomaterials.2c00069 · 2022 · External reference
Vascular endothelial growth factor receptor type 2-targeted contrast-enhanced US of pancreatic cancer neovasculature in a genetically engineered mouse model: potential for earlier detection
10.1148/radiol.14140568 · 2015 · External reference
Thy1-Targeted Microbubbles for Ultrasound Molecular Imaging of Pancreatic Ductal Adenocarcinoma
10.1158/1078-0432.ccr-17-2057 · 2018 · External reference
Cascade Ultrasonic Cavitation Enables Microbubble–Nanoparticle Hybrid to Broadly Accumulate and Penetrate into Pancreatic Ductal Adenocarcinoma
10.1002/sstr.202500077 · 2025 · External reference
The synergistic potential of mechanotherapy and sonopermeation to enhance cancer treatment effectiveness
10.1038/s44341-025-00017-3 · 2025 · External reference
Barriers and opportunities in pancreatic cancer immunotherapy
10.1038/s41698-024-00681-z · 2024 · External reference
Immunosuppressive tumor microenvironment in pancreatic cancer: mechanisms and therapeutic targets
10.3389/fimmu.2025.1582305 · 2025 · External reference
Recent advances in ultrasound-targeted nanobubbles combined with cancer immunotherapy: Mechanisms, applications, and challenges
10.1016/j.fmre.2024.10.017 · 2026 · External reference
Ultrasound in tumor immunotherapy: Current status and future developments
10.1016/j.jconrel.2020.04.023 · 2020 · External reference
Ultrasound-mediated microbubble destruction enhances gene transfection in pancreatic cancer cells
10.1007/s12325-008-0051-9 · 2008 · External reference
CRISPR/Cas technologies in pancreatic cancer research and therapeutics: recent advances and future outlook
10.1007/s12672-025-03383-5 · 2025 · External reference
Gene editing in cancer therapy: overcoming drug resistance and enhancing precision medicine
10.1038/s41417-025-00959-9 · 2025 · External reference
Applications of genome editing technologies in the treatment of human diseases
10.1038/s41434-026-00627-z · 2026 · External reference
Therapeutic pCRISPRi Delivery to Lung Squamous Cell Carcinoma by Combining Nanobubbles and Ultrasound
10.3390/pharmaceutics17081053 · 2025 · External reference
High-Performance Delivery of a CRISPR Interference System via Lipid-Polymer Hybrid Nanoparticles Combined with Ultrasound-Mediated Microbubble Destruction for Tumor-Specific Gene Repression
2023 · External reference
Radiotherapy in Pancreatic Cancer: To Whom, When, and How?
10.3390/cancers15133382 · 2023 · External reference
The Current Role of Radiation in Pancreatic Cancer and Future Directions
2023 · External reference
Radiation combined with ultrasound and microbubbles: A potential novel strategy for cancer treatment
10.1016/j.zemedi.2023.04.007 · 2023 · External reference
Focused Ultrasound and Ultrasound Stimulated Microbubbles in Radiotherapy Enhancement for Cancer Treatment
10.1177/15330338231176376 · 2023 · External reference
Acoustic Cluster Therapy (ACT) – A novel concept for ultrasound mediated, targeted drug delivery
10.1016/j.ijpharm.2015.09.047 · 2015 · External reference
Abstract 6221: First-in-human study of acoustic cluster therapy consisting of PS101 combined with chemotherapy and insonation in patients with liver metastases of colorectal cancer origin
10.1158/1538-7445.am2024-6221 · 2024 · External reference
Acoustic cluster therapy: An overview of research in cancer treatment
10.1121/10.0027527 · 2024 · External reference
Phase I trial of acoustic cluster therapy (ACT) with chemotherapy in patients with liver metastases of gastrointestinal origin (ACTIVATE study)
10.1200/jco.2021.39.15_suppl.tps3145 · 2021 · External reference
Acoustic Cluster Therapy (ACT) enhances the therapeutic efficacy of paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice
10.1016/j.jconrel.2016.06.018 · 2016 · External reference
Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice
2019 · External reference
Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study
10.1118/1.4808149 · 2013 · External reference
A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer
10.1016/j.jconrel.2016.10.007 · 2016 · External reference
Clinical study of ultrasound and microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in digestive system
10.21147/j.issn.1000-9604.2018.05.09 · 2018 · External reference
Clinical sonochemotherapy of inoperable pancreatic cancer using diagnostic ultrasound and microbubbles: a multicentre, open-label, randomised, controlled trial
10.1007/s00330-023-10210-4 · 2024 · External reference
Treatment of inoperable pancreatic adenocarcinoma with focused ultrasound and microbubbles in patients receiving chemotherapy
10.1016/j.wfumbo.2025.100080 · 2025 · External reference
Unresolved reference
2024 · External reference
