Research graph
References from Niche-specific immune and microbial signatures across the healthy upper respiratory tract mucosa. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021
10.1016/s1473-3099(24)00176-2 · 2024 · External reference
Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019
10.1016/s1473-3099(22)00510-2 · 2022 · External reference
Prevalence of human respiratory pathogens and associated mucosal cytokine levels in young children and adults: a cross-sectional observational study in the Netherlands during the winter of 2012/2013
2024 · External reference
Mucosal vaccines — fortifying the frontiers
10.1038/s41577-021-00583-2 · 2022 · External reference
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands
10.1016/j.mucimm.2024.03.008 · 2024 · External reference
Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination
10.1038/s41467-022-35165-w · 2022 · External reference
10.1016/j.vaccine.2021.01.032
10.1016/j.vaccine.2021.01.032 · 2021 · External reference
Estimating the global and regional burden of lower respiratory infections attributable to leading pathogens and the protective effectiveness of immunization programs
10.1016/j.ijid.2024.107268 · 2024 · External reference
Transmissibility and transmission of respiratory viruses
10.1038/s41579-021-00535-6 · 2021 · External reference
The mucosal immune system of the upper respiratory tract and recent progress in mucosal vaccines
10.1016/j.anl.2021.07.003 · 2022 · External reference
Editorial: Immunoregulation at mucosal surfaces
10.3389/fimmu.2022.983201 · 2022 · External reference
The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract
10.1152/physrev.00020.2023 · 2024 · External reference
The mucosal immune system in the oral cavity—an orchestra of T cell diversity
10.1038/ijos.2014.48 · 2014 · External reference
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
10.1084/jem.20230911 · 2024 · External reference
The respiratory microbiome is linked to the severity of RSV infections and the persistence of symptoms in children
2024 · External reference
Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure
10.1164/rccm.201712-2567oc · 2018 · External reference
Chemokine profiling in children and adults with symptomatic and asymptomatic respiratory viral infections
10.1016/j.jinf.2021.10.012 · 2021 · External reference
Identification of biomarkers for disease severity in nasopharyngeal secretions of infants with upper or lower respiratory tract viral infections
10.1093/cei/uxac083 · 2022 · External reference
Metatranscriptomics to characterize respiratory virome, microbiome, and host response directly from clinical samples
2021 · External reference
Laboratory medicine in low-income and middle-income countries: progress and challenges
10.1016/s0140-6736(18)30308-8 · 2018 · External reference
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
10.3791/56413 · 2018 · External reference
Small-volume detection: platform developments for clinically-relevant applications
10.1186/s12951-021-00852-1 · 2021 · External reference
Identification of Respiratory Viruses in Asymptomatic Subjects: Asymptomatic Respiratory Viral Infections
10.1097/inf.0b013e31817e695d · 2008 · External reference
Evaluation of Four Commercial Multiplex Molecular Tests for the Diagnosis of Acute Respiratory Infections
10.1371/journal.pone.0130378 · 2015 · External reference
Viral detection using a multiplex polymerase chain reaction–based assay in outpatients with upper respiratory infection
10.1016/j.diagmicrobio.2012.10.016 · 2013 · External reference
Immunoglobulins in Nasal Secretions of Healthy Humans: Structural Integrity of Secretory Immunoglobulin A1 (IgA1) and Occurrence of Neutralizing Antibodies to IgA1 Proteases of Nasal Bacteria
10.1128/cdli.7.1.31-39.2000 · 2000 · External reference
Immunoglobulin levels in saliva in individuals with selective IgA deficiency: Compensatory IgM secretion and its correlation with HLA and susceptibility to infections
10.1007/bf00918659 · 1989 · External reference
Secretory IgA: Designed for Anti-Microbial Defense
10.3389/fimmu.2013.00222 · 2013 · External reference
Possible utilization of salivary IFN-IL-4 ratio as a marker of chronic stress in healthy individuals
10.1002/npr2.12157 · 2021 · External reference
Effect of age and season on respiratory mucosal immune marker profiles
10.1016/j.jaci.2023.12.009 · 2024 · External reference
The potential of saliva as an accessible and sensitive sample type for the detection of respiratory pathogens and host immunity
10.1016/s2666-5247(23)00135-0 · 2023 · External reference
Oral Dysbiosis in Severe Forms of Periodontitis Is Associated With Gut Dysbiosis and Correlated With Salivary Inflammatory Mediators: A Preliminary Study
10.3389/froh.2021.722495 · 2021 · External reference
Immune Tolerance in the Oral Mucosa
10.3390/ijms222212149 · 2021 · External reference
The microbiota of the respiratory tract: gatekeeper to respiratory health
10.1038/nrmicro.2017.14 · 2017 · External reference
Host and environmental factors shape upper airway microbiota and respiratory health across the human lifespan
10.1016/j.cell.2024.07.008 · 2024 · External reference
Relationships between bacteria and the mucus layer
10.1016/j.carres.2024.109309 · 2024 · External reference
Diagnostic testing preferences can help inform future public health response efforts: Global insights from an international survey
10.1371/journal.pgph.0003547 · 2024 · External reference
Accuracy and Acceptance of a Self-Collection Model for Respiratory Tract Infection Diagnostics: A Concise Clinical Literature Review
10.1016/j.jen.2021.04.006 · 2021 · External reference
Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis
10.1038/s41467-019-13036-1 · 2019 · External reference
Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash
10.1371/journal.pone.0169805 · 2017 · External reference
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
10.1093/nar/gks1219 · 2013 · External reference
Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA
10.1128/aem.59.3.695-700.1993 · 1993 · External reference
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample
10.1073/pnas.1000080107 · 2011 · External reference
A communal catalogue reveals Earth’s multiscale microbial diversity
10.1038/nature24621 · 2017 · External reference
Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform
10.1128/aem.01043-13 · 2013 · External reference
phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
10.1371/journal.pone.0061217 · 2013 · External reference
Implementing a Class of Permutation Tests: The coin Package
10.18637/jss.v028.i08 · 2008 · External reference
Multi-Omics Factor Analysis—a framework for unsupervised integration of multi-omics data sets
10.15252/msb.20178124 · 2018 · External reference
Development and Standardization of a High-Throughput Multiplex Immunoassay for the Simultaneous Quantification of Specific Antibodies to Five Respiratory Syncytial Virus Proteins
10.1128/msphere.00236-19 · 2019 · External reference
Persistence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 in Relation to Symptoms in a Nationwide Prospective Study
10.1093/cid/ciab172 · 2021 · External reference
Development and validation of a multiplex immunoassay for the simultaneous determination of serum antibodies to Bordetella pertussis, diphtheria and tetanus
10.1016/j.jim.2008.02.018 · 2008 · External reference
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
10.1111/j.2517-6161.1995.tb02031.x · 1995 · External reference
Reducing bias in microbiome research: Comparing methods from sample collection to sequencing
10.3389/fmicb.2023.1094800 · 2023 · External reference
Naïve Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
10.1128/aem.00062-07 · 2007 · External reference
Associations of faecal microbiota with influenza-like illness in participants aged 60 years or older: an observational study
10.1016/s2666-7568(20)30034-9 · 2021 · External reference
Possible utilization of salivary IFN-IL-4 ratio as a marker of chronic stress in healthy individuals
10.1002/npr2.12157 · ExternalCitation · doi-reference
Immunoglobulin levels in saliva in individuals with selective IgA deficiency: Compensatory IgM secretion and its correlation with HLA and susceptibility to infections
10.1007/bf00918659 · ExternalCitation · doi-reference
The mucosal immune system of the upper respiratory tract and recent progress in mucosal vaccines
10.1016/j.anl.2021.07.003 · ExternalCitation · doi-reference
Relationships between bacteria and the mucus layer
10.1016/j.carres.2024.109309 · ExternalCitation · doi-reference
Host and environmental factors shape upper airway microbiota and respiratory health across the human lifespan
10.1016/j.cell.2024.07.008 · ExternalCitation · doi-reference
Viral detection using a multiplex polymerase chain reaction–based assay in outpatients with upper respiratory infection
10.1016/j.diagmicrobio.2012.10.016 · ExternalCitation · doi-reference
Estimating the global and regional burden of lower respiratory infections attributable to leading pathogens and the protective effectiveness of immunization programs
10.1016/j.ijid.2024.107268 · ExternalCitation · doi-reference
Effect of age and season on respiratory mucosal immune marker profiles
10.1016/j.jaci.2023.12.009 · ExternalCitation · doi-reference
Accuracy and Acceptance of a Self-Collection Model for Respiratory Tract Infection Diagnostics: A Concise Clinical Literature Review
10.1016/j.jen.2021.04.006 · ExternalCitation · doi-reference
Development and validation of a multiplex immunoassay for the simultaneous determination of serum antibodies to Bordetella pertussis, diphtheria and tetanus
10.1016/j.jim.2008.02.018 · ExternalCitation · doi-reference
Chemokine profiling in children and adults with symptomatic and asymptomatic respiratory viral infections
10.1016/j.jinf.2021.10.012 · ExternalCitation · doi-reference
Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands
10.1016/j.mucimm.2024.03.008 · ExternalCitation · doi-reference
10.1016/j.vaccine.2021.01.032
10.1016/j.vaccine.2021.01.032 · ExternalCitation · doi-reference
Laboratory medicine in low-income and middle-income countries: progress and challenges
10.1016/s0140-6736(18)30308-8 · ExternalCitation · doi-reference
Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019
10.1016/s1473-3099(22)00510-2 · ExternalCitation · doi-reference
Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021
10.1016/s1473-3099(24)00176-2 · ExternalCitation · doi-reference
The potential of saliva as an accessible and sensitive sample type for the detection of respiratory pathogens and host immunity
10.1016/s2666-5247(23)00135-0 · ExternalCitation · doi-reference
Associations of faecal microbiota with influenza-like illness in participants aged 60 years or older: an observational study
10.1016/s2666-7568(20)30034-9 · ExternalCitation · doi-reference
The mucosal immune system in the oral cavity—an orchestra of T cell diversity
10.1038/ijos.2014.48 · ExternalCitation · doi-reference
A communal catalogue reveals Earth’s multiscale microbial diversity
10.1038/nature24621 · ExternalCitation · doi-reference
The microbiota of the respiratory tract: gatekeeper to respiratory health
10.1038/nrmicro.2017.14 · ExternalCitation · doi-reference
Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis
10.1038/s41467-019-13036-1 · ExternalCitation · doi-reference
Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination
10.1038/s41467-022-35165-w · ExternalCitation · doi-reference
Mucosal vaccines — fortifying the frontiers
10.1038/s41577-021-00583-2 · ExternalCitation · doi-reference
Transmissibility and transmission of respiratory viruses
10.1038/s41579-021-00535-6 · ExternalCitation · doi-reference
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample
10.1073/pnas.1000080107 · ExternalCitation · doi-reference
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
10.1084/jem.20230911 · ExternalCitation · doi-reference
Identification of biomarkers for disease severity in nasopharyngeal secretions of infants with upper or lower respiratory tract viral infections
10.1093/cei/uxac083 · ExternalCitation · doi-reference
Persistence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 in Relation to Symptoms in a Nationwide Prospective Study
10.1093/cid/ciab172 · ExternalCitation · doi-reference
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
10.1093/nar/gks1219 · ExternalCitation · doi-reference
Identification of Respiratory Viruses in Asymptomatic Subjects: Asymptomatic Respiratory Viral Infections
10.1097/inf.0b013e31817e695d · ExternalCitation · doi-reference
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
10.1111/j.2517-6161.1995.tb02031.x · ExternalCitation · doi-reference
Naïve Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
10.1128/aem.00062-07 · ExternalCitation · doi-reference
Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform
10.1128/aem.01043-13 · ExternalCitation · doi-reference
Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA
10.1128/aem.59.3.695-700.1993 · ExternalCitation · doi-reference
Immunoglobulins in Nasal Secretions of Healthy Humans: Structural Integrity of Secretory Immunoglobulin A1 (IgA1) and Occurrence of Neutralizing Antibodies to IgA1 Proteases of Nasal Bacteria
10.1128/cdli.7.1.31-39.2000 · ExternalCitation · doi-reference
Development and Standardization of a High-Throughput Multiplex Immunoassay for the Simultaneous Quantification of Specific Antibodies to Five Respiratory Syncytial Virus Proteins
10.1128/msphere.00236-19 · ExternalCitation · doi-reference
The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract
10.1152/physrev.00020.2023 · ExternalCitation · doi-reference
Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure
10.1164/rccm.201712-2567oc · ExternalCitation · doi-reference
Small-volume detection: platform developments for clinically-relevant applications
10.1186/s12951-021-00852-1 · ExternalCitation · doi-reference
Diagnostic testing preferences can help inform future public health response efforts: Global insights from an international survey
10.1371/journal.pgph.0003547 · ExternalCitation · doi-reference
phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
10.1371/journal.pone.0061217 · ExternalCitation · doi-reference
Evaluation of Four Commercial Multiplex Molecular Tests for the Diagnosis of Acute Respiratory Infections
10.1371/journal.pone.0130378 · ExternalCitation · doi-reference
Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash
10.1371/journal.pone.0169805 · ExternalCitation · doi-reference
Multi-Omics Factor Analysis—a framework for unsupervised integration of multi-omics data sets
10.15252/msb.20178124 · ExternalCitation · doi-reference
Implementing a Class of Permutation Tests: The coin Package
10.18637/jss.v028.i08 · ExternalCitation · doi-reference
Secretory IgA: Designed for Anti-Microbial Defense
10.3389/fimmu.2013.00222 · ExternalCitation · doi-reference
Editorial: Immunoregulation at mucosal surfaces
10.3389/fimmu.2022.983201 · ExternalCitation · doi-reference
Reducing bias in microbiome research: Comparing methods from sample collection to sequencing
10.3389/fmicb.2023.1094800 · ExternalCitation · doi-reference
Oral Dysbiosis in Severe Forms of Periodontitis Is Associated With Gut Dysbiosis and Correlated With Salivary Inflammatory Mediators: A Preliminary Study
10.3389/froh.2021.722495 · ExternalCitation · doi-reference
Immune Tolerance in the Oral Mucosa
10.3390/ijms222212149 · ExternalCitation · doi-reference
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
10.3791/56413 · ExternalCitation · doi-reference
