References

Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes

10.1001/jama.2013.276305 · ExternalCitation · doi-reference

Diabetes mellitus exacerbates post-myocardial infarction heart failure by reducing sarcolipin promoter methylation

10.1002/ehf2.12789 · ExternalCitation · doi-reference

Free Radicals in Health and Disease

10.1002/mco2.70396 · ExternalCitation · doi-reference

Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

10.1007/s00125-019-05043-0 · ExternalCitation · doi-reference

Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats

10.1007/s00125-020-05333-y · ExternalCitation · doi-reference

Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models

10.1007/s12035-018-1195-5 · ExternalCitation · doi-reference

Relation of Copeptin with Diabetic and Renal Function Markers Among Patients with Diabetes Mellitus Progressing Towards Diabetic Nephropathy

10.1016/j.arcmed.2020.05.018 · ExternalCitation · doi-reference

Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation

10.1016/j.bbadis.2021.166238 · ExternalCitation · doi-reference

Endoplasmic reticulum stress and unfolded protein response: Roles in skeletal muscle atrophy

10.1016/j.bcp.2025.116799 · ExternalCitation · doi-reference

Dual role of macrophages in skeletal muscle atrophy: Mechanisms and therapeutic strategies

10.1016/j.bcp.2025.117589 · ExternalCitation · doi-reference

The cGAS-STING signaling pathway: A central regulator and novel therapeutic target in skeletal muscle pathophysiology

10.1016/j.bcp.2026.117854 · ExternalCitation · doi-reference

Network of cell death in myocardial ischemia-reperfusion injury: mechanisms and targeted therapeutic strategies

10.1016/j.bcp.2026.117999 · ExternalCitation · doi-reference

Mechanisms and therapeutic potential of the cGAS-STING signaling pathway in macrophage activation and polarization

10.1016/j.bcp.2026.118031 · ExternalCitation · doi-reference

The central role of endoplasmic reticulum stress in Parkinson’s diseas e and targeted therapeutic strategies

10.1016/j.bcp.2026.118218 · ExternalCitation · doi-reference

Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells

10.1016/j.cbi.2014.10.007 · ExternalCitation · doi-reference

Urinary kidney injury molecule-1 in renal disease

10.1016/j.cca.2018.09.011 · ExternalCitation · doi-reference

Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism

10.1016/j.cmet.2020.10.019 · ExternalCitation · doi-reference

A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice

10.1016/j.kint.2018.05.002 · ExternalCitation · doi-reference

Plasma endostatin predicts kidney outcomes in patients with type 2 diabetes

10.1016/j.kint.2018.09.019 · ExternalCitation · doi-reference

Receptor activator of NF-κB mediates podocyte injury in diabetic nephropathy

10.1016/j.kint.2021.04.036 · ExternalCitation · doi-reference

Legacy effect of intensive glucose control on major adverse cardiovascular outcome: Systematic review and meta-analyses of trials according to different scenarios

10.1016/j.metabol.2020.154308 · ExternalCitation · doi-reference

One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

10.1016/j.molcel.2019.06.039 · ExternalCitation · doi-reference

Insulin in the brain: there and back again

10.1016/j.pharmthera.2012.07.006 · ExternalCitation · doi-reference

Diabetic peripheral neuropathy: current perspective and future directions

10.1016/j.phrs.2013.12.005 · ExternalCitation · doi-reference

Management of inflammation in cardiovascular diseases

10.1016/j.phrs.2021.105912 · ExternalCitation · doi-reference

Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications

10.1016/j.phrs.2022.106135 · ExternalCitation · doi-reference

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

10.1016/j.redox.2018.02.013 · ExternalCitation · doi-reference

Serine and glycine metabolism in cancer

10.1016/j.tibs.2014.02.004 · ExternalCitation · doi-reference

Diabetic retinopathy

10.1016/s0140-6736(09)62124-3 · ExternalCitation · doi-reference

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

10.1016/s0140-6736(19)30772-x · ExternalCitation · doi-reference

Effects on the incidence of cardiovascular events of the addition of p ioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

10.1016/s2213-8587(17)30317-0 · ExternalCitation · doi-reference

Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIOR ITY): a prospective observational study and embedded randomised placebo-controlled trial

10.1016/s2213-8587(20)30026-7 · ExternalCitation · doi-reference

Vascular endothelial cells synthesize nitric oxide from L-arginine

10.1038/333664a0 · ExternalCitation · doi-reference

Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cel l apoptosis and diabetic retinopathy

10.1038/nm.2052 · ExternalCitation · doi-reference

Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics

10.1038/s41380-023-02066-3 · ExternalCitation · doi-reference

Knockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy

10.1038/s41419-021-03750-4 · ExternalCitation · doi-reference

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

10.1038/s41467-019-09735-4 · ExternalCitation · doi-reference

Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy

10.1038/s41467-022-29060-7 · ExternalCitation · doi-reference

Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast

10.1038/s41467-022-33052-y · ExternalCitation · doi-reference

Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes

10.1038/s41588-020-0615-4 · ExternalCitation · doi-reference

Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles

10.1038/s41598-020-64349-x · ExternalCitation · doi-reference

Specific PKC βII inhibitor: one stone two birds in the treatment of di abetic foot ulcers

10.1042/bsr20171459 · ExternalCitation · doi-reference

Ectopic lipid accumulation: potential role in tubular injury and inflammation in diabetic kidney disease

10.1042/cs20180702 · ExternalCitation · doi-reference

10-year follow-up of intensive glucose control in type 2 diabetes

10.1056/nejmoa0806470 · ExternalCitation · doi-reference

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

10.1056/nejmoa1504720 · ExternalCitation · doi-reference

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

10.1056/nejmoa1603827 · ExternalCitation · doi-reference

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

10.1056/nejmoa1611925 · ExternalCitation · doi-reference

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

10.1056/nejmoa1811744 · ExternalCitation · doi-reference

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

10.1056/nejmoa1812389 · ExternalCitation · doi-reference

Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

10.1056/nejmoa1901118 · ExternalCitation · doi-reference

Dapagliflozin in Patients with Chronic Kidney Disease

10.1056/nejmoa2024816 · ExternalCitation · doi-reference

Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood-brain barrier

10.1093/eurheartj/ehaa207 · ExternalCitation · doi-reference

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

10.1093/eurheartj/ehaa898 · ExternalCitation · doi-reference

Panvascular medicine: an emerging discipline focusing on atherosclerotic diseases

10.1093/eurheartj/ehac448 · ExternalCitation · doi-reference

Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® tri al

10.1093/eurheartj/ehv728 · ExternalCitation · doi-reference

JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: result s from a Phase 2 randomized controlled clinical trial

10.1093/ndt/gfx377 · ExternalCitation · doi-reference

Associations of urinary epidermal growth factor and monocyte chemotactic protein-1 with kidney involvement in patients with diabetic kidney disease

10.1093/ndt/gfy314 · ExternalCitation · doi-reference

Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway

10.1096/fj.202002247rr · ExternalCitation · doi-reference

Potential mechanisms of metabolic reprogramming induced by ischemia-reperfusion injury in diabetic myocardium

10.1111/1753-0407.70018 · ExternalCitation · doi-reference

Retinal and circulating miRNA expression patterns in diabetic retinopathy: An in silico and in vivo approach

10.1111/bph.14665 · ExternalCitation · doi-reference

AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy

10.1111/cns.70657 · ExternalCitation · doi-reference

Ten-year observational follow-up of PROactive: a randomized cardiovascular outcomes trial evaluating pioglitazone in type 2 diabetes

10.1111/dom.12608 · ExternalCitation · doi-reference

Modulation of human monocyte CD36 by type 2 diabetes mellitus and other atherosclerotic risk factors

10.1111/j.1365-2362.2011.02475.x · ExternalCitation · doi-reference

Arginase inhibition improves endothelial function in patients with familial hypercholesterolaemia irrespective of their cholesterol levels

10.1111/joim.12461 · ExternalCitation · doi-reference

Compartmentalization of Mammalian folate-mediated one-carbon metabolism

10.1146/annurev.nutr.012809.104810 · ExternalCitation · doi-reference

ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria i n VEGF signaling and angiogenesis

10.1152/ajpcell.00346.2016 · ExternalCitation · doi-reference

Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases

10.1152/ajpheart.00201.2016 · ExternalCitation · doi-reference

Protein glycation: a firm link to endothelial cell dysfunction

10.1161/01.res.0000137876.28454.64 · ExternalCitation · doi-reference

Oxidative stress and diabetic complications

10.1161/circresaha.110.223545 · ExternalCitation · doi-reference

Evaluation of Glomerular Hemodynamic Function by Empagliflozin in Diabetic Mice Using In Vivo Imaging

10.1161/circulationaha.118.037418 · ExternalCitation · doi-reference

Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure

10.1161/circulationaha.120.049606 · ExternalCitation · doi-reference

Improved arterial compliance by a novel advanced glycation end-product crosslink breaker

10.1161/hc3801.097806 · ExternalCitation · doi-reference

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

10.1172/jci18127 · ExternalCitation · doi-reference

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

10.1172/jci59903 · ExternalCitation · doi-reference

Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice

10.1186/s12933-016-0408-3 · ExternalCitation · doi-reference

Urinary small extracellular vesicles derived CCL21 mRNA as biomarker l inked with pathogenesis for diabetic nephropathy

10.1186/s12967-021-03030-x · ExternalCitation · doi-reference

The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

10.1186/s12974-019-1638-6 · ExternalCitation · doi-reference

TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus

10.1186/s12974-019-1688-9 · ExternalCitation · doi-reference

Endogenous asymmetric dimethylarginine accumulation contributes to the suppression of myocardial mitochondrial biogenesis in type 2 diabetic rats

10.1186/s12986-020-00486-4 · ExternalCitation · doi-reference

Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes

10.1212/wnl.0000000000004586 · ExternalCitation · doi-reference

Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease

10.1681/asn.2016101101 · ExternalCitation · doi-reference

A Ternary Synergistic eNOS Gene Delivery System Based on Calcium Ion and L-Arginine for Accelerating Angiogenesis by Maximizing NO Production

10.2147/ijn.s363168 · ExternalCitation · doi-reference

Impaired Amino Acid and TCA Metabolism and Cardiovascular Autonomic Neuropathy Progression in Type 1 Diabetes

10.2337/db19-0145 · ExternalCitation · doi-reference

Epigenetic Mechanisms in Diabetic Vascular Complications and Metabolic Memory: The 2020 Edwin Bierman Award Lecture

10.2337/dbi20-0030 · ExternalCitation · doi-reference

Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study

10.2337/dc20-0892 · ExternalCitation · doi-reference

The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes

10.2337/dc20-2684 · ExternalCitation · doi-reference

Prediction of Major Adverse Cardiovascular Events From Retinal, Clinic al, and Genomic Data in Individuals With Type 2 Diabetes: A Population Cohort Study

10.2337/dc21-1124 · ExternalCitation · doi-reference

Effects of sorbinil on glomerular structure and function in long-term- diabetic rats

10.2337/diab.38.7.839 · ExternalCitation · doi-reference

Mitochondria, endothelial cell function, and vascular diseases

10.3389/fphys.2014.00175 · ExternalCitation · doi-reference

The Role of Aldose Reductase in Beta-Amyloid-Induced Microglia Activation

10.3390/ijms232315088 · ExternalCitation · doi-reference

Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications

10.3390/ijms26073016 · ExternalCitation · doi-reference

The Dual Role of Interleukin-6 in the Pathophysiology of Skeletal Muscle: Mechanisms, Challenges, and Therapeutic Prospects

10.3390/ph19060868 · ExternalCitation · doi-reference

Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model

10.7150/thno.16803 · ExternalCitation · doi-reference

METTL3-mediated N6-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication

10.7150/thno.63441 · ExternalCitation · doi-reference